• Molecular & Cellular Toxicology
• /
• v.2 no.3
• /
• pp.185-192
• /
• 2006

To elucidate the molecular mechanisms associated with early renal injury induced by gentamicin, the most commonly used antibiotics worldwide in the treatment of Gram-negative bacterial infections. We have identified genes differentially expressed at different duration of gentamicin administration. C57BL/6 female mice were treated daily with gentamicin (20 mg/kg, 100 mg/kg, and 200mg/kg) for 7 days and then sacrificed at day 1, 3, and 7 after administration. Standard blood biochemistry and histopathological observation indicative of nephrotoxicity were made. Total RNA was extracted from the kidney for microarray analysis using Affymetrix $GeneChip^{\circledR}$. Five hundred and seventy eight genes were identified as being either up-or down-regulated over 2-fold changes during early renal injury (p<0.05) and were analyzed by hierarchical clustering. The results showed that the genes involved in early immune responses were differentially regulated during early renal injury. Principal component analysis (PCA) confirmed sample separation according to the degree of renal toxicity. In addition, we identified two potential biomarkers that may predict early renal toxicity. This data may contribute to elucidate of the genetic events during early renal injury and to discover the potential biomarkers for nephrotoxicity induced by gentamicin.

• Molecular & Cellular Toxicology
• /
• v.1 no.4
• /
• pp.237-247
• /
• 2005

Several features of the implant surface, such as roughness, topography, and composition play a relevant role in implant integration with bone. This study was conducted in order to determine the effects of various thin layer hydroxyapatite (HA) coatings on anodized Ti surfaces on the biological responses of a human osteoblast-like cell line (MG63). MG63 cells were cultured on A (100 nm HA coating on anodized surface), B (500-700 nm HA coating on anodized surface), C ($1{\mu}m$ HA coating on anodized surface), and control (non HA coating on anodized surface) Ti. The morphology of these cells was assessed by SEM. The cDNAs prepared from the total RNAs of the MG63 were hybridized into a human cDNA microarray (1,152 elements). The appearances of the surfaces observed by SEM were different on each of the four dental substrate types. MG63 cells cultured on A, C and control exhibited cell-matrix interactions. It was B surface showing cell-cell interaction. In the expression of several genes were up-, and down-regulated on the different surfaces. The attachment and expression of key osteogenic regulatory genes were enhanced by the surface morphology of the dental materials used.

• Asian Journal of Innovation and Policy
• /
• v.9 no.2
• /
• pp.187-206
• /
• 2020

Under the on-going evolution of the COVID-19 pandemic, estimating the economic impact of the pandemic is highly uncertain and challenging. This situation makes it difficult for policymakers, governors, and economic entities to formulate appropriate responses and decision makings. To provide useful information about the effect of the COVID-19 pandemic on the Korean economy, this study examined macroeconomic impact analysis stemming from the pandemic shocks with different scenarios for the Korean economy. Based on three scenarios using the growth rate of 2020 GDP and consumer expenditure patterns, the 2021 GDP by industry sector was forecast with two new approaches. First, the recovering process of the Korean economy from the shock was analyzed by applying a Flex-IO method. Second, a new forecasting approach combined with an IO coefficient matrix was applied to forecast the future GDP changes. The findings of this study are summarized as follows: First, the total GDP growth rate under the Pessimistic Scenario demonstrates less rebound from the shock than that of the Base Scenario. Second, agriculture, culture, and tourism-related sectors that are suffering from the severe losses of COVID-19 showed lower resilience than other different industries. Third, information and communications technology (ICT) industry maintains a stable growth trend and is expected to take the leading role for the Korean economy in the post-COVID-19 and the Industry 4.0 eras. The findings deliver that it needs to analyze how government expenditure responding the shock into the forecasting model, which can be more useful and reliable to simulate the resilience from the pandemic.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.34 no.3
• /
• pp.239-245
• /
• 1989

This experiment was conducted to study the physiological and ecological responses of agronomic characters related to source and sink relation in rice. Standard deviation and coefficient of variability of agronomic characters by individual tiller were greatly influenced by the lower internodes in the length of internode, flag leaf in the leaf blade, lower leaf blade in the leaf width, and the number and spikelets of secondary rachis branch in panicle. In relation to the parts of source and sink of rice plant and the number of spikelet in panicle, the number of spikelet was significantly correlated with the length and leaf area of second leaf blade, the length of second internode, and culm diameter of third internode. The correlation of the length of panicle with the length of internode and leaf blade was greatly influenced by the length of second leaf blade and second internode. The number of spikelet was increased with increasing the second rachis branch rather than first rachis branch. The content of total inorganic nutrients was greatest at leaf blade followed by leaf sheath and internode, and panicle.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.35 no.7
• /
• pp.721-735
• /
• 2011

This study: 1) identifies differences in consumers' perceived similarity of extended products to their parent product in terms of brand attributes, 2) identifies the influence of the perceived similarity on consumer's attitude toward and purchase intention of extended products (i.e., brand extension effect), and 3) examines the moderating effect of Brand Relationship Quality (BRQ) on brand extension effects. A survey questionnaire was distributed to a convenience sample of individuals aged 20-39. A total of 576 valid responses were used for the final analysis. The results showed that: 1) the consumers perceived more similarity in the extended products when the extended products maintain more consistent attributes with their parent product, 2) the higher the perceived similarity was then the higher the brand extension effect, and 3) brand relationship quality moderated the influence of perceived similarity on attitude and purchase intention. When consumers build a high relationship quality with a brand, then the brand extension effect is likely to be high regardless of the perceived similarity of the extended products. This study consequently has its own contribution in that it empirically examined the brand extension effect in the fashion field and evidenced the role of BRQ in brand extension.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.38 no.2
• /
• pp.216-230
• /
• 2014

The importance of the Chinese fashion market is increasing; therefore, this study investigates the possibility of implementing a Word-of-Mouth (WOM) marketing strategy among Chinese students in Korea. This study examines the effects of consumer characteristics (similarity, opinion leadership, and fashion innovativeness), awareness of Korean fashion brands, satisfaction with Korean fashion products on WOM experiences and WOM behavior (off-line as well as on-line). A total of 161 responses from Chinese students in Korea were gathered and analyzed using SPSS 20.0 for descriptive statistics, factor analysis, and regression analysis. The results show that consumer characteristics (except similarity) significantly influence WOM experiences, opinion leadership influence off-line WOM behavior, and fashion innovativeness influence online WOM behavior. However, similarity has no influence on WOM experiences and WOM behavior. Second, Korean brand awareness affect both WOM experiences and behavior; however, satisfaction with Korean fashion products only affected WOM experiences. This study showed the feasibility of conducting a WOM marketing strategy using the WOM effects of Chinese students in Korea. The study may help the Korean apparel industries establish an entry strategy for the Chinese market.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.44 no.1
• /
• pp.33-52
• /
• 2020

Some consumers question the safety of imported fashion products. We examine the effects of the use of an ecolabel, product category, and country of origin on consumer responses such as perceived physical risk, attitude towards a product, subjective norm, and intention to purchase imported fashion products. A sample of 508 adults in their 30s to 40s participated in online survey experiments. The survey experiments used 2 (the use of the ecolabel vs no label) × 4 (country of origin: China, Dominican Republic, Norway, and the United States) between-subjects and 4 (product category: men/women's wear, children's wear, underwear, and accessories) within-sub-jects factorial design. A total of 32 product-catalog images (stimuli) and eight versions of the questionnaire were developed. The use of the ecolabel is identified as having a significantly lower perceived physical risk than the no-label. The consumers' perceived physical risk also differs depending on product category and country of origin. Consumers perceive a higher physical risk about children's wear and underwear than other product categories as well as fashion products sourced from developing countries than from developed countries. The reduction of physical risk is found to facilitate consumers' purchase decision-making process.

• Journal of Food Hygiene and Safety
• /
• v.2 no.2
• /
• pp.57-65
• /
• 1987

ABSTRACT - To examine antihypertensive components of Ganoderma lucidum in Korea, two kinds of fruiting bodies (J and K) were used for extraction with water and the extracts were purified by ethanol precipitation and dialysis. Three fractions, i.e., the aqueous total extract(A), the ethanol supernatant(B} and the purified precipitate(C), were compared for antihypertensive activity in anesthetized spontaneously hypertensive rats (SUR). Although fractions A and B showed the activity, fraction C did not. Particularly, fraction B of sample K produced 44.3% reduction in diastolic blood pressure and 30.6% reduction in heart rate after i.v. administration of a dose of 10 mg/kg. Direct effects of this fraction B to the heart were observed in the isolated blood perfused heart preparation of the dog. It induced positive chronotropic and inotropic responses dose-dependently in the case of sample J. In the case of sample K, marked chronotropic and inotropic effects on atrial muscle but not on ventricular muscle were induced. In both samples, coronary blood flow (CBF) was dose-relatedly increased.reased.

• Journal of Life Science
• /
• v.15 no.3 s.70
• /
• pp.382-386
• /
• 2005

To investigate the effects of simulated acid rain (SAR) on growth and biochemical defense responses of plant, garden balsam (Impatiens balsamina L.) was subjected to four levels of SAR based on pH (5.6, 4.0, 3.0, 2.0) and placed in the growth chambers for 2 weeks. SAR drastically inhibited both height and dry weight of garden balsam. The content of total carotenoid was tended to decrease, but the level of malondialdehyde was significantly increased by SAR. As the pH levels decreased from 5.6 to 2.0, the content of dehydroascorbate and oxidized glutathione of the plant were significantly increased. The enzyme (superoxide dismutase, ascorbate peroxidase etc.) activities of the plant affected by SAR were increased as the pH decreased. The results indicate that garden balsam may receive oxidative stresses by the application of SAR and by which the plant growth can be significantly retarded. A biochemical protective mechanism might be activated to nullify the oxidative stresses generated through SAR.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.4
• /
• pp.698-709
• /
• 2016

Career maturity and the acquisition of entrepreneurial knowledge are important in entrepreneurship education for youth, and the environments surrounding youths influence their mental state and academic achievement. This study aims to analyze the influences of an educational program and environment in entrepreneurship education for youths on the mindset and the entrepreneurial intention for proper career decisions according to the education climate and entrepreneurial knowledge. A total of 216 questionnaires were collected from students who participated in a creative and entrepreneurial tour of Incheon. After excluding 30 questionnaires with unreliable responses, 186 were empirically analyzed using SPSS 18.0 and Amos 18.0. The results show that the quality of education service and education environment decide the education climate, and the entrepreneurial knowledge has a positive influence on entrepreneurial intention. This research is significant because it strategically establishes directions for entrepreneurial education and as practical research for achieving outcomes of entrepreneurial education.