• 한국컴퓨터정보학회논문지
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• 제23권10호
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• pp.135-141
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• 2018

In this paper, we propose to evaluate the effect of resistin-like molecule alpha ($Relm{\alpha}$) on the progression of anemia of inflammation. Anemia of inflammation is a common feature of inflammatory disorders, including chronic kidney disease, infections, and rheumatoid arthritis. $Relm{\alpha}$ is highly up-regulated in various inflammatory states, especially those involving asthma, intestinal inflammation, and parasitic diseases, and regulates the pathogenesis of those diseases. However, the role of $Relm{\alpha}$ in anemia of inflammation is unknown. To explore the roles of $Relm{\alpha}$ in anemia of inflammation in vivo, we generated mouse model of the disease by injecting 0.25 mg/kg lipopolysaccharides (LPS) intraperitoneally into $Relm{\alpha}-deficient$ and wild-type (WT) mice daily for 10 days. Research data was expressed as differences between LPS-treated $Relm{\alpha}-deficient$ and WT mice by a two-tailed non-parametric Mann-Whitney U-test using GraphPad Instat program. The results of the study are as follows: LPS-treated $Relm{\alpha}-deficient$ mice had significantly (p<0.05) lower hemoglobin contents, hematocrit levels and red blood cell indices including mean corpuscular volume, mean corpuscular hemoglobin than WT controls. This decrease was accompanied by significant (p<0.05) increase in total white blood cell and monocyte counts in the blood. However, there was no significant difference in mRNA levels of hepatic hepcidin and renal erythropoietin between the two animal groups. Taken together, these results indicates that $Relm{\alpha}$ deficiency exacerbates the anemia by increasing inflammation, suggesting therapeutic value of $Relm{\alpha}$ in the treatment of anemia of inflammation.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2017년도 제48회 춘계학술대회논문집
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• pp.838-842
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• 2017

위성용 단일추진제 시스템에 적용되는 핵심부품 중 하나인 추력기 밸브는 솔레노이드 방식을 이용하여 추진제를 공급/차단한다. 밸브에 장착되는 원형 판스프링은 마찰과 반복운동에 의한 위치변형 및 파티클이 없다. 본 연구에서는 원형 판스프링 소재, 두께, 반경을 고정변수로 원형 판스프링 내부 패턴의 너비를 설계변수로 설정하여 유한요소해석 및 검증시험을 하였다. 시험결과 변위에 따른 스프링 상수 k가 선형적인 특성이 나타났다. 원형 판스프링 총면적에 따른 스프링력의 경향성을 통해 원형 판스프링의 설계가 가능함을 확인하였다.

• 한국자원식물학회지
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• 제28권4호
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• pp.400-410
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• 2015

Juniperus chinensis (Cupressaceae) is a valuable woody plant resource, but this rare plant is only distributed in restricted regions in Korea. In this study, we surveyed the geographic distribution regions, variation of sex ratio and the dynamics of natural populations of J. chinensis. in order to establish conservation strategies for the sustainable conservation of this important resource tree. The 17 natural populations of J. chinensis are restrictively distributed in the shore cliffs of (1) Ulleungdo island, (2) Gyeongju-si to Gangneung-si of the eastern coast, the riverside cliff along (3) Donggang-river of Jungsun-gun and Pyeongchang-gun and (4) branch of Nakdonggang-river in Uiseong-gun. The populations in Ulleungdo island showed continuous population distribution of over 200 individuals, but populations in other regions had discontinuous population distribution of under 200. The population of J. chinensis surveyed in Korea was estimated in ca. 3,200 individuals. The sex ratio (male/female) among populations of J. chinensis was diverse with variation from 0.46~1.67 range, but showed no significance. The sex ratio of the total individuals by species level was 0.74, and the percentage of female tree was significantly higher than the male. The results of dynamics analysis within population among regions showed that seedlings and saplings of J. chinensis in three regions surveyed were continuously regenerating. The distribution of DBH class showed a stable population structure of inverse J shape graph, but fragmentation and decrease in populations because of invading broad-leaved shrubs and trees from the surroundings were concerned. Further studies, and in situ and ex situ conservation strategies for the sustainable conservation on natural populations of this rare resources woody plant, J. chinensis in Korea are recommended.

• 한국정보처리학회논문지
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• 제5권8호
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• pp.1997-2012
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• 1998

병렬 시스템에서 순차 자바 프로그램을 재 사용할 수 있기 위해서는 자바 프로그램 내에 존재하는 병렬성을 찾아내는 것이 중요하다. 자바 프로그램을 병렬 시스템에서 실행할 경우 루프는 전체 수행 시간 중 많은 부분을 차지하므로 병렬성 검출의 기본이 되지만 데이터 종속으로 인하여 완전한 병렬 수행을 쉽게 이룰 수 없다. 따라서, 본 논문은 기존의 중첩 루프 구조를 갖는 자바 프로그래밍에서 데이터 종속성 분석에 의한 종속 그래프를 구성하여 묵시적 병렬성을 검출하는 방법을 제안한다. 또한 재구성 컴파일러에 의하여 자바 원시 프로그램을 자바 프로그래밍 언어 자체에서 지원하는 다중스레드 기법으로 변환하여 병렬 시스템에서 실행하는 방법을 제안한다. 스레드 문장으로 변환된 프로그램에 대해 루프의 반복계수와 스레드 수를 매개변수로 하여 성능 분석을 하였다. 재구성 컴파일러에 의한 장점은 사용자의 병렬성 검출에 대한 오버해드를 줄이고, 순차 자바 프로그램에 대한 효과적인 병렬성 검출을 가능하게 하여 병렬 시스템에서 실행 시간을 단축할 수 있다.

• 한국토양비료학회지
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• 제33권2호
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• pp.79-84
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• 2000

주요 과수재배지 토양에 대한 화학적 독성을 파악하기 위하여 사과 239, 배 369, 포도 168, 복숭아 101, 합계 877포장에서 주간 중간지점의 토양을 채취분석하여 토양화학적 특성에 따라 토양비옥도를 구분하였다. 주요 과수 주산단지 토양화학성분의 적정수준 비율은 3.0~65.2%로서 대부분의 과수원이 부적지였으며 토양층위별 화학성분은 하층으로 내려 갈수록 일정하게 감소되는 경향을 보여 시비관리가 동일한 지역에서는 표층토 20cm 깊이의 토양 화학성분 함량만 알면 층토의 성분함량을 추정할 수 있으며 또한 과종별 표토의 토양화학성분함량의 과부족율을 추정할 수 있었다.

• Journal of Preventive Medicine and Public Health
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• 제52권2호
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• pp.101-108
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• 2019

Objectives: To objectively determine and compare the physical activity (PA) levels of adults newly diagnosed with type 2 diabetes (T2D) and adults without T2D in Vietnam using an accelerometer. Methods: A total of 120 participants with newly diagnosed T2D and 120 adults without T2D were recruited from a large hospital in Hanoi, the capital city of Vietnam. All participants wore an ActiGraph GT3X accelerometer for at least 5 days, including 1 weekend day. Freedson cut-off points were used to estimate different intensities of PA. In addition, comparisons between groups were made with respect to achieving the World Health Organization (WHO) and International Diabetes Federation (IDF) recommended PA guidelines. Results: Men with T2D had significantly lower levels of PA than men without T2D. The respective multivariable-adjusted mean values of daily step count, daily light-intensity, moderate-intensity, and moderate-to-vigorous-intensity PA were approximately 14%, 19%, and 22% lower in the men with T2D than in their non-T2D counterparts. However, women with T2D accumulated a greater number of steps per day than women without T2D. Only 59.2% of the adults with T2D met the minimum recommended level of PA (WHO and IDF), compared to 74.2% of adults without T2D (p<0.05). After adjusting for potential confounders, participants with T2D experienced 50.0% significantly lower odds of achieving PA recommendations. Conclusions: Vietnamese men with T2D were less physically active than those without T2D, and adults with T2D were less likely to meet PA guidelines. The results suggest a need for integrating PA into the self-management of this chronic condition.

• Archives of Plastic Surgery
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• 제49권3호
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• pp.462-470
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• 2022

Background Reactive oxygen species cause serious damage to the physiological function of tissues. Determination of total antioxidant capacity of skin tissue is one of the determinants of damaged tissue function. Mast cells (MCs) are one of the groups of cells that are invited to the site of injury. The healing process begins with the rapid release of various types of MCs' intermediate factors at the site of injury. Bone marrow mesenchymal stem cell (BMMSC) production and secretion have been shown to regenerate the skin. The aim of this research was to evaluate the wound-healing and antioxidant effects of BMMSCs per MCs. Methods Fifty-four albino Wistar male rats were divided into three groups: (1) nonsurgery, (2) surgery, and (3) surgery + BMMSCs. Groups 2 and 3 were operated with a 3 × 8 cm flap and in group 3, cell injections (7 × 10⁹ cell injection at the time of surgery) were performed. After days 4, 7, and 15, percentage of the surviving tissue, histological characteristics, superoxide dismutase (SOD) activity, and amount of malondialdehyde (MDA) were measured in the groups. For results, Graph Pad Prism 8 software was used, and data were analyzed and compared by analysis of variance and Tukey test. Results BMMSCs' application decreased the amount of MDA, increased SOD activity and survival rate of the flaps, and improved the histological characteristics. Conclusion This study revealed the protective effects BMMSCs alongside MCs against oxidative stress on the survival of the flaps. However, for clinical use, more research is needed to determine its benefits.

• 척추신경추나의학회지
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• 제17권2호
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• pp.131-139
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• 2022

Objectives This study aimed to analyze the medical utilization of low back pain (LBP) patients after back surgery and estimate the medical costs of Korean and Western medicine collaborative treatment, odds ratio, and hazard ratio between the two groups using the 2019 Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS-2019). Methods Data management and descriptive analysis, logistic regression, and survival analysis were conducted for defining and estimating the LBP patients after back surgery in the NPS 2019 dataset. Results A total of 216,424 patients out of 991,189 were identified as having LBP. Among the patients with LBP, 1,734 were treated with surgery while 214,690 were not. Among those who had surgery, 937 were treated with conventional treatments only and 797 underwent Korean medicine treatments. The odds ratio of the logistic regression analysis was 0.7129, suggesting that Korean medical treatment experience group had a 28.7% lower risk of reoperation than the Western medical treatments only group. The hazard ratio of the survival analysis was 0.9145; thus, the risk probability of reoperation was estimated to be approximately 8.55% lower. The 50% risk of reoperation was 69 days (0.5044) for the conventional group, and 97 days (0.5008) for the Korean medical group in the survival analysis using the Kaplan-Meier graph. Conclusions These results could be utilized in future studies in conducting economic evaluation for estimating cost-effectiveness of Western medicine and Korean medicine treatment compared to Western medicine alone in LBP patients after back surgery in a South Korean perspective. mended and should be applied while taking the necessary precautions.

• Mass Spectrometry Letters
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• 제14권2호
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• pp.42-47
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• 2023

Carthamus tinctorius L. (known as safflower) is a valuable oil plant whose importance is increasing rapidly in the world due to its high adaptation to arid regions. The seeds of this unique plant are especially used in edible oil, soap, paint, varnish and lacquer production. Its flowers are used in vegetable dye production and medicinal purposes beside its features as a coloring and flavoring in food. After the oil is removed, the remaining pulp and plant parts are used as animal feed, and dry straw residues are used as fuel. Beside all these features, its usage as a herbal medicinal plants for various diseases has gained importance on recent years. In this study, it was designed a plant metabolomic approach which transfers all the recent data processing strategies of untargeted metabolomics in clinical applications to the present study. Q-TOF LC/MS-based analysis of the extracts (70% ethanol, hexane, and chloroform) for both seed and flowers was performed using a C18 column (Agilent Zorbax 1.8 µM, 100 × 2.1 mm). Differences were observed in seed and fruit extracts and these differences were visualized using principal component analysis (PCA) plots. The total number and intersections of the peaks in the extracts were visualized using peak count comparison graph. Based on the experimental results, the number of the detected peaks for seeds was higher than the ones for the flowers for all solvent systems to extract the samples.

• Journal of Korea Trade
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• 제27권3호
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• pp.103-118
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• 2023

Purpose - This study aims to examine the dynamic relationship between the variables impacted by the Regional Comprehensive Economic Partnership (RCEP) and the level of intra-industry trade among member states, with the ultimate objective of deducing the short- and long-term effects of RCEP on trade. Design/methodology - This study focuses on tariffs, GDP growth rates, and the proportion of regional FDI to total FDI as research variables, and employs a panel vector autoregression model and GMM-style estimator to investigate the dynamic relationship between RCEP and intra-industry trade among member countries. Findings - The study finds that the level of intra-industry trade between member states is positively impacted by both tariffs and intra-regional FDI. The impulse response graph shows that tariffs and FDI within the region can promote intra-industry trade among member countries, with a quick response. However, the contribution rates of tariffs and intra-regional FDI are not particularly high at approximately 1.5% and 1.4%, respectively. In contrast, the contribution rate of GDP growth can reach around 8.5%. This implies that the influence of economic growth rate on intra-regional trade in industries is not only long-term but also more powerful than that of tariffs and intra-regional FDI. Originality/value - The originality of this study lies in providing a new approach to investigating the potential impact of RCEP while avoiding the limitations associated with the GTAP model. Additionally, this study addresses existing gaps within the research, further contributing to the research merit of the study.