• 셀메드
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• 제3권3호
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• pp.22.1-22.10
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• 2013

Traditional Chinese medicine (TCM) in single herb or formula prescription has been used for thousands of years. Many of them possess antioxidant activity and the activity may contribute the therapeutic effect. This paper would review the relationship of traditional herbal medicine and antioxidant with particular reference to ginseng. This medicinal herb has been used worldwide with extensive tonic effect. The comet assay, a technique for DNA protecting and damaging investigation would be introduced and the application of comet assay on TCM would be discussed.

• 한국식품위생안전성학회지
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• 제12권4호
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• pp.315-320
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• 1997

Panax ginseng C.A. Meyer has been extensively used in the traditional oriental medicine as a restorative, tonic and prophylatic agent. This study was devised to develop a chemopreventive agent from panax ginseng to be able to suppress the genotoxicity and oxidative damage by ractive oxygen species, which are involved with cancer or aging. Ginseng petroleum ether extract (GPE) and one of its fraction, P2, showed an antioxidative effect on the lipid peroxidiphenyl-2-picryl hydrazil (DppH) radical generation. They also showed the suppressive effect of H2O2 or KO2 induced DNA damage by single cell gel electrophoresis (SCGE). Results from our study indicate that GPE and P2 are capable of protecting lipid peroxidation, and oxidative DNA damage. Therefore, GPE and P2 may be useful chempreventive agents which are involved with cancer and aging.

• Pediatric Infection and Vaccine
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• 제4권1호
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• pp.155-159
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• 1997

We had experienced a case of pericarditis associated with Mycoplasma and Salmonella co-infection. This 5-year old boy presented with high fever and generalized tonic-clonic seizure. The diagnosis was based on the markedly increased serial titer of Widal test and cold agglutinin with Mycoplasma indirect hemmagglution test during hospitalization. The electrocardiogram revealed P-R interval prolongation and an echocardiogram revealed moderate pericardial effusion. The patient treated with ceftriaxone and erythromycin for 2 weeks, and responded to the treatment well. We report this case with brief review of the related literatures.

• 생약학회지
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• 제32권1호통권124호
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• pp.43-48
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• 2001

Epimedii Herba has been used for tonic, cardiotonic, impotency, amnestic and diuretic. Icariin, a main component was isolated from the Epimedii Herba and identified by the spectroscopic methods. In order to evaluate the quality of Epimedii Herba purchased from various regions of Korea, quantitative determination of icariin in Epimedii Herba using HPLC method has been conducted. Quantitative analysis showed the average amount of icariin in commercial 42 samples was 0.34% on the dry weight basis.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.289-289
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• 1994

흰쥐 적출 대동맥을 이용하여 혈관근의 $Na^{+}$/$Ca^{2+}$ 교환계의 기능과 성질을 구명코자 $Na^{+}$/$Ca^{2+}$ 교환계를 통한 수축 반응을 관찰하고 이때의 조직내 $Ca^{2+}$ 농도, cGMP 농도 및 이 수축에 대한 차단제와 저산소 처리의 영향을 조사하였다. 흰쥐 적출 대동맥은 $Na^{+}$ free 영양액하에서 수축반응을 일으켰고 이 수축 반응 ($Na^{+}$ free 수축반응)은 KCl 농도 증가에 비례하여 증가하였다. KCI 21.6mM 하의 $Na^{+}$ free유발 수축반응은 amiloride전처리하에서 용량-의존성으로 억제되었고 특히 tonic 수축반응이 예민하게 소실되었으며, benzamil과 verapamil 전처리하에서도 유의하게 억제되었다.

• 생약학회지
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• 제18권3호
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• pp.188-190
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• 1987

A triterpene glycoside was first isolated from berries of Rubus coreanus Miquel in the family of Rosaceae, which have been used as a tonic in chinese drug. The compound was identified as $28-{\beta}-D-glycopyranosyl$ ester of $2{\alpha},3{\beta},19{\alpha},23-tetrahydroxyurs-12-en-28-oic$ acid by IR, MS, $^{1}H-NMR$, $^{13}C-NMR$ spectra.

• 생약학회지
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• 제40권4호
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• pp.286-288
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• 2009

'SogDan(續斷)' is one of the crude drugs used mainly as a tonic and analgesic. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of SogDan from Korea, the anatomical characteristics of Phlomis umbrosa Turcz. and Phlomis koraiensis Nakai were studied. As a result, it was clarified that SogDan from Korea was the root of Phlomis umbrosa.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1994년도 춘계공동학술대회논문집; 창원대학교; 08월 09일 Apr. 1994
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• pp.394-398
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• 1994

The aim of the present study was to determine the influence of vibration frequency and muscle contraction level at constant vibration displacement amplitudes on a commonly observed motor response elicited by local vibratory stimulation, i.e., the Tonic Vibration Reflex (TVR). Vibration was applied to the distal tendons of the hand flexor muscles. Changes in activity of the hand flexor and extensor muscles were analyzed as a function of the vibration frequency (40-200 Hz), displacement amplitude(200.mu.m and 300.mu.m peak-to-peak), and the initial contraction level of the flexor muscles (0%, 10%, and 20% of the maximal voluntary contraction: MVC). The main results indicate that the TVR increases with vibration frequency up to 100-150 Hz and decreases beyond, and the TVR attains its maximum at 10% MVC. It appears that high frequency vibration tends to induce less muscle/tendon stress. Such a result is of particular importance for the design of handheld vibrating tools.

• Journal of Applied Biological Chemistry
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• 제48권4호
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• pp.207-212
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• 2005

Prolyl endopeptidase (PEP, EC 3.4.21.26), also referred to as prolyl oligopeptidase, has been suggested to participate in learning and memory processes by cleaving peptide bonds on carboxyl side of prolyl residue within neuropeptides of less than 30 amino acids, and is abundant in brains of amnestic patients. Therefore, compounds possessing PEP inhibitory activity can be good candidate of drug against memory loss. Upon examination for PEP inhibition from traditional medicinal plants having tonic, stimulating, and anti-amnestic effects, Corni Fructus (Cornus officinallis) showed significant PEP inhibition. Ursolic and oleanolic acids, components of Corni Fructus, inhibited PEP with $IC_{50}$ values of $17.2\;{\pm}\;0.5$ and $22.5\;{\pm}\;0.7\;{\mu}M$, respectively.

• Journal of Korean Neurosurgical Society
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• 제42권5호
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• pp.355-362
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• 2007

Hemifacial spasm (HFS) is characterized by tonic clonic contractions of the muscles innervated by the ipsilateral facial nerve. Compression of the facial nerve by an ectatic vessel is widely recognized as the most common underlying etiology. HFS needs to be differentiated from other causes of facial spasms, such as facial tic, ocular myokymia, and blepharospasm. To understand the overall craniofacial abnormalities and to perform the optimal surgical procedures for HFS, we are to review the prevalence, pathophysiology, differential diagnosis, details of each treatment modality, usefulness of brainstem auditory evoked potentials monitoring, debates on the facial EMG, clinical course, and complications from the literature published from 1995 to the present time.