• Journal of Ginseng Research
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• 제40권4호
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• pp.437-444
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• 2016

Background: Although Korean Red Ginseng (KRG) has been traditionally used for a long time, its anti-inflammatory role and underlying molecular and cellular mechanisms have been poorly understood. In this study, the anti-inflammatory roles of KRG-derived components, namely, water extract (KRG-WE), saponin fraction (KRG-SF), and nonsaponin fraction (KRG-NSF), were investigated. Methods: To check saponin levels in the test fractions, KRG-WE, KRG-NSF, and KRG-SF were analyzed using high-performance liquid chromatography. The anti-inflammatory roles and underlying cellular and molecular mechanisms of these components were investigated using a macrophage-like cell line (RAW264.7 cells) and an acute gastritis model in mice. Results: Of the tested fractions, KGR-SF (but not KRG-NSF and KRG-WE) markedly inhibited the viability of RAW264.7 cells, and splenocytes at more than 500 mg/mL significantly suppressed NO production at $100{\mu}g/mL$, diminished mRNA expression of inflammatory genes such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interferon-${\beta}$ at $200{\mu}g/mL$, and completely blocked phagocytic uptake by RAW264.7 cells. All three fractions suppressed luciferase activity triggered by interferon regulatory factor 3 (IRF3), but not that triggered by activator protein-1 and nuclear factor-kappa B. Phospho-IRF3 and phospho-TBK1 were simultaneously decreased in KRG-SF. Interestingly, all these fractions, when orally administered, clearly ameliorated the symptoms of gastric ulcer in HCl/ethanol-induced gastritis mice. Conclusion: These results suggest that KRG-WE, KRG-NSF, and KRG-SF might have anti-inflammatory properties, mostly because of the suppression of the IRF3 pathway.

• Nuclear Engineering and Technology
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• 제52권10호
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• pp.2196-2203
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• 2020

A dryout mechanism model for rectangular narrow channels at high pressure conditions is developed by assuming that the Kelvin-Helmholtz instability triggered the occurrence of dryout. This model combines the advantages of theoretical analysis and empirical correlation. The unknown coefficients in the theoretical derivation are supported by the experimental data. Meanwhile, the decisive restriction of the experimental conditions on the applicability of the empirical correlation is avoided. The expression of vapor phase velocity at the time of dryout is derived, and the empirical correlation of liquid film thickness is introduced. Since the CHF value obtained from the liquid film thickness should be the same as the value obtained from the Kelvin-Helmholtz critical stability under the same condition, the convergent CHF value is obtained by iteratively calculating. Comparing with the experimental data under the pressure of 6.89-13.79 MPa, the average error of the model is -15.4% with the 95% confidence interval [-20.5%, -10.4%]. And the pressure has a decisive influence on the prediction accuracy of this model. Compared with the existing dryout code, the calculation speed of this model is faster, and the calculation accuracy is improved. This model, with great portability, could be applied to different objects and working conditions by changing the expression of the vapor phase velocity when the dryout phenomenon is triggered and the calculation formula of the liquid film.

• 방송공학회논문지
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• 제9권1호
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• pp.74-82
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• 2004

디지털 방송에서 애플리케이션은 셋톱박스(TV 수신기)에서 수행되는 응용프로그램을 말하며, 연동형 애플리케이션은 비디오내의 특정 시각에 정해진 일을 수행하는 애플리케이션이다. 본 논문에서는 연동형 애플리케이션을 구현하는데 필요한 개념, 표준 및 기술을 분석하고, 이들을 통합하여 연동형 애플리케이션을 구현하는 방법을 제안한다. 본 논문은 특히 유럽식 데이터 방송 표준인 DVB-MHP를 염두에 두고 기술한다. DVB-MHP 규약에서는 비디오와 애플리케이션을 동기화 시키는 방법으로 스케줄드 스트림 이벤트 방법을 권장하고 있다. 이 방법은 방송중간에 스케줄드 스트림 이벤트를 전송하고 애플리케이션이 스트림 이벤트를 수신, 스트림 이벤트에 명시된 시각에 스트림 이벤트를 처리하는 방법이다. 현재 상용으로 사용되고 있는 전송 스트림 생성기, 즉, 다중화기는 스트림 이벤트를 사용할 수 있도록 전송 스트림을 생성해 주지 않기 때문에 본 논문에서는 본 연구팀이 개발한 실험실용 스트림 생성기를 이용하여 필요한 전송 스트림을 생성하였다. 그리고 실제로 하나의 연동형 애플리케이션을 구현하여 테스트했다. 그 결과 연동형 애플리케이션이 스트림 이벤트를 성공적으로 처리함을 확인하였다. 구현된 애플리케이션에서 스트림 이벤트들은 의도한 시점으로부터 240ms 이내에서 비디오와 동기화 되었는데, 이 시간은 비디오와 그래픽 이미지간의 동기화 오차에 대한 허용치이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.703-712
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• 2016

Monoclonal antibodies with specific antigens have been widely used as targeted therapy for cancer. Hep88 mAb is a monoclonal antibody which shows specific binding with anti-cancer effects against the HepG2 cell line. However, its mechanisms of action are still not completely understood. We examined cell cycling and apoptosis by flow cytometry and mRNA expression of factors involved in apoptosis and paraptosis in Hep88 mAb-treated HepG2 cells by real-time PCR. The cell-cycle analysis demonstrated that growth-inhibitory activity was associated with G2/M cell cycle arrest. Hep88 mAb induced a significant increase in apoptotic cell populations in a dose- and time-dependent manner. The mRNA expression results also suggested that the process triggered by Hep88 mAb involved up-regulation of tumor suppressor p53, pro-apoptotic Bax, Cathepsin B, Caspase-3 and Caspase-9, with a decrease of anti-apoptotic Bcl-2 - thus confirming paraptosis and apoptosis programmed cell death. These findings represent new insights into the molecular mechanisms underlying the anti-cancer properties of Hep88 mAb in liver cancer cells.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.125-131
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• 2017

Status epilepticus is the most common serious neurological condition triggered by abnormal electrical activity, leading to severe and widespread cell loss in the brain. Lithium has been one of the main drugs used for the treatment of bipolar disorder for decades, and its anticonvulsant and neuroprotective properties have been described in several neurological disease models. However, the therapeutic mechanisms underlying lithium's actions remain poorly understood. The muscarinic receptor agonist pilocarpine is used to induce status epilepticus, which is followed by hippocampal damage. The present study was designed to investigate the effects of lithium post-treatment on seizure susceptibility and hippocampal neuropathological changes following pilocarpine-induced status epilepticus. Status epilepticus was induced by administration of pilocarpine hydrochloride (320 mg/kg, i.p.) in C57BL/6 mice at 8 weeks of age. Lithium (80 mg/kg, i.p.) was administered 15 minutes after the pilocarpine injection. After the lithium injection, status epilepticus onset time and mortality were recorded. Lithium significantly delayed the onset time of status epilepticus and reduced mortality compared to the vehicle-treated group. Moreover, lithium effectively blocked pilocarpine-induced neuronal death in the hippocampus as estimated by cresyl violet and Fluoro-Jade B staining. However, lithium did not reduce glial activation following pilocarpine-induced status epilepticus. These results suggest that lithium has a neuroprotective effect and would be useful in the treatment of neurological disorders, in particular status epilepticus.

• 한국해양공학회지
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• 제21권6호
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• pp.72-80
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• 2007

The tsunami that resulted from the Central East sea Earthquake, which registered 7.7 on the Richter scale, that occurred over the entire water region in Akita on May. 26, 1983 and the tsunami that was triggered by the Southwest off Hokkaido Earthquake (7.8 on the Richter scale) that occurred in Southwest off Hokkaido on July 12, 1993 are representative cases that led to considerable damage in life and property, not only in Japan but also in Korea. In this study, multi-grid method was used in order to reproduce sufficiently the shoaling effect that occurs as water depth becomes shallow in the shallow water region and moving boundary condition was introduced to consider the runup in the coastal region. For the tsunamis that exerted considerable effect on the East Sea coast of Korea that were caused by the Central East Sea Earthquake in 1983 and the Southwest off Hokkaido Earthquake in 1993, characteristics like water level rise and propagation in the East Sea coast will be examined using numerical simulations. At the same time, these values will be compared with observed values. In addition, maximum water level rise and change in the water level with respect to time that were caused by the tsunamis were examined at each location along the East sea coast. Usefulness of numerical analysis was verified by comparing with observed values.

• 복식문화연구
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• 제10권1호
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• pp.37-48
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• 2002

The following paper deals with the interaction between an Austrian art trend from the late 19th century until World War I, the Vienna Separatist Movement, and the Vienna Workshop dress and its ornaments in part designed by the artists belonging to the former mentioned school. Gustav Klimt′s paintings along with his photographs and pictures and articles published in the "Wiener Mode" magazine were subject of analysis. The focus was on Klimt′s paintings with female themes whereby a comparative analysis was made between the development of the forms, hues and ornaments of clothing and the style of paintings at that time. The whole development was classified into three phases. The first period from 1897∼1905 marks the birth of the Vienna Separatists along with the clothing reform movement. The heyday of the Separatists represents the second phase from 1906∼1913 and the decline of the very school and the Vienna Workshop period lasts from 1913∼1918. Refromed dresses were started to be recognized as alternatives, from 1897 when the Separatists started to gain foot until 1o05, and Kimt and Van de Velde published designs that were comfortable and elegant. From 1906 to 1913 the expressionism and Reform Mode of the Vienna artists started to flourish. But during the War the Separatist Movement, which triggered the modernazation of Vienna declined and instead the decorative art of Vienna Workshops started to develop. The asymmetric design of the dress, exotic patterns, shades of complementary colors and reformed clothing were frequently used by Kimt and other Separatists. This is an instance where fashion design directly influenced art and different branches can reflect the same aesthetic standards within the same time frame.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.213-222
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• 2014

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2005년도 춘계종합학술대회
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• pp.667-670
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• 2005

보안과 감시에 대한 사람들의 관심이 높아지면서 무인화에 초점을 맞춘 CCTV(Closed-circuit Television) 시장이 형성되었고, 디지털 영상 압축 기술과 인터넷이 급격히 발전함으로써 인터넷 기반의 웹 카메라가 새롭게 등장하였다. 웹 카메라의 특징은 기존의 CCTV와 다르게 장소에 구별 없이 네트워크가 이루어지는 곳에서 CCTV보다 좋은 화질의 영상을 볼 수 있는 것이다. 그러나 시스템 관리자에게는 웹 브라우저에서 웹 카메라 서버로 접속된 사용자에게만 해당 카메라의 영상을 보여주는 웹 카메라의 방식은 불편한 단점이다. 이에 본 논문에서는 여러 영상을 단일화면으로 구성한 멀티비전 인터페이스와 시스템 관리의 효율성을 높이기 위해 영상을 저장하는 기능 및 특정 시간에 저장이 이루어지는 스케줄링 기능을 구현 및 설계하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 춘계합동학술대회 논문집
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• pp.172-175
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• 2002

The technique of induced discharge by a pulsed CO2 laser is being applied to control electrical discharge path, material processing, triggered lightning for protecting the power equipments. In this paper, we have investigated about the characteristics of the induced discharge at atmospheric conditions by using a plasma channel, which is produced when a pulsed CO2 laser radiation is focused by a focusing mirror as a trigger source. A plasma channel produced by laser radiation has an effect on decreasing the threshold voltage and inducing the discharge in both needle electrodes. We have confirmed a delay time between a produced plasma channel and an electrical discharge after laser radiation. We provided the decreased voltage lower than the natural discharge voltage between electrode type of needles and was induced the discharge by forming a plasma channel between them. In this research we could understand the time delay of induced discharge by laser radiation, and the characteristics of the discharge cause by the decrease in the threshold voltage, and the polarity effect by changes of plasma channel positions between two electrodes.