• 대한한의학방제학회지
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• 제19권1호
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• pp.183-194
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• 2011

Objectives : To estimate the shelf-life by long-term storage test of Pyungwi-san. Methods : Experiments were conducted to evaluate the stability such as the selected physicochemical, heavy metal, microbilogical experiment under an acceleration test and long-term storage test of Pyungwi-san in different storage under room temperature, refrigeration and freezing. Futhermore, HPLC analysis was performed for the determinations of glycyrrhizin in the Pyungwi-san on an Inertsil ODS-3 column(250 mm ${\times}$ 4.6 mm, 5 um) using solvent 35% acetonitrile include 0.05% phosphoric acid at 254 nm. The flow rate was 1.0 mL/min. Results : The significant change was not showed in pH, heavy metal, microbiological, identification test and quantitative analysis based on acceleration test and long-term storage test. Retention time of glycyrrhizin in HPLC chromatogram was about 16.065 min and calibration curve showed good linearity($R^2$ = 0.9999). The contents of glycyrrhizin in acceleration test and long-term storage test were 0.068~0.076 mg/mL and 0.066~0.077 mg/mL, respectively. Shelf-lifes of room temperature, refrigeration and freezing by long-term storage test were predicted 41, 24 and 34 months, respectively. Conclusions : The suggested shelf-life would be helpful on the storage and distribution of herbal medicine.

• 청정기술
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• 제18권3호
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• pp.312-319
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• 2012

말라카이트 그린은 염료로 사용되지만 유해한 독성 물질이다. 본 연구에서는 제올라이트에 의한 말라카이트 그린의 흡착특성을 조사하였다. 일정한 양의 제올라이트에 대해 초기농도, 접촉시간, pH 및 흡착온도 등이 말라카이트 그린의 흡착에 미치는 영향을 회분식 및 칼럼흡착실험을 통하여 연구하였다. 회분식흡착실험을 통해 흡착등온선을 구한 결과 말라카이트 그린의 흡착평형관계는 $25{\sim}45^{\circ}C$ 범위에서 Freundlich 식이 잘 적용되었다. 흡착등온식으로 부터 평가된 k와 ${\beta}$ 값은 각각 23.60~46.88, 0.225~0.347이었다. 입자내 확산모델을 사용하여 흡착기구를 결정하였다. 고정층의 운전조건이 파과곡선에 미치는 영향을 조사하였다. 말라카이트 그린의 유입농도와 초기유속이 증가함에 따라 파과시간은 감소하였다. 층높이가 증가함에 따라 파과시간이 증가하였는데, 흡착대의 길이는 비슷한 양상을 나타냈다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.396-396
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• 2013

The resistive random access memory (ReRAM) has several advantages to apply next generation non-volatile memory device, because of fast switching time, long retentions, and large memory windows. The high mobility of monolayered graphene showed several possibilities for scale down and electrical property enhancement of memory device. In this study, the monolayered graphene grown by chemical vapor deposition was transferred to $SiO_2$ (100 nm)/Si substrate and glass by using PMMA coating method. For formation of metal-oxide nanoparticles, we used a chemical reaction between metal films and polyamic acid layer. The 50-nm thick BPDA-PDA polyamic acid layer was coated on the graphene layer. Through soft baking at $125^{\circ}C$ or 30 min, solvent in polyimide layer was removed. Then, 5-nm-thick indium layer was deposited by using thermal evaporator at room temperature. And then, the second polyimide layer was coated on the indium thin film. After remove solvent and open bottom graphene layer, the samples were annealed at $400^{\circ}C$ or 1 hr by using furnace in $N_2$ ambient. The average diameter and density of nanoparticle were depending on annealing temperature and times. During annealing process, the metal and oxygen ions combined to create $In_2O_3$ nanoparticle in the polyimide layer. The electrical properties of $In_2O_3$ nanoparticle ReRAM such as current-voltage curve, operation speed and retention discussed for applictions of transparent and flexible hybrid ReRAM device.

• Journal of Ginseng Research
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• 제44권2호
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• pp.229-237
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• 2020

Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.

• 대한핵의학회지
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• 제21권2호
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• pp.183-190
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• 1987

In Raynaud's phenomenon, the authors measured finger blood flow after ice water exposure by analyzing the time activity curve of radionuclide angiography on both hands. The results were as follows: 1) The digital blood flow did not decrease after ice water exposure in normal subjects. 2) In the patients with Raynaud's phenomenon, there were two groups: the one had decreased digital blood flow after cold exposure, and the other had paradoxically increased digital blood flow after cold exposure. 3) There was no difference in the digital blood flow of hand in room temperature between the normal and the patients with reduced digital blood flow after cold exposure, but the digital blood flow of the hand in room temperature was markedly reduced in the patients with paradoxically increased flow after cold exposure. 4) In the static image the difference was not significant in comparision with the dynamic study, because it represents pooling of the blood in the vein rather than flow. 5) After the treatment with nifedipine, the digital blood flow increased. In conclusion, the radionuclide angiography was useful in measuring the digital blood flow in Raynaud's phenomenon, and further studies with various drugs is expected.

• Advances in nano research
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• 제7권4호
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• pp.249-263
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• 2019

In the current paper, an exact solution method is carried out for analyzing the thermo-mechanical vibration of curved FG nano-beams subjected to uniform thermal environmental conditions, by considering porosity distribution via nonlocal strain gradient beam theory for the first time. Nonlocal strain gradient elasticity theory is adopted to consider the size effects in which the stress for not only the nonlocal stress field but also the strain gradients stress field is considered. It is perceived that during manufacturing of functionally graded materials (FGMs) porosities and micro-voids can be occurred inside the material. Material properties of curved porous FG nanobeam are assumed to be temperature-dependent and are supposed to vary through the thickness direction of beam which modeled via modified power-law rule. Since variation of pores along the thickness direction influences the mechanical and physical properties, porosity play a key role in the mechanical response of curved FG nano-structures. The governing equations and related boundary condition of curved porous FG nanobeam under temperature field are derived via the energy method based on Timoshenko beam theory. An analytical Navier solution procedure is utilized to achieve the natural frequencies of porous FG curved nanobeam supposed to thermal loading. The results for simpler states are confirmed with known data in the literature. The effects of various parameters such as nonlocality parameter, porosity volume fractions, thermal effect, gradient index, opening angle and aspect ratio on the natural frequency of curved FG porous nanobeam are successfully discussed. It is concluded that these parameters play key roles on the dynamic behavior of porous FG curved nanobeam. Presented numerical results can serve as benchmarks for future analyses of curve FG nanobeam with porosity phases.

• 한국전산구조공학회논문집
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• 제37권1호
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• pp.57-65
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• 2024

내화 구조물에서는 환기 계수, 재료 탄성 계수, 항복 강도, 열팽창 계수, 외력 및 화재 위치에서 불확실성이 관찰된다. 환기 불확실성은 화재 온도에 영향을 미치고, 이는 다시 구조물 온도에 영향을 미친다. 이러한 온도는 재료 특성과 함께 불확실한 구조적 응답으로 이어지고 있다. 화재 시 구조적 비선형 거동으로 인해 몬테카를로 시뮬레이션을 사용하여 화재 취약성을 계산하는데, 이는 시간이 많이 소요된다. 따라서 머신러닝 알고리즘을 활용해 화재 취약성 분석을 예측함으로써 효율성을 높이고 정확성을 확보하려는 연구가 진행되고 있다. 이 연구에서는 화재 크기, 위치, 구조 재료 특성의 불확실성을 고려하여 철골 모멘트 골조 건물의 화재 취약성을 예측했다. 화재 시 비선형 구조 거동 결과를 기반으로 한 취약성 곡선은 로그 정규 분포를 따른다. 마지막으로 제안한 방법이 화재 취약성을 정확하고 효율적으로 예측할 수 있음을 보여주었다.

• Spatial Information Research
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• 제20권3호
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• pp.39-50
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• 2012

본 연구는 금강유역을 대상으로 과거 약 30년간의 기상 수문시계열자료들을 수집해 다양한 통계분석을 수행하여 기후변화의 영향을 정량적으로 파악하고자 하였다. 기상자료로 금강유역 기상관측소 8개소의 37개년(1973~2009)의 기온, 강수량, 상대습도 자료를 수집하였고, 하천수위자료는 수위자료와 수위-유량관계곡선의 신뢰성 문제, 이후 수행될 장기유출분석을 고려하여 공주, 규암 수위관측소의 36개년(1973~2008)의 자료를 이용하였다. 수집된 자료의 평균, 표준편차, 왜곡도, 변동계수를 산출하여 연 계절별로 수문기상인자의 경년변화를 파악한 결과 기상인자 중 강수량의 변동성이 가장 크게 나타나 경년별 변화가 큰 것으로 분석되었다. 수문학적 지속성 분석을 위해 Run 검정, Turning Point 검정, Anderson Exact검정을 이용하여 시계열자료에 주기성이 있는지 분석한 결과 기온과 강수는 무작위성, 상대습도, 하천수위는 지속성을 가지는 인자로 분석되었고 지하수위는 관측소별, 기간별로 무작위성과 지 속성이 혼재되어 있는 것으로 나타났다. 또한, 경향성 분석을 위해 단순 선형 회귀분석과 Mann-Kendall 검정법을 이용한 결과 기온은 연 계절 모두 증가경향이 나타났고, 강수량은 여름에만 증가경향이 나타났으며, 상대습도는 뚜렷한 감소경향을 보였다. 본 연구의 결과는 기후변화로 인해 발생될 수 있는 수자원의 영향을 평가하고 미래 물 관리 적응기술 개발 및 계획 수립을 위한 자료로 활용될 수 있을 것으로 사료된다.

• Korean Chemical Engineering Research
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• 제51권4호
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• pp.500-505
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• 2013

본 연구에서는 가스 하이드레이트 생성 시 첨가된 이온성 액체가 미치는 생성속도의 향상효과를 조사하였다. 이온성 액체로는 Hydroxyethyl-methyl-morpholinium chloride (HEMM-Cl)을 사용하였다. 메탄 하이드레이트의 상평형 곡선을 구하고 생성유도시간과 메탄가스의 소모량을 측정하였다. 20~20,000 ppm의 HEMM-Cl을 준비하여 하이드레이트가 생성될 수 있는 70 bar, 274.15 K 조건에서 실험을 수행하였다. 하이드레이트 생성 속에 대한 비교를 위해 순수한 물과 대표적인 촉진제인 sodium dodecyl sulfate를 같은 조건에서 실험하였다. 실험 결과, 이온성 액체인 HEMM-Cl은 상평형 곡선을 더 높은 압력과 낮은 온도 쪽으로 이동시켰다. 이온성 액체의 첨가 시에는 메탄 하이드레이트의 생성유도시간이 거의 나타나지 않는 것을 알 수 있었다. 메탄가스의 소모량은 모든 농도에서 향상되었고 1,000 ppm에서 가장 많은 양의 가스를 흡수하는 것으로 나타났다. 이온성 액체는 가스 하이드레이트 생성 촉진을 유도하는 것으로 나타났으며 가스저장, 수송 등의 응용기술 개발에 적용이 기대된다.

• 한국식품조리과학회지
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• 제27권1호
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• pp.63-73
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• 2011

Cabbage (Baechu) Kimchi in its truncated form was placed in four different packing materials, Ny/PE/LLDP, OPP/AL/PE, PP and PET, and quality changes were observed during storage. Changes in pH and total acidity showed an x-shaped cross-curve as pH decreased and total acidity increased during storage. PP tray showed the slowest change at $5^{\circ}C$ with time. The pH was initially 6.25, but decreased to 4.12~4.16 at 20 days, and total acidity showed a 4 to 4.8-fold increase after 20 days of storage compared to the initial value. During storage at $5^{\circ}C$, total bacterial count and lactic acid bacterial count rapidly increased after 4 days. The total bacterial quantity decreased after a period of time and there were differences according to packaging material; OPP/AL/PE packaging showed the most dramatic decrease. Change in microbial count mostly followed a similar pattern to that of total acidity for all packaging materials. Changes in the color of Kimchi liquid, when examined by color index in $L{\cdot}b$/a form, rapidly decreased over time, similar to pH. Small Ny/PE/PP and OPP/AL/PE packages of Kimchi were examined for changes in free volume inside the packaging. After 13 days of storage at $5^{\circ}C$, the volume was 243 mL, but storage at $20^{\circ}C$ resulted in a volume of 372 mL, a more than 1.5-fold increase in free volume. There were changes in the quality characteristics of small package Kimchi according to storage temperature and packaging material, and large changes in pH, total acidity, and microbial count were evident upon storage at $5^{\circ}C$ for 8 days, which was the optimum palatability period. Mostly, PP treatment showed the slowest quality changes upon storage at $5^{\circ}C$. However, due to small package Kimchi's fast consumption system, the appropriate choice of packaging material must consider the product's turnover ratio. Further, the varieties of small package Kimchi should be diversified according to different consumer preferences by offering Kimchi with different maturity levels. Further, since the leading consumer base ranges in age from the teens to thirties, the development of various products targeting such consumers is necessary.