• Proceedings of the Korean Nuclear Society Conference
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• 1996.05a
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• pp.21-27
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• 1996

KAERI has recently developed the nuclear design code MASTER for the application to reactor physics analyses for pressurized water reactors. Its neutronics model solves the space-time dependent neutron diffusion equations with the advanced nodal methods. The major calculation categories of MASTER consist of microscopic depletion, steady-state and transient solution, xenon dynamics, adjoint solution and pin power and burnup reconstruction. The MASTER validation analyses, which are in progress aiming to submit the Uncertainty Topical Report to KINS in the first half of 1996, include global reactivity calculations and detailed pin-by-pin power distributions as well as in-core detector reaction rate calculations. The objective of this paper is to give an overall description of the CASMO/MASTER code system whose verification results are in details presented in the separate papers.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.10 no.3
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• pp.185-219
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• 1981

To analyze two dimensional incompressible laminar natural convection in a rectangular enclosure heated from below and cooled by a horizontal ceiling and two vertical walls, he primitive Navier-Stokes equations and the energy equation were solved numerically in time dependent form by a marker and cell method. A successive over-relaxation method for the elliptic portion of the problem and an explicit method for the parabolic portion were applied for the range of Grashoff number of $5{\times}10^3\;to\;5{\times}10^4$ to get the transient and steady state dimensionless temperature and velocity profiles. For the range of aspect ratio $L/H{\leqq}2.4$ in which only a pair of convection rolls exists mean Nusselt number calculated are as follows : $$N_{NU}0.89\;N_{Gr}^{0.2}(H/L)^{0.45}$$ By path lines drawn by marker particle trajectories roll number of cellular motion were observed for various aspect ratio of the enclosure.

• Structural Engineering and Mechanics
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• v.85 no.2
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• pp.217-231
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• 2023

The bending analysis of sandwich functionally graded (FG) beams under temperature circumstances is performed in this article utilizing Navier's solution-based parabolic shear deformation theory. For the first time, a comparative study has been carried out between the exponential and sigmoidal sandwich FGM beams under thermal conditions. During this investigation, temperature-dependent material characteristics are postulated. Both symmetric and unsymmetric sandwich examples have been studied. The effect of gradation law, gradation coefficient, and thickness scheme on beam behavior has been thoroughly investigated. Three possible temperature combinations at the top and bottom surfaces of the beam are also investigated. Beams with a higher proportion of ceramic to metal are shown to be more resistant to thermal stresses than beams with a higher proportion of metal.

• Journal of the Korean Society for Precision Engineering
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• v.11 no.6
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• pp.143-157
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• 1994

This paper is concerned with the position control of electrohydraulic servo system under parameter variation. An adaptive sliding mode control which uses the direct parameter estimation scheme, is proposed to design a robust controller for fast and accurate control of the system. It is shown that the adaptive sliding mode control algorithm is robust and effective in attaining fast and accurate position control of system under time-dependent parameter variation. It is also shown experimentally that chattering phenomena in a sliding mode control can significantly be reduced by using boundary layer technique, and that new approach in sliding mode control introducing a term proportional to the distance between the current state and the sliding surface in the control law is effective to obtain fast response and to increase stability of the system. Computer simulation on the dynamic performance of the control system is also presented.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.1 no.1
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• pp.53-68
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• 1981

Most clays under sustained load exhibit time-dependent deformation because of creep movement of soil particles and many investigators have attempted to relate their findings to the creep behavior of natural ground and to the long-term stability of slopes. Since the creep behavior of clays may assume a variety of forms depending on such factors as soil plasticity, activity and water content, it is difficult and complicated to analyse the creep behavior of clays. Rheological models composed of linear springs in combination with linear or nonlinear dashpots and sliders, are generally used for the mathematical description of the time-dependent behavior of soils. Most rheological models, however, have been proposed to simulate the behavior of secondary compression for saturated clays and few definitive data exist that can evaluate the behavior of non-saturated clays under the action of sustained stress. The clays change gradually from a solid state through plastic state to a liquid state with increasing water content, therefore, the rheological models also change. On the other hand, creep is time-dependent, and also the effect of thixotropy is time-function. Consequently, there may be certain correlations between creep behavior and the effects of thixotropy in compacted clays. In addition, the states of clay depend on water content and hence the height of the specimen under drained conditions. Futhermore, based on present and past studies, because immediate elastic deformation occurs instantly after the pressure increment without time-delayed behavior, the factor representing immediate elastic deformations in the rheological model is necessary. The investigation described in this paper, based on rheological model, is designed to identify the immediate elastic deformations and the effects of thixotropy and height of clay specimens with varing water content and stress level on creep deformations. For these purposes, the uniaxial drain-type creep tests were performed. Test results and data for three compacted clays have shown that a linear top spring is needed to account for immediate elastic deformations in the rheological model, and at lower water content below the visco-plastic limit, the effects of thixotropy and height of clay specimens can be represented by the proposed rheological model not considering the effects. Therefore, the rheological model does not necessitate the other factors representing these effects. On the other hand, at water content higher than the visco-plastic limit, although the state behavior of clays is visco-plastic or viscous flow at the beginning of the test, the state behavior, in the case of the lower height sample, does not represent the same behavior during the process of the test, because of rapid drainage. In these cases, the rheological model does not coincide with the model in the case of the higher specimens.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.489-494
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• 2014

Background: Psychiatric patients appear to be at lower risk of cancer. Some antipsychotic drugs might have inhibitory effects on tumor growth, including penfluridol, a strong agent. To test this, we conducted a study to determine whether penfluridol exerts cytotoxic effects on tumor cells and, if so, to explore its anti-tumor mechanisms. Methods: Growth inhibition of mouse cancer cell lines by penfluridol was determined using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was determined by clonogenic cell survival and trypan blue assays. Animal tumor models of these cancer cells were established and to evaluate penfluridol for its anti-tumor efficacy in vivo. Unesterified cholesterol in cancer cells was examined by filipin staining. Serum total cholesterol and tumor total cholesterol were detected using the cholesterol oxidase/p-aminophenazone (CHOD-PAP) method. Results: Penfluridol inhibited the proliferation of B16 melanoma (B16/F10), LL/2 lung carcinoma (LL/2), CT26 colon carcinoma (CT26) and 4T1 breast cancer (4T1) cells in vitro. In vivo penfluridol was particularly effective at inhibiting LL/2 lung tumor growth, and obviously prolonged the survival time of mice bearing LL/2 lung tumors implanted subcutaneously. Accumulated unesterified cholesterol was found in all of the cancer cells treated with penfluridol, and this effect was most evident in LL/2, 4T1 and CT26 cells. No significant difference in serum cholesterol levels was found between the normal saline-treated mice and the penfluridol-treated mice. However, a dose-dependent decrease of total cholesterol in tumor tissues was observed in penfluridol-treated mice, which was most evident in B16/F10-, LL/2-, and 4T1-tumor-bearing mice. Conclusion: Our results suggested that penfluridol is not only cytotoxic to cancer cells in vitro but can also inhibit tumor growth in vivo. Dysregulation of cholesterol homeostasis by penfluridol may be involved in its anti-tumor mechanisms.

• Smart Structures and Systems
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• v.20 no.5
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• pp.619-636
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• 2017

Magnetorheological (MR) damper is a type of controllable device widely used in vibration mitigation. This device is highly nonlinear, and exhibits strongly hysteretic behavior that is dependent on both the motion imposed on the device and the strength of the surrounding electromagnetic field. An accurate model for understanding and predicting the nonlinear damping force of the MR damper is crucial for its control applications. The MR damper models are often identified off-line by conducting regression analysis using data collected under constant voltage. In this study, a MR damper model is integrated with a model for the power supply unit (PSU) to consider the dynamic behavior of the PSU, and then a real-time nonlinear model updating technique is proposed to accurately identify this integrated MR damper model with the efficiency that cannot be offered by off-line methods. The unscented Kalman filter is implemented as the updating algorithm on a cyber-physical model updating platform. Using this platform, the experimental study is conducted to identify MR damper models in real-time, under in-service conditions with time-varying current levels. For comparison purposes, both off-line and real-time updating methods are applied in the experimental study. The results demonstrate that all the updated models can provide good identification accuracy, but the error comparison shows the real-time updated models yield smaller relative errors than the off-line updated model. In addition, the real-time state estimates obtained during the model updating can be used as feedback for potential nonlinear control design for MR dampers.

• Journal of the Korean Chemical Society
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• v.55 no.3
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• pp.385-391
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• 2011

The time-dependent density functional theory (TDDFT) method has been carried out to investigate the excitedstate hydrogen-bonding dynamics of phenol-$(H_2O)_2$ complex. The geometric structures and infrared (IR) spectra in ground state and different electronically excited states ($S_1$ and $T_1$) of the hydrogen-bonded complex have been calculated using the density functional theory (DFT) and TDDFT method. A ring of three hydrogen bonds is formed between phenol and two water molecules. We have demonstrated that the intermolecular hydrogen bond $O_1-H_2{\cdots}O_3-H$ of the three hydrogen bonds is strengthened in $S_1$ and $T_1$ states. In contrast, the hydrogen bond $O_5-H_6{\cdots}O_1-H$ is weakened in $S_1$ and $T_1$ states. These results are obtained by theoretically monitoring the changes of the bond lengths of the hydrogen bonds and hydrogen-bonding groups in different electronic states. The hydrogen bond $O_1-H_2{\cdots}O_3-H$ strengthening in both the $S_1$ and $T_1$ states is confirmed by the calculated stretching vibrational mode of O-H (phenol) being red-shifted upon photoexcitation. The hydrogen bond strengthening and weakening behavior in electronically excited states may exist in other ring structures of phenol-$(H_2O)_n$.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.4
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• pp.347-355
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• 2016

Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha ($TNF-{\alpha}$) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of $TNF-{\alpha}$ on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and Western blotting respectively. The formation of intracellular ROS was determined with fluorescence probe $CM-DCFH_2-DA$. The endothelial ox-LDL uptake was evaluated with DiI-ox-LDL. The effect of CPT on LOX-1 expression was also evaluated with SD rats. $TNF-{\alpha}$ induced LOX-1 expression in a dose- and time- dependent manner in endothelial cells. $TNF-{\alpha}$ induced ROS formation, phosphorylation of $NF-{\kappa}B$ p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT. $NF-{\kappa}B$ inhibitor BAY11-7082 and ERK inhibitor PD98059 inhibited $TNF-{\alpha}-induced$ LOX-1 expression. CPT and NAC suppressed $TNF-{\alpha}-induced$ LOX-1 expression and phosphorylation of $NF-{\kappa}B$ p65 and ERK in rat aorta. These data suggested that $TNF-{\alpha}$ induced LOX-1 expression via ROS activated $NF-{\kappa}B/ERK$ pathway, which could be inhibited by CPT. This study provides new insights for the anti-atherosclerotic effect of CPT.

• Earthquakes and Structures
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• v.10 no.2
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• pp.409-428
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• 2016

To realise the full benefits of a self-centering seismic resilient system, the designer must ensure that the entire structure does indeed re-center following an earthquake. The idealised flag-shaped hysteresis response that is often used to define the cyclic behaviour of self-centering concrete systems seldom exists and the residual drift of a building subjected to an earthquake is dependent on the realistic cyclic hysteresis response as well as the dynamic loading history. Current methods that are used to ensure that re-centering is achieved during the design of self-centering concrete systems are presented, and a series of cyclic analyses are used to demonstrate the flaws in these current procedures, even when idealised hysteresis models were used. Furthermore, results are presented for 350 time-history analyses that were performed to investigate the expected residual drift of an example self-centering concrete wall system during an earthquake. Based upon the results of these time-history analyses it was concluded that due to dynamic shake-down the residual drifts at the conclusion of the ground motion were significantly less than the maximum possible residual drifts that were observed from the cyclic hysteresis response, and were below acceptable residual drift performance limits established for seismic resilient structures. To estimate the effect of the dynamic shakedown, a residual drift ratio was defined that can be implemented during the design process to ensure that residual drift performance targets are achieved for self-centering concrete wall systems.