• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.167-174
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• 2014

Tumor angiogenesis, growth and metastasis are three closely related processes. We therefore investigated the effects of barbigerone on all three in the B16F10 tumor model established in both zebrafish and mouse models, and explored underlying molecular mechanisms. In vitro, barbigerone inhibited B16F10 cell proliferation, survival, migration and invasion and suppressed human umbilical vascular endothelial cell migration, invasion and tube formation in concentration-dependent manners. In the transgenic zebrafish model, treatment with $10{\mu}M$ barbigerone remarkably inhibited angiogenesis and tumor-associated angiogenesis by reducing blood vessel development more than 90%. In vivo, barbigerone significantly suppressed angiogenesis as measured by H and E staining of matrigel plugs and CD31 staining of B16F10 melanoma tumors in C57BL/6 mice. Furthermore, it exhibited highly potent activity at inhibiting tumor growth and metastasis to the lung of B16F10 melanoma cells injected into C57BL/6 mice. Western blotting revealed that barbigerone inhibited phosphorylation of AKT, FAK and MAPK family members, including ERK, JNK, and p38 MAPKs, in B16F10 cells mainly through the MEK3/6/p38 MAPK signaling pathway. These findings suggested for the first time that barbigerone could inhibit tumor-angiogenesis, tumor growth and lung metastasis via downregulation of the MEK3/6/p38 MAPK signaling pathway. The findings support further investigation of barbigerone as a potential anti-cancer drug.

• The Journal of the Acoustical Society of Korea
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• v.16 no.3
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• pp.64-72
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• 1997

In this paper, study and experiments are performed for finding recognition unit fit which can be used in large vocabulary recognition system. Specifically, a phoneme that is currently used as recognition unit and a syllable in which Korean is well characterized are selected. From comparisons of recognition experiments, the study is performed whether a syllable can be considered as recognition unit of Korean recognition system. For report of an objective result of the comparison experiment, we collected speech data of a male speaker and processed them by hand-segmentation for phoneme boundary and labeling to construct speech database. And for training and recognition based on HMM, we used HTK (HMM Tool Kit) 2.0 of commercial tool from Entropic Co. to experiment in same condition. We applied two HMM model topologies, 3 emitting state of 5 state and 6 emitting state of 8 state, in Continuous HMM on training of each recognition unit. We also used 3 sets of PBW (Phonetically Balanced Words) and 1 set of POW(Phonetically Optimized Words) for training and another 1 set of PBW for recognition, that is "Speaker Dependent Medium Vocabulary Size Recognition." Experiments result reports that recognition rate is 95.65% in phoneme unit, 94.41% in syllable unit and decoding time of recognition in syllable unit is faster by 25% than in phoneme.

• The Journal of Engineering Geology
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• v.11 no.3
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• pp.255-267
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• 2001

A comparison study is performed to understand the coupling behavior of the thermal, hydraulic, and mechanical interactions in the vicinity of an underground radwaste repository, assumed to be located at a depth of 500 m, within a granitic rock mass with a 58$^{\circ}$ dipping fault passing through the roof-wall intersection of the repository cavern. The two dimensional universal distinct element code, UDEC is used for the analysis. The model includes a granitic rock meas, a canister with PWR spent fuels surrounded by the compacted bentonite inside a deposition hole, and the mixed bentonite backfilled in the rest of the space within a repository cavern. The coupling behavior of hydromechanical, thermomechanical, and thermohydromechanical interaction has been studied and compared. The effect of the time-dependent decaying heat, from the radioactive materials in PWR spent fuels, on the repository and its surroundings has been studied. A steady state flow algorithm is used for the hydraulic analysis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.4
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• pp.7-13
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• 2012

The performance of blind equalization algorithm ISCA was compared with MSCA that is used for the minimization of the inter symbol interference which occurs in the time dispersive communication channel for digital transmission. Because of the non-linearities of a magnitude and phase transfer characteristics of a communication channel, the transmitting signal will be received that band limited and time dispersived. Therefore the distortion was compensated by using the self adaptive equalizer at the receiving side, then passing through the detector for the decision of "1" or "0". At this time the Constellation Dependent Constant is played an important role in the adaptive equalizer used on the receiver. In order to calculation of this constant, the ISCA and MSCA was used the second order statistics. The ISCA and MSCA which are possible to compensation of mensioned transfer function simulataneously, are improved the performance of original SCA algorithm and then was compared the performance by computer simulation. For this, the recovered constellation, residual isi and MSE was used, and a result of performance comparison, the ISCA algorithm has better than the MSCA in every performance index. But on the steady state of equalizer, the variation of performance due to the CME terms in the MSCA equalization algorithm was less than the ISCA, so MSCA has better stability.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.469-474
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• 2002

In recent years, modularization of engine parts has increased the application of plastic products in air intake systems. Plastic intake manifolds provide many advantages including reduced weight, contracted cost, and lower intake air temperatures. These manifolds, however, have some weakness when compared with customary aluminium intake manifolds, in that they have low sound transmission loss because of their lower material density. This low transmission loss of plastic intake manifolds causes several problems related to flow noise, especially when the throttle is opened quickly. The physical processes, responsible for this flow noise, include turbulent fluid motion and relative motion of the throttle to the airflow. The former is generated by high-speed airflow in the splits between the throttle valve and the inner-surface of the throttle body and surge-tank, which can be categorized into the quadrupole source. The latter induces the unsteady force on the flow, which can be classified into the dipole source. In this paper, the mechanism of noise generation from the turbulence is only investigated as a preliminary study. Stochastic noise source synthesis method is adopted for the analysis of turbulence-induced, i.e. quadrupole noise by throttle at quick opening state. The method consists of three procedures. The first step corresponds to the preliminary time-averaged Navier-Stokes computation with a $k-\varepsilon$ turbulence model providing mean flow field characteristics. The second step is the synthesis of time-dependent turbulent velocity field associated with quadrupole noise sources. The final step is devoted to the determination of acoustic source terms associated with turbulent velocity. For the first step, we used market available analysis tools such as STAR-CD, the trade names of fluid analysis tools available on the market. The steady state flows at three open angle of throttle valve, i.e. 20, 35 and 60 degree, are numerically analyzed. Then, time-dependent turbulent velocity fields are produced by using the stochastic model and the flow analysis results. Using this turbulent velocity field, the turbulence-originated noise sources, i.e. the self-noise and shear-noise sources are synthesized. Based on these numerical results, it is found that the origin of the turbulent flow and noise might be attributed to the process of formulation and the interaction of two vortex lines formed in the downstream of the throttle valve. These vortex lines are produced by the non-uniform splits between the throttle valve and inner cylinder surface. Based on the analysis, we present the low-noise design of the inner geometry of throttle body.

• The Korean Journal of Rheology
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• v.11 no.1
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• pp.9-17
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• 1999

Viscoelastic characteristics of cured phenolic resin/carbon fiber composite materials were investigated through glass transition and degradation reaction processes in the high temperature region up to $400^{\circ}C$. A typical glass transition of the cross-linked thermoset polymer was followed by irreversible degradation reactions, which were exhibited by the increasing storage modulus and loss modulus peak. A degradation master curve was constructed by using the vertical and horizontal shift factors, both of which complied well with the Arrhenius equation in light of the kinetic expression of degradation rate constants. Using an analogy to the Havriliak-Negami equation in dielectric relaxation phenomena, a viscoelastic modeling methodology was developed to characterize the frequency- and temperature-dependent complex moduli of the degrading thermoset polymer composite systems. The temperature-dependent relaxation time of the degrading composites was determined in a continuous fashion and showed a minimum relaxation time between the glass transition and degradation reaction regions. The capability of the developed modeling methodology was demonstrated by describing the complex behavior of the viscoelastic complex moduli of reacting phenolic resin composite systems.

• Wind and Structures
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• v.10 no.1
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• pp.1-22
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• 2007

The suppression of aerodynamic response of long-span suspension bridges during erection and after completion by using single TMD and multi TMD is presented in this paper. An advanced finite-element-based aerodynamic model that can be used to analyze both flutter instability and buffeting response in the time domain is also proposed. The frequency-dependent flutter derivatives are transferred into a time-dependent rational function, through which the coupling effects of three-dimensional aerodynamic motions under gusty winds can be accurately considered. The modal damping of a structure-TMD system is analyzed by the state-space approach. The numerical examples are performed on the Akashi Kaikyo Bridge with a main span of 1990 m. The bridge is idealized by a three-dimensional finite-element model consisting of 681 nodes. The results show that when the wind velocity is low, about 20 m/s, the multi TMD type 1 (the vertical and horizontal TMD with 1% mass ratio in each direction together with the torsional TMD with ratio of 1% mass moment of inertia) can significantly reduce the buffeting response in vertical, horizontal and torsional directions by 8.6-13%. When the wind velocity increases to 40 m/s, the control efficiency of a multi TMD in reducing the torsional buffeting response increases greatly to 28%. However, its control efficiency in the vertical and horizontal directions reduces. The results also indicate that the critical wind velocity for flutter instability during erection is significantly lower than that of the completed bridge. By pylon-to-midspan configuration, the minimum critical wind velocity of 57.70 m/s occurs at stage of 85% deck completion.

• The Korean Journal of Physiology and Pharmacology
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• v.1 no.2
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• pp.169-183
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• 1997

We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current ($I_{K(V)}$) and 'A-like' transient outward K current ($I_{to}$) with patch-clamp technique in single smooth muscle cells (SMCs) isolated from rabbit basilar artery, and investigated the characteristics of them. The time-courses of activation were well fitted by exponential function raised to second power ($n^2$) in $I_{K(V)}$ and fourth power ($n^4$) in $I_{to}$. The activation, inactivation and recovery time courses of $I_{to}$ were much faster than that of $I_{K(V)}$. The steady-state activation and inactivation of $I_{K(V)}$ was at the more hyperpolarized range than that of $I_{to}$ contrary to the reports in other vascular SMCs. Tetraethylammonium chloride (TEA; 10 mM) markedly inhibited $I_{K(V)}$ but little affected $I_{to}$. 4-Aminopyridine (4-AP) had similar inhibitory potency on both currents. While a low concentration of $Cd^{2+}$ (0.5 mM) shifted the current- voltage relationship of $I_{to}$ to the positive direction without change of maximum conductance, $Cd^{2+}$ did not cause any appreciable change for $I_{K(V)}$.

• Journal of the Korean Geotechnical Society
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• v.30 no.4
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• pp.21-34
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• 2014

This paper studies the time-dependent behaviors of tunnel and surrounding ground due to tunnel deterioration. In the first part, the literature on deterioration characteristics of tunnels was reviewed. In the second part, a numerical analysis was performed to investigate the behavior of concrete lining on the typical section of Korean high-speed rail tunnel (weathered rock) after determination of input variables related to deterioration impact. The result shows that the settlement at the crown of tunnel and surface ground increased up to 7.0% and 30.2% of the total settlements during construction stage, respectively, and the internal convergence reduction of 9.0 mm for concrete linings was generated within 30 years after completion of tunnel construction. Also the loosening height increased up to 2.55 times of tunnel height within 50 years, which is higher than that of Terzaghi's recommendation on ultimate state. Due to this process of extending zones, it is found that additional loads were applied to concrete lining with the axial stress about 3.20~3.66 MPa, which accelerates tunnel deterioration. Finally the quantitative design approach to evaluate time-dependent behavior of lining and surrounding ground due to tunnel deterioration was proposed.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2022.11a
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• pp.243-244
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• 2022

In this paper, experiments were conducted on signal amplification of polymer capsules for application to Ground Penetrating Radar so as to enable real-time monitoring of polymer capsules inside concrete using the Morphology Dependent Resonance phenomenon. A TEM CELL and a vector network analyzer were used to analyze the difference in resonance frequency depending on the material of the sphere and the presence or absence of fracture. In order to manufacture a capsule of a size that can be measured using millimeter waves used in GPR, we manufactured a capsule with a 3D printer and analyzed the effects of the presence or absence of coating and the size of the capsule on the resonance frequency. Resonant frequency or signal amplification is more affected by diameter than coating. The capsule showing the highest amplification is the resin-coated 50 mm diameter capsule with a 316-fold increase and the lowest capsule is the uncoated 10 mm diameter capsule with a signal amplification of 11.9 times. These results demonstrate the potential of GPR to measure the position and state of self-healing capsules, which are small-sized polymers, in real time using millimeter waves.