• The Korean Journal of Physiology and Pharmacology
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• v.10 no.2
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• pp.71-77
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• 2006

The goal of this study was to analyze the effects of genistein, a widely used tyrosine kinase inhibitor, on cloned Shaw-type $K^+$ currents, Kv3.1 which were stably expressed in Chinese hamster ovary (CHO) cells, using the whole-cell configuration of patch-clamp techniques. In whole-cell recordings, genistein at external concentrations from 10 to $100{\mu}M$ accelerated the rate of inactivation of Kv3.1 currents, thereby concentration-dependently reducing the current at the end of depolarizing pulse with an $IC_{50}$ value of $15.71{\pm}0.67{\mu}M$ and a Hill coefficient of $3.28{\pm}0.35$ (n=5). The time constant of activation at a 300 ms depolarizing test pulses from -80 mV to +40 mV was $1.01{\pm}0.04$ ms and $0.90{\pm}0.05$ ms (n=9) under control conditions and in the presence of $20{\mu}M$ genistein, respectively, indicating that the activation kinetics was not significantly modified by genistein. Genistein $(20{\mu}M)$ slowed the deactivation of the tail current elicited upon repolarization to -40 mV, thus inducing a crossover phenomenon. These results suggest that drug unbinding is required before Kv3.1 channels can close. Genistein-induced block was voltage-dependent, increasing in the voltage range $(-20\'mV{\sim}0\'mV)$ for channel opening, suggesting an open channel interaction. Genistein $(20{\mu}M)$ produced use-dependent block of Kv3.1 at a stimulation frequency of 1 Hz. The voltage dependence of steady-state inactivation of Kv3.1 was not changed by $20{\mu}M$ genistein. Our results indicate that genistein blocks directly Kv3.1 currents in concentration-, voltage-, time-dependent manners and the action of genistein on Kv3.1 is independent of tyrosine kinase inhibition.

• Proceedings of the KOR-KST Conference
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• 2003.02a
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• pp.127-150
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• 2003

This research presents a novel application of static traffic assignment methods, but with a variable time value, for estimating the market share of a high-speed rail (HSR) in the NW-SE corridor of Korea which is currently served by the airline (AR), conventional rail (CR), and highway (HWY) modes. The proposed model employs the time-space network structure to capture the interrelations among all competing transportation modes, and to reflect their supply- and demand-sides constraints as well as interactions through properly formulated link-node structures. The embedded cost function for each network link offers the flexibility for incorporating all associated factors, such as travel time and fare, in the model computation, and enables the use of a distribution rather than a constant to represent the time-value variation among all transportation mode users. To realistically capture the tripmakers' value-of-time (VOT) along the target area, a novel method for VOT calibration has been developed with aggregate demand information and key system performance data from the target area. Under the assumption that intercity tripmakers often have nearly "perfect" travel information, one can solve the market share of each mode after operations of HSR for each O-D pair under the time-dependent demand with state-of-the-art traffic assignment. Aside from estimating new market share, this paper also investigated the impacts of HSR on other existing transportation modes.

• Bulletin of the Korean Chemical Society
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• v.31 no.10
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• pp.2791-2796
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• 2010

In the present study, we constructed a membrane inlet assembly for selective permeation of volatile airborne organic compounds for subsequent analysis by time-of-flight mass spectrometry. The time-dependent diffusion of analytes through a $75\;{\mu}m$ thick polydimethylsiloxane membrane was measured by monitoring the ion signal after a step change in the sample concentration. The results fit well to a non-steady-state permeation equation. The diffusion coefficient, response time, and sensitivity were determined experimentally for a range of polar (halogenated) and nonpolar (aromatic) compounds. We found that the response times for several volatile organic compounds were greatly influenced by the alkyl chain length as well as the size of the substituted halogen atoms. The detection limits for benzene, ethylbenzene, and 2-propanol were 0.2 ppm, 0.1 ppm, and 3.0 ppm by volume, respectively, with a linear dynamic range greater than three orders of magnitude. These results indicate that the membrane inlet/time-of-flight mass spectrometry technique will be useful for a wide range of applications, particularly for in situ environmental monitoring.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.5 no.4
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• pp.35-42
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• 1991

Recently, HID lamps have been considered as important in regard to the trend of energy saving, and increasingly and diversely used in various ways. This paper will show the simulating models concerning high-pressure arc discharge system directly applicable for its design and manufacture, and analyze its various characteristics. For warm-up characteristics, the evaporating process of inner atoms is described in terms of second-order differential equation: for the thermal conduction from are axis to discharge wall and outer bulb, its transfer process is introduced according to five first-order differential equations. Under the steady state satisfying LTE, the time-variant characteristics are suggested by means of time-dependent energy balance equation derived from fluid equations, approximation of radiation energy and material functions in the discharge tube. The simulating models concerning these equations are then applied for high-pressure mercury lamp.

• Journal of Mechanical Science and Technology
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• v.15 no.5
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• pp.656-664
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• 2001

A theoretical analysis is performed to describe the qualitative behavior of transient buoyant flows in a vertical channel. Consideration is given to the case of a fluid with a pre-existing stratification. The fluid motion is generated by giving impulsive anti-symmetric step-changes in temperature at the vertical left ad right sidewalls. The qualitative character of the flow is shown to be classified in the Rayleigh number (Ra)-Prandtl number ($sigma$) diagram. The transitory approach to the steady state can be monotonic or oscillatory, depending on ($sigma$-1)$^2$$pi$$^4$ 4$sigma$$R_a$. The prominent characteristics of time-dependent flow are discussed for large $R_a$. The profiles of temperature and velocity in the transient phase are depicted, which disclose distinctive time scales of motion. The transient process is shown to be sensitive to the Prandtl number. The detailed evolutions of flow and temperature fields are illustrated for large $R_a$.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.7 s.124
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• pp.624-631
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• 2007

PFA (power flow analysis) has been recognized as a useful method in vibration analysis of medium-to-high frequency ranges. Until now, PFA method has been developed for steady-state vibration problems. In this paper, PFA method has been expanded to transient problem. New energy governing equations are derived considering time dependent terms in beam and plate. Analytic solutions of those equations are found in simple beam and plate, and are verified by comparing with modal solutions.

• Journal of the Korean Operations Research and Management Science Society
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• v.18 no.3
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• pp.51-63
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• 1993

We consider a cyclid server system under N-policy. This system consists of multiple queues served in a cyclic order by a single server. In this paper, we consider the following control policy. Every time server polls one queue, the server inspects the state of the queue. If the total number of units is found to have reached or exceeded a pre-specified value, the server begins to serve the queue until it is empty. As soon as the queue becomes empty, the server polls next queue. An approximate analysis of this system is presented. Sever vacation model is used as an analytical tool. However, server vacation periods are considered to be dependent on the service times of respective queues. The results obtained from the approximate analysis are ompared with simulation results.

• Transactions on Electrical and Electronic Materials
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• v.17 no.2
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• pp.109-112
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• 2016

We demonstrated an alternative electrically controlled birefringence liquid crystal (ECB-LC) system with ion beam (IB)-irradiated yttrium gallium oxide (YGaO) alignment films using a sol-gel process. The surface roughness of the films was dependent on the annealing temperature; aggregated particles on surface were observed at lower annealing temperatures, whereas a smooth surface could be obtained with higher annealing temperatures. Higher transmittance in the visible region was observed at higher annealing temperatures. The film had an amorphous crystallographic state irrespective of the annealing temperature. Furthermore, ECB-LC cell with our IB-irradiated YGaO film yielded faster response time when compared to ECB-LC cell with rubbed polyimide. Considering the fast response time and high transmittance, the IB-irradiated YGaO-base LC system is a powerful alternative application for the liquid crystal display industry.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.10
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• pp.908-916
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• 2000

In this paper, the characteristics of moisture ventilation in the lithium ion battery manufacturing dry room are studied numerically using standard $k-\varepsilon$ turbulence model. Both the steady-state and the unsteady behaviors of moisture ventilation are analyzed by considering local and uniform moisture generation. In order to evaluate the characteristics of moisture ventilation, three scales of ventilation efficiency and characteristic ventilation time are presented from the numerical results. It was shown that moisture distribution was dependent strongly on the flow field. The characteristics of moisture ventilation were improved by 20% and 40% in terms of the 1st scale of ventilation efficiency (SVE1) and the 2nd scale of ventilation efficiency (SVE2), respectively, through the modifications of design variables such as the addition of inlets, outlets and partition. A significant improvement in the characteristic ventilation time and the moisture exhaust efficiency was also made by these modifications.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.8
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• pp.696-702
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• 2004

An optimal trajectory generation algorithm for capturing a moving object by a mobile robot in real-time is proposed in this paper. The linear and rotational velocities of the moving object are estimated using the Kalman filter, as a state estimator. For the estimation, the moving object is tracked by a 2-DOF active camera mounted on the mobile robot, which enables a mobile manipulator to track the mobile robot until the capturing moment. The optimal trajectory for capturing the moving object is dependent on the initial conditions of the mobile robot as well as the moving object. Therefore, real-time trajectory planning for the mobile robot is definitely required for the successful capturing of the moving object. The performance of proposed algorithm is verified through the real experiments and the superiority is demonstrated by comparing to other algorithms.