• Title/Summary/Keyword: time-dependent effect

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Antithrombotic Activity of Extracts from the Aromatic Herb Elsholtzia splendens

  • Kim, Won Shik;Lim, Yong
    • Biomedical Science Letters
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    • v.23 no.3
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    • pp.277-280
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    • 2017
  • Elsholtzia splendens, which grows on moist soil of mountainous regions, is widely distributed at all regions of Korea, especially at Mountain Ji ri. It is categorized as a Labiatae plant which is dried aerial part. It has the following medicinal properties; removal of fever, alleviation of pain, a good antiphlogistic agent as well as antibacterial effects. However, the effects of E. splendens on thrombosis and platelet activation are not precisely understood. We performed this study to develop antithrombotic agents from oriental medicine herb extracts. E. splendens inhibited platelet aggregation induced by arachidonic acid and U46619 in a concentration dependent manner. E. splendens did not show an effect on anticoagulation as determined by prothrombin time (PT) or activated partial thromboplastin time (aPTT). We also tested the effects of E. splendens using a carotid artery thrombosis rat model induced by 35% $FeCl_3$ treatment. E. splendens significantly inhibited thrombus weight compared with the control group. These results show that E. splendens may be developed as a potential antiplatelet activity agent for treatment of cardiocerebrovascular disease and atherosclerosis.

The Secondary Chamber Pressure Characteristics of Sonic/Supersonic Ejector-Diffuser System (음속/초음속 이젝터 시스템의 2차정체실 압력특성)

  • Jung, S.J.;Lee, J.H.;Lee, K.H.;Choi, B.G.;Kim, H.D.
    • Proceedings of the KSME Conference
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    • 2001.11b
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    • pp.646-651
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    • 2001
  • The present study is an experimental work of the sonic/supersonic air ejector-diffuser system. The pressure-time dependence in the secondary chamber of this ejector system is measured to investigate the steady operation of the ejector system. Six different primary nozzles of two sonic nozzles, two supersonic nozzles, petal nozzle, and lobed nozzle are employed to drive the ejector system at the conditions of different operating pressure ratios. Static pressures on the ejector-diffuser walls are to analyze the complicated flows occurring inside the system. The volume of the secondary chamber is changed to investigate the effect on the steady operation. the results obtained show that the volume of the secondary chamber does not affect the steady operation of the ejector-diffuser system but the time-dependent pressure in the secondary chamber is a strong function of the volume of the secondary chamber.

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Optimization of Job-Shop Schedule Considering Deadlock Avoidance (교착 회피를 고려한 Job-Shop 일정의 최적화)

  • Jeong, Dong-Jun;Lee, Du-Yong;Im, Seong-Jin
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.24 no.8 s.179
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    • pp.2131-2142
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    • 2000
  • As recent production facilities are usually operated with unmanned material-handling system, the development of an efficient schedule with deadlock avoidance becomes a critical problem. Related researches on deadlock avoidance usually focus on real-time control of manufacturing system using deadlock avoidance policy. But little off-line optimization of deadlock-free schedule has been reported. This paper presents an optimization method for deadlock-free scheduling for Job-Shop system with no buffer. The deadlock-free schedule is acquired by the procedure that generates candidate lists of waiting operations, and applies a deadlock avoidance policy. To verify the proposed approach, simulation resultsare presented for minimizing makespan in three problem types. According to the simulation results the effect of each deadlock avoidance policy is dependent on the type of problem. When the proposed LOEM (Last Operation Exclusion Method) is employed, computing time for optimization as well as makespan is reduced.

Soy Isoflavones Do Not Alter the Effects of Fructooligosaccharide on the Intestinal Ecosystem of Colon-Cancer Model Rats

  • Sung, Hye-Young;Lim, Young-Jee;Choi, Young-Sun
    • Food Science and Biotechnology
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    • v.15 no.6
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    • pp.931-936
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    • 2006
  • This study sought to investigate any additive or interactive effects that soy isoflavones may have on the ecosystem of the gut, which is influenced by fructooligosaccharide (FOS) in colon-cancer model rats. Male Sprague-Dawley rats treated with 1,2-dimethylhydrazine were given experimental diets containing 0, 3, 6, or 9% FOS with or without 0.1% soy isoflavone for 12 weeks. In addition to the effects of FOS dosage on the gut ecosystem, dietary supplementation with soy isoflavone reduced the number of colonic aberrant crypts (ACs). The fecal weight, fecal pH, and gut transit time significantly decreased in a dose-dependent manner in rats fed FOS and the fecal concentration of bifidobacteria was higher in rats fed FOS than in control rats. The fecal output of total short-chain fatty acids, acetate, and propionate was significantly increased by the presence of FOS and was negatively correlated with the number of ACs, whereas the fecal output of butyrate showed no significant correlation with FOS dosage. The addition of soy isoflavone to the diet did not result in any significant differences in gut ecosystem parameters. Therefore, we conclude that the suppressive effect of soy isoflavone on ACs was not associated with the intestinal ecosystem, which was significantly altered by the dosage of FOS.

Structure-property relations for polymer melts: comparison of linear low-density polyethylene and isotactic polypropylene

  • Drozdov, A.D.;Al-Mulla, A.;Gupta, R.K.
    • Advances in materials Research
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    • v.1 no.4
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    • pp.245-268
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    • 2012
  • Results of isothermal torsional oscillation tests are reported on melts of linear low density polyethylene and isotactic polypropylene. Prior to rheological tests, specimens were annealed at various temperatures ranging from $T_a$ = 180 to $310^{\circ}C$ for various amounts of time (from 30 to 120 min). Thermal treatment induced degradation of the melts and caused pronounced decreases in their molecular weights. With reference to the concept of transient networks, constitutive equations are developed for the viscoelastic response of polymer melts. A melt is treated as an equivalent network of strands bridged by junctions (entanglements and physical cross-links). The time-dependent response of the network is modelled as separation of active strands from and merging of dangling strands with temporary nodes. The stress-strain relations involve three adjustable parameters (the instantaneous shear modulus, the average activation energy for detachment of active strands, and the standard deviation of activation energies) that are determined by matching the dependencies of storage and loss moduli on frequency of oscillations. Good agreement is demonstrated between the experimental data and the results of numerical simulation. The study focuses on the effect of molecular weight of polymer melts on the material constants in the constitutive equations.

Ionization Behaviors by Types of Soil due to Lightning Impulse Voltages in a Hemishperical Electrode System (반구형 전극계에서 뇌임펄스전압에 의한 토양의 종류별 이온화 특성)

  • Lee, Kyu-Sun;Park, Geon-Hun;Kim, Hoe-Gu;Lee, Bok-Hee
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.58 no.1
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    • pp.119-125
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    • 2009
  • This paper deals with the characteristics of soil ionization affecting the dynamic performance of grounding systems under lightning impulse voltage. A concentric hemispherical electrode system was employed in order to facilitate the field calculation and analysis of the experimental results. The parameters such as the ionization threshold and breakdown field intensity, the pre-ionization and the post ionization resistances, the time-lag to ionization, the transient impedance, the equivalent ionized radius for various soil media were measured and analyzed. The dynamic characteristics of ionization processes under lightning impulse voltage are strongly dependent on the types of soil and water content. As a result, a soil ionization reduces the ground resistance and there is a little effect of applied impulse polarity on the soil ionization threshold field intensity. Although the ionization threshold field intensity of wet clay with 30% water content is the highest, its ionized zone was found to be the smallest amongst the test samples.

Survival of Colorectal Cancer Patients in the Presence of Competing-Risk

  • Baghestani, Ahmad Reza;Daneshvar, Tahoura;Pourhoseingholi, Mohamad Amin;Asadzade, Hamid
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6253-6255
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    • 2014
  • Background: Colorectal cancer (CRC) is considered to be a main cause of malignancy-related death in the world, being commonly diagnosed in both men and women. It is the third leading cause of cancer dependent death in the world and there are one million new cases diagnosed per year. In Iran the incidence of colorectal cancer has increased during the last 25 years and it is the fifth cause of cancer in men and the third in women. Materials and Methods: In this article we analyzed the survival of 475 colorectal patients of Taleghani hospital in Tehran with the semi-parametric competing-risks model. Results: There were 55% male cases and at the time of the diagnosis most of the patients were between 48 and 67years old. The probability of a patient death from colorectal cancer with survival of more than 25 years was about 0.4. Body mass index, height, tumour site and gender had no influence. Conclusions: According to these data and by using semi-parametric competing-risks method, we found out that only age at diagnosis has a significant effect on these patient survival time.

Reliability Evaluation Through Moisture Sorption Characterization of Electronic Packaging Materials (전자 패키징 소재의 수착 특성화를 통한 신뢰성 평가)

  • Park, Heejin
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.9
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    • pp.1151-1158
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    • 2013
  • Knowledge of the moisture sorption properties of a material is essential for optimal material development and analysis of the delamination failure caused by vapor pressure at the interlayer during the manufacturing process of integrated packaging devices. In this paper, both temperature dependent absorption and desorption properties according to temperature and humidity model are parameterized and the effects of water activities and temperature are discussed. The activation energy obtained from the parameterized diffusivity determines the acceleration factor for the equivalency of moisture sorption levels, which enables the effect of moisture diffusivity on the equivalent elapsed testing time required for evaluating the reliable life time to be estimated. The acceleration factor evaluated at the reliability testing standard of the flexible packaging module is exampled.

Stochastic characteristics of reinforcement corrosion in concrete beams under sustained loads

  • Huang, Le;Jin, Xianyu;Fu, Chuanqing;Ye, Hailong;Dong, Xiaoyu
    • Computers and Concrete
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    • v.25 no.5
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    • pp.447-460
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    • 2020
  • This paper deals with the characteristics of reinforcement corrosion in concrete beams under the influence of sustained loads. The evolution and distribution laws of the reinforcement corrosion were measured periodically over time. The results show that sustained load exhibits a pronounced exacerbating effect on the reinforcement corrosion, and enlarges the nonuniformity level of corrosion as the load level increases. Accompanied with the continuous formation of the rust, the corrosion rate was also observed to be highly nonlinear and time-dependent. Moreover, to visually and quantitatively analyze the distribution of reinforcement corrosion, the 3D scanning technology combined with the probability statistics analysis was adopted, and the observed nonuniformity can be well described by the Gumbel distribution. Finally, an approach based on the three-phase spherical model was proposed to estimate the reinforcement corrosion, taking account of the effects of sustained load on the changes of concrete porosity and oxygen diffusivity.

The Conductivity of Silica Sand by Terahertz Electromagnetic Pulses (테라헤르츠 영역에서 분말 이산화규소의 도전률 측정에 관한 연구)

  • 전태인;김근주
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2001.05a
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    • pp.303-306
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    • 2001
  • Using THz time-domain spectroscopy (THz-TDS), the power absorption and the real conductivity of silica sand are measured terahertz frequency range. It is impossible to measure the characterization of the silica sand by simple electrical measurements using mechanical contacts, e.g., Hail effect or four-point probe measurements. However, the THz-TDS technique can measure not only electrical but also optical characterization of the sample. Also this technique can measure frequency dependent results. Especially, the real conductivity was increased according to THz frequency this is unusual material compare with metal and semiconductor materials; the measured real conductivity are not followed by the simple Drude theory.

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