• Earthquakes and Structures
• /
• v.10 no.2
• /
• pp.409-428
• /
• 2016

To realise the full benefits of a self-centering seismic resilient system, the designer must ensure that the entire structure does indeed re-center following an earthquake. The idealised flag-shaped hysteresis response that is often used to define the cyclic behaviour of self-centering concrete systems seldom exists and the residual drift of a building subjected to an earthquake is dependent on the realistic cyclic hysteresis response as well as the dynamic loading history. Current methods that are used to ensure that re-centering is achieved during the design of self-centering concrete systems are presented, and a series of cyclic analyses are used to demonstrate the flaws in these current procedures, even when idealised hysteresis models were used. Furthermore, results are presented for 350 time-history analyses that were performed to investigate the expected residual drift of an example self-centering concrete wall system during an earthquake. Based upon the results of these time-history analyses it was concluded that due to dynamic shake-down the residual drifts at the conclusion of the ground motion were significantly less than the maximum possible residual drifts that were observed from the cyclic hysteresis response, and were below acceptable residual drift performance limits established for seismic resilient structures. To estimate the effect of the dynamic shakedown, a residual drift ratio was defined that can be implemented during the design process to ensure that residual drift performance targets are achieved for self-centering concrete wall systems.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2010.09a
• /
• pp.736-742
• /
• 2010

This study was conducted to characterize on the relationships of rainfall intensity and infiltration rate of rainfall dependent on unit weight change in the gneissic weathered soil by a column test equipment. In this study, volumetric water content and pore water pressure were measured using TDR sensors and tensiometers at regular time intervals. Rainfall conditions including continuous rainfall and repeated rainfall were selected in order to know the effect of antecedent rainfall. In the condition of rainfall intensity 20mm/h and the unit weights of soil as $1.35g/cm^3$, $1.55g/cm^3$ and $1.61g/cm^3$, average rainfall infiltration rate was $2.814{\times}10^{-3}cm/sec$, $1.969{\times}10^{-3}cm/sec$ and $1.252{\times}10^{-3}cm/sec$ respectively. The higher rainfall intensity and lower unit weight of soil, the faster average infiltration rate. Overflow in the column was happened except rainfall condition of rainfall intensity 20mm and soil unit weight $1.35g/cm^3$. Increasing the soil unit weight, overflowed water was increased and occurrence time was faster.

• BMB Reports
• /
• v.34 no.2
• /
• pp.102-108
• /
• 2001

A time-dependent folding process was used to determine whether or not protein disulfide isomerase (PDI) plays an important role in the maturation of nascent lactoferrin polypeptides. Interaction between lactoferrin and PDI was analyzed according to the co-immunoprecipitation of the two proteins. The results indicate that lactoferrin folding requires a significant interaction with PDI and its binding is relatively brief compared to other nascent polypeptides. The amount of lactoferrin interacting with PDI increases up to half a minute and sharply decreases beyond this time point. During the refolding process that follows reduction by DTT, lactoferrin polypeptides heavily interact with PDI and the interaction period was extended compared to the normal folding process. In terms of the temperature effect on PDI-lactoferrin interaction, PDI binds to lactoferrin polypeptides longer at a lower temperature (here, $25^{\circ}C$) than $37^{\circ}C$. The lactoferrin-PDI interaction was also studied in vitro. According to the in vitro experiment data, PDI was still functional in cell lysates assisting lactoferrin folding into the mature form. PDI interacts with lactoferrin polypeptides for an extended period during the folding in vitro. During the refolding process in vitro, intermolecular aggregates and refolding oligomers matured into a functional form after PDI binds to the lactoferrin. These results suggest that PDI provides a prolonged chaperoning activity in the refolding processes and that there appears to be a greater requirement for PDI chaperone activity in the refolding of lactoferrin polypeptides.

• Korean Management Science Review
• /
• v.25 no.2
• /
• pp.57-71
• /
• 2008

We study factors that affect consumers' switching behaviors among service providers in Korean mobile telecommunications service market. For empirical analysis, quarterly time series data from the first quarter of 2004 through the second quarter of 2007 were used. We chose the number of switchers to each mobile service provider in each quarter as dependent variables. Independent variables include acquisition costs per subscriber, which play the role of subsidy to mobile handset, switching costs, time trend, structural change effect, and waiting demand effects. Through the empirical analysis, we found that each provider's churn-in customers are affected by different factors. Specifically, the number of churn-in customers into SK Telecom is explained mainly by SK Telecom's customer acquisition costs and waiting demand from KTF, while the number of customers switching into KTF is better explained by switching costs from the previous service provider and waiting demand from SK Telecom. Those who chose LG Telecom as their new provider, on the other hand, were mainly attracted by LG Telecom's high subscriber acquisition cost.

• Journal of Applied Biological Chemistry
• /
• v.48 no.4
• /
• pp.178-182
• /
• 2005

Nitric oxide (NO) produced from endothelial cells plays a critical role in vascular physiology. The regulation of endothelial NO synthase (eNOS) involves various mechanisms including multiple Ser/Thr phosphorylations. Recently, eNOS-Ser617 was newly recognized to be phosphorylated in response to humoral factors including vascular endothelial growth factor. However, it remains unknown whether and how eNOS-Ser617 phosphorylation is stimulated by shear stress, the primary stimulus of endothelial NO production. This issue was explored in the present study using cultured bovine aortic endothelial cells (BAECs). Over-expression of a constitutively active protein kinase B(Akt) mutant in BAECs increased Ser617 phosphorylation while constitutively active protein kinase A mutant had no effect. When BAECs were subjected to an arterial level of laminar shear stress, eNOS-Ser617 phosphorylation was clearly increased in a time-dependent manner. Shear stress also stimulated Akt phosphorylation at Thr308, one of the key regulatory sites. The time courses of eNOS-Ser617 and Akt-Thr308 phosphorylations appeared to be very similar. These results suggested that eNOS-Ser617 phosphorylation, mediated by Akt, is a physiological response to the mechanical shear stress, involved in the regulation of NO production in endothelial cells.

• Journal of the Korean Professional Engineers Association
• /
• v.42 no.4
• /
• pp.45-50
• /
• 2009

The modal split structure of the Korea's transportation system has been dominated by road-oriented structure. The shortage of the inftrastructure to accommodate the rapidly increasing travel demand has brought about socio-economic losses such as severe traffic congestion and high logistic costs, and thereby weakened the competitiveness of the country. Highway transportation sector is more vulnerable to energy consumption comparing with railway sector since the highway sector is dependent mostly on fossil fuels for its energy source. In 2006 annual road cogestion costs in Korea reached 24.6 trillion won, with an average annual growth rate of 5.4%. The annual road congestion cost of intercity highways were 9.2 trillion won. As the new cities that recently developed are located far from Seoul area, the boundary of commuting in Seoul metropolitan area is extended. It makes passengers have longer trips with longer travel time, and the congestion problem to be more serious. In this regards, Gyeonggi Provincial Government proposed a deeper underground metropolitan express train system for the greater Metropolitan area. which is named as GTX. Gyeonggi Province suggested 3 key underground lines, based on the outcome of the feasibility study conducted by the Korea Society of Transportation, and submitted to the Ministry of Land Transportation and Maritime Affairs for its review. If the project is approved for construction and completed in 2016, the daily volume of surface traffic bound for Seoul will be reduced substantially and therefore the users will be benefitted for time savings by an annual amount of 2 trilion won every year.

• Korean Journal of Medicinal Crop Science
• /
• v.20 no.5
• /
• pp.345-352
• /
• 2012

This experiment was conducted to verify whether one time feeding of Lythrum salicaria root crude extract (LSR extract) exhibits liver protecting activities in acutely ethanol administrated rat. Experiment groups were composed of normal, negative control (alcohol control), 2 positive control (Hovenia dulcis extract 900 mg/kg and milk thisle 100 mg/kg), betulinic acid (20 mg/kg), a compound separated from LSR, and 3 LSR (100, 300, 900 mg/kg) groups. LSR treated groups showed decrease (p < 0.05) in serum triglyceride by dose-dependent manner. The content of serum albumin and the activity of ADH and ALDH in LSR extract fed rats were increased (p < 0.05) dependently on the administration amounts. Our study indicated that one time supplement of LSR downregulates oxidative stress and shows liver protective activity in the acute alcohol-fed rats.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.495-498
• /
• 2013

Epidermal growth factor receptor (EGFR) is over-expressed in several human cancers. This would suggest that inhibition of EGFR is a reasonable approach for cancer treatment. In this study we investigated EGFR blocking and its effects on the mediated signaling such as MAPK and STATb in HT29 cells. For this aim we used FITC-labeled EGFR antisense oligonucleotides encapsulated with PAMAM nanoparticles to inhibit EGFR expression. Cellular uptake of antisense was investigated by fluorescence microscopy and flow cytometry analysis. The effect of EGFR antisense on the expression of EGFR in HT29 cells was examined by real time PCR and Western blots, which showed that antisense encapsulated with PAMAM decreased the level of EGFR mRNA and protein. In addition, real time PCR results confirmed that EGFR inhibition had an effective role in the reduction of EGFR dependent downstream genes. In conclusion, EGFR antisense encapsulated with PAMAM nanoparticles down regulated EGFR and EGFR-mediated genes.

• Journal of Families and Better Life
• /
• v.11 no.1
• /
• pp.22-34
• /
• 1993

The purposes of this study are as follows: 1) To estimate the amounts of differences in service expenditures resulting from the effects of mother's marital and employment status. 2) To find out the relationship of socio-economic variables to expenditures for time-saving durables and services Data were taken from the 1988-1989 Consumer Expenditure Survey. The sample consisted of 2,216 families with 334 single-mother families and 1,792 married-mother families. Tobit regres-sion analyses were used to test of variables related to expenditures for (a) food away from home. (b) clothing care (c) child care (d) domestic services and (e) total services. The results of this study were as follows; 1) The percentage difference from non-employed married-mother families was higher for employed single-mother families than for other types of families indicating the positive effect on expenditures on market substitutes of mother's marital and employment status. 2) The father's wage rate was associated only with expenditures for domestic services. A positive relationship was found between family nonlabor income and domestic services Total family income was positively associated with expenditues for all dependent variables. There was a negative relationship between expenditures for child care and age of mother squared. Mother's education was associated with expenditures in all categories. Families of nonwhite spent less on time-saving durables. food away from home, and total services and spent more on apparel services than families of white mothers. The presence of young child was positively related to total services and child care services and negatively related to food away from home.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2008.11a
• /
• pp.409-412
• /
• 2008

This study were evaluated the corrosion threshold reached at steel reinforcement in latex modified concrete(LMC). Accelerated testing was accomplished to the evalate the diffusion coefficient of LMC mix, and the time dependent constants of diffusion. Also, average chloride diffusion coefficient was estimated. From the average chloride ion diffusion coefficient, the time which critical chloride contents at depth of reinforcement steel was estimated. Test results indicated that the corrosion threshold reached at reinforcement in LMC are effected on the mix proportion factor including latex content, and water-cement ratio.