• Archives of Plastic Surgery
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• v.38 no.5
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• pp.636-641
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• 2011

Purpose: There are multiple dependent variables commonly attributed to survival of replanted digits. The ischemia time is thought to be a clinically relevant factor. However, controversy exists as large hand centers have reported successful replant outcomes independent of ischemic time. In this study, we present a single institution experience on the effect of ischemia time on the survival of completely amputated digits. Methods: A retrospective review of a single institution experience was performed. This cohort included all comers who had suffered complete amputation of a digit (Zone 2-4) and underwent replantation from 2003 to 2009. Demographic information as well as injury mechanism, ischemic time, and replantation outcome were recorded for each patient. Chi-square was used to analyze the result. Results: Mean age was 35.5 years old (2-69). Mean replantation survival was 89.5% (37/317). Survival rates were 94, 88, and 88% in respective groups of 0~6, 6~12, of > 12 hours of ischemia time. In chi-square analysis, there was no difference with $p$ value of 0.257. No other independent patient factors showed statistically significant relationship to replant survival rate. In the group with longest ischemia time (12~18 hours) replant survival rate was 88% (37/42). Conclusion: Prolonged ischemia time is commonly believed to be a contributing factor for replant survival. However, our experience has shown that survival rate is uniform up to 18 hours of ischemia.

• Polymer(Korea)
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• v.31 no.3
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• pp.263-268
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• 2007

Most of current works on the PEO-salt electrolytes has been focused on the enhancement of ionic conductivity with an addition of nano-ceramic fillers, but the significant drop of the conductivity with storage time is still in question and has been frequently overlooked. The conductivity drop with aging time has been assumed to come from the incorporation of ceramic particles. However, according to authors, the reported high-temperature values of the conductivity of pure $PEO_8LiCIO_4$ electrolytes are nearly in agreements, but the low temperature values are in great discrepancy reaching up to 10000 times. It indicates that the conductivity at ambient temperature is greatly dependent on the thermal history and sample preparations. In this paper, we showed that the ionic conductivities of both $PEO_8LiCIO_4$ and $PEO_8LiClO_4/Al_2O_3$ polymer electrolytes are strongly dependent on the thermal pretreatment and aging time. The conductivity drop with aging time of both ceramic-free and ceramic composite electrolytes has been measured to be nearly parallel. We showed that the conductivity relaxation with aging time is inherent irrespective of the incorporation of nano-ceramic fillers, since the PEO electrolytes at ambient temperature are in two-phase nature being in non-equilibrium state, never reaching completion.

• Science of Emotion and Sensibility
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• v.13 no.1
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• pp.129-146
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• 2010

System response times(SRTs) are getting important while increasing the function of system. In the past, most research studied SRTs on situation of computer usage. There are lacking the research on simple domain. This study focuses on behavioral and emotional effect on situation of cell phone usage(experience 1; independent variables: degree of SRTs, dependent variables: behavioral and emotional evaluation). And this study investigates the behavioral and emotional effect in same SRTs on different situation(experience 2; independent variables: degree of SRTs, usage mode, dependent variables: behavioral and emotional evaluation, stress, mental strain). The result indicated that long SRTs increased problem solving time and negative emotion. User evaluated the system differently according to usage mode after they performed the same task. In other word, if user had a strong goal, then they felt more negative emotion and mental effort than the user don't have a strong goal. In the goal mode group, it was important there are being of delay or not. This study demonstrated that SRTs and usage mode influence user's emotion and behavior performance in same task.

• Archives of Pharmacal Research
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• v.29 no.10
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• pp.898-903
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• 2006

The antiplatelet and antithrombotic activities of Korean Red Ginseng (KRG) were examined on rat carotid artery thrombosis in vivo, and platelet aggregation in vitro and ex vivo. Administration of KRG to rats not only prevented carotid artery thrombosis in vivo in a dose-dependent manner, but also significantly inhibited ADP- and collagen-induced platelet aggregation ex vivo, while failed to prolong coagulation times such as activated partial thromboplastin time (APTT) and prothrombin time (PT), indicating the antithrombotic effect of KRG might be due to its anti platelet aggregation rather than anticoagulation effect. In line with the above observations, KRG inhibited U46619-, arachidonic acid-, collagen- and thrombin-induced rabbit platelet aggregation in vitro in a concentration-dependent manner, with $IC_{50}$ values of $620{\pm}12$, $823{\pm}22$, $722{\pm}21$ and $650{\pm}14\;{\mu}g/mL$, respectively. Accordingly, KRG also inhibited various agonists-induced platelet serotonin secretions as it suppressed platelet aggregation. These results suggest that KRG has a potent antithrombotic effect in vivo, which may be due to antiplatelet rather than anticoagulation activity, and KRG intake may be beneficial to the individuals with high risks of thrombotic and cardiovascular diseases.

• Journal of Marine Life Science
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• v.7 no.1
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• pp.15-20
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• 2022

Glioblastoma is one of the highly aggressive central nervous system tumors and it is difficult to treat owing its anatomical location. Peptides are novel class of drugs which has the potential to cross the blood brain barrier and exerts its anti-tumor activity. Here, we discovered a novel peptide from abalone (Haliotis discus hannai) next generation sequencing (NGS) data and tested its anticancer effect on glioblastoma cell line SNU-489. The anticancer activity was measured using a cytotoxicity assay in a time and dose-dependent manner. A concentration and time dependent increase in the cytotoxicity was seen in cells treated with the novel peptide. The highest cytotoxicity rate of about 67% was observed in SNU-489 cells treated with 200 µM peptide for 48 hrs. However, the cytotoxic effect was not or less observed in a normal skin cell line HaCaT at similar concentration, thus, evident of peptide's cell specific anticancer activity. In addition, the gene expression level of necroptosis-related genes was analyzed by qRT-PCR to elucidate the anticancer mechanism of the novel peptide. RIPK3 expression was significantly increased by 9.6-fold in 200 µM of novel peptide treatment group, and MLKL expression level was significantly elevated by 2-fold in 100 µM treated group compared to the control group. Therefore, this study confirmed that the novel abalone-derived peptide has anticancer potency, and it causes cancer cell death through the necroptosis mechanism. Collectively, these results suggest that the novel peptide could be candidate anticancer agent for the treatment of glioblastoma in the future.

• Information Systems Review
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• v.20 no.2
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• pp.209-226
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• 2018

Location-based services have distinctive service characteristics compared to the past online commerce used on the desktop. In any place, mobile communication devices can be used to access online and utilize online shopping, and it is more convenient for users. In addition, by providing shopping and service information specific to each location, it is possible to provide convenience to the consumers according to their locations. In addition, it provides scarcity of information as well as location, thereby increasing consumers' desire to purchase. In this study, we investigated the effect of scarcity on the Purchase intention of consumers in location-based services. The steps of scarcity are: first, a step without scarcity, Second, providing time limit information, Third, providing quantity limitation information, Fourth, the experiment was designed to provide time and quantity limitation, and 4 groups were analyzed through experimental stimuli The purpose of this study is to verify the moderating effect of the dependent variable on the degree of scarcity by adding 'ubiquity', 'interactivity' and 'privacy' which are characteristics of location-based service. As a result of the analysis, scarcity of time and scarcity of quantity limitation scarcity stimuli showed a moderating effect on ubiquity, interactivity and consumer's purchase intention, and these variables also directly or indirectly affected positively. Consumer confidence was found to have a negative effect on consumers' purchase intentions.

• Korean Journal of Animal Reproduction
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• v.17 no.2
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• pp.85-92
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• 1993

In the previous study, we observed that Purine has a time dependent effect in maintaining the oocytes in meiotic arrest, and human fetal cord serum(HFCS) and human mature follicular fluid(HMFF) reverse the GVBD suppressed by purines. And it was reported that purine has a harmful effect on the development of oocytes or embryos, when they were cultured for a long time, in vitro. Therefore this study was performed to investigate the effects of purine on extrusion rates of 1st pb and viability of oocytes cultured for a long time, in vitro. Immature oocytes(GV stage) were collected from ovaries of 25~28 day old ICR mice at 48 hrs after PMSG injection. Cumulus-enclosed and denuded oocytes collected were assigned randomly to one of several culture conditions. Some of the oocytes were cultured in 4mM hypoxanthine for 24hr, and the extrusion rates of 1st pb and viability of the oocytes were assessed at every 12 hrs. In the viability, the oocytes showed granulation, pigmentation of cytoplasm or lysis of 1st pb extruded were regarded as degenerating oocytes. Also some of the oocytes were cultured in hypoxanthine for 12 hrs then the resulting oocytes were transferred to hypoxanthine-free medium and cultured for 12 hrs to determine whether the inhibitory effect of hypoxanthine on the 1st pb extrusion was reversible. The rest of the oocytes were cultured in medium containing hypoxanthine and adenosine for 18 hrs to compare the 1st pb extrusion be attendant upon hte concentration of HFCS or HMFF supplemented. Hypoxanthine suppressed the extrusion of 1st pb and viability of the oocytes significantly, when they were cultured for more than 12 hrs and the harmful effect of hypoxanthine was showed in denuded oocytes, prominently. The suppressive effect of hypoxanthine was reversed by just removal of the hypoxanthine from the cultrue medium. Also there was no difference in reverse the pb extrusion rate suppressed between HFCS and HMFF. The extrusion rate of 1st pb in medium containing adenosine and hypoxanthine was increased in line with the concentration of HFCS or HMFF supplemented. Hypoxanthine suppressed the extrusion of 1st pb and viability of the oocytes significantly, when they were cultured for more than 12 hrs and the harmful effect of hypoxanthine was showed in denuded oocytes, prominetly. The suppressive effect of hypoxanthine was reversed by just removal of the hypoxanthine fromthe culture medium. Also there was no difference in reverse the pb extrusion rate suppressed between HFCS and HMFF. The extrusion rate of 1st pb in medium containing adenosine and hypoxanthine was increased in line with the concentration of HFCS or HMFF supplemented.

• The Journal of the Acoustical Society of Korea
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• v.32 no.2
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• pp.95-103
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• 2013

An underwater acoustic (UWA) communication in shallow water is strongly affected by the water surface and the seabed acoustical properties. Every reflected signal to receiver experiences a time-variant scattering in sea surface roughness and a grazing-angle-dependent reflection loss in bottom. Consequently, the performance of UWA communication systems is degraded, and high-speed digital communication is disrupted. If there is a dominant signal path such as a direct path, the received signal is modeled statistically as Rice fading but if not, it is modeled as Rayleigh fading. However, it has been known to be very difficult to reproduce the statistical estimation by real experimental evaluation in the sea. To give an insight for this scattering and grazing-angle-dependent bottom reflection loss effect in UWA communication, authors conduct experiments to quantify these effects. The image is transmitted using binary frequency shift keying (BFSK) modulation. The quality of the received image is shown to be affected by water surface scattering and grazing-angle-dependent bottom reflection loss. The analysis is based on the transmitter to receiver range and the receiver depth dependent image quality and bit error rate (BER). The results show that the received image quality is highly dependent on the transmitter-receiver range and receiver depth which characterizes the channel coherence bandwidth.

• Journal of Astronomy and Space Sciences
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• v.12 no.1
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• pp.123-132
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• 1995

We developed a S/W system to simulate the orbit tracking data as nearly equal as the real data obtained at the tracking antenna by modeling various causes that could have effects on the tracking data (range, range rate, azimuth, elevation) of an artificial satellite. Using the S/W developed we produced delay values of tracking data due to the light-time effect and the terrestrial atmosphere. According to the simulation results due to the Earth atmosphere, the values delayed by the troposhpere were increased as the temperature, relative humidity, and pressure of the troposphere are more larger. However, delay values due to the ionosphere were dependent on both the maximum electron density and the frequencies used. They are more and more increased as the maximum electron density and frequency are more larger. And the delaying values by the light-time effect are more larger by the fast orbital motion as the altitude of an artificial satellite is more lower.

• Journal of the Korean Applied Science and Technology
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• v.36 no.4
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• pp.1349-1357
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• 2019

The purpose of this study was to investigate to effect of core exercise with swiss ball on sarcopenia index in agriculture older women. A total of 30 subjects(15 Ex group, 15 Con group, 65 over agriculture older woman) were participated in this study. Intervention group were assigned to performing a progressive core exercise training program for 12 weeks(2 time/week). Dependent variable were grip strength, chair stand, muscle mass, 4m gait speed, Timed up and go, and 400m walking. As a result were following. Grip strength was not significantly difference but chair stand was significantly difference in time. And muscle mass was significantly difference in groups. And 4m gait speed, Timed up and go and 400m walking were significantly difference in time. In conclusion, lower body muscle strength and short physical performance battery by muscle activating with core muscle strength training.