• Archives of Pharmacal Research
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• v.24 no.5
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• pp.441-445
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• 2001

Resveratrol, a trihydroxystilbene found in grapes and several plants, has been shown to be active in inhibiting multistage carcinogenic process. Using resveratrol as the prototype, we synthesized several analogs and evaluated their growth inhibitory effect using cultured human cancer cells. In the present report we show that one of the resveratrol analogs, 3, 5,2',4'-tetramethoxy-trans-stilbene, potentiated the inhibition of cancer cell growth. Prompted by the strong growth Inhibitory activity of the compound ($IC_{50}$; $0.8{\mu}$ g/ml) compared to resveratrol ($IC_{50}$; $18{\mu}$ug/ml) in cultured human colon cancer cells (Col2), we performed an action mechanism study using the compound. The compound induced the accumulation of cellular DNA contents in the sub-CO phase DNA contents of the cell cycle by in a time-dependent manner. The morphological changes were also consistent with an apoptotic process. This result indicated that the compound induced apoptosis of cancer cells, and may be a candidate for use in the development of potential cancer chemotherapeutic or cancer chemopreventive agents.

• Nuclear Engineering and Technology
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• v.32 no.4
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• pp.410-423
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• 2000

A two-dimensional numerical model is developed and applied to the LAVA-EXV tests performed at the Korea Atomic Energy Research Institute (KAERI) to investigate the external cooling effect on the thermal margin to failure of a reactor pressure vessel (RPV) during a severe accident. The computational program was written to predict the temperature profile of a two-dimensional spherical vessel segment accounting for the conjugate heat transfer mechanisms of conduction through the debris and the vessel, natural convection within the molten debris pool, and the possible ablation of the vessel wall in contact with the high temperature melt. Results of the sensitivity analysis and comparison with the LAVA-EXV test data indicated that the developed computational tool carries a high potential for simulating the thermal behavior of the RPV during a core melt relocation accident. It is concluded that the main factors affecting the RPV failure are the natural convection within the debris pool and the ablation of the metal vessel, The simplistic natural convection model adopted in the computational program partly made up for the absence of the mechanistic momentum consideration in this study. Uncertainties in the prediction will be reduced when the natural convection and ablation phenomena are more rigorously dealt with in the code, and if more accurate initial and time-dependent conditions are supplied from the test in terms of material composition and its associated thermophysical properties.

• Biomolecules & Therapeutics
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• v.2 no.1
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• pp.11-15
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• 1994

The detoxifying properties of cruciferous vegetables components have been the subject of several recent investigations. Evidences from many biochemical and pharmacological studies indicated that higher consumption of cruciferous vegetables is associated with lower incidence of harmful actions such as hepatotoxicity and oxidative stress in animal and human populations. Recently, it has been reported that drug metabolizing and detoxifying enzyme activities were increased by cruciferous vegetable extract in which sinigrin is known to be a main active component, accounting for about 2 to 3 percents of total extract. The detoxifying effect of sinigrin has been well reported in several literatures. The metabolism of sinigrin in animal, however, has not been reported yet. That led us to study the metabolism of sinigrin in rat. Sinigrin is nown to be metabolized into three compounds, i.e., allyl isothiocyanate, glucose and potassium phosphate in cruciferous vegetables. Allyl isothiocyanate was formed in rat hepatic mitochondrial fraction in dose and incubation time dependent manner, that was confirmed by HPLC. Glucose formation was came up with results similar to that of allyl isothiocyanate. Three hours after i.p. administration of sinigrin to rat, allyl isothiocyanate appeared in rat liver, and five hours later it was detected in liver and blood. The above results suggested that sinigrin might be metabolized into allyl isothiocyanate, glucose and potassium phosphate in rat.

• Korean Journal of Veterinary Service
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• v.17 no.3
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• pp.247-254
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• 1994

To elucidate the action of the cholinergic nerve on the isolated uterine smooth muscle of the pig, effects of electrical transmural nerve stimulation and acetylcholine were investigated on the pretreatment of the physostigmine ; cholinestrase inhibitor and atropine ; cholinergic receptor blocker from physiograph. 1. The contractile response induced by acetylcholine was responsed in the concentration of 10^{-8}$ M at first and the maximum contractility was concentration of $10^{-6}$ M. 2. The contractile response induced by electrical transmural nerve stimulation(20 V, 0.5 Msec, 20 sec) was the frequency(2-64 Hz) -dependent manner. 3. The contractile response induced by acetylcholine was completely blocked by the pretreatment with cholinergic receptor blocker, atropine and was increased by the pretrement of cholinestrase inhibitor, physostigmine. 4. The contractile response induced by electrical transmural nerve stimulation was completely blocked by the pretreatment with cholinergic receptor blocker, atropine, and was increased by the pretretment of cholinestrase inhibitor, physostigmine. These findings suggest that it was powerful excitatory action by cholinergic nerve on uterine smooth muscle of the pig.

• Magazine of the Korea Concrete Institute
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• v.11 no.1
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• pp.99-107
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• 1999

In this paper, the prediction method of the differential column shortening for cracked reinforced concrete tall buildings due to the construction sequence is presented. The cracked sectional properties from the strain and curvature of the sectional centroid is directly used. And the stiffness matrix of concrete elements considering the axial strain-curvature interaction effect is adopted. The creep and shrinkage properties used in the predictions were calculated in accordance with ACI 209, CEB-FIP 1990, and B3 model code. In order to demonstrate the validity of this algorithm, the prediction by the proposed method are compared with both the results of the in-situ test and the results by other simplified method. The proposed method is in good agreement with experimental results, and better than the simplified method.

• International Journal of Advanced Culture Technology
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• v.6 no.3
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• pp.151-162
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• 2018

In deriving the economic order quantity (EOQ) formula, it is tacitly assumed that the buyer has to pay product price while receiving the product from the supplier. However, as a marketing policy, some suppliers permit a delay in payments to the buyers to increase demand for the product they made. Credit transactions would have a positive effect on both suppliers and buyers. For a supplier who offers trade credit, it is an effective means of price differentiation to increase the demand for the product. Availability of opportunity to delay the payment in buyer effectively reduces the cost of holding stocks and therefore, the buyer has a lot of price options to choose his sales price for a customer. Since the buyer's order is affected by the customer's demand, the problems of determining the sales price and EOQ are interdependent and must be solved simultaneously. From this perspective, this paper evaluates the problem of determining the optimal sales price and EOQ for the buyer at the same time when the supplier allows a delay in payments for the product whose demand is represented as a function that decreases linearly with the sales price. For the analysis, it is also assumed that inventory is exhausted not only by customer's but also by decay.

• Journal of the Korean Ceramic Society
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• v.30 no.1
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• pp.62-68
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• 1993

Densification of alumina powder, grain size and fracture toughness of sintered body by hot pressing after cold compaction were investigated and compared to traditional hot pressing process (without cold cyclic compaction). To achieve a higher densification and to reduce the hot pressing time, hot pressing after cold cyclic compaction was more efficient compared to traditional hot pressing. This phenomenon resulted from the increment of packing densityby the acceleration fo rearrangement of powders under cold cyclic compaction. The grain size of sintered body was only dependent on relative density, and densification during hot pressing was governed by thelattice diffusion. Comprisons of grain size, densification mechanism and fracture toughness resulted from hot pressing after/without cold cyclic compaction showed that a low cyclic pressure may not effect on the fragmentation of alumina powders.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.10
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• pp.811-816
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• 2018

When applying the MLFMM algorithm to a large scattering problem, the accuracy of the calculation of the transfer function has a crucial effect on the final simulation results. The numerical accuracy for the double integral on the unit sphere is strongly dependent on the sampling number. With an increasing the sampling points, the overall required memory and running time of the MLFMM simulation also increases. Hence, an optimal over-sampling rate for the number of the sampling points is numerically obtained, which is verified for a real large scattering problem.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5325-5329
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• 2015

Farnesiferol C is a natural compound with various anti-cancer properties that belongs to the class of sesquiterpene coumarins. However, the low bioavailability of farnesiferol C limits its therapeutic potential. Here, we overcame this problem utilizing dendrosome nano-particles and evaluated the anti-cancer effect of dendrosomal farnesiferol C (DFC) on the AGS gastric cancer cell line. The 3-(4,5-dimethyl-thiazol-2yl)-2,5- diphenyl tetrazolium bromide (MTT) assay and reverse transcriptase-polymerase chain reaction (RT-PCR) were respectively used to detect the anti-proliferative properties of DFC and expression ratio of Bax/Bcl-2 as a hallmark of apoptosis. Compared to the void farnesiferol C (FC), our data showed that DFC significantly suppresses the proliferation of AGS cells in a time- and dose-dependent manner (P<0.01). Also, DFC meaningfully increased the expression ratio of Bax/Bcl-2 in AGS cells (P<0.01). The findings demonstrate that our nano-based formulation of farnesiferol C could be considered as a potential therapeutic agent in cancer targeting.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4615-4619
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• 2013

Background: Artesunate, extracted from Artemisia annua, has been proven to have anti-cancer potential. Allicin, diallyl thiosulfinate, the main biologically active compound derived from garlic, is also of interest in cancer treatment research. This object of this report was to document synergistic effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo. Methods: After treatment with artesunate and allicin at various concentrations, the viability of osteosarcoma cells was analyzed by MTT method, with assessment of invasion and motility, colony formation and apoptosis. Western Blotting was performed to determine the expression of caspase-3/9, and activity was also detected after drug treatment. Moreover, in a nude mouse model established with orthotopic xenograft tumors, tumor weight and volume were monitored after drug administration via the intraperitoneal (i.p.) route. Results: The viability of osteosarcoma cells in the combination group was significantly decreased in a concentration and time dependent manner; moreover, invasion, motility and colony formation ability were significantly suppressed and the apoptotic rate was significantly increased through caspase-3/9 expression and activity enhancement in the combination group. Furthermore, suppression of tumor growth was evident in vivo. Conclusion: Our results indicated that artesunate and allicin in combination exert synergistic effects on osteosarcoma cell proliferation and apoptosis.