• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권5호
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• pp.357-362
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• 2012

Cherubism is a rare familial disease of childhood, characterized by proliferative lesion, which is within the maxilla and mandible. In a typical case, painless symmetric expansile lesions develop in the jaws. It shows substitution of the bone by proliferating fibrous tissue exhibiting mature fibroblasts and a number of multinucleated giant cells within an intercellular matrix. Usually, the disease manifests in early childhood, and becomes more marked until puberty, at which time the bony lesions begin to regress. As such, conservative approaches to management are advisable. However, excision of tissue through enucleation or curettage appears to be necessary in more aggressive cases, to reduce the maxillofacial deformity after puberty and to ensure a successful outcome without the risk of progression, requiring additional resection. This report describes 2 cases of manifestation of cherubism of oral and maxillofacial region. We present diagnosis, radiological - histopathologic features, and treatment of cherubism.

• Asian-Australasian Journal of Animal Sciences
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• 제25권9호
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• pp.1338-1350
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• 2012

This review focuses on the nutritional effects from birth until age at first calving on growth, mammary developmental changes, and first-lactation milk yield in heifer calves. The advancement in the genetic potential and the nutritional requirements of the animals has hastened the growth rate. Genetic selection for high milk yield has suggested higher growth capacity and hence increasing nutritional inputs are required. Rapid rearing by feeding high energy or high concentrate diets not only reduces the age of sexual maturity but also lowers the time period of attaining the age of first calving. However, high energy diets may cause undesirable fat deposition thereby affecting future milk yield potential. Discrepancies exist whether overfed or overweight heifers at puberty can influence the mammary development and future milk yield potential and performance. The data on post-pubertal nutritional management suggested that body weight at calving and post-pubertal growth rate is important in first lactation milk yield. There is a continuous research need for strategic feeding that accelerates growth of dairy heifers without reduction in subsequent production. Nutritional management from birth, across puberty and during pregnancy is critical for mammary growth and for producing a successful cow. This review will mostly highlight studies carried out on dairy breeds and possible available opportunities to manipulate nutritional status from birth until age at first calving.

• Clinical and Experimental Reproductive Medicine
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• 제42권2호
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• pp.72-76
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• 2015

$17{\alpha}$-hydroxylase and 17,20-lyase are enzymes encoded by the CYP17A1 gene and are required for the synthesis of sex steroids and cortisol. In $17{\alpha}$-hydroxylase deficiency, there are low blood levels of estrogens, androgens, and cortisol, and resultant compensatory increases in adrenocorticotrophic hormone that stimulate the production of 11-deoxycorticosterone and corticosterone. In turn, the excessive levels of mineralocorticoids lead to volume expansion and hypertension. Females with $17{\alpha}$-hydroxylase deficiency are characterized by primary amenorrhea and delayed puberty, with accompanying hypertension. Affected males usually have female external genitalia, a blind vagina, and intra-abdominal testes. The treatment of this disorder is centered on glucocorticoid and sex steroid replacement. In patients with $17{\alpha}$-hydroxylase deficiency who are being raised as females, estrogen should be supplemented, while genetically female patients with a uterus should also receive progesterone supplementation. Here, we report a case of a 21-year-old female with $17{\alpha}$-hydroxylase deficiency who had received inadequate treatment for a prolonged period of time. We also include a brief review of the recent literature on this disorder.

• 복식문화연구
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• 제15권1호
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• pp.37-57
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• 2007

The purpose of this study was to analyze the body measurements of boys and girls at puberty and to provide the fundamental data for pubescent apparel manufacturers to produce clothing that reflect their physical characteristics. A total of 549 boys and 529 girls aged between 10 and 14 were measured in the capital area from March 4 to April 3, 2004. Data were collected from 35 anthropometric items and 12 photographic items per a person. SPSS Ver. 12 program was used in data analysis including means, standard deviation, t-test and Duncan test. The main results of this study were as follows. They showed the significant difference of their growth in accordance with the increase of their ages. There were also the difference between boys and girls. As for height and length items, boys showed a slow growth at the age of $10{\sim}11\;and\;12{\sim}13$. Those at the age of $11{\sim}12\;and\;13{\sim}14$ showed rapid growth. That is, an active growth was followed by a slow growth and that phenomenon repeatedly occurred. On the other hand, girls showed remarkable growth at the age $10{\sim}11$ and the growth rate gradually slowed down afterward. Regarding circumference items, boys at the age of $11{\sim}12\;and\;13{\sim}14$ showed remarkable growth. This results showed that boys at the age of $11{\sim}12$ had vertical growth and horizontal growth at the same time and for those at the age of $13{\sim}14$, growth was more conspicuous in horizontal direction. Meanwhile, for girls, the growth rate was high at the age of $11{\sim}12$, somewhat later than the age of the growth of height and length. As for breadth-related items and depth-related items, for both sexes two items grew steadily throughout the ages, breadth-related items showed a higher growth rate than that of depth-related items. This study analyzed the body measurements of pubescent boys and girls and the results showed that, for boys, an active physical growth took place at the age of 13 according to previous studies, but the findings of this study suggested that the phenomenon now occurred at the age of $11{\sim}12$, which proved that physical growth took place earlier than before. Also, an active growth was followed by a slow growth. Girls at puberty showed remarkable growth of height at the age of $10{\sim}11$ that is consistent with previous studies and then showed horizontal growth at the age of around 12, having a voluminous body shape.

• Clinical and Experimental Pediatrics
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• 제49권12호
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• pp.1257-1262
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• 2006

The age of puberty represents a very critical time in the life history of every young woman. The menarche stands as primary indicator of the onset of sexual maturation in females. By late adolescence, 75% of girls experience some problem associated with menstruation. Delayed, irregular, painful, and heavy menstrual bleeding are leading reasons for physician office visits by adolescents, and dysmenorrhea is the leading reason for school absenteeism among girls. This article discusses normal menstrual function during adolescence, then reviews the clinical presentation, evaluation, and management of adolescent dysmenorrhea, dysfunctional uterine bleeding, amenorrhea, and polycystic ovary syndrome.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.31-31
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• 1999

Characterization of mutant mice has been utilized as an animal model for the study of human inherited diseases. In addition to the pathogenesis stduy using the mutant mice, the mice have been used for the identification of the genes causing the phenotypes. Functional cloning and positional cloning are two approaches, depending on the phenotypes of the mutant mice. Though it takes a long time positional cloning has been well used to identify the gene of which function can not be presumed from the mouse phenotype. Recently by the advance of the molecular tools and the human genome project close to 10,000 genetic markers are developed to make the procedure faster. We obtained a new mutant mouse, sims, spontaneously arose and the affected mouse has a mild tremor and seizure was observed. Homozygote in either sex is sterile since uterus growth in female and seminal vesicle in male are not induced for the growth in puberty, implying the abnormal hormonal regulation during puberty. Supporting this, there is no detectable testosterone in the serum of the mutant male and the brain of the mutant is 30% heavier than littermate. To identify the location of the mutated gene, intraspecies cross to CAST/Ei was carried out and the 37 affected mice was analyzed for the linkage. The gene was mapped on chromosome 18, 20 cM from the centromere. More than 500 F2 progenies have been analyzed for the linkage and the locus becomes narrow within 3cM between Egrl and Fgf gene.f gene.

• 농촌지도와개발
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• 제14권2호
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• pp.471-491
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• 2007

The purpose of this study were (1) to thumbnail sketch of present general condition of foreigners and international marriage in Korea, (2) to study special trend of international marriage in rural Korea, particularly immigration connected with poverty, and (3) to focus on prospect of the problem of mixed-bloods, especially half blood children in rural Korea. Many of foreigners were treated discriminatingly, for example racial discrimination and wage discrimination. And discrimination to mixed-blood children will be happen in future. They are in a disadvantageous position because of economic status and appearances. Half blood children have korean nationality because one of his parent is korean. When they grow up and reach their the age of puberty and the age of working, they will resist to discrimination in working and marriage. I had examined precedent studies, and class theory in general, and to suggest it is time to looking for way of reduce social cost and way of coexistence.

• Industrial Engineering and Management Systems
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• 제15권4호
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• pp.290-297
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• 2016

The successful transfer of technology, needs to recognize the industrial purposes, resources, technology, innovation and the mode of transmission, methods of transmission, influential factors, it's how to recruit and how to develop, and each of these cognitive relies on special expertise. One of the important technologies is automotive technology, and s technology is important for the transition and its development in recent years. Hence, in this paper, after studying Iran and the world's automotive and emerging technologies situation, the status of commercial vehicles and s technology model are studied based on external models, technical specifications, and cost. In this way, we examine the incidence and the applicability of the technology used in the production of heavy-duty vehicles, in recent years, with the passage of time, and we examine the technology lifecycle, from the perspective of physical characteristics and technical features. The results show that the technology of the studied heavy-duty vehicles (Titan) is close to the time of his fall, because spending puberty, so, according to the investigation of new technologies, we should strive to create changes in vehicle technology.

• Asian-Australasian Journal of Animal Sciences
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• 제22권11호
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• pp.1574-1580
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• 2009

To evaluate the effect of different housing systems on sow behavior, 80 gilts were randomly allocated at puberty to four treatments: i) sow stall in gestation followed by farrowing crate (SC), ii) group housing with individual feeding in gestation followed by farrowing crate (GC), iii) ESF (Electronic Sow Feeding) system in gestation followed by farrowing crate (EC), and iv) ESF system followed by group farrowing pen (EG). Behavioral observations were carried out on a total of 16 animals per treatment at the following stages: first day of allocation to housing treatment, day of service, 80 days after service, 109 days after service on entry to farrowing accommodation, 24 h before farrowing, day of farrowing, 14, 27 and 28 days after farrowing, at weaning. On each occasion, individual animals were observed for a 24 period with one minute time sampling. There were significant differences (p<0.001) between stages of the reproductive cycle for all the behavior patterns in all treatments. On the first day in experimental housing treatments, sows spent more time rooting and dog-sitting. Activity and investigatory behavior decreased as pregnancy progressed. An activity peak was apparent just before farrowing, followed by a high level of inactivity on the day of farrowing. Time spent active, eating and drinking increased as lactation progressed, and greatest activity and locomotion was seen immediately following weaning. There were significant differences between housing treatments (p<0.01) for standing, moving, eating, drinking, dog-sitting and lying. During pregnancy SC sows spent more time standing, rooting, drinking and dog sitting, while EC sows spent less time rooting and drinking and more time lying. During lactation, GC sows spent more time standing, moving and eating, less time dog sitting and lateral lying. Nursing frequency was reduced in GC sows (p<0.001). The maternal and piglet behaviors were influenced strongly by environment during lactation. However, it was also shown that previous housing history can influence the maternal behavior in the pre-farrowing stage and during early lactation.

• Clinical and Experimental Pediatrics
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• 제56권10호
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• pp.417-423
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• 2013

Vitamin D is an essential component of bone and mineral metabolism; its deficiency causes growth retardation and skeletal deformities in children and osteomalacia and osteoporosis in adults. Hypovitaminosis D (vitamin D insufficiency or deficiency) is observed not only in adults but also in infants, children, and adolescents. Previous studies suggest that sufficient serum vitamin D levels should be maintained in order to enhance normal calcification of the growth plate and bone mineralization. Moreover, emerging evidence supports an association between 25-hydroxyvitamin D (25[OH]D) levels and immune function, respiratory diseases, obesity, metabolic syndrome, insulin resistance, infection, allergy, cancers, and cardiovascular diseases in pediatric and adolescent populations. The risk factors for vitamin D insufficiency or deficiency in the pediatric population are season (winter), insufficient time spent outdoors, ethnicity (non-white), older age, more advanced stage of puberty, obesity, low milk consumption, low socioeconomic status, and female gender. It is recommended that all infants, children, and adolescents have a minimum daily intake of 400 IU ($10{\mu}g$) of vitamin D. Since the vitamin D status of the newborn is highly related to maternal vitamin D levels, optimal vitamin D levels in the mother during pregnancy should be maintained. In conclusion, given the important role of vitamin D in childhood health, more time spent in outdoor activity (for sunlight exposure) and vitamin D supplementation may be necessary for optimal health in infants, children, and adolescents.