• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.503-511
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• 2017

This study was conducted to evaluate the anti-inflammatory activity and clinical efficacy of a sample (A.C.C. extracts) obtained by distillation extraction of 14 herbal medicines including Phellodendron bark. To confirm this, the amount of nitric oxide (NO) produced by the cells in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) and the changes in the production of inflammatory cytokines such as tumor necrosis factor (TNF)-${\alpha}$, interleukin(IL)-$1{\beta}$ and IL-6 were determined. The results showed that A.C.C. extracts strongly inhibited the production of NO and inflammatory cytokines increased by LPS without cytotoxicity. In addition, A.C.C. extracts showed strong bacterial reduction rates of 99.9% in Pseudomonas aeruginosa, Staphylococcus aureus, MRSA (Methicillin-resistant Staphylococcus aureus), Candida albicans and Streptococcus mutans. These findings indicate that A.C.C. extracts are effective ingredients with a strong antimicrobial effect together with an anti-inflammatory effect. In addition, when A.C.C. extracts were applied to infants and toddlers who were suffering from diaper rash, itching, and perspiration symptoms, symptoms of rash, atopy, rash, itching, and heat rash were improved. After the lapse of time, it was visually confirmed that it was considerably relaxed. These findings confirm that A.C.C. extracts comprise a clinically effective anti-inflammatory and anti-bacterial agent that alleviates symptoms such as diaper rash and fever and may therefore be an effective alternative to inflammatory diseases.

• Korean Journal of Plant Resources
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• v.24 no.1
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• pp.98-104
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• 2011

We investigated inhibitory effects of ginseng extracts against compound 48/80-induced responses in rat peritoneal mast cells. Initially, we optimized extraction condition with various temperature and time for recovery of high saponin contents in extracts. Using a primary rat peritoneal mast cells, we examined whether ginseng extracts inhibit compound 48/80-induced histamine release form rat mast cells. High red ginseng-spercific saponin containing extracts were recovered at $85^{\circ}C$ for 48 hr, and had no cytotoxicity with relatively high dose of extracts on rat peritoneal mast cells(<0.5 mg/ml). For examine of ameliorate effects of mast cells responses by ginseng extract, we pre-treated the extracts or saline to mast cells and treated compound 48/80. In results, compound 48/80 treatment was increased histamine release (approximately 30%) from mast cells than normal group, whereas ginseng treatment was completely inhibited histamine release. These results suggested that ginseng extracts inhibits the compound 48/80-induced mast cell activation, and ginseng extracts is a candidate for effective therapeutic tools of allergic diseases.

• Journal of Life Science
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• v.26 no.6
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• pp.651-656
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• 2016

Bee pollen is produced by honeybees and is considered one of the most balanced and nourishing nutritional supplements available. Historically, bee pollen has been prescribed for its healing properties and consumed for its high-energy supply. Recent research has provided evidence that bee pollen has diverse biological activities, such as anti-oxidant, anti-inflammatory, anti-bacterial, and even anti-cancer effects. However, the outer membrane of the pollen grain, exine, is highly resistant to most acidic solutions, high pressure, and even digestive enzymes, and the resulting low bioavailability limits its nutritional and clinical applications. This study applied a wet-grinding method to destroy the exine effectively, and it then examined the pollen's enhanced biological activity. First, microscopic observations provided strong evidence that wet grinding destroyed the exine time-dependently. In addition, the content of polyphenols, well-known ingredients of bee pollen and used as internal standards for the quality control of commercial pollen preparations, increased up to 11-fold with wet grinding. Further, the anti-oxidant activity demonstrated on the ABTS anti-oxidant assay, as well as the DPPH radical scavenging assay, was also dramatically increased. Together, the results presented here support a new technology by which bee pollen can be used as a resource for medical, nutritional, and cosmetic applications.

• Journal of KIISE:Databases
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• v.30 no.5
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• pp.507-520
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• 2003

In this paper, an automatic construction method of theme melody index for large music database and an associative content-based music retrieval mechanism in which the constructed theme melody index is mainly used to improve the users' response time are proposed. First, the system automatically extracted the theme melody from a music file by the graphical clustering algorithm based on the similarities between motifs of the music. To place an extracted theme melody into the metric space of M-tree, we chose the average length variation and the average pitch variation of the theme melody as the major features. Moreover, we added the pitch signature and length signature which summarize the pitch variation pattern and the length variation pattern of a theme melody, respectively, to increase the precision of retrieval results. We also proposed the associative content-based music retrieval mechanism in which the k-nearest neighborhood searching and the range searching algorithms of M-tree are used to select the similar melodies to user's query melody from the theme melody index. To improve the users' satisfaction, the proposed retrieval mechanism includes ranking and user's relevance feedback functions. Also, we implemented the proposed mechanisms as the essential components of content-based music retrieval systems to verify the usefulness.

• Journal of KIISE:Software and Applications
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• v.29 no.7
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• pp.465-475
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• 2002

An object-oriented framework supports efficient component-based software development by providing a flexible architecture that can be decomposed into easily modifiable and composable classes. Object-oriented frameworks require thorough testing as they are intended to be reused repeatedly In developing numerous applications. Furthermore, additional testing is needed each time the framework is modified and extended for reuse. To test a framework, it must be instantiated into a complete, executable system. It is, however, practically impossible to test a framework exhaustively against all kinds of framework instantiations, as possible systems into which a framework can be configured are infinitely diverse. If we can classify possible configurations of a framework into a finite number of groups so that all configurations of a group have the same structural or behavioral characteristics, we can effectively cover all significant test cases for the framework testing by choosing a representative configuration from each group. This paper proposes a systematic method of classifying object structures of a framework hotspot and extracting structural test patterns from them. This paper also presents how we can select an instance of object structure from each extracted test pattern for use in the frameworks hotspot testing. This method is useful for selection of optimal test cases and systematic construction of executable test target.

• Nuclear Engineering and Technology
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• v.26 no.4
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• pp.461-470
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• 1994

Sorption experiments of $^{60}$ Co, $^{85}$ Sr. and $^{137}$ Cs onto sandstone particles in a batch were carried out to investigate the migration mobility. Sorption kinetics and reversibility as well as sorption mechanisms were examined. Sorption reaction occurred mostly within 10 hours on the outer surface of the sandstone particle but diffusion into the inner surface of the mineral has still occurred after that time. In order to distinguish sorption types of radionuclides, a sequential chemical extraction was introduced. The sorbed radionuclides were then extracted by applying different solutions of synthetic groundwater, CaCl$_2$, KCl and KOX-HA Especially KCl is adopted to extract the ion-exchanged cesium. Sorption types considered are reversible sorption under groundwater condition, ion exchange, association with ferro-manganese oxides or oxyhydroxides, and irreversible fixation. Strontium sorbs onto the sandstone surface mainly by fast and reversible ion exchange reaction. However, cobalt and cesium do not sorb by simple process. The main sorptive binding of cobalt was the association with ferro-manganese oxides and the secondary one was irreversible fixation. Diffusion into the lattice of minerals controlled the sorption rate of cobalt The main sorptin type of cesium was irreversible fixation, while ion exchange reaction was the secondary importance. Hence the oreder of migration mobility for the three radionuclides was Sr$^{2＋}$ ＞ Co$^{2＋}$ ＞ Cs$^{＋}$ in the sandstones.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.6
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• pp.1049-1060
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• 2018

Soil conditioning is one of the key factors for successfull tunnel excavations utilizing the earth pressure-balanced (EPB) shield tunnel boring machine (TBM) by increasing the tunnel face stability and extraction efficiency of excavated soils. In this study, conditioning agents are mixed with the weathered granite soils which are abundant in the Korean peninsula and the workability of the resulting mixture is evaluated through the slump tests to derive and propose the most suitable conditioning agent as well as the most appropriate agent mix ratios. However, since it is cumbersome to perform the slump tests all the time either in the laboratory or in-situ, a simpler test may be needed instead of the slump test; the fall cone test was proposed as a substitute. In this paper, the correlation between the slump value obtained from the slump test and the cone penetration depth obtained from the proposed fall cone test was obtained. Test results showed that a very good correlation between two was observed; it means that the simpler fall cone test can be used to assess the suitability of the conditioned soils instead of the more cumbersome slump test.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.45-51
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• 2021

With the development of deep learning, semantic segmentation methods are being studied in various fields. There is a problem that segmenation accuracy drops in fields that require accuracy such as medical image analysis. In this paper, we improved PSPNet, which is a deep learning based segmentation method to minimized the loss of features during semantic segmentation. Conventional deep learning based segmentation methods result in lower resolution and loss of object features during feature extraction and compression. Due to these losses, the edge and the internal information of the object are lost, and there is a problem that the accuracy at the time of object segmentation is lowered. To solve these problems, we improved PSPNet, which is a semantic segmentation model. The multi-scale attention proposed to the conventional PSPNet was added to prevent feature loss of objects. The feature purification process was performed by applying the attention method to the conventional PPM module. By suppressing unnecessary feature information, eadg and texture information was improved. The proposed method trained on the Cityscapes dataset and use the segmentation index MIoU for quantitative evaluation. As a result of the experiment, the segmentation accuracy was improved by about 1.5% compared to the conventional PSPNet.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3D
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• pp.445-450
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• 2008

Recently, environmental and ecological approaches is in progress in urban stream, especially the guarantee of instream flow becomes very important. In this paper, it is suggested that water volume estimation method utilizing the topographical shape data obtained by field investigation and satellite image to manage the urban stream efficiently. The data obtained at Gap River is the study area are analysed and those results are as belows. First, surveying to investigate topographic shape characteristics of urban stream is carried out. In details, the gradient characteristics from water surface to bottom in case of sand area and in case of grass area are 0.013 and 0.065 respectively. In conclusion, the gradient characteristic of grass area is five times bigger than that of sand area. Besides, IKONOS image is classified by spectrum analysis and Minimum Distance Method and the sand area extraction method by the generalization method as Median filter is suggested to calculate water volume. Finally, mapping process on the sand area extracted from the topographical shape field data in river and satellite images is carried out by the GIS spatial analysis. And on the assumption that the water level was 1m at that time when satellite image was taken, the water volume was $225,258m^3$. It is clarified that the effect of water volume improvement was about 10.5% in comparison with water volume that had no consideration on the gradient characteristics of sand-bar.

• Journal of Food Hygiene and Safety
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• v.38 no.3
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• pp.89-98
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• 2023

Currently, no guidelines exist regarding the maximum residues of pesticides in edible oil which is a processed food commonly consumed in Korea. This lack of guidelines hinders the evaluation of the safety of edible oil in terms of pesticide contamination. In this study, an analysis method based on heat distillation and GC-MS/MS was established by optimizing the extraction and purification procedure for 68 pesticides. Important variables in the thermal distillation procedure included heating temperature and time, and we found the nitrogen flow rate as a mobile phase and the type of dissolving solvent were not considerably affected. The determination coefficient (R²) of the residual pesticide was 0.99 or higher, and the quantitative limit (LOQ) was 0.01-0.02 mg/L. The average recovery rate (n=5) was 66.1-120.0% and the relative standard deviation was lower than ±10% when 68 pesticides were spiked at concentrations of 0.01-0.02, 0.1, and 0.5 mg/L. In addition, the within-laboratory precision was less than ±11%, meeting the Korea Food and Drug Safety Evaluation Institute's Guidelines on Standard Procedures for Preparing Food Testing Methods (2016). Therefore, the test method developed in this study can be used as a test method for managing the safety of the residual pesticide concentration in edible oil.