• 한국전산유체공학회:학술대회논문집
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• 2004.10a
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• pp.161-164
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• 2004

A finite volume numerical model is developed for simulating non-equilibrium electroosmotic flow in micro- and nanochannels. The Guoy-Chapman model is adopted to compute the flow and electric potential. The Nernst-Planck equation is employed to trace unsteady transports of ionic species, i.e., time-dependent net charge density. A new set of boundary conditions based on surface charge density are designed rather than using the conventionally-employed zeta potential. A few issues for an efficient computation of electroosmotic flows are discussed. Representative computational examples are given to illustrate the robustness of the numerical model.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.663-668
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• 1996

A two-dimensional continuum model for the prediction of the hydrogen mixing phenomena in the containment compartment under the severe accident conditions is developed. The model could predict well the distribution of time-dependent hydrogen concentration for selected HEDL Experiment. For a simulation of these experiments, the hydrogen is mixed uniform over the test compartment. To predict the extent of non-uniform distribution, the dominant factors such as the geometrical shape of obstacle and velocity of source injection in mixing phenomena are investigated. If the obstacle disturbing the flow of gas mixture exists in the compartment, the uniform distribution of hydrogen may be not guaranteed. The convective circulation of gas flow is separately formed up and down of the obstacle position, which makes a difference of hydrogen concentration between the upper and lower region of the compartment. The recirculation flow must have a considerable mass flow rate relative to velocity of the source injection to sustain the well-mixed conditions of hydrogen.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.2
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• pp.356-368
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• 1992

The strongly interactive flow field near a missile afterbody containing a centered exhaust jet is numerically investigated. The thin shear layer and full formulation of compressible, Reynolds I averaged Navier-Stokes equations are solved. A time-dependent implicit numericals algorithm is used to obtain solution for a variety of flow conditions. Turbulence closure is implemented by the Baldwin-Lomax algebraic eddy viscosity model. An adaptive grid technique is adopted to resolve flow regimes with large gradients and to improve the accuracy and efficiency of the computation, Numerical results show good agreemement with experimental data in all regimes.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.6
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• pp.792-801
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• 2000

The problem of phase change from liquid to solid in the inviscid plane-stagnation flow is theoretically investigated. The solution at the initial stage of freezing is obtained by expanding it in powers of time, and the final equilibrium state is determined from the steady-state governing equations. The transient solution is dependent on the three dimensionless parameters, but the equilibrium state is determined by one parameter of (temperature ratio/conductivity ratio). The effect of the fluid flow on the growth rate of the solid in the pure conduction problem can be clearly seen from the solution of the initial stage and the final equilibrium state. The characteristics of the transient heat transfer at the surface of the solid and the liquid side of the solid-liquid interface for all the dimensionless parameters are elucidated.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.1
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• pp.1-11
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• 2000

This study investigates the problem of phase change from liquid to solid in the inviscid stagnation flow. The solution of dimensionless governing equations is determined by the three dimensionless parameters of (temperature ratio/conductivity ratio), Stefan number, and diffusi-vity ratio. The solution at the initial stage of freezing is obtained by expanding it in powers of time, and the final equilibrium state is determined from the steady-state governing equations. The equilibrium state is dependent on (temperature ratio/conductivity ratio), but is independent of Stefan number and diffusivity ratio. The effect of fluid flow on the pure conduction problem can be clearly seen from the solution of the initial stage and the final equilibrium state, and the characteristics of the solidification process for all the dimensionless parameters are elucidated.

• International Journal of Oral Biology
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• v.32 no.3
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• pp.113-118
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• 2007

Treatment of oral cancers with chemotherapeutic agents become evaluated as an effective method to reduce cancer cell proliferation. Anti-proliferative and anti-oral cancer activities of momordin I on oral cancer cells were evaluated in this study. Momordin I was originally purified from a natural product, Ampelopsis radix and showed the antiproliferative activity against oral carcinoma, KB cells. Obtained $IC_{50}$ value was approximately $10.4{\mu}g/ml$. Time-and dose-dependent chromosomal DNA fragmentations were observed in momordin I-treated KB cells. Flow cytometry analysis showed time-dependent apoptotic cell appearance after treatment of momordin I. Approximately 18.6% apoptotic cells were observed at 72 hours after $20{\mu}g/ml$ of momordin I treatment. These observation were consistent with the results obtained in DNA fragmentation analysis. These data suggest that momordin I has anti-proliferative effect and induces cell death in KB cells through apoptosis.

• Journal of Ocean Engineering and Technology
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• v.15 no.4
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• pp.46-52
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• 2001

SMAC method, one of the numerical simulation techniques, is modified from the original MAC method for the time-dependent variation of fluid flows. The Navier-Stokes equations for incompressible time-dependent viscous flow are applied, and Also marker particles which present the visualization of fluid flows are used. In this study, two-dimensional numerical simulations of the overtopping are carried out by SMAC method, and the simulation results are visualized, In addition to, motion pictures are made for efficient visualization of the simulation results. This numerical simulation could also be applied to the design of coastal structures as dike and revetment.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.323-326
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• 2006

Numerical solutions for spin-up problem of a thermally stratified fluid in a cylinder with an insulating sidewall and time-dependent rotation rate are presented. Detailed results are given for aspect ratio of O(1), fixed Ekman number $10-^{4}$, Rossby number 0.05 and Prandtl number O(1). Angular velocity of a cylinder wall changes with following formula, $\Omega_f=\Omega_i+\Delta\Omega[1-\exp(-t/t_c)]$. Here, this $t_c$, value, which is very significant in present study, represents that how fast/slow the angular velocity of the cylinder wall reaches final angular velocity. The normalized azimuthal velocity and meridional flow plots for several tc value which cover ranges of the stratification parameter S(1 ~ 10) are presented. The role of viscous-diffusion and Coriolis term in present study is examined by diagnostic analysis of the azimuthal velocity equation.

• Journal of the Korean Society of Safety
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• v.3 no.1
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• pp.15-19
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• 1988

The falling ball viscometer has been widely used for measuring the viscosity of the Newtonian fluids because of its simple theory and low cost. The use of the falling ball viscometer for measuring the non-Newtonian viscosity has been of interest to rheologists for some years. The analysis of the experimental results in a falling ball viscometer rest on Stokes law which yields the terminal velocity for a sphere moving through an infinite medium of fluids. An attempt to use the falling ball viscometer to measure the non-Newtonian viscosity in the intermediate shear rate ranEe was sucessfully accomplished by combining the direct experimental obserbations with a simple analytical model for the average shear-stress and shear rate at, the surface of a sphere. In the experiments with highly viscoelastic polyacrylamide solutions the terminal velocity was observed to be dependent on the time interval between the dropping of successive balls. The time-dependent phenomenon was used to determine characteristic diffusion times of the concentrated solutions of polyacrylamide.

• Biomolecules & Therapeutics
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• v.26 no.3
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• pp.328-334
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• 2018

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dose-dependent inhibition of cell growth with an $IC_{50}$ of $15{\mu}M$ and no to little effect on normal human MCF-10A breast cells. To define the mechanism of these anti-proliferative effects of PA, we determined its effect critical molecular events known to regulate the cell cycle and apoptotic machinery. Immunofluorescence and flow cytometric analysis of Annexin V-FITC staining provided evidence for the induction of apoptosis. PA treatment of BC cells resulted in increased activity/expression of mitochondrial cytochrome C, caspases 7, 8 and 9 with a significant increase in the Bax:Bcl-2 ratio, suggesting the involvement of a mitochondrial-dependent apoptotic pathway. Furthermore, cell cycle analysis using flow cytometry showed that PA treatment of cells resulted in G0/G1 arrest in a dose-dependent manner. Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dose-dependent (i) induction of $p21^{WAF1/Cip1}$ and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1. These findings suggest that PA may be an effective therapeutic agent against BC.