• 한국자원식물학회지
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• 제5권2호
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• pp.73-84
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• 1992

Many types of compounds have been isolated from higher plants till now, that is, alkaloids, terpenes, lignans, steroids and so on. One of them, named as RA series Cyclic hexapeptides isolated from Rubia akane and R. cordijofia also have strong antineoplastic activity against various types of tumors. Till now 10 kinds ofRA series compounds were isolated and named as RA - I, II, III, IV, V, VI, VII, VIII, IX and X. Moreover,monogl-ucoside of RA - V newly Isolated from same plant. Many kinds of derivatives including natural RAcompounds were tested for QSAR, and one of them, RA - VII was screened up as a most suitable substance asan antitumor agent. RA - VII(=RA-700) has strong cytotoxic activity against KB cells, P388 Iymphocyticleukemia and MM2 mammary carcinoma cells. RA - VII has been under investigation for Phase I clinical trials.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 추계학술대회 논문집
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• pp.613-618
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• 2008

Proto-type Korean High Speed Train(HSR 350x) had developed in 2002 through G7 High Speed Train R&D project from 1996, had carried successful trial running test up to 350km/h and has been executing running test more than 0.2 Mil. kilometers of accumulated running distance to insure reliability on service line till July 2008. Even though the R&D project has finished by Oct. 2007, the proto-type train HSR 350x has maintaining various measuring functions and test facilities till now. So it may be needed a suggestion on the direction of practical use in public purpose of the HSR 350x. This study has suggested several directions of practical use in public purpose of the HSR 350x, and feasibilities for each alternatives of practical use in order to contribute making reasonable decision for practical use of the train in public purpose for the future.

• 한국대기환경학회지
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• 제15권5호
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• pp.697-700
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• 1999

• International Journal of Industrial Entomology and Biomaterials
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• 제12권2호
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• pp.75-80
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• 2006

Changes in the levels of protein and free amino acids in the haemolymph of three selected races of the silkworm, Bombyx mori viz., PM, $NB_4D_2$ and $CSR_2$, were investigated during 4th moult, 5th instar and pupal period. The levels of total protein in the haemolymph, increased from first day of 5th instar till sixth day. From seventh day till spinning, the protein levels decreased in all the three races. A sustained decrease in the haemolymph proteins was observed during the pupal development in all the three races. The levels of free amino acids, which were high during 4th moult, declined through the 5th age of larval development till spinning. PM showed a relatively higher free amino acid level (3.192 mg/ml) in haemolymph followed by $NB_4D_2$ (2.601 mg/ml) and $CSR_2$ (2.35 mg/ml). The free amino acid levels decreased gradually from prepupal stage but increased again at the end of pupal period. Racial differences in the changes in the levels of protein and free amino acids in the haemolymph were observed in the larvae and pupae when subjected to two high temperature regimes of $30^{\circ}C$ and $35^{\circ}C$. The results showed that high temperature induces specific changes in the metabolism (reversible thermal stress) that have different adaptive value in different races of the silkworm. Relatively higher increase in the free amino acid levels in the haemolymph of Pure Mysore presumably provides protective cover to tissues against high temperature by an increase in osmolarity and reduction in evaporative water loss. The absence of such a mechanism may be responsible for temperature susceptibility of the bivoltine races like $NB_4D_2$ and $CSR_2$.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제17권2호
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• pp.137-152
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• 1995

This study was designed to evaluate the bone formation capability of the bone substitute when compared with autogenic bone, freeze-dried demineralized allogeneic bone and bioglass into parietal bone of the rats. We made the parietal bone defects in $7{\times}7mm$ size on rats and has performed the bone graft in each experimental groups. Postoperatively 1, 2, 4, 6, 8, weeks, each specimen stained with H & E, Masson's trichrome methods. We evaluated the osteogensis capability in each groups. The result were as follow : 1. Inflammatory cell infiltration approached at 1 week and disappeared at 4 weeks in all experimental group, expecially severe in freeze-dried demineralized allogeneic bone group. 2. New capillry proliferation was increased in autogeneic bone graft group than any other groups and was increased till 2 weeks and decreased in freeze-dried demineralized allogeneic bone group and was few in bioglass group. 3. Osteoblastic activity increased in autogeneic bone and freeze-dried demineralized allogeneic bone groups till 4 weeks, and decreased in 6 weeks which no difference between these groups. But, few occurred in bioglass group till 6 weeks. 4. Initial osteoclastic activity was prominent in freeze-dried demineralized allogeneic bone group and few in autogeneic bone group. 5. New bone formation bega at 1 week in autograft and freeze-dried demineralized allogenic bone groups, but, mild new bone formation at 8 weeks in bioglass.

• 한국환경과학회지
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• 제22권11호
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• pp.1509-1517
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• 2013

So far, most studies associated with soil carbon sequestration have been focused on long term aspect. However, information regarding soil carbon sequestration in short term aspect is limited. This study was conducted to determine changes of soil organic carbon content and stability of carbon in response to compost application rate and tillage management during rice growing season(150 days) in short term aspect. Under pot experiment condition, compost was mixed with an arable soil at rates corresponding to 0, 6, 12, and 24 Mg/ha. To determine effect of tillage on soil carbon sequestration, till and no-till treatments were set up in soils amended with application rate of 12 Mg/ha. Compost application and tillage management did not significantly affect soil organic carbon(SOC) content in soil at harvest time. Bulk density of soil was not changed significantly with compost application and tillage management. These might result from short duration of experiment. While hot water extractable organic carbon(HWEOC) content decreased with compost application, humic substances(HS) increased. Below ground biomass of rice increased with application of compost and till operation. From the above results, continuos application of compost and reduce tillage might improve increase in soil organic carbon content and stability of carbon in long term aspect.

• 한국임상수의학회지
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• 제18권1호
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• pp.7-13
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• 2001

Depending on the degree of exocrine pancreatic insufficiency, there are inconsistent values in the serum trypsin-like immunoreactivity (TLI), hematology, and serology. To determine the correlation between those values and complete pancreatic insufficiency, 10 pancreatectomized dogs as the treated group and 10 sham operation dogs as control group were used. The entire treated group showed significant decrease in serum TLI level from 2.63$\pm$0.20 ng/ml (day 0) to 1.81$\pm$0.43 ng/ml at day 1 after the pancreatectomy (p<0.05) and the decline maintained till the end of the experiment. Blood glucose level gradually increased, but albumin level showed significant decrease (p<0.05) at day 1 and maintained the decline. Three clinical signs were observed such as depression, vomiting, and diarrhea. The entire treated group showed diarrhea throughout the experiment, but depression and vomiting were gradually diminished. The activity of serum alkaline phosphatase in the treated group increased till day 2 then decreased, on the other hand, control group showed continuous increase till day 4, and then decreased. Only experimental group showed the increased alanine aminotransferase activity at day 1. Serum lipase activity in the treated group jumped up at day 1 and then dropped down, which was even lower than the control. Regarding serum amlyase activity gradually decreased. According to these results, the assay of trypsin-like immunoreactivity showed the consistent result, so it suggests that TLI is an useful tool to determine the pancreatic exocrine function and possible diagnosis of exocrine pancreatic insufficiency compared to the simple assay of plasma amylase and lipase.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제17권4호
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• pp.365-378
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• 1995

Allogeneic bone grafting has recently been used in oral and maxillofacial regions to restore the cosmetic and functional problem. There are several types of allogeneic bone grafts ; bone powder, bone chips, bone blocks. Empirically, it is thought to be better to combine the allogeneic bone chips to any type of tissue adhesive not to displace during packing and condensing. But, there are no reports about using tissue adhesive in allogeneic bone grafting. This experimental study is designed to investigate the effect of the fibrin adhesive on bone healing process after demineralized allogeneic bone grafting in 60 rats. In control groups (30 rats), routine demineralized allogeneic bone grafting were done in 7 ${\times}$ 7mm calvarial bone defects which were drilled intentioally. And we used the fibrin adhesive for holding the bone particle in experimental groups (30 rats). Each experimental specimen was sacrified at 1, 2, 4, 6, 8 weeks postoperatively The results were as follows : 1. The degree of inflammatory cell infiltrations were more prominent in experimental than in control groups till 2 weeks. 2. Early fibroblast proliferation and new capillary proliferation were uncorporated around graft sites in the experimental groups later than in control groups at early stages. 3. Osteoblastic activity in control group was more prominent at 2 weeks. 4. Osteoblastic activity in experimental groups was more prominent than in control group till 4 weeks. 5. New bone formation was more in control group than experimental group till 3 weeks, but similar appearance after that time. As above results, initial bone healing within 2 weeks were more processed in without adhesive group than with adhesive group. But above 4 weeks; similar bone healing were observed.

• 한국작물학회지
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• 제41권3호
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• pp.370-375
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• 1996

포승통의 미사질식양토인 간척지에서 벼 건답직파재배 가능성을 구명하고자 서안벼를 공시하고, 간이온실에서는 시용 및짚의 양과 토양수분조건을 달리 하여 파종심도별 벼의 출아율을 조사하고, 실제 포장 시험에서는 산파후 로타리 복토 유무에 따른 벼의 입모 및 수량성의 차리를 비교 검토한 결과는 다음과 같다. 1. 볏짚 처리(특히, 4ton, 6ton/ha)가 무처리보다 출아율이 높았다. 2. 헥타르 당 볏짚 4ton을 처리하고 파종심도가 얕을수록 출아율이 높았으며 초장도 현저히 커졌다. 3. 토양수분의 적습조건은 과습조건보다 출아율이 높았으며, 초장은 적습조건에서 파종심도가 얕을수록 커졌다. 4. 산파후 로타리 복토유무별 입모수는 로타리무복토(73개 /m$^2$)가 로타리복토(44개 /m$^2$)보다 많았다. 5. m$^2$ 당 수수는 로타리무복토가 로타리복토보다 많았고, 수량도 같은 경향을 보였다.

• 한국농공학회논문집
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• 제57권5호
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• pp.61-67
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• 2015

Effect of tillage on time of initial runoff, runoff coefficient, NPS pollution load, soil erosion and crop productivity were studied. Eight runoff plots of $5{\times}30m$ on loamy sand field that were 4 respective plots of 3 % and 8% slope were prepared. Treatment included conventional tillage (CT) and no-till (NT). Time of initial runoff from NT retarded between 247~261 % compared with that from CT. Under 3% slope, runoff coefficient in NT was 63.5 % lower than that in CT. The reduction under 8 % slope was 61.7 %. Differences in runoff reduction between 3% and 8% plots were not significant. NT could reduce more than 60 % of NPS pollution and between 50~85 % of sediment if compared with CT. Productivity of NT was also shown that it was not lower than that of CT. It was expected that the results could be used as a fundamental data for estimating a reduction load in Korea TMDL from a no-till BMP on loamy sand agricultural fields.