• 제목/요약/키워드: thrombus

검색결과 340건 처리시간 0.033초

행경홍화탕(行俓紅花湯)의 항혈전(抗血栓) 효과(效果)에 대(對)한 실험적(實驗的) 연구(硏究) (The Experimental Study on Antithrombotic Effect of Heanggyonghonghwatang)

  • 김의일;신용완;김수민;이정은;유동열
    • 대한한방부인과학회지
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    • 제19권2호
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    • pp.1-17
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    • 2006
  • Purpose : The Purpose of this research was to investigate the effects of antithrombotic activities of Haenggyonghonghwatang (HGHHT). Methods : Measured the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD soulution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. Each of the groups consisted in 8 mice, was divided into Normal, Control, and HGHHT. All of these 3 group were supplied a saline solution and after an hour the control group brought the dextran extravasated blood. Also the HGHHT group was dosed to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood as well as the Control group. Results : The results were obtained as follows. HGHHT inhibited platelet aggregation induced by ADP and epinephrine significantly as compared with the control group. HGHHT showed fibrinolytic activity insignificantly as compared with the control group. HGHHT increased blood flow rate significantly as compared with the control group in vitro, but insignificantly as compared with the control group in vivo. HGHHT inhibited pulmonary embolism induced by collagen and epinephrine(inhibitive rate 50%). HGHHT increased number of platelet, fibrinogen amount and shortened prothrombin time, activated partial thromboplastin time significantly as compared with the control group in thrombus model induced by dextran. Conclusion : HGHHT is effective antithrombotic activity from experimental result.

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痔瘡과 痔瘻에 對한 文獻的 考察 (A Literatural study on the hemorrhoids and hemorrhoids complicated by anal fistula)

  • 노현찬;노석선
    • 한방안이비인후피부과학회지
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    • 제10권1호
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    • pp.284-305
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    • 1997
  • A Literatural study on the etiological factors, classification, prescription of hemorrhoids and hemorrhoids complicated by anal fistula following results were obtained. 1. The cause of hemorrhoids are long time sit, long time gate, overfatigue, overeating, imbalance of stool( constipation or diarrhea), pregnant fertility(overfatigue after childbirth, insufficiency of middle warmer energy), uncontrol sexual excess, pathgenic factors of wetness, heat, wind, dry, genetic cause, excess of anxiety, pile up of heat poison, weakness of entrails and viscera. The cause of hemorrhoid complicated by anal fistula are attack of external wind, heatness, dry, fire, wetness(pathgenic factors), inapporiate treatment and chronic disease, greasy diet, excess of anxiety, constipation, uncontrol sexual excess, obstacle of circulation of vital energy and blood on anal site. 2. Classification of hemorrhoids are female hemorrhoids, male hemorrhoids, pulse hemorrhoids, intestines hemorrhoids, vital energy hemorrhoids, wine hemorrhoids, blood hemonhoids, flowing hemorrhoids. Classification with other method are external hemorrhoids, internal hemorrhoids, mixed hemorrhoids, excrescence hemorrhoids, nipple homorrhoids. External hemorrhoids is classified of varicosis of hemorrhoidal vein, connective tissue form, thrombus form. Classification of hemorrhoid complicated by anal fistula are simple lower hemorrhoid, lower mixed hemorrhoid, deep hemorrhoid, outer of one hole hemorrhoid, a horseshoe hemorrhoids. Once more classificated of four are space of sphincter muscle form, penetration sphincter muscle form, upper of sphincter muscle form, outer of sphincter muscle form. 3. Therapy method of hermorrhoid and hemorrhoid complicated by anal fistula are internal method, fumigation method method, ointment, method of close with medicine, necrotizing method, hot medicated compress( gxternal method), injection, insertion, bind, (operation) and acupuncture therapy (the others method) 4. Herb medicine for many used of internal method are Scutellaria baikalensis George(黃芩), Coptis japonia Makino(黃連), Rehmania giutinosa Liboschitz ex Fischer & Meyer(生地黃), Poncirus trifoliata Refinesque(枳殼), Sanguisorba officinalis Linne(地楡), Sophora japonica L.(槐花), Cnidium officinale Makino (川芎), Astragalus membranaceus Bunge(황기), Angelica gigas Nakai (當歸). 5. Herb medicine for many used of fumigation are Schlechtendalia Chinesis J. Bell (五倍子), Artemisia Vulgaris L. var indica Maxim(艾葉), Poncirus trifoliata Refinesque (枳殼), Nepeta japonica Maximowicy(荊芥), And herb medicine for many used of ointment are Calomelas(輕粉), Alum(白礬), Boswellia carterii Birdwood(乳香), Os Draconis Fossilia Ossis Mastodi(龍骨).

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터키산 앙고라(Turkish Angora) 고양이에서 발생한 특발성 동맥 색전혈전증(arterial thromboembolism: ATE) 1례 (Idiopathic Arterial Thromboembolism(ATE) in a Turkish Angora Cat)

  • 한성국;김정현;정순욱;박희명
    • 한국임상수의학회지
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    • 제25권1호
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    • pp.23-26
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    • 2008
  • 2일간의 구토와 침울을 동반한 후지마비를 주증상으로 내원한 2년령의 암칫 터키 앙고라 고양이에서 약한 대퇴 동맥 맥박, 후지의 청색증이 관찰되었으나 흉부 청진, 흉부 방사선, 심초음파 상에서 이상소견을 보이지 않았으며 복부 초음파상에서 복부 대동맥내의 색전으로 판단되는 고에코성 물질이 확인되었다. 대동맥 혈전의 원인이 될 수 있는 다양한 진단 검사를 시행한 결과, 특발성 안장 색전혈전증으로 진단하였다. Heparin sodium, aspirin 및 diltiazem으로 4주간 치료하였으나 양쪽 후지의 병변은 진행적이고 비가역적으로 괴사되어 대퇴부를 절단한 결과, 30개월 이상 임상적으로 건강한 생활을 하고 있다.

이엽식 고분자판막의 수력학적 특성평가 및 동물실험 (In-vitro Evaluation of a Bileaflet Polymer Valve and Preliminary Animal Tests)

  • 김철생;박복춘;서수원;한동근;이규백;최진욱;김인영;김희찬;김영하
    • 대한의용생체공학회:의공학회지
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    • 제13권3호
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    • pp.225-234
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    • 1992
  • In order to use a low cost polymer valve in our total artificial heart and ventricular assist device, we have developed a slit-type bileaflet polymer valve[BPV 1. The aim of this study is to determine the hydrodynamic effectiveness of the newly-designed BPV and its feasibility for temporary use in the blood pumps. For hydrodynamic comparison, we investigated in-vitro the pressure drop across the valve, the leakage volume, the flow rate and the flow pattern of the BPV, two mechanical valves and a trileaflet polymer valve. We employed the ventriculo-pulmonary bypassing method for in-vivo tests of the BPV's together vilh our electrohydraulic left venIn ricular assist device in mongrel dogs. The BPV showed adquate gydrodynamic performances and in the preliminary animal bests, there was no xvi dence of thrombus formation on the valve leaflets and around the struts. Detailed results obtained from the animal tests will be separately reported. This report involves the design criteria, fabrication and hydrodynamic charateristics of she BPV, and the basic merits and demerits of the valve are dis- cussed from the hydrodynamic point of view.

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당뇨백서(糖尿白鼠)의 대퇴동맥(大腿動脈) 미세혈관문합(微細血管吻合) 후(後) 내피세포(內皮細胞)의 재생(再生)에 관한 연구(硏究) (RE-ENDOTHELIZATION OF MICROVASCULAR ANASTOMOSIS IN DIABETIC RAT FEMORAL ARTERY ; A SCANNING ELECTRON MICROSCOPIC STUDY)

  • 류선열;김영재
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제14권1_2호
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    • pp.77-88
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    • 1992
  • Recently, diabetic patients are increasing in the field of microvascular surgery. Diabetes melltius is known to be related to arterial damage, platelet malfunction and thrombus formation. After microvascular anastomosis, delayed repair and vascular occlusion occurred more frequently in diabetic state. This study was performed to investigate the patency rate and process of endothelial healing after microvascular anastomosis of femoral artery in diabetic rat by scanning electron microscope. The animals were divided into two groups, 20 diabetic-induced and 20 non-diabetic groups. Diabetes was induced with a injection of Streptozotocin(50mg/kg b.w., Sigma Chemical Co.) to tail vein. The results obtained were as follows: 1. Macroscopically, anastomotic site was intact except a few cases showed minimal inflammatory sign around the wound site. But the inflammatory change was frequently occurred in diabetic-induced group. 2. The patency rate was 95% (19/20) in non-diabetic group and 65% (13/20) in diabetic-induced group. 3. In the non-diabetic group, anstomotic region was mostly endothelized by the alignment along the long axis of vessel but stitchs were not covered with endothelial cells. The thichkening of vessel wall was not observed. 4. In the diabetic-induced group, anastomotic region was not endothelized but covered with blood cellular components and connective tissue instead of endothelial cells. The thickening of the vessel wall was prominent in some diabetic-induced rats. These results suggest that diabetes was related to delayed regeneration of endothelium of vessels after microsurgical anastomosis.

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새로운 생체적합성 폴리펩티드공중합체의 합성과 혈액적합성에 관한 연구 : 측쇄에 에틸렌글리콜을 함유하는 폴리펩티드 공중합체의 혈액적합성 (Synthesis and Blood Compatibility of New Biocompatible Copolypeptides : Blood Compatibility of Copolypeptide Having Ethylene Glycol Oligomers Substituted in the Side Chain)

  • 강인규;박상동;조종수;성용길
    • 대한화학회지
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    • 제36권6호
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    • pp.947-954
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    • 1992
  • Poly (γ-benzyl L-glutamate) (PBLG)와 말단에 아미노기를 갖는 Polyethylene glycol (PEG)의 치환반응을 행하여 PEG-grafted PBLG (PEG-g-PBLG)를 합성하였다. 또한 PEG-g-PBLG 필름표면에 ethanolamine(EA)을 치환반응하여 표면에 히드록시그룹을 갖는 PEG-g-PBLG-EA 필름을 얻었다. 폴리펩티드중합체와 혈액성분과의 상호작용에 관한 실험결과, PEG-g-PBLG 상에서의 혈소판의 점착율 및 형태변화는 PEG-g-PBLG-EA보다 적게 나타났고, PEG-g-PBLG상에서의 혈장 단백질의 응고시간은 PEG-g-PBLG-EA 또는 PBLG의 응고시간보다 길게 나타났다. 이들 결과는 혈액응고시간 및 혈액응고량을 조사한 실험결과와 일치하였다. 따라서 폴리펩티드상의 히드록시그룹은 혈액성분과의 상호작용을 강하게 하여 혈액적합성이 저하하는 반면, PEG-g-PBLG는 비교적 좋은 혈액적합성을 나타냄을 알 수 있었다.

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전갈(全蝎) 추출물(抽出物)이 혈전증(血栓症), 전뇌허혈(全腦虛血) 및 뇌세포독성(腦細胞毒性)에 미치는 영향(影響) (Study on the effect of Buthus martensi Karsch extract on thrombosis and brian damage)

  • 백명현;황영근;정지천;강정준;김성훈
    • 동국한의학연구소논문집
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    • 제8권1호
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    • pp.171-190
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    • 1999
  • 본 실험은 전갈 추출물이 어혈병태 모델과 KCN으로 유발된 전뇌허혈, 뇌세포독성 등에 미치는 영향을 관찰하였다. 전갈은 Dextran에 의해 유도된 혈전으로 감소된 혈소판수, fibrinogen량, hemocrit치를 유의성 있게 증가시키고, 증가된 prothrombin time을 유의성 있게 단축시켰다. 전갈은 thrombin과 ADP에 의해 유도된 혈소판 응집을 억제하였으나 collagen에 의해 유도된 혈소판 응집에는 저해효과를 나타내지 않았다. 또한 collagen과 epinephrine에 의해 유도된 pulmonary embolism에 대하여 보호 효과를 나타내었다. 전갈은 KCN에 의한 전뇌허혈 유발 실험에서 혼수시간을 유의성 있게 단축시켰고, Amyloid ${\beta}$ protein(25-35)에 의해 유도된 PC12 세포의 독성에 대하여 보호효과를 나타내었다.

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간세포암의 간동맥 화학색전술 후 발생한 급성 폐손상 1예 (A Case of Acute Lung Injury Complicated by Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma)

  • 조세행;김주항;김병수;장준
    • Tuberculosis and Respiratory Diseases
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    • 제42권5호
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    • pp.781-786
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    • 1995
  • 간세포암에 이환된 61세 남자에서 lipiodol과 doxorubicin을 이용하여 간동맥 항암 화학 색전술을 시행하였고 3일 후 급성 호흡 부전증이 발병하였으며 임상 양상 및 방사선학적 소견상 급성 폐부종 및 폐렴에 의한 급성 폐손상에 합당하였다. 감염, 혈전 및 종괴에 의한 폐색전증, 울혈성 심부전에 의한 급성 호흡 부전증의 가능성을 배제하기 위하여 혈액, 객담 배양 검사를 시행하였으나 균주는 동정되지 않았고 복부 전산화 단층 촬영, 복부 핵자기 공명 영상, 심 초음파 등을 시행하였으나 심장이나 하대 정맥에서 종괴나 혈전을 발견할 수 없었으며 심기능은 정상이었다. 상기 소견으로 본 환자의 급성 호홉 부전증의 원인으로서 lipiodol에 의한 폐 지방전색증을 추정하게 되었다. 환자는 보전적 요법을 시행받고 증상 발현 4주 후 임상증상 및 흉부 단순 촬영상 호전을 보여 퇴원하였다. 저자 등은 lipiodol과 doxorubicin을 이용하여 간세포암의 화학색전술을 시행 후 lipiodol에 의한 폐지방 색전증이 원인인 급성 폐손상이 발생한 종례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

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메치실린 내성 황색포도상구균 세균성 심내막염에 의한 패혈성 폐색전증 1예 (A Case of Septic Pulmonary Embolism Associated with MRSA Infective Endocarditis)

  • 이기종;김나영;김자선;윤한결;오미정;김도훈;조상균;류한영;배영아;김대봉;신미경;진재용
    • Tuberculosis and Respiratory Diseases
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    • 제69권2호
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    • pp.124-128
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    • 2010
  • Septic pulmonary embolism is the process in which an infected thrombus becomes detached from its site of origin and lodges in a pulmonary artery, and is usually associated with infective endocarditis, especially right-sided, or infection-associated with indwelling catheters, peripheral septic thrombophlebitis, and periodontal diseases, etc. Here, we report a case of septic pulmonary embolism associated with tricuspid valve infective endocarditis. A 23-year-old female was admitted to our hospital, due to fever, sore throat, and myalgia. In her past medical history, she had undergone a surgical operation for closure of a ventricular septal defect, but was informed that the operation resulted in an incomplete closure. The initial chest radiograph demonstrated multiple rounded, parenchymal nodules in various sizes; several nodules had central lucency suggesting cavitations. Echocardiography demonstrated a large vegetation attached to the septal tricuspid valve leaflet, extending from right ventricular inflow tract to outflow tract. Computed tomography of thorax revealed bilateral peripheral nodules and wedge-shaped consolidation at various sizes, mostly accompanied by cavitations.

코일 위치에 따른 측방 동맥류 내부 혈류 유동의 변화 (The Change of Flow Characteristics in Lateral Aneurysm Models for Different Coil Locations)

  • 이계한;송계웅;변홍식
    • 대한의용생체공학회:의공학회지
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    • 제23권5호
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    • pp.375-383
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    • 2002
  • 코일을 이용한 동맥류 색전술은 동맥류 내부에 코일을 삽입하여 혈류 유동의 정체를 유도하여 혈전을 형성시키므로 동맥류를 폐색하는 방법이다. 코일을 이용하여 동맥류를 부분 폐색할 경우 동맥류의 폐색 위치에 따라 동맥류 내부의 유동 특성이 변하며, 이는 동맥류 내부의 현전 형성에 영향을 미칠 수 있다. 본 연구에서는 내경 동맥에서 발생한 측방 동맥류에 코일로 인한 부분 폐색이 발생할 경우, 부분 폐색 위치 및 내경 동맥의 곡률 반경의 변화에 따른 동맥류 내부 혈류 유동의 변화를 생체외 모델 실험을 이용하여 측정하여, 효율적인 동맥류 폐색 위치를 제시하고자한다. 내경동맥에서 발생한 측방 동맥류 내부에 코일을 동맥류 천정 근위부, 천정 원위부, 목 근위부 및 목 원위부에 각각 삽입하여 폐색 위치가 다른 모델을 제작하여, 입자영상속도계를 이용하여 속도장을 측정하였다. 동맥류 주머니의 원위부 폐색은 근위부 폐색에 비해 동맥류 내부고의 유입되는 유동이 적었으므로 동맥류 원위부 폐색이 혈전의 형성 및 동맥류 색전에 효율적임을 나타냈다. 동맥류 목 원위부 폐색은 천정 원위부 폐색에 비해 동맥류 내부로 혈류 유입을 효율적으로 차단하였으므로, 목 원위부 폐색이 동맥류 색전에 가장 효율적인 위치임을 알 수 있었다.