• Toxicological Research
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• v.17
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• pp.71-77
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• 2001

The brain of the aged dog possesses senile plaques and amyloid angiopathy, which characterize Alzheimer's disease brains. We have defined the dementia condition of aged dogs and examined which mechanism(s) is responsible for the condition. A series of studies revealed that the dementia condition in aged dogs is significantly related to the number of apoptotic brain cells including both neurons and glial cells, but not to the number of senile plaques. On the other hand, 5-azacytidine (5AzC) is a cytidine analogue, and is thought to induce kinds of cell differentiation possibly through hypomethylation of genomic DNA. We have revealed neuronal apoptosis induced in 5AzC-treated fetal mice and PC12 cells. The ribosomal protein L4 (rpL4) gene is expressed prior to the apoptosis in the PC12 cell system. Therefore, the involvement of the rpL4 gene expression in age-related brain cell apoptosis in dogs may contribute to the investigation of Alzheimer's dementia.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.53 no.1
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• pp.98-106
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• 2017

In order to investigate the effect of land reclamation on the life of local fishermen, a survey was conducted with the 246 people living in 12 different adjacent villages located in Hwasung District. It was found that income of residents decreased, while the amount of debts increased after reclamation. 65% of the people surveyed answered that their economic situation became worse than before and they blamed the decrease of fishery resources as the main cause. It further led to the loss of the family's means of livelihood. 40% of the people surveyed claimed that they wanted to leave the fishing village and believed that reclamation divested them of all their hope for the future. Regarding to the effect of reclamation project on the image of Hwasung District, most of the respondents have a negative view on the reclamation project. They have negative views even on the tourism, regional welfare, employment of community residents and local infrastructure. Therefore, it can be concluded that local community residents thought that reclamation project had negatively influenced their overall quality of life.

• Lingua Humanitatis
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• v.8
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• pp.95-127
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• 2006

This paper is a study of "poetry therapy", a subject now in lively in literary discussion circles. Modern literary text attaches great importance to the readers' response. As such, there is growing interest in the effects of communication brought on by the interaction of participants in a discourse. Poetry, in essence, has therapeutic attributes of treating, through an aesthetic psychology, destruction resulting from the alienation from life and psychological pain of distortion. The rise of the concept of eco-poetry and the capacity for psychological cleansing and adjustment (which restores balance through communication and psychological circulation) is a reflection of new trend in research - approaching the alienation felt by modern people through restoration of sense of life. Although Kim Hyun-seung's life and the road his poetry took was not smooth, he nevertheless was firm in his sustained effort to unify socio-ethical conscience and conscience of faith through the process of spiritual inquiry. The most outstanding aspects of Kim Hyun-seung's aesthetic achievement lie in his contribution toward the therapeutic capacity of modern poetry. Kim Hyun-seung's poetryhas the following effects: 1)The therapeutic capacity of modern poetry, through catharsis at large, does not remain only at the level of cleansing and adjustment. 2)The therapeutic capacity of modern poetry has the function of emptying out the self through more fundamental spiritual awakening and insight. 3)Only then can one truly realize the transcendence of being a true self as well as the balanced inquiry of spirituality which can be described as "emptying out".

• BMB Reports
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• v.42 no.6
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• pp.380-386
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• 2009

In neurodegenerative diseases, such as Alzheimer' and Parkinson', microglial cell activation is thought to contribute to CNS injury by producing neurotoxic compounds. Prothrombin and kringle-2 increase levels of NO and the mRNA expression of iNOS, IL-1$\beta$, and TNF-$\alpha$ in microglial cells. In contrast, the human prothrombin kringle-2 derived peptide NSA9 inhibits NO release and the production of pro-inflammatory cytokines such as IL-1$\beta$, TNF-$\alpha$, and IL-6 in LPS-activated EOC2 microglia. In this study, we investigated the anti-inflammatory effects of NSA9 in human prothrombin- and kringle-2-stimulated EOC2 microglia. Treatment with 20-100 ${\mu}M$ of NSA9 attenuated both prothrombin- and kringle-2-induced microglial activation. NO production induced by MAPKs and NF-$\kappa$B was similarly reduced by inhibitors of ERK (PD98059), p38 (SB203580), NF-$\kappa$B (N-acetylcysteine), and NSA9. These results suggest that NSA9 acts independently as an inhibitor of microglial activation and that its effects in EOC2 microglia are not influenced by the presence of kringle-2.

• Korean Journal of Agricultural Science
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• v.40 no.4
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• pp.277-280
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• 2013

This study was carried out to compare the productivity and to evaluate the stability for the introduced sweet corn hybrids; Sunnychocolat, 7168Y and Gammiok as a check hybrids. The used materials were planted at Anseong and Daejeon by randomized block design with 3 replications on 21 April, 2013. In productivity of the used hybrid corns, plant and ear height showed comparatively stable as a 183.5 cm to 226.5 cm and 45.8 cm to 80.9 cm, respectively. In yield per 10a, number of ears was higher in Sunnychocolat than check, while Gammiok was very poor in kernel setting length and marketability. Beside, stability of the used hybrids also showed highly in the introduced hybrids than check in the ratio of ear to plant height, tolerance to environmental stress and low lodging. As results above, we thought that these introduced hybrids will be well adapted in domestic cultivation and growth habit as like other hybrid corns.

• Proceedings of the KSPS conference
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• 1996.10a
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• pp.378-378
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• 1996

Human beings and chimpanzees are very much alike. and scientists say there is only 1% difference between them. Contrary to our expectations, the difference lies not in brains but in tracheas ( windpipes ). Those of human beings are bigger and longer than those of chimpanzees. Thu means more air is inspired and expired as breath. About breath there are interesting descriptions in the Bible. In the Genesis it says God made a man out of soil and breathed life-giving breath into his nostrils and the man began to live. In other part it says life exists between incoming breath and outgoing breath. Thus breath plays key role is our life. In Hebrew and Greek, breath and spirit are the same words. In Hebrew it is ‘Luahf’ and in Greek, ‘Pneuma’ With breath and mouth organs human beings produced voice, and with haritage and through leaning we train our voice to reach the level of language which convey our culture. My contention is to realize the gift of voice and train it so that it can perform proper function as a tool of conveying our thought and culture. This is a kind of practice of speech and it may be called speechology. It includes the following practical methods: 1. Try to read aloud. 2. Encourage recitation, 3. Make public speaking as possible. 4. Learn theories of phonetics; such as about pronunciation, accent, intonation, prominence, assimilation and so on.

• Journal of Technologic Dentistry
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• v.33 no.4
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• pp.403-411
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• 2011

Purpose: The purpose of this study was to examine the health promotion behavior of dental technology students. Methods: The subjects in this study were 255 dental technology students in three different colleges in Gyeonggi province. A survey was conducted from April 1st to June 30th 2011, and the collected data were analyzed with SPSS 12.0 program. Results: Dental technology students thought that subjective health is good(89.0%). When was health bad, expose that nutrition, health responsibility, life appreciation, exercise, stress management and oral health care are low(p<0.05). Education level of mothers that oral health care of children is low examine. When inhabit with family was expose that nutrition and oral health care go well(p<0.05). When get social support, respect of life appeared high. As respect of life is high, stress administration went well. As health responsibility is high, nutrition went well, and did well oral health care as health responsibility is high(p<0.01). Conclusion: Recognize importance of health to an university students, and it is very important to do it as form desirable habit.

• Journal of Family Resource Management and Policy Review
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• v.15 no.1
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• pp.71-91
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• 2011

This qualitative case study examines how mid-life housewives perceive age, react to aging, and experience the changing of their appearance that comes with age. The participants of this study were eight housewives four full-time housewives and four working housewives in middle adulthood. This study was conducted through in-depth interviews that were based on an unstructured questionnaire, and the data was collected from January 2010 to October 2010. Findings are as follows: during mid-life, housewives continue to exert efforts toward self-development, and toward self-actualization that can unleash the potential of their "multi-self". The housewives of the Entering Middle Adulthood self-actualization period believe that the material self as manifested in appearance is the most important component of the multi-self. Indeed, both groups of housewives thought a great deal about the criterion of appearance for their age and were concerned about others' viewpoints, social stereotypes, the appearance "norm," and other characteristics related to appearance. The full-time housewives made efforts to improve their social selves, and the working housewives tried to enhance their spiritual selves. The viewpoints of husbands are often internalized into housewives' internal points of view; therefore the relationships of housewives with their husbands were crucial both to the confidence the women felt in their appearance, and to their satisfaction in life.

• BMB Reports
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• v.48 no.7
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• pp.367-368
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• 2015

It has long been thought that glucocorticoid receptor (GR) functions as a DNA-binding transcription factor in response to its ligand (a glucocorticoid) and thus regulates various cellular and physiological processes. It is also known that GR can bind not only to DNA but also to mRNA; this observation points to the possible role of GR in mRNA metabolism. Recent data revealed a molecular mechanism by which binding of GR to target mRNA elicits rapid mRNA degradation. GR binds to specific RNA sequences regardless of the presence of a ligand. In the presence of a ligand, however, the mRNA-associated GR can recruit PNRC2 and UPF1, both of which are specific factors involved in nonsense-mediated mRNA decay (NMD). PNRC2 then recruits the decapping complex, consequently promoting mRNA degradation. This mode of mRNA decay is termed "GR-mediated mRNA decay" (GMD). Further research demonstrated that GMD plays a critical role in chemotaxis of immune cells by targeting CCL2 mRNA. All these observations provide molecular insights into a previously unappreciated function of GR in posttranscriptional regulation of gene expression. [BMB Reports 2015; 48(7): 367-368]

• Journal of fish pathology
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• v.15 no.1
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• pp.1-7
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• 2002

On April of 2000 and February of 2001, a disease characterized by darkening, ascites and enlargement of the spleen occurred in flounder, Paralichthys olivaceus, farmed near northern and eastern coasts of Korea. Various degree of necrosis including liquefactive-type was observed mainly in hemopoietic tissue of spleen and kindney. Certain tissue such as branchial soft tissue including epithelium showed a similar necrotic findings. But some tissues such as intentine had several necrotic clusters of wandering cells, being possibly leukocytes. Necrotic evidences of blood cells were evident in various tissues including hemopoietic tissues. Necrobiotic bodies were frequently encountered in blood smear preparations. Bullet type-virious were detected in the spleenic cells. Each virion was about 500 nm in diameter and 170nm in length. From these results, this disease was thought to be a rhabdoviral disease.