• 제목/요약/키워드: third

검색결과 33,142건 처리시간 0.046초

Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells

  • Xiong, Wei;Jiang, Yong-Xin;Ai, Yi-Qin;Liu, Shan;Wu, Xing-Rao;Cui, Jian-Guo;Qin, Ji-Yong;Liu, Yan;Xia, Yao-Xiong;Ju, Yun-He;He, Wen-Jie;Wang, Yong;Li, Yun-Fen;Hou, Yu;Wang, Li;Li, Wen-Hui
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권8호
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    • pp.3395-3402
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    • 2015
  • Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.

Analysis of composite plates using various plate theories -Part 2: Finite element model and numerical results

  • Bose, P.;Reddy, J.N.
    • Structural Engineering and Mechanics
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    • 제6권7호
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    • pp.727-746
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    • 1998
  • Finite element models and numerical results are presented for bending and natural vibration using the unified third-order plate theory developed in Part 1 of this paper. The unified third-order theory contains the classical, first-order, and other third-order plate theories as special cases. Analytical solutions are developed using the Navier and L$\acute{e}$vy solution procedures (see Part 1 of the paper). Displacement finite element models of the unified third-order theory are developed herein. The finite element models are based on $C^0$ interpolation of the inplane displacements and rotation functions and $C^1$ interpolation of the transverse deflection. Numerical results of bending and natural vibration are presented to evaluate the accuracy of various plate theories.

海安 鹽濕地 植生의 純生産性 推定法의 比較 (Comparison of Estimation Methods for Primary Net Production at Herbaceous Coastal Marsh Vegetation)

  • Ryu, Beung Tae;Joon-Ho Kim
    • The Korean Journal of Ecology
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    • 제8권3호
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    • pp.133-140
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    • 1985
  • Aboveground net productions of four stands in the coastal salt marsh of Incheon were estimated with three different methods: first method was to measure peak live standing crop; second to measure both live and dead standing crops; thrid to measure live and dead standing crops and dead disappearance as well. Net productions estimated by the first method were lowest with a difference of 28~50% from those by the third method. Whereas estimates by the second method approximated considerably to those by the third method with a difference of 4~15%. The third method figured out the highest values and seemed to be most appropriate in estimating net production of herbaceous community. Form these results it is known that live standing crop, dead standing crop and dead disappearance respectively accounted for about 60, 30, 10% of net production estimated by the third method. Annual net productions estimated by the third method for Suaeda japonica-Salicornia herbacea, Artemisia scoparia-Limonium tetragonum, Calamagrostis epigeios, and Sonchus brachyotus-Setaria viridis stand were 650, 1, 080, 1, 409 and 1, 126 g.$m^{-2}.yr^{-1}$, respectively.

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Isolated Sphenoid Sinus Mucocele Presenting as Third Nerve Palsy

  • Lee, Jae-Chul;Park, Sang-Kyu;Jang, Dong-Kyu;Han, Young-Min
    • Journal of Korean Neurosurgical Society
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    • 제48권4호
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    • pp.360-362
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    • 2010
  • A sphenoid mucocele often presents late due to its deep seated anatomical site. And it has varied presentation due to its loose relationship to the cavernous sinus and the base of the skull. We describe a case of large sphenoid sinus mucocele. A middle aged old man suddenly developed third cranial nerve palsy. Brain imaging study revealed an isolated sphenoid sinus mucocele, compressing right cavernous sinus. Endoscopic marsupialization of the mucocele via transnasal approach led to complete resolution of the third cranial nerve palsy. Involvement of the third cranial nerve in isolated mucocele is rare but important neurosurgical implications which must be excluded. In addition, proper and timely treatment must be performed to avoid permanent neurologic deficit.

Antimicrobial and Antioxidative Activities of Cornis fructus Extracts

  • Chun, Hyun-Ja;Choi, Won-Hyung;Lee, Jeong-Ho;Lee, In-A;Lee, Ji-Su;Baek, Seung-Hwa
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.139.2-140
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    • 2003
  • Tannin-rich fruit of Cornus officinalis Sieb. et Zucc has been used as an ingredient in several prescriptions of Oriental medicine. Cornis fructus was extracted by successive extraction. Cornis fructus extracts were investigated for antimicrobial and antioxidative activities. Antimicrobial effects used disk diffusion method. All extracts were examined against Streptococcus mutans. (omitted)

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경량전철 차량용 제3궤조 집전장치의 개발 (A Development of the Third Rail Current Collecting Shoegear for the Light Rail Transit)

  • 정락교;김연수;박성혁;이병송;최규형
    • 한국철도학회논문집
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    • 제3권4호
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    • pp.185-193
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    • 2000
  • In general, a third rail current collecting shoegear is widely used in the light rail transit system since it is more efficient and economical than an overhead pantograph. Therefore, its specification is prescribed in the Korean standard specifications for the light rail transit for its applications. This paper describes the development of the third rail current collecting shoegears which is suitable to Korean situation and satisfactory to the Korean standard specifications. Two types are developed for the steel wheel and the rubber tyred AGT system, and various experiments are executed. It is found that performance of the third rail current collecting shoegear developed is proved acceptable.

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제3자 물류기업의 파트너쉽 성공요인에 관한 연구 : 중국 산동성을 중심으로 (Critical Success Factors For Affecting Formation of Partnership between Shippers and Third-Party Logistics Providers: Focus on China)

  • 오문갑
    • 통상정보연구
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    • 제11권1호
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    • pp.117-137
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    • 2009
  • Although the third-party logistics are activated and researched in many ways in the advanced countries, China is still on the beginning phase of the third-party logistics and has announced few studies on them. Especially, the study on factors affecting formation for partnership between shippers and third-party logistics providers has never been announced in China, and few empirical studies on them have been done. In order to verify established hypothesis, the empirical analysis is conducted as follows. Totally 500 copies of questionnaire were drawn up and distributed. Amid them 160 copies were collected, finally 155 copies were used for this study as valid samples. The questionnaire used nominal scale and 5 Likert scale. Statistics of collected data were under the data coding process, and analyzed by applying SEM program.

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Orthodontic Traction of the Impacted Mandibular Third Molars to Replace Severely Resorbed Mandibular Second Molars

  • Hwang, Soonshin;Choi, Yoon Jeong
    • Journal of Korean Dental Science
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    • 제9권1호
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    • pp.42-48
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    • 2016
  • Prophylactic removal of impacted third molars is a common procedure in dentistry, but the necessity of routine extraction is still controversial. When impacted third molars caused severe apical root resorption of the second molars, orthodontic traction of the third molars after extraction of the damaged second molars could minimize alveolar bone defect and preserve the patient's natural teeth. By well-planned orthodontic treatment, functional occlusion was established avoiding extraction of the impacted teeth and eliminating the possibility of a large bone defect after extraction.

Surgical extraction of mandibular third molar in pterygomandibular space: a case report

  • Lee, Young-Kyu;Park, Sung-Soo;Myoung, Hoon
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제39권5호
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    • pp.242-245
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    • 2013
  • Impacted mandibular third molars are located between the second mandibular molar and mandibular ramus. However, ectopic mandibular third molars with heterotopic positions are reported in the subcondylar or pterygomandibular space. The usual cause of malposition is a cyst or tumor, and malposition without a pathology is rare. This case report described an impacted mandibular third molar in the pterygomandibular space without any associated pathology.