• 항공우주시스템공학회지
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• 제9권2호
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• pp.13-18
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• 2015

Micro planar type liquid propellant thruster was fabricated by MEMS manufacturing process for micro/nano satellites applications. 90 wt.% hydrogen peroxide was used as propellant and for propellant decomposition, Pt/Al2O3 was used as catalyst. Micro thruster structure was made by 5 photosensitive glasses patterned with thruster component profiles. Objective thrust was 50 mN and required hydrogen peroxide mass flow was 2.1 ml/min, which was supplied by syringe pump and teflon tube in experimental test. Performance test said that average steady thrust was approximately 30 mN, around 60% of objective thrust, and transient time was about 5 sec. It is estimated that extended response time was due to high thermal energy loss of micro scale thruster and low enthalpy input by propellant mass flow.

• Annals of Clinical Neurophysiology
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• 제21권1호
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• pp.1-6
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• 2019

Anhidrosis refers to the condition in which the body does not respond appropriately to thermal stimuli by sweating. Sweating plays an important role in maintaining the body temperature, and its absence should not be overlooked since an elevated body temperature can cause various symptoms, even leading to death when uncontrolled. The various neurological disorders that can induce anhidrosis make a detailed neurological evaluation essential. The medication history of the patient should also be checked because anhidrosis can be caused by various drugs. The tests available for evaluating sweating include the quantitative sudomotor axon reflex sweat test, thermoregulatory sweat test, sympathetic skin response, and electrochemical skin conductance. Pathological findings can also be checked directly in a skin biopsy. This review discusses the differential diagnosis and evaluation of anhidrosis.

• 한국초전도ㆍ저온공학회논문지
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• 제10권1호
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• pp.62-66
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• 2008

The characteristic of the superconducting magnetic energy storage(SMES) system is faster response, longer life time, more economical, and environment friendly than other uninterruptible power supply(UPS) using battery. So, the SMES system can be used to develop methods for improving power quality where a short interruption of power could lead to a long and costly shutdown. Recently, cryogen free SMES has developed using BSCCO(Bismuth Strontium Calcium Copper Oxide) wire. We fabricated and tested the conduction cooling system for the 600 kJ class HTS SMES. The experiment was accomplished for the simulation coils. The simulation coils were made of aluminium, it is equivalent to thermal mass of 600 kJ HTS SMES coil. The coil is cooled with two GM coolers through the copper conduction bar. In this paper, we report that the test results of cool-down and heat loads characteristics of the simulation coils. The developed conduction cooling system adapted to 600 kJ HTS SMES system and cope with the unexpected sudden heat impact, too.

• The Korean Journal of Pain
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• 제19권1호
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• pp.17-21
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• 2006

Background: Cyclic guanosine monophosphate (cGMP) plays an important role in the modulation of nociception. Although local sildenafil produces antinociception, by increasing cGMP through the inhibition of phosphodiesterase 5, the effect of spinal sildenafil has not been determined. The authors evaluated the effects of intrathecal sildenafil on the nociceptive behavior evoked by formalin injection and thermal stimulation. Methods: Lumbar intrathecal catheters were implanted into rats, with formalin and Hot-Box tests used as nociceptive models. The formalin-induced nociceptive behavior (flinching response) and withdrawal latency to radiant heat were measured, and the general behaviors also observed. Results: The intrathecal administration of sildenafil produced dose-dependent suppression of the flinches in both phases in the formalin test, and increased the withdrawal latency in the Hot-Box test. No abnormal behaviors were noted. Conclusions: Sildenafil, an inhibitor of phosphodiesterase 5, is active against the nociceptive state evoked in the spinal cord by formalin and thermal stimulations. Accordingly, spinal sildenafil may be useful in the management of pain.

• 대한기계학회논문집B
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• 제34권2호
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• pp.179-184
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• 2010

스트레이트 휜 히트 싱크가 장착된 공간에 팁 클리어런스(tip clearance)와 바이패스 유동이 열성능에 미치는 영향을 실험적으로 규명하고자 한다. 수평 및 수직 방향으로의 바이패스 유동에 의한 열성능 평가는 열식 질량 유량계(MFC)와 소형 풍동으로 이루어진다. 팁 클리어런스와 바이패스 유동에 의한 히트 싱크의 열성능은 열저항을 통하여 평가한다. 실험 결과, 스트레이트 휜 히트 싱크의 열저항은 팁 클리어런스가 증가함에 따라 점진적으로 증가하며, 유동 가이드 장치는 바이패스 유동을 감소하는 역할을 한다. 본 연구에서는 동일 유량 조건에서 히트 싱크의 입구에서 유동 가이드 장치까지의 거리에 따라 스트레이트 휜 히트 싱크의 최적값이 존재함을 확인하였다. 히트 싱크로 유입되는 유량이 증가함에 따라 유동 가이드 장치에 의한 열성능 개선 정도는 증가한다.

• 시스템엔지니어링학술지
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• 제18권2호
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• pp.75-93
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• 2022

Machine learning (ML) data-driven meta-model is proposed as a surrogate model to reduce the excessive computational cost of the physics-based model and facilitate the real-time prediction of a nuclear power plant's transient response. To forecast the transient response three machine learning (ML) meta-models based on recurrent neural networks (RNNs); specifically, Long Short Term Memory (LSTM), Gated Recurrent Unit (GRU), and a sequence combination of Convolutional Neural Network (CNN) and LSTM are developed. The chosen accident scenario is a control element assembly withdrawal at power concurrent with the Loss Of Offsite Power (LOOP). The transient response was obtained using the best estimate thermal hydraulics code, MARS-KS, and cross-validated against the Design and control document (DCD). DAKOTA software is loosely coupled with MARS-KS code via a python interface to perform the Best Estimate Plus Uncertainty Quantification (BEPU) analysis and generate a time series database of the system response to train, test and validate the ML meta-models. Key uncertain parameters identified as required by the CASU methodology were propagated using the non-parametric Monte-Carlo (MC) random propagation and Latin Hypercube Sampling technique until a statistically significant database (181 samples) as required by Wilk's fifth order is achieved with 95% probability and 95% confidence level. The three ML RNN models were built and optimized with the help of the Talos tool and demonstrated excellent performance in forecasting the most probable NPP transient response. This research was guided by the Systems Engineering (SE) approach for the systematic and efficient planning and execution of the research.

• 지질공학
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• 제25권1호
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• pp.131-148
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• 2015

본 연구는 지열시스템 열교환 효율의 개선방안을 모색하기 위한 것으로 금속재질의 열교환기인 동관 및 스테인레스관과 기존 지열시스템에 많이 적용되는 PE관을 이용하여 지열열교환기의 재질에 따른 열전달 효율을 비교 분석하였다. 또한 지하매질의 지하수에 포함되어 있는 지하수열을 동시 활용할 경우의 열전달 효율 변화를 평가하고 그 적용성을 검토하였다. 열교환기 내의 유속, 유량 및 열교환기의 구경을 조절함으로써 열교환기의 재질에 따른 열전달 효율을 평가 후 현장실증시험 설계인자를 도출하였다. 열교환 효율과 유효 열전도도는 현장 열전달 효율 시험 및 열응답 시험을 통해 변화양상을 분석하였다. 분석결과 금속재질이 PE관에 비해 높은 열전달 효율을 보였으며, 유량에서의 구경증대에 따른 열전달효율은 크지 않았으나 유속에서의 구경증대에 따른 열전달효율은 높아지는 것을 확인하였다.

• 한국항공우주학회지
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• 제39권2호
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• pp.106-113
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• 2011

본 논문에서는 균일 열부가 하중을 받는 사각판의 자유 진동특성을 실험을 통하여 연구하였다. 사각판의 재질은 알루미늄, 강재 및 스테인레스 강이고 사각판의 재원은 0.1 $\times$ 0.1 $\times$ 0.002 m 이다. 열부가 하중을 위해 적외선 석영 램프를 사용하였고, 전력조절을 위해 PCS(Power Control System)을 사용하였으며, 주파수 함수를 얻기 위해 비접촉식 진동측정 장비를 사용하였다. 부가한 온도 조건은 상온에서부터 $300^{\circ}C$까지 $50^{\circ}C$간격으로 부가하였다. 경계조건은 번지코드를 사용하여 자유-자유 조건을 구현하였다. 사각판의 전면 전체를 균일하게 가열하였다.

• Journal of Chest Surgery
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• 제45권6호
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• pp.368-379
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• 2012

Background: Bioprostheses for cardiovascular surgery have limitations in their use following as calicification. ${\alpha}$-galactosidase epitope is known as a stimulant of immune response and then shows a progressing calcification. The objective of this study was to evaluate histologic characteristics and mechanical properties of decellularization and treated with ${\alpha}$-galactosidase. Materials and Methods: Bovine pericardial tissues were allocated into three groups: fixation only with glutaraldehyde, decellularization with sodium dodesyl sulfate and decellularization plus treatment with ${\alpha}$-galactosidase. We confirmed immunohistological characteristics and mechanical properties as fatigue test, permeability test, compliance test, tensile strength (strain) test and thermal stability test. Results: Decellularization and elimination of ${\alpha}$-gal were confirmed through immunohistologic findings. Decellularization had decreased mechanical properties compared to fixation only group in permeability (before fatigue test p=0.02, after fatigue test p=0.034), compliance (after fatigue test p=0.041), and tensile strength test (p=0.00). The group of decellularization plus treatment with ${\alpha}$-galactosidase had less desirable mechanical properties than the group of decellularization in concerns of permeability (before fatigue test p=0.043) and strain test (p=0.001). Conclusion: Favorable decellularization and elimination of ${\alpha}$-gal were obtained in this study through immunohistologic findings. However, those treatment including decellularization and elimination of ${\alpha}$-gal implied the decreased mechanical properties in specific ways. We need more study to complete appropriate bioprosthesis with decellularization and elimination of ${\alpha}$-gal including favorable mechanical properties too.

• Biomolecules & Therapeutics
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• 제5권2호
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• pp.150-157
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• 1997

Capsaicin cream has been used to attenuate the pain associated with diabetic neuropathy, rheum-atoid arthritis, osteoarthritis and postherpetic neuralgia. But its common side effect, local irritation, limits the use of it and there is still a need for a new analgesic devoid of this side effect. This study was conducted to compare the local irritant effect of DA-5018, a new capsaicin derivative, with that of capsaicin in various animal models and human beings. Capsaicin, applied topically to the mouse ear, produced dose-dependent increase of ear volume and the frequency of ear scratching behavior in mice. Neither ear volume nor scratching behavior was affected by DA-5018. In eye wiping test of rat, DA-5018 was 10 times less irritant than capsaicin. Capsaicin administered intradermally into the rat paw elicited paw lick/lift response with a potency which was three times that of DA-5018. Zostrix-HP (0.075% capsaicin cream), but not DA-50180.3% cream, increased ear volume of rat and induced thermal hyperalgesia in normal and carrageenan inflamed paws. Six day-treatment of Zostrix-HP failed to develop tolerance against this thermal hyperalgesia. In human beings, Zostrix-HP produced burning sensation and itching in more than 90% of volunteers involved and its maximum irritant effect was significantly higher than that of DA-5018 cream. These results suggest that local irritation and burning sensation produced by DA-5018 is much less than capsaicin.