• 한국간호교육학회지
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• 제28권4호
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• pp.400-410
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• 2022

Purpose: This study aimed to understand the keywords and major topics of the educational goals and objectives of nursing educational institutions in South Korea. Methods: From May 10 to May 20, 2022, the educational goals and objectives of all 201 nursing educational institutions in South Korea were collected. Using the NetMiner program, degree and degree centrality, semantic structure, and topic modeling were analyzed. Results: The top keywords and semantic structures of educational goals included 'respect for human (life)-spirit-science-based on, global-competency-professional nurse-nursing personnel-training, professional-science-knowledge-skills, and patients-therapeutic care-relationship.' The educational goals' major topics were clients well-being based on science and respect for human life, a practicing nurse with capabilities and spirit, fostering a nursing personnel with creativity and professionalism, and training of global nurses. The top keywords and semantic structures of the educational objectives included 'holistic care-nursing-research-action-capability, critical thinking-health-problem solving-capability, and efficiency-communication-collaboration-capability.' The educational objectives' major topics were 'nursing professionalism, communication and problem-solving capability; a change of healthcare environments and a progress of nursing practices; fostering professional nurses with creativity and global capability; and clients' health and nursing practice.' Conclusion: Educational goals in nursing presented specific nursing values and concepts, such as respect for human life, therapeutic care relationships, and the promotion of well-being. Educational objectives in nursing presented the competencies of nurses as defined by the Korean Accreditation Board of Nursing Education (KABONE). Recently, the KABONE announced new program outcomes and competencies, which will require the revision of educational goals. To achieve those educational objectives, it is suggested that the expected level of competencies be clearly defined for nursing graduates.

• 한국전문물리치료학회지
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• 제17권1호
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• pp.53-61
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• 2010

This study investigated the relationships between Work-related musculoskeletal disorders (WMSDs), contributing factors, and the occupational stress of physical therapists. Self-reported questionnaires were given to 180 physical therapists in Gangwon Province. Variables examined included the prevalence of pain sites related to WMSDs; pain intensity; pain pattern; and job stress, which is thought to involve the physical environment; job demand; insufficient job control; interpersonal conflict; job insecurity; organizational system; reward system; and occupational culture. Among physical therapists, work-related musculoskeletal pain commonly affected the low back (30.1%), shoulder (29.3%), and wrist (12.2%). The sites of work-related musculoskeletal pain treated medically were the low back (22.8%), shoulder (19.8%), neck (12.7%), and wrist (12.1%). "Repeating the same work constantly" was suggested to be the major cause of the pain. The younger therapists were significantly more likely to feel high job stress due to the physical environment (p<.05), job demand (p<.05), and organizational system (p<.01). Women were more likely to feel greater job stress related to job demand, insufficient job control, the organization system, and job rewards. Men were more likely to feel greater job stress related to job insecurity. Weak positive relationships were observed between work-related musculoskeletal pain and job stress, which is thought to involve the physical environment; job demand; insufficient job control; interpersonal conflict; job insecurity; organizational system; reward system; and occupational culture. Physical therapists appear to be at higher risk of WMSDs because 80.1% of the physical therapists studied experienced work-related musculoskeletal pain. To reduce the risk, we need intervention strategies such as preventive education, ergonomically designed medical equipment, a psychosocial approach to work conditions, improved mechanical conditions related to therapeutic patterns, and an institutional infrastructure with sufficient personnel and scheduling.

• BMB Reports
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• 제31권5호
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• pp.459-467
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• 1998

A new set of functional group interaction energy descriptors relevant to the ACE (Angiotensin-Converting Enzyme) inhibitory peptide, QSAR (Quantitative Structure Activity Relationships), is presented. The functional group interaction energies approximate the charged interactions and distances between functional groups in molecules. The effective energies of the computationally derived geometries are useful parameters for deriving 3D-QSAR models, especially in the absence of experimentally known active site conformation. ACE is a regulatory zinc protease in the renin-angiotensin system. Therapeutic inhibition of this enzyme has proven to be a very effective treatment for the management of hypertension. The non bond interaction energy values among functional groups of six-feature of ACE inhibitory peptides were used as descriptor terms and analyzed for multivariate correlation with ACE inhibition activity. The functional group interaction energy descriptors used in the regression analysis were obtained by a series of inhibitor structures derived from molecular mechanics and semi-empirical calculations. The descriptors calculated using electrostatic and steric fields from the precisely defined functional group were sufficient to explain the biological activity of inhibitor. Application of the descriptors to the inhibition of ACE indicates that the derived QSAR has good predicting ability and provides insight into the mechanism of enzyme inhibition. The method, functional group interaction energy analysis, is expected to be applicable to predict enzyme inhibitory activity of the rationally designed inhibitors.

• 한국산학기술학회논문지
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• 제20권8호
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• pp.321-330
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• 2019

본 연구의 목적은 한국판 자기자비 척도(Korean self-compassion scale)의 신뢰도와 타당도를 검증하기 위해 교정기관 종사자들을 대상으로 수집된 자료와 관련된 척도들 간 관계를 알아보는 것이다. 자기자비척도의 타당화를 위해 312부의 설문지가 최종분석에 포함되었으며, 상관분석, 탐색적-확인적 요인분석을 실시하였다. 관련 척도와 신뢰도를 알아보기 위해 한국인 직무스트레스 척도(Korean occupational stress scale), 우울척도(The center for epidemiological studies depression scale), 소진척도(Maslach burnout inventory scale), 스트레스 지각척도(perceived stress scale), 삶의 만족도 척도(satisfaction with life scale)를 사용하였다. 탐색적 요인분석결과 자기자비척도는 자기친절, 자기비난, 보편적 인간성, 고립, 마음챙김, 과잉동일시로 구성된 6요인 모형이 3요인 혹은 2요인 모형보다 더 높은 모형적합도를 보였다. 최종 모형인 6요인 간 서로 유의미한 상관을 보이는 것으로 나타났으며 직무스트레스, 소진, 스트레스 지각, 삶의 만족도 척도들과 유의미한 상관이 있는 것으로 나타났다. 이러한 결과들은 자기자비척도가 스트레스 상황에 지속적으로 노출되는 위험요인을 낮추고, 치료적 관계를 유지할 수 있는 보호요인을 측정하는 도구임을 시사한다. 연구결과를 기반으로 연구의 함의점과 추후연구를 논의하였다.

• 한국정보통신학회논문지
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• 제23권10호
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• pp.1209-1215
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• 2019

의사소통은 간호사가 대상자와의 치료적 관계 및 다양한 직종간의 협력관계를 형성하여 성공적인 간호중재를 이끄는데 있어 중요한 요소이며 이에 간호대학생들에게 효과적인 의료인 간의 의사소통 능력 함양 할 수 있는 의사소통 교육프로그램을 개발하고 그 효과를 분석하여 간호교육 전략을 모색하고자 하였다. 연구대상은 P 대학교 간호학과 4학년에 재학중인 학생 54명이며, 연구결과, 대상자의 의사소통명확성 (t=-7.75, p<.001)과 셀프리더십 (t=-4.43, p<.001)은 유의한 차이가 있었고, 의사소통 만족도는 교육 후에 점수가 증가하였으나 유의한 차이가 없었다 (t=-1.22, p=.226). 결론적으로 SBAR를 활용한 학제간 의사소통 교육프로그램은 간호대학생의 의사소통명확성과 셀프리더십에 긍정적인 효과가 있으며 다양한 시나리오의 개발과 반복 훈련을 할 수 있는 지속인 교육개발이 필요하다.

• 대한간호학회지
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• 제27권1호
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• pp.178-188
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• 1997

As a descriptive survey, this study was attempted to get basic data necessary to recognize the factors that disturb the therapeutic atmosphere of hospital wards as perceived by nurses and hospitalized patients, to identify differences between the perceptions of the nurses and of patients. The subjects, 159 patients in Pusan National Hospital and 68 nurses working there were sampled between March 18 and April 13, 1996. The tool used to measure the disturbing factors was an amended form of the one developed by Kim, Mae Ja(1983). The differences between each subject's score for each factor were analyzed using means & SD. and the highest 3 items above the mean score for each factor were collected and compared. The results are described below : 1. Subject's perception of main disturbing factors : patients reported that the main factors were 'loss of role & economic trouble', 'the prognosis of disease', 'the change of daily life' but nurses replied that the main factors were' the prognosis of disease', 'the communication trouble with the medical team & interpersonal relationships'. 'The change of daily life' was not a perceved factor by nurses, but ranked third by the patients. 2. Subject's perception degree of each disturbing factor : (1) among the items related to interpersonal relationship. the patient group reported that the worst disturbance was dur to severely ill patients in the same room' but the nurse group regarded 'greed to monopolize wheelchairs or other supplies' as the worst disturbance. (2) among the items related to physical factors. the patient group regarded 'limitations to wash their body, physical pain and limitations in physical activity' as the worst disturbance, but the nurse group regarded' physical pain', and 'limitations to activity or change of appearance' as the worst disturbance. (3) among the items related to the change of daily activity, the patient group regarded 'the boredom of hospitalization or infavorable diet' as the worst disturbance, but the nurse group regarded 'too much noise or unclean room' as the worst disturbance. (4) among the items related to the communication trouble with medical team, the patient group regarded 'the ignorance of their disease due to poor information. the inability to understand the language of the medical team or the difficulty in seeing physician in time' as the worst disturbance, but the nurse group regarded 'the inability to trust physicians and physician's poor attention to patients' as the worst disturbance.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2563-2566
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• 2013

Background: Interleukin-33 (IL-33) has recently been implicated in tumor immunity. The aim of this study was to explore the clinical role of serum IL-33 in patients with non-small-cell lung cancer (NSCLC). Methods: Sera collected from 250 healthy volunteers (HV), 256 patients with benign lung diseases (BLD) and 262 NSCLC cases were subjected to IL-33 ELISA and relationships between serum IL-33 and clinical characteristics were evaluated. Results: Circulating IL-33 levels were higher in the NSCLC group in comparison with the HV and BLD groups (p<0.001). Using a cut-off level 68 pg/ml (95% specificity in the HV group), IL-33 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that serum IL-33 was an independent prognostic factor in the entire NSCLC group [hazards ratio (HR) = 0.64 for low versus high IL-33 levels, 95% confidence interval (CI) 0.50-0.82; p<0.001] and in 165 selected patients with locally advanced or metastatic disease receiving chemoradiotherapy or chemotherapy (HR 0.70, 95% CI 0.52-0.94; p=0.013). Conclusions: IL-33 is a promising potential diagnostic and prognostic marker in NSCLC, independent of the therapeutic intervention.

• 생명과학회지
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• 제18권7호
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• pp.1011-1014
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• 2008

TAS2R38 유전자의 일배체형과 미맹 간익 관계에 대한 이해는 개인에 따라 다양한 음식 선호도의 유전학적 기초와 쓴맛에 대한 민감도로 예측할 수 있는 건강과의 관계에 관한 연구에 많은 도움을 줄 것이다. 또한, TAS2R38과 같이 생체내에서 표현형에 강력한 영향을 준다고 알려진 유전자에 대한 정보는 인간의 미각에 대한 생리학, 생화학적 기능, 분자적 구조를 설명하기 위한 연구에 중요한 정보를 제공할 것이다. 이러한 연구 결과들은 앞으로 각종 인공 감미료 등의 섭취가 증가하면서 급증하고 있는 미각장애에 대한 분자유전학적인 진단과 유전자 치료의 기틀을 마련하는데 기여할 것이다.

• 대한간호학회지
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• 제37권6호
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• pp.994-1002
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• 2007

Purpose: This study was to identify the effects of hope intervention on hope and depression of cancer patients staying at home. Methods: The study design was a randomized control group design. The subjects consisted of forty cancer patients randomly selected who were registered at S-Gu Public Health Center. Hope intervention, which was composed of hope assessment, hope objective setting, positive self identity formation, therapeutic relationships, spiritual & transcendental process improvement, positive environmental formation and hope evaluation, was provided from November 20, 2006 to January 26, 2007. Results: The 1-1 hypothesis, "The experimental group which received hope intervention will have a higher score of hope than the control group", was supported(t=-3.253, p= .003). The 1-2 hypothesis, "The experimental group which received hope intervention will have a higher level of hope index than the control group", was supported (t=-4.001, p= .000). Therefore the 1st hypothesis, "The experimental group which received hope intervention will have a higher level of hope than the control group" was supported. The 2nd hypothesis, "The experimental group which received hope intervention will have a lower level of depression than the control group", was not supported (t=1.872, p= .070). Conclusion: Hope intervention is an effective nursing intervention to enhance hope for patient with cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1085-1091
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• 2014

Matrix metalloproteinases (MMPs) are a family of zinc dependent extracellular matrix (ECM) remodelling endopeptidases having the ability to degrade almost all components of extracellular matrix and implicated in various physiological as well as pathological processes. Carcinogenesis is a multistage process in which alteration of the microenvironment is required for conversion of normal tissue to a tumour. Extracellular matrix remodelling proteinases such as MMPs are principal mediators of alterations observed in the microenvironment during carcinogenesis and according to recent concepts not only have roles in invasion or late stages of cancer but also in regulating initial steps of carcinogenesis in a favourable or unfavourable manner. Establishment of relationships between MMP overproduction and cancer progression has stimulated the development of inhibitors that block proteolytic activity of these enzymes. In this review we discuss the MMP general structure, classification, regulation roles in relation to hallmarks of cancer and as targets for therapeutic intervention.