• Journal of Music and Human Behavior
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• v.16 no.2
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• pp.53-77
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• 2019

The purpose of this study was to review the literature on music interventions with older adults and to analyze the rationale for the type of intervention and type of music selected. A search of KCI journals for research including older adults and music-based interventions identified 33 published articles, and 23 of these studies met the criteria for inclusion in this analysis. Included studies were analyzed in terms of the contents of the interventions and the appropriateness of the rationale reported for selecting the intervention and music. Each study was analyzed in terms of the relevance of the reported rationale to target goals and the characteristics of the study participants. The results showed that many of the included studies incorporated a variety of activities but failed to include a valid rationale for using those activities to achieve the target goals. Also, many of the studies tended to select music based on participants' preferences or perceived familiarity without thorough consideration of the therapeutic function of music in the given intervention. This study presents how music therapy interventions with older adults have been conducted without sufficient attention to the selection of the intervention and presented music. There remains a need to delineate which intervention and music characteristics should be utilized to obtain particular outcomes with specific populations.

• Journal of Music and Human Behavior
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• v.15 no.1
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• pp.95-118
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• 2018

With the recent emphasis on evidence-based research and practice, the field of music therapy has called for rigorous reviews of the scientific data and for therapeutic rationales for research procedures. The purpose of this study was to review studies that used a rhythm task as a therapy intervention in terms of whether they provided a rationale for the components related to the intervention. The components included activity rationale, music rationale, intervention validity, intervention format (individual or group), intervention development (contour), duration, and intervention provider. A total of 41 studies were selected: 22 studies were implemented by music therapists and 19 by professionals in other related fields. In terms of seven assessment categories, only 10 studies were found to report more than four items which are related to a rationale of interventions. The 10 studies identified were further examined to determine if their intervention rationale differed depending on whether the study included a researcher-formulated intervention or an existing music therapy protocol. Of the 10 studies, six used a researcher-formulated rhythm intervention, and four used an existing music therapy protocol. Those studies that used an existing music therapy protocol also provided a clear rationale for music selection, whereas those that used a researcher-formulated rhythm task tended to provide an activity rationale. The results of this study suggest that researchers need to be clearer about their interventions and provide an evidence-based rationale for why and how they use a rhythm task.

• International Journal of Stem Cells
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• v.16 no.1
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• pp.16-26
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• 2023

Despite long-term research achievements, the development of cell therapy (CT) products remains challenging. This is because the risks experienced by the subject and therapeutic effects in the clinical trial stage are unclear due to the various uncertainties of CT when administered to humans. Nevertheless, as autologous cell products for systemic administration have recently been approved for marketing, CT product development is accelerating, particularly in the field of unmet medical needs. The human experience of CT remains insufficient compared with other classes of pharmaceuticals, while there are countless products for clinical development. Therefore, for many sponsors, understanding the rationale of human application of an investigational product based on the consensus and improving the ability to apply it appropriately for CT are necessary. Thus, defining the level of evidence for safety and efficacy fundamentally required for initiating the clinical development and preparing it using a reliable method for CT. Furthermore, the expertise should be strengthened in the design of the first-in-human trial, such as the starting dose and dose-escalation plan, based on a sufficiently acceptable rationale. Cultivating development professionals with these skills will increase the opportunity for more candidates to enter the clinical development phase.

• IMMUNE NETWORK
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• v.9 no.6
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• pp.209-235
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• 2009

There has been an explosion of literature focusing on the role of regulatory T (Treg) cells in cancer immunity. It is becoming increasingly clear that Treg cells play an active and significant role in the progression of cancer, and have an important role in suppressing tumor-specific immunity. Thus, there is a clear rationale for developing clinical strategies to diminish their regulatory influences, with the ultimate goal of augmenting antitimor immunity. Therefore, manipulation of Treg cells represent new strategies for cancer treatment. In this Review, I will summarize and review the explosive recent studies demonstrating that Treg cells are increased in patients with malignancies and restoration of antitumor immunity in mice and humans by depletion or reduction of Treg cells. In addition, I will discuss both the prognostic value of Treg cells in tumor progression in tumor-bearing hosts and the rationale for strategies for therapeutic vaccination and immunotherapeutic targeting of Treg cells with drugs and microRNA.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.311-320
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• 2019

Discogenic pain which develops during the degenerative process of intervertebral disc is an intractable disease of musculoskeletal system. Unlike other diseases in modern medical science, it is not clinically confirmed through objective imaging and clinicopathologic index. Moreover, current technology has been facing difficulties finding fundamental treatment. This study examined through reviewing literature whether the therapeutic rationales of interventional procedures for the discogenic pain, such as nerve block, intradiscal electrothermal therapy and nucleoplasty, are valid and whether safety reviews such as preclinical tests are carried out faithfully during the technology development process. As a result, it is presumed that there is not yet an interventional treatment for discogenic pain, whose therapeutic rationale has been objectively verified. And there are some cases of interventional treatment that have not been adequately equipped with the preclinical test steps necessary to review the safety of the procedure during the technology development process. In conclusion, since there is still no interventional treatment for discogenic pain which has clear therapeutic rationale, it is necessary to recognize that a more careful approach is needed to judge whether the procedure is performed in clinical settings. And medical ethical issues may arise for some interventional treatment that are deemed to have been carried out without a thorough review of safety.

• Journal of Music and Human Behavior
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• v.21 no.1
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• pp.89-113
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• 2024

With increasing interest in the emotional responses to music, research on the regulatory mechanisms of music has been ongoing. This study examines the fidelity of music emotion regulation (MER) studies by analyzing the quality of rationales provided for using music to induce emotional regulation. A total of 45 internationally published studies were collected for review, and analysis was conducted on criteria related to the use of music, including duration, number of pieces, selection rationale, and the selecting agent. Despite the research objectives aiming to investigate the emotional regulation effects of music, it was found that the majority of studies lacked specific information about the music used, and there was weak consistency among the studies. Additionally, reliable evidence for music activities, music selection, and music implementation time was not provided, and there was a lack of logical basis for the regulatory mechanisms of music. The results of this study imply the necessity for fidelity to the rationale of music emotion regulation to establish itself as a research area. Such rigorous fidelity will contribute to increasing the replicability and integrity of research on the therapeutic uniqueness of music.

• Proceedings of the KSPS conference
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• 2006.11a
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• pp.31-36
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• 2006

Research in the Center for Pediatric Auditory and Speech Sciences (CPASS) is attempting to characterize or phenotype children with speech delays based on acoustic-phonetic evidence and relate those phenotypes to chromosome loci believed to be related to language and speech. To achieve this goal we have adopted a highly interdisciplinary approach that merges fields as diverse as automatic speech recognition, human genetics, neuroscience, epidemiology, and speech-language pathology. In this presentation I will trace the background of this project, and the rationale for our approach. Analyses based on a large amount of speech recorded from 18 children with speech delays will be presented to illustrate the approach we will be taking to characterize the acoustic phonetic properties of disordered speech in young children. The ultimate goal of our work is to develop non-invasive and objective measures of speech development that can be used to better identify which children with apparent speech delays are most in need of, or would receive the most benefit from the delivery of therapeutic services.

• Journal of Yeungnam Medical Science
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• v.22 no.2
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• pp.131-140
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• 2005

Heart failure is a clinical syndrome comprised of a number of symptoms and signs associated with congestion and/or hypoperfusion. Specific pharmacologic therapies have been developed to slow disease progression from early to more advanced stages. Once symptoms have developed, aggressive multimodality interventions are instituted to alleviate symptoms and improve clinical status and quality of life; especially in those patients that present symptoms. Recently, an evolving adjunctive therapeutic modality, that involves using implanted electrical devices: cardiac resynchronization with or without implantable cardioverter defibrillators (ICD). has been used for management. Cardiac resynchronization therapy (CRT) is a proven treatment for selected patients with heart failure-induced conduction disturbances and ventricular dyssynchrony. When used in combination with stable, optimal medical therapy, CRT is designed to reduce symptoms and improve cardiac function by restoring the mechanical sequence of ventricular activation and contraction. This review summarizes the rationale, procedure, clinical trials, and clinical indications for CRT.

• Molecules and Cells
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• v.44 no.7
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• pp.433-443
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• 2021

Multi-omics approaches are novel frameworks that integrate multiple omics datasets generated from the same patients to better understand the molecular and clinical features of cancers. A wide range of emerging omics and multi-view clustering algorithms now provide unprecedented opportunities to further classify cancers into subtypes, improve the survival prediction and therapeutic outcome of these subtypes, and understand key pathophysiological processes through different molecular layers. In this review, we overview the concept and rationale of multi-omics approaches in cancer research. We also introduce recent advances in the development of multi-omics algorithms and integration methods for multiple-layered datasets from cancer patients. Finally, we summarize the latest findings from large-scale multi-omics studies of various cancers and their implications for patient subtyping and drug development.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.2
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• pp.138-144
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• 2017

The pharmacological rationale of Agastache rugosa (AR) or Pogostemon cablin (PC), which have been used in traditional Korean medicine to treat dampness pattern or syndrome in gastrointestinal tract, was investigated on the gastrointestinal disorders. In-vivo model studies that examined the effect on the gastrointestinal disorders of AR or PC were collected. They were classified into disease-induced in-vivo models or non-disease in vivo models. The target disease, animal species, induction method, administration, and outcomes (changes in morphological and histological parameter, or blood and fluid) of each study were analyzed. The therapeutic mechanism of AR or PC extract was evaluated by the induced diseases and the changes in outcomes. There were contradictory reports on gastrointestinal motility of AR or PC in disease non-disease in-vivo model. AR or PC inhibited gastrointestinal motility in disease model of increased gastrointestinal motility, while promoted motility in disease model of decreased gastrointestinal motility. AR or PC also inhibited inflammatory changes in gastrointestinal inflammation model. These results suggest that the bidirectional regulation of gastrointestinal motility and the improvement of gastrointestinal inflammatory disorders might underpin traditional therapeutic effect of AR or PC, that is effect to resolve dampness of gastrointestinal tract.