• Archives of Plastic Surgery
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• 제33권2호
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• pp.181-186
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• 2006

Myocutaneous flaps have improved the management of soft tissue defects on buttocks and lower extremity. However, there are several inherent disadvantages of muscle flaps such as functional deficits of the donor sites and the bulkiness at the recipient site. To overcome these disadvantages, we have used perforator-based fasciocutaneous rotation flaps for reconstruction of the buttock and lower extremity defects. From March 2003 to February 2005, we have treated 14 patients using perforator-based fasciocutaneous rotation flaps. 10 flaps were based on perforators of the gluteus maximus muscle, and 4 flaps were nourished by perforators from the tibialis anterior and posterior system. The mean postoperative follow-up period was about 1 year. The technique involves localization of the flap perforators preoperatively with a Doppler. The flaps were elevated superficial to the fascia with preservation of one to three perforators. The donor site is then closed primarily. All flaps completely survived and there was no perioperative complications. There was no functional disability of the donor area with esthetically pleasing results. Perforator-based fasciocutaneous rotation flaps for the reconstruction of buttock and lower extremity defects are excellent alternatives to musculocutaeous flaps. The vascularity of the flaps is robust and dissection is technically easy. Perforator flaps do not require sacrificing muscles, but provide sufficient volume and are durable Furthermore, these flaps result in less scar formation and allow more liberal dissection with safety. We conclude that perforator-based fasciocutaneous rotation flaps are very useful for reconstruction of the buttock and lower extremity.

• 한국발생생물학회지:발생과생식
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• 제22권3호
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• pp.263-273
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• 2018

Aquaporin (AQP) 3, a facilitated transporter of water and glycerol, expresses in placenta and fetal membranes, but the detailed localization and function of AQP3 in placenta remain unclear. To elucidate a role of AQP3 in placenta, we defined the expression and cellular localization of AQP3 in placenta and fetal membranes, and investigated the structural and functional differences between wild-type and AQP3 null mice. Gestational sacs were removed during mid-gestational period and amniotic fluid was aspirated for measurements of volume and composition. Fetuses with attached placenta and fetal membranes were weighed and processed for histological assessment. AQP3 strongly expressed in basolateral membrane of visceral yolk sac cells of fetal membrane, the syncytiotrophoblasts of the labyrinthine placenta and fetal nucleated red blood cell membrane. Mice lacking AQP3 did not exhibit a significant defect in differentiation of trophoblast stem cells and normal placentation. However, AQP3 null fetuses were smaller than their control litter mates in spite of a decrease in litter size. The total amniotic fluid volume per gestational sac was reduced, but the amniotic fluid-to-fetal weight ratio was increased in AQP3 null mice compared with wild-type mice. Glycerol, free fatty acid and triglyceride levels in amniotic fluid of AQP3 null mice were significantly reduced, whereas lactate level increased when compared to those of wild-type mice. These results suggest a role for AQP3 in supplying nutrients from yolk sac and maternal blood to developing fetus by facilitating transport of glycerol in addition to water, and its implication for the fetal growth in utero.

• Journal of Korean Neurosurgical Society
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• 제30권9호
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• pp.1072-1078
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• 2001

Objectives : There is continuing controversy about the benefits of decompressive craniectomy in massive cerebral edema following space occupying hemispheric cerebral infarction. The aims of this study are to determine the effectiveness and to confirm the life-saving nature of decompressive craniectomy with dural augmentation for massive cerebral infarction. Patients and Methods : We present twelve patients with medically uncontrollable hemispheric cerebral infarction. All were treated with extensive craniectomy and duroplasty without resection of necrotic tissue. We evaluated various characteristics(size of hemispheric infarction, Glasgow Coma Scale, volume of low density and midline shift in CT) at three different periods(preoperative, immediate postoperative and 3-4weeks after operation) and evaluated effectiveness of hemicraniectomy for massive cerebral edema after large hemispheric infarction. Results : All patients have survived from surgery. Nine patients with nondominant hemispheric infarction showed significant functional recovery with minimal assistance, and remaining two patients with dominant hemispheric infarction and one patient with nondominant hemispheric infarction have functionally dependent. The volume of low density and midline shift in CT were significantly reduced after decompressive craniectomy. Conclusions : Our results indicate that decompressive craniectomy with dural augmentation without resection of necrotic tissue for massive cerebral hemispheric infarction not only reduce the mortality and infarction size but also significantly improve the outcome, especially for nondominant hemispheric infarction.

• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.346-351
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• 2016

Objective : Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI. Methods : We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institutes of Health Stroke Scale increment ${\geq}2$ points during 24 hours despite receiving standard treatment. Regional parameter ratios, such as cerebral blood flow and volume (rCBV) ratio (ipsilateral value/contralateral value) on perfusion MRI were analyzed to investigate the association with EPI. Results : Sixty-four patients were enrolled in total. EPI was present in 18 (28%) subjects and all EPI occurred within 3 days after hospitalization. Diabetes mellitus, rCBV ratio and regional time to peak (rTTP) ratio showed statically significant differences in both groups. Multi-variate analysis indicated that history of diabetes mellitus [odds ratio (OR), 6.13; 95% confidence interval (CI), 1.55-24.24] and a low rCBV ratio (rCBV, <0.85; OR, 6.57; 95% CI, 1.4-30.27) was significantly correlated with EPI. Conclusion : The incidence of EPI is considerable in patients with acute MCA territory infarction caused by MCA occlusion. We suggest that rCBV ratio is a useful neuro-imaging parameter to predict EPI.

• Archives of Plastic Surgery
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• 제42권3호
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• pp.334-340
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• 2015

Background Full-thickness skin grafts (FTSGs) are generally considered unreliable for coverage of full-thickness finger defects with bone or tendon exposure, and there are few clinical reports of its use in this context. However, animal studies have shown that an FTSG can survive over an avascular area ranging up to 12 mm in diameter. In our experience, the width of the exposed bones or tendons in full-thickness finger defects is <7 mm. Therefore, we covered the bone- or tendon-exposed defects of 16 fingers of 10 patients with FTSGs. Methods The surgical objectives were healthy granulation tissue formation in the wound bed, marginal de-epithelization of the normal skin surrounding the defect, preservation of the subdermal plexus of the central graft, and partial excision of the dermis along the graft margin. The donor site was the mastoid for small defects and the groin for large defects. Results Most of the grafts (15 of 16 fingers) survived without significant surgical complications and achieved satisfactory functional and aesthetic results. Minor complications included partial graft loss in one patient, a minimal extension deformity in two patients, a depression deformity in one patient, and mild hyperpigmentation in four patients. Conclusions We observed excellent graft survival with this method with no additional surgical injury of the normal finger, satisfactory functional and aesthetic outcomes, and no need for secondary debulking procedures. Potential disadvantages include an insufficient volume of soft tissue and graft hyperpigmentation. Therefore, FTSGs may be an option for treatment of full-thickness finger defects with bone or tendon exposure.

• 한국의류산업학회지
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• 제21권2호
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• pp.133-140
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• 2019

This study developed smart fashion prototypes that provide utilitarian functionality by combining Fashion and Electronics regarding the IT focused convergence tendency in modern industries. A convergence R&D workshop was performed by Fashion design majors and Engineering majors for the study. As a result, 5 functional smart fashion prototypes were developed and the outline of each prototype are as follows. The $1^{st}$ prototype, 'Hidden Camera Detecting Coat' focused on gender-related crimes. The coat uses infrared lighting and LED technologies to provide a function to detect hidden cameras in suspicious public spaces such as toilets. The $2^{nd}$ prototype, 'Heating-massage Suit' targeted patients with musculoskeletal system difficulties. The suit uses heating and vibration technologies to provide a heating massage treatment for patients with ongoing difficulties in their daily lives. The $3^{rd}$ prototype is an air-bag jacket to prevent sexual molestation on public transportation. The jacket extends its volume through pressure sensing, air compressing, motors and 3D-printing technology to secure the wearer's personal preventive space between the user's body and others. The $4^{th}$ prototype is a town wear for people suffering from synesthesia. People with synesthesia inadvertently see colors when exposed to certain sounds. This town wear uses sound sensing, air compressing, motors and 3D-printing technology to provide sound prevention and a comfortable sound playing function. The $5^{th}$ prototype is a set of a vest and a gloves for visually impaired people. The vest and gloves uses DMS, voice playing, vibration technology to provide distance measuring and warning functions.

• 한국식품저장유통학회지
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• 제17권5호
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• pp.667-673
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• 2010

특수미 품종인 고아미2호는 취반용 쌀로는 적합하지 않으므로 가공용 기능성 곡류소재로서의 활용성을 알아보고자 제빵 시 강력분의 일부를 쌀가루로 대체하였으며 일반 쌀 품종인 추청벼 쌀가루와의 제빵특성을 비교하였다. 쌀가루의 호화특성은 고아미2호는 전분 호화 시 호화개시온도가 높고 전분 팽윤 현상이 억제되어 호화 점도가 매우 낮았다. 강력분에 쌀가루를 10~30% 대체한 혼합분의 mixograph특성은 고아미2호 복합분은 쌀가루 함량이 증가 할수록 가수량이 증가하였으나 추청벼 복합분은 쌀가루함량 증가 시 반죽 안정도가 현저하게 감소되었다. 복합분을 활용한 식빵에서 고아미2호 쌀빵은 쌀가루 증가와 함께 부피 감소와 함께 빵 내부의 경도가 현저하게 증가하였다. 그러나 추청벼 쌀빵은 최대 30%까지 대체 시 빵의 부피 및 경도에서 유의한 차이가 관찰되지 않았으므로 강력분의 일부를 대체한 쌀빵 가공을 위해서는 난소화성 다당류 함량이 높은 고아미2호보다는 일반 쌀 품종인 추청벼가 적합하였다.

• 대한기계학회논문집B
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• 제36권10호
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• pp.1033-1041
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• 2012

본 논문에서는 석탄의 물리적 화학적 구조에 의한 직접탄소 연료전지 내부의 전기화학 반응 특성의 변화에 대하여 연구하였다. 석탄의 구조, 표면적 및 기공체적, 작용기의 분포 등을 분석하기 위하여 다양한 분석 기법(TGA, XRD, BET, XPS)을 사용하였다. 석탄 내부에 존재하는 탄소의 강력한 결정구조는 연료의 비표면적 및 기공크기를 축소시켜 고 전류밀도 영역에서 급격한 포텐셜의 감소를 초래한다. 표면에 분포하는 작용기는 저전류 밀도 영역에서의 전기화학 반응에 영향을 미치며, 제한 전류밀도 및 최대 전력밀도는 전체 탄소의 양과 밀접한 상관관계를 가지고 있다는 것을 확인할 수 있었다. 전해질의 물질전달 향상 및 작동온도에 의한 영향도 논하였다.

• 한국미생물·생명공학회지
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• 제30권3호
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• pp.253-257
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• 2002

쌀대신에 보리를 이용한 Monascus 고상배양의 기본적인 발효 특성을 연구함을 통하여, 대규모 고상배양 시스템을 통한 천연 적색색소의 생산 가능성을 검토하고자 하였다. 색소의 생산은 고상배양 3일후부터 6일까지 꾸준한 증가추세를 나타내었다. 종균의 접종량이 6∼8%사이일 경우에는 배양후 60시간만에 색소생산이 시작되었으며, 접종량이 5%이하일 경우에는 색소생산이 70시간 이후로 늦어지는 것으로 나타났다. 보리 배지를 30∼40분 동안 증자할 경우에는 색소 발현 시점이 45시간 내외로 단축되었으며, 증자시간이 20분 이하일 경우에는 배지의 불충분한 호화로 인하여 색소생산 시점이 길어졌다. 공기공급량이 0.6∼0.8 vvm사이에서 홍국균의 생장 및 색소의 생산이 활발히 일어났고, 고상배지의 초기 pH를 6으로 조절했을 때 균사성장과 색소발현 능력이 가장 우수하였다 한편 고상배양으로 7일동안 발효한 홍국보리를 사용하여 식중독미생물에 대한 항균여부를 확인한 결과, Escherichia coli, Salmonella 수Phimurium의 생장을 저해함을 확인하였다. 이상과 같이, 보리를 원료로 한 대규모 고상발효 시스템을 활용함으로써 Monascus sp. 유래의 천연색소 및 대사산물의 대량생산 가능성을 확인하였다.

• 센서학회지
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• 제11권3호
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• pp.125-131
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• 2002

호흡기류는 모든 호흡기능검사시 계측해야 하는 필수적인 생체신호이다. 기존에 사용되는 호흡기류 계측기들은 검사의 신뢰도와 위생상의 문제가 상존해 있는 바, 새로운 계측기술을 창안하였다 베르누이의 물리적 에너지 보존원리에 입각하여 양방향 호흡기류를 평균동압력으로 변환함으로써 호흡기류를 계측하는 기법을 도입하였다. 플라스틱 재질의 계측소자를 종이 재질의 호흡관에 체결한 기능성 일회용 호흡관을 설계 제작하였다. 미국 흉부학회의 표준 실험방법에 따라 계측의 정밀도를 평가한 결과 용적계측의 95% 신뢰구간이 약 ${\pm}1.5%$이었다. 미국 흉부학회의 오차기준이 ${\pm}3%$이고 상용센서들의 오차 측정치가 최대 ${\pm}8%$까지 도달함을 닥 때 월등히 정확한 계측이 가능하였다. 일회용으로 설계 제작한 결과 사공간과 위생상의 문제도 없으므로 기존의 호흡기류 계측기술들이 내포하는 문제점들을 모두 제거하였다. 따라서 본 연구의 기능성 일회용 호흡관은 폐활량계와 같은 임상검사를 위한 호흡기류 계측장치에 유용하게 적용될 수 있다.