• 한국식품조리과학회지
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• 제31권5호
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• pp.581-587
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• 2015

This study was conducted to investigate the antioxidative and antimicrobial activities of Korean dandelion (Taraxacum coreanum). Water extracts, ethanol extracts and methanol extracts were used to examine the free radical scavenging activity, total flavonoid content, total polyphenol content and antimicrobial activity. The free radical scavenging activity, total flavonoid, total polyphenol and total antioxidant activity of the water extracts were higher than those of the other extraction solvents. The antimicrobial activties of Korean dandelion extracts were examined on several food borne illness microorganisms using the paper disc diffusion method. Inhibition zones were observed on Staphylococcus aureus subsp. aureus, Listeria monocytogenes, Bacillus subtilis, Bacillus cereus and Escherichia coli in ethanol extracts. Inhibition zones were also observed on Listeria monocytogenes in water extracts. The physico-chemical properties of Korean dandelion tea according to the roasting time and soaking amount of tea were studied. The pH of the dandelion tea significantly decreased while the soluble solid contents significantly increased with increased roasting time (p<0.01). The lightness of the dandelion tea decreased and the turbidity increased with increased roasting time. In sensory evaluation, the sensory scores for the color, flavor and total acceptability were highest in the 40 min roasted tea. These results suggest that the water extract of Korean dandelion could be used as an antioxidative and antimicrobial functional food source. The optimum roasting time for Korean dandelion tea was 40 min at $200^{\circ}C$.

• 종양간호연구
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• 제3권2호
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• pp.112-121
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• 2003

The purpose of these study was to analyze the contents and trend of researches done on oncology nursing in the past five years in Korea and to suggest its direction for the future research. Methods: 214 nursing studies published from 1998 to 2003 were selected for the analysis. They were examined for the source, design of study, type of subjects, the intervention outcomes of experimental research, the key words and theme of the oncology research. Results: 1. 139(64.9%) of 214 studies were masters thesis and doctoral dissertations. There were 196(91.6%) quantitative researches and 18 qualitative researches. Quantitative research consisted of 28(14.3%) experimental and 168(85.7%) non- experimental studies. Among non-experimental studies, there were 53 correlations, 78 descriptives, 14 comparatives and 23 methodological studies. 2.The main subjects of the study were cancer patients in general(43.7%) and breast cancer patients (18.3%). According to the treatment types, patients receiving chemotherapy were the highest number distribution as 23 of all researches. 3. Social support, fatigue, stress, hope, and quality of life were the most frequently used concepts in correlational studies.4. Education, providing information, oral care, exercise, relaxation and foot massage were the most frequent nursing interventions. Most frequently measured outcomes variable were self-care, pain control, nausea & vomiting, oral discomfort and anxiety. 5. Key words used most frequently were quality of life, educational need, pain controls and fatigue. 6. The themes of qualitative researches were illness experience, family experience and adaptation process. More than 50% of qualitative researches used phenomenologic method. Conclusion: Researches on cancer nursing in Korea have been increased. Descriptive design is being dominant and few experimental studies are being done For the future, it is necessary to conduct international studies to compare, replicate and to establish the effective nursing interventions.

• 보건행정학회지
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• 제10권3호
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• pp.169-187
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• 2000

Cigarette smoking has been identified as the most important source of preventable morbidity and premature mortality (WHO, 1995), The prevalence of smoking among men is very high in Korea. This study estimated productivity losses due to smoking in Korea, 1997. The derivation of cost estimates for mortality, disability, hospitalization and use of physician services related to cigarette smoking is bas 어 on the calculation of attributable fractions suggested by MacMahon and Cole and Smoking-Attributable Mortality, Morbidity, and Economic Cost(SAMMEC) software. To estimate the number of deaths from neoplastic, cardiovascular, respiratory diseases associated with cigarette smoking, estimates for adults(aged 20 years and over) were based on 1997 mortality data, 1995 data on smoking prevalence from Korea Institute for Health and Social Affairs. Smoking-attributable indirect morbidity cost data were obtained from the National Federation of Medical Insurance. As the result of cost estimation, these productivity losses were 336-430 billion won. During 1997, 8,620-10,804 deaths were attributed to smoking. Cigarette smoking resulted in 133,991-169,422 Years of Potential Life Lost (YPLL) to life expectancy. For smoking -attributable indirect mortality costs, the present value of future earnings(PVFE) for the age at death are 299-384 billion won. Smoking-attributable indirect morbidity costs, the costs of lost productivity for persons who are disabled by smoking-related chronic diseases are 37-46 billion won. In this study the productivity losses due to smoking were restricted to the health effects of smoking. It is possible that these costs were underestimated with the limitation of the data. Smoking is the leading preventable cause of illness and death. The results of this study can be used as elementary data for antismoking policy.

• 대한미생물학회지
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• 제22권2호
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• pp.155-162
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• 1987

To determine the prevalence of antibiotic resistance in fecal E. coli and to investigate possible associations between antibiotic resistance and other plasmid-mediated virulence properties, antibiotic disk susceptibility tests for nine antibiotics were done on 141 strains of E. coli isolated from diarrheal children and well controls. Eighty two percent of the test strains were resistant to one or more antibiotics. Antibiotics to which the test strains were most resistant in descending order were ampicillin (85%), trimethoprim/sulfamethoxazol (60%), and cephalothin (55%). Seventy nine percent of these resistant strains were resistant to two or more antibiotics. All 141 test strains were sorted into enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), enteroadherent E. coli (EAEC) and non-pathogenic E. coli and the percentages of strains resistant to multiple antibiotics were compared. Among ETEC regardless of its source, multiple drug resistance was more frequent in strains producing heatstable enterotoxin (ST) only than in strains producing only heat-labile enterotoxin (LT) or both. In EAEC, multiple resistance was more frequently associated with strains isolated from diarrheal patients than with those from well controls. The major antibiotic resistance patterns possessed by multiple resistant enteropathogenic strains were $SXT^R$ $AM^R$, $CR^R$, and $SXT^R$ $AM^R$ $CR^R$. Of 28 ST- producing $SXT^R$ ETEC, 26(96%) were also resistant to ampicillin and 17 (61%) were resistant to cephalothin. The similar pattern was observed in EAEC and EPEC as well. This study has important implications for the treatment of E. coli diarrhea with antibiotics because it is possible that dissemination of virulence could occur under the force of selective antibiotic pressure. In addition, this study suggests that the in vivo efficacy of SXT in treating diarrheal illness be reevaluated.

• Tuberculosis and Respiratory Diseases
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• 제84권3호
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• pp.226-236
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• 2021

Background: Although the Quidel Sofia rapid influenza fluorescent immunoassay (FIA) is widely used to identify influenza A and B, the diagnostic accuracy of this test remains unclear. Thus, the objective of this study was to determine the diagnostic performance of this test compared to reverse transcriptase-polymerase chain reaction. Methods: A systematic literature search was performed using MEDLINE, EMBASE, and the Cochrane Central Register. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and a hierarchical summary receiver-operating characteristic curve (HSROC) of this test for identifying influenza A and B were determined using meta-analysis. A sensitivity subgroup analysis was performed to identify potential sources of heterogeneity within selected studies. Results: We identified 17 studies involving 8,334 patients. Pooled sensitivity, specificity, and DOR of the Quidel Sofia rapid influenza FIA for identifying influenza A were 0.78 (95% confidence interval [CI], 0.71-0.83), 0.99 (95% CI, 0.98-0.99), and 251.26 (95% CI, 139.39-452.89), respectively. Pooled sensitivity, specificity, and DOR of this test for identifying influenza B were 0.72 (95% CI, 0.60-0.82), 0.98 (95% CI, 0.96-0.99), and 140.20 (95% CI, 55.92-351.54), respectively. The area under the HSROC for this test for identifying influenza A was similar to that for identifying influenza B. Age was considered a probable source of heterogeneity. Conclusion: Pooled sensitivities of the Quidel Sofia rapid influenza FIA for identifying influenza A and B did not quite meet the target level (≥80%). Thus, caution is needed when interpreting data of this study due to substantial betweenstudy heterogeneity.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.330-335
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• 2001

The occurrences of occupational illness and injury have been seriously underestimated in Korea. Surveillance systems for occupational diseases have recently emerged as important strategies for the control of occupational hazards and the implementation of intervention programs to protect workers. However, health service providers do not actively diagnose occupational diseases and are unwilling to report occupational diseases. With the rapid growth of Internet usage in Korea, the computer network has become the predominant means of communicating and sharing information. Therefore, we developed a web-based updated information and education network to assist the health services providers in reporting occupational diseases. Information systems for occupational disease surveillance were also designed to support occupational disease reporting. Commonly available database systems, such as web databases, are useful to manage occupational diseases data efficiently. Standardized case definitions and report guidelines were also established, which included cumulative trauma disorder, occupational asthma, occupational contact dermatitis, and occupational cancer. This system may provide the basis of an efficient and continuously updated source of educational information and provide specific information concerning the occurrence of occupational diseases in specific areas. Background information on occupational diseases obtained in this way will be invaluable for preventing hazards and enforcing occupational disease prevention programs. Moreover, our experiences in establishing these information systems will be of great use in other countries and settings.

• 셀메드
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• 제4권1호
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• pp.2.1-2.17
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• 2014

The plant kingdom is considered to be a repository of modern medicine, attributable to their rich source of bio-active molecules and secondary metabolites. It is indeed the Nutraceuticals that enhance immunity and ensure a healthier life because of their prophylactic and therapeutic values. Over centuries, papaya [Caricaceae; (Carica papaya Linn.)] is a renowned nutritious and medicinal plant. Each part of the papaya like root, stem, leaf, flower, fruit, seed, rinds, and latex has its own nutraceutical properties. It serves as food, cooking aid, and Ethnomedicine to prevent and treat wide-range of diseases and disorders. It has also been traditionally used as appetite enhancer, meat tenderizer, purgative, medicinal acne, abortifacient and vermifuge. Over decades, a series of scientific attempts were made to authenticate the nutraceutical properties of papaya. These studies validated that the papaya has antiplasmodial, antitrichochramal, antitrichomonal, antidengue, and anti-cancer activities. They have also exhibited that papaya possesses antiseptic, antiparasitic, anti-inflammatory, antidiabetic, and contraceptive features, and it helps in the management of sickle-cell anaemia, HIV, heart diseases and digestional disorders too. Nevertheless, the responsible bio-active molecules and their mode of actions remain indistinct and imprecise, and this calls for further pharmacological and clinical research on them. Conclusively, papaya is one of the naturally gifted plants; though its nutraceutical properties as a food or as a quasi-drug are poorly understood or undervalued by people. Accordingly, this scrutiny, demand for instigation of public health awareness campaigns to promote papaya consumption, so that the society shall acquire optimal benefits of papaya and in turn prevent and alleviate various diseases and illness.

• 한국축산식품학회지
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• 제39권1호
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• pp.84-92
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• 2019

Listeria monocytogenes is a major cause of serious foodborne illness in the dairy foods. Although Caenorhabditis elegans model is well established as a virulence model of pathogenic bacteria, its application on L. monocytogenes is critically unclear. The objective of this study was to carry out an evaluation of L. monocytogenes toxicity using C. elegans nematode as a simple host model. We found that C. elegans nematodes have high susceptibility to L. monocytogenes infection, as a consequence of accumulation of bacteria in the worms' intestine. However, L. innocua, which is known to be non-toxic, is not accumulate in the intestine of worms and is not toxic similarly to Escherichia coli OP50 known as the normal feed source of C. elegans. Importantly, immune-associated genes of C. elegans were intensely upregulated more than 3.0-fold when they exposed to L. monocytogenes. In conclusion, we established that C. elegans is an effective model for studying the toxicity of L. monocytogenes and we anticipate that this system will result in the discovery of many potential anti-listeria agents for dairy foods.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권2호
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• pp.163-173
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• 2020

Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.

• 한국산학기술학회논문지
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• 제11권12호
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• pp.4907-4921
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• 2010

본 연구의 목적은 대학생들의 DNR(Do Not Resuscitate)과 관련된 인식 및 태도를 파악하여 임상에서 사용할 수 있는 DNR에 대한 객관적인 기준을 마련하는데 도움이 되는 기초자료를 제공하고자 시도된 서술적 조사연구이다. 연구대상은 대구광역시 일개 전문대학생 1267명을 대상으로 하였다. 자료수집기간은 2010년 7월1일부터 7월31일까지였으며, 자료수집방법은 구조화된 질문지를 사용하였다. 자료 분석은 SPSS 17.0 Program을 이용하여 실수와 백분율을 구하였고, $x^2$-test로 분석하였다. DNR에 대한 간호대학생과 비 보건계열대학생 인식 및 태도를 비교한 결과, 인식에 있어서 DNR에 대한 필요성, DNR 찬성 이유, DNR 반대 이유, DNR 결정 주체자의 인식에서 유의한 차이가 있었고, 태도에서는 가족 DNR시행, 자기자신 DNR시행에서 유의한 차이가 있었다. DNR정보제공에 대한 간호 대학생과 비 보건계열대학생의 인식을 비교한 결과 DNR에 대한 정보제공 필요성, DNR 정보제공 시기, DNR 정보 제공 결과, DNR 정보제공 지침서에서 유의한 차이가 있었다. 대상자의 일반적 특성에 따른 DNR 필요성 인식차이에서 종교, 헌혈경험에서 유의한 차이가 있었고, DNR 결정 주체자에 대한 인식차이에서 종교, 형제 자매수에서 유의한 차이가 있었다. 대상자의 일반적 특성에 따른 가족 DNR시행에 대한 태도에서 성별, 연령, 경제상태, 종교, 형제 자매수, 가족중 질환 및 사망자, 헌혈경험에서 유의한 차이가 있었고 자기자신 DNR시행에 대한 태도 차이에서 성별, 경제상태, 종교, 형제 자매수, 가족중 질환 및 사망자에서 유의한 차이가 있었다. 본 연구결과를 바탕으로 DNR에 관한 기준을 마련하기 위하여 더 많은 후속 연구가 필요하다고 사료된다.