• 제목/요약/키워드: the poor breast

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수치해석을 이용한 하천제방 배수통문의 안정성 평가 연구 (Numerical Studies for the Safety Estimation of Box-Culvert in Levee)

  • 김진만;최봉혁;오세용;김경민
    • 한국수자원학회논문집
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    • 제39권6호
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    • pp.479-486
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    • 2006
  • 본 연구에서는 하천제방 배수통문의 안정성 평가를 위하여 배수통문 설치에 따른 영향, 차수공 길이에 의한 영향, 배수통문 하부지반 투수성 저하에 따른 영향 등을 평가하고자 2차원 침투해석을 수행하였다. 해석결과 배수통문 설치에 따라 하천제방의 침투 및 사면안정성이 저하되며, 흥벽 및 선단 하부에 설치되는 차수공은 배수통문 주변의 다짐 불량 및 공동에 의해 발생되는 파이핑을 방지할 수 있으므로, 해수통문 설계 시 반드시 설치가 요구되며, 중앙부 차수공의 경우 제체 전체의 침투해석을 통하여 파이핑에 대한 안정성이 떨어지는 경우 차수벽의 개념으로 설치가 유도되어야 할 것으로 평가되었다. 한편, 하천제방 매수통문과 같은 하천구조물이 설치된 제방의 안정성 평가는 2차원 침투해석의 경우 주변 지반으로의 침투에 의한 포화영역의 소산을 고려하지 못하므로 합리적인 침투해석을 위해서는 주변 지반으로의 침투를 평가할 수 있는 3차원 침투해석에 의해 평가되어야 할 것으로 판단된다.

MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1

  • Li, Gen;Li, Li;Sun, Qi;Wu, Jiezhou;Ge, Wei;Lu, Guanghua;Cai, Ming
    • Molecules and Cells
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    • 제41권6호
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    • pp.523-531
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    • 2018
  • Tumour metastasis is one of the most serious challenges of cancer as it is the major cause of mortality in patients with solid tumours, including osteosarcoma (OS). In this regard, anti-metastatic genes have potential for metastasis inhibition strategies. Recent evidence showed the importance of breast cancer metastasis suppressor 1 (BRMS1) in control of OS invasiveness, but the regulation of BRMS1 in OS remains largely unknown. Here, we used bioinformatics analyses to predict BRMS1-targeting microRNAs (miRNAs), and the functional binding of miRNAs to BRMS1 mRNA was evaluated using a dual luciferase reporter assay. Among all BRMS1-targeting miRNAs, only miR-151b, miR-7-5p and miR-3200-5p showed significant expression in OS specimens. Specifically, we found that only miR-3200-5p significantly inhibited protein translation of BRMS1 via pairing to the 3'-UTR of the BRMS1 mRNA. Moreover, we detected significantly lower BRMS1 and significantly higher miR-3200-5p in the OS specimens compared to the paired adjacent non-tumour bone tissues. Furthermore, BRMS1 and miR-3200-5p levels were inversely correlated to each other. Low BRMS1 was correlated with metastasis and poor patient survival. In vitro, overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Thus, our study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.

간호학생 실습이 지역주민의 보건지식 및 태도에 미치는 영향 -연세대학교 간호대학 보건간호학 실습을 중심으로- (A Survey of the Effect of Nursing Students on Community Health Knowledge)

  • 조원정;김의숙;이정숙
    • 대한간호학회지
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    • 제3권2호
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    • pp.111-119
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    • 1973
  • The purpose of this study was to determine whether or not the delivery of health services effects the health knowledge of the recipients of that service. 10 was hypothesized that the practical application of theory, though health services rendered by public health nursing students during their field experiences. would have a positive relationship with the quantity and quality of health knowledge of the female population of a given community. In April 1970, ninety five women(between an age 15-49) from Koyang-Gun were interviewed regarding their knowledge and attitudes in four areas of health: maternal health, child health. family planning and tuberculosis prevention. After 11 years(Nov. l971), during which time the women received home visits by student nurses, the women were again interviewed using the original questionnaire. Additionally, they were asked where they had received information about each question. During the 1$\frac{1}{2}$ year period the visits were made by a total of 112 students. They visited the community twice a week. The result were as follows: Maternal health There was marked improvement in the knowledge of specific aspects of maternal health such as the proper instruments needed for cutting the cord and nutritional precaution of pregnancy (p<0.05). In each case 42.0 percent of more of this knowledge was attributed to information gained from the nursing students. However even after the nursing students'visits, the knowledge of other general areas of maternal remained poor. Child health There were increases in the knowledge of the respondents for the time to supplement breast feeding and for time to wean infants (p<0.05). In each case 35.0 percent or more of this information was attributed to the student. The increase in knowledge regarding types of immunization was more often attributed to the clinic nurse than to the nursing students. Knowledge of the necessity of booster immunization was poor both before and after the visits by the nursing students. Family planing There were significant increases in correct information regarding the time of I.U.D. insertion (P<0.05) and method of taking the oral pill (P<0.05). More than 42.0 percent of the increase was attributed to the nursing students'visits. However there was a slight decrease in correct information about concept of family planning. Tuberculosis There was a general lack of improvement in all areas concerned with tuberculosis. Two thirds of the respondents felt tuberculosis was hereditary and did not know what B.C.G. was. From this study, it could be concluded that in specific area the health knowledge of the female population studied was positively effected by the visits of the nursing students. The study also, suggests, however, that there was a marked unevenness in the overall increase in health knowledge. This raises serious questions which require further research. Suggested areas for further research are (1) Adequacy of the course content preparing nurses for the field experience. (2) A public health nursing manual for student reference. (3) Where and when specific aspects of health can be taught most effectively.

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마을 내 잔존 노거수의 생육현황 및 실태진단 - 경주시 현곡면을 중심으로 - (Diagnosis of the growth status and actual condition of the remaining old trees in the village - Focused on Hyeongok-myeon in Gyeongju-si -)

  • 김영훈;덩베이지아;천겅;유주한
    • 한국환경복원기술학회지
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    • 제23권6호
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    • pp.109-123
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    • 2020
  • The purpose of this study is to provide basic data for the establishment of future countermeasures by diagnosing the growth status and actual condition of undesignated old trees distributed in Hyeongok-myeon, Gyeongju, Gyeongsangbuk-do. The number of old trees surveyed was 2 weeks in Gajeong-ri, 2 weeks in Haguri, 3 weeks in Nae-Tae-ri, 1 week in Nawon-ri, 6 weeks in Oryu-ri, 3 weeks in Sangguri, and 2 weeks in Sohyeon-ri, The trees species composition was 6 trees Celtis sinensis Pers., 1 Diospyros lotus L. trees, 4 trees Salix chaenomeloides Kimura trees, 2 Styphnolobium japonicum L. trees, and 7 Zelkova serrata (Thunb.) Makino trees. Growth status is 7.1~22.0m in height, 14.6~25.1m in long axis, 10.2~19.2m in short axis, root diameter is 76.0~236.4cm, diamter at breast height is 67.0~220.0cm, soil acidity is pH4.9~7.0, soil The hardness was measured to be 4.0-27.0mm. The result grade of the scoring data of health information is represented by monitoring generally, monitoring critically, and absolute monitoring, and it was confirmed that out of the 20 trees population in Hyeongok-myeon, the general monitoring grade was 7 weeks, the major monitoring grade was 13 weeks, and there was no absolute monitoring grade. Accordingly, the number of old trees of the general surveillance level was maintained at the current level, and ecological surgical operations were introduced for the major surveillance level, but the case of village forests should be different, and sequential treatments were the old tree urgently needed. The level and bark of the target tree, the state of the crown, the root exposure, the presence of pests and pests, the vitality and the ground condition, the degree of pollution are normal, poor, or very poor, operation and protection management, soil improvement, removal of cover, and disinfection were urgently needed for the old trees with the surveyed data. In order to compensate for these matters, continuous monitoring and management measures for the old number should be sought.

위암 환자에서 p53과 HSP27의 임상병리학적 의의 (Clinicopathological Significance of p53 and HSP27 in Gastric-cancer Patients)

  • 이하균;권성준;백승삼
    • Journal of Gastric Cancer
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    • 제4권3호
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    • pp.169-175
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    • 2004
  • Purpose: The tumor suppressor gene p53 has been shown to be a factor in the carcinogenesis or progression of gastric cancer. The mutant p53 has been reported to cause a higher risk of lymph-node metastasis. Futhermore, mutation of the p53 has been linked to a poor prognosis for gastric cancer. The heat shock protein-27 (HSP27), a stress protein, has also been reported to be a poor prognostic factor in ovarian and breast cancers. However, in gastric-cancer patients, controversies exist as to its influence on the prognosis. In the present study, we used an immunohistochemical stain to observe the effects of p53 and HSP27 on the clinicopathological factors and on the prognosis for gastric-cancer patients. Materials and Methods: To evaluate the significance of p53 and HSP27 in gastric cancer patients, we analyzed 212 cases of gastric cancer (stage I.IV). Tissue samples of 212 patients were stained immunohistochemically for the mutant p53 protein and for HSP27. The correlations between protein expression and the clinicopathological factors were investigated. Results: The overall expression rates for p53 and HSP27 were $36.9\%\;and\;27.8\%$, respectively. p53 and HSP27 were correlated to each other because the HSP27 expression rate was higher in the p53-positive group (P=0.046). Statistically, the p53 and the HSP27 expression rates were significantly increased in the case of tumor invasiveness, lymphatic metastasis and vessel involvement. Therefore, they play a role in cancer progression. The 5-year survival rates of the p53-positive and the p53-negative groups were $62.8\%\;and\;60.1\%$, respectively (P=0.793) while the 5-year survival rates for the HSP27-positive and HSP27-negative groups were $54.2\%\;and\;63.1\%$, respectively (P=0.090). Conclusion: p53 and HSP27 were correlated to each other in our immunohistochemical study of gastric carcinomas and they were not independent prognostic factors in gastric- cancer patients. However, further studies are needed to determine their prognostic values for gastric-cancer patients.

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강원도 영서지역 소나무 마을숲의 생장환경과 관리방안 (Growth Environments and Management Strategies for Pinus densiflora Village Groves in Western Gangwon Province)

  • 조현길;서옥하;최인화;안태원
    • 한국환경생태학회지
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    • 제25권6호
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    • pp.893-902
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    • 2011
  • 본 연구의 목적은 마을 주변의 전통 소나무숲을 선정하여 숲의 구조와 생장실태를 조사하고, 양호한 생장과 보전을 위한 관리방안을 수립하는 것이었다. 연구대상 소나무숲은 강원도 영서지역에 분포하는 12개소를 선정하였다. 숲의 조성시기는 개소별로 최소 50~최대 200년 전이었고, 소나무의 평균 흉고직경과 밀도는 각각 27~52cm, 0.5~9.3주/$100m^2$이었다. 생장기반인 토양환경은 소나무 생장에 대개 양호한 편이었으나, 토성이 사토로서 보비력이 낮은 2개소의 경우 토양양분이 현저하게 낮았다. 일부 숲은 복토, 답압 등으로 인해 근계생장 장해에 따른 수세저하가 나타났다. 수간의 수피탈저 및 공동피해가 6개소에서 발생하였고, 그 원인은 인위적 외상, 전정 부주의, 동해 등이었다. 병해는 그을음잎마름병, 갈색무늬병 등이 6개소에서 발생하였고 피해정도는 경미하였다. 충해의 경우는 솔잎혹파리에 의한 피해로서 피해정도는 6개소에서 경미하였으나, 2개소에서는 상대적으로 더 현저하였다. 이와 같이, 연구대상 소나무숲의 생장저해를 야기하는 주 요인은 양분부족, 복토 및 답압, 수간훼손, 병충해 등이었다. 이들 원인별 문제점을 개선하여 해당 소나무숲을 보전할 관리방안을 모색하였다. 관리방안은 유기물과 석회 시용, 복토 제거, 토양굴기와 자갈포설, 목도설치 또는 우드칩 포장, 목책 및 보호틀 제공, 수간 외과수술, 수세강화, 수간주사 등 생장환경을 개선하거나 수간훼손과 병충해를 제어할 대책을 포함하였다.

신생아와 영유아 로타바이러스 위장염의 임상 경과에 대한 비교 (Comparison of Clinical Manifestations of Rotaviral Gastroenteritis between Neonates and Infants)

  • 박민경;박재옥;김창휘
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제9권2호
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    • pp.153-161
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    • 2006
  • 목 적: 로타바이러스는 영유아 급성 설사증의 대표적인 원인 병원체로써 전 세계에 걸쳐 분포한다. 신생아에서의 로타바이러스 감염은 1975년에 Chrysite 등에 의해 처음 보고된 후 원내 장염의 중요한 원인체로 알려졌으며, 신생아는 영유아와 다른 임상 양상을 보이는 경우가 많다. 신생아의 로타바이러스 감염증의 임상적 고찰에 대한 연구가 부족하여 저자는 로타바이러스 감염으로 입원한 신생아와 영유아를 대상으로 임상 양상의 차이를 알아보고자 하였다. 방 법: 2001년 2월 1일부터 2003년 1월 31일까지 순천향대학교 부천병원에 장염으로 입원하여 시행한 로타바이러스 항원 검사 양성인 신생아 104명, 영유아 250명을 대상으로 성별, 계절별 분포, 임상 증상, 동반된 질환, 수유 방법에 따른 발생 빈도 등을 비교하였다. 결 과: 계절별로 보면 영유아에서는 2~6월 사이에, 신생아는 10~12월 사이에 발생률이 높았다. 임상 증상은 영유아에서는 설사, 구토, 발열이 가장 흔했고, 경련이 발생한 경우가 있었으며, 신생아에서는 발열과 설사 증상 외에 탈수와 동반된 대사성 산증, 황달, 보챔, 무호흡, 혈변, 위 잔류, 끙끙거림의 비특이적인 증상이 통계학적으로 유의하게 나타났다. 그밖에 통계학적인 유의성은 없으나 수유량 감소, 기면, 구토 등의 증상도 보였다. 동반된 질환으로 영유아는 상기도 감염, 폐렴, 기관지염 등의 호흡기 질환이 많았으며, 그밖에 요로감염, 장중첩증, 출혈성 위염, 간염, 가와사키병이 동반되었다. 신생아에서는 괴사성 장염이 의미 있게 동반되었고, 그밖에 상기도 감염, 폐렴, 요로감염이 있었다. 수유 방법에 있어서는 로타바이러스 감염 환아 중 신생아와 영아 모두 분유 수유아가 모유 수유아보다 많았으나 통계학적으로 유의하지는 않았다. 결 론: 신생아에서의 로타바이러스 감염은 영유아와 달리 황달, 보챔, 무호흡, 혈변, 위 잔류, 수유량 감소, 기면 등의 비특이적인 증상이 발생하는 경우가 많으므로 염두에 두고 진단하려고 노력해야 한다. 로타바이러스는 영유아는 물론 신생아에서도 중요한 원인체로 밝혀지고 있으므로 향후 로타바이러스 감염의 보다 쉽고 간편한 진단 방법, 병원체 분리, 감염 경로, 면역 반응 및 예방과 치료에 대한 연구가 더 필요할 것으로 생각된다.

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도시 내 자연환경(산림, 하천)과 근린공원의 연결 현황 평가 및 연결방안 (The Evaluation of Connectivity between Natural Environment (Forests and Rivers) and Neighborhood Parks Inside Cities in Gyeonggi-do)

  • 성현찬;김수련;강다인;황소영
    • 한국환경복원기술학회지
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    • 제18권5호
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    • pp.49-59
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    • 2015
  • In this research, the connectivity status between natural environment (forests and rivers) and urban parks in view of ecological networks in a city is evaluated and on the basis of these evaluation results, a future connectivity enhancing recommendations are suggested. As a result, the 96.8% of the connectivity role of the neighborhood parks were core or connected parks and as in terms of the ecological pattern on the outer park, 84.1% of the case neighborhood parks were connected to the ecological element at least one side. Therefore, it can be expected to play a role as corridor that enables the direct connection with the natural environment if the connection plan is well established. As a result of connectivity evaluation of the parks, inside of the parks had low ecological element overall and had low connectivity, outside of the parks had 1.5 times more of low connectivity parks than high connectivity parks, and had similar disconnections such as facilities(fence, soundproof walls, breast walls, etc.), developments(roads, apartment complexes, industrial complexes, etc.), or poor greens regardless of the neighborhood with the ecological elements. To increase the connectivity of ecological network, the cities already built shall secure primarily green territory where can connect with the isolated park due to the surrounding with the developing areas and when planning for new cities or residential complexes, it shall establish a connection plan with the nearby at the beginning.

여대생의 브래지어 착용과 선호에 관한 연구 (A Study on the Wearing and Preferences of Brassiere for Female College Students)

  • 반홍우;최종명;권수애;손부현
    • 한국생활과학회지
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    • 제18권5호
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    • pp.1093-1101
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    • 2009
  • To provide basic data to manufacture superior brassieres, we performed a survey on the wearing and buying habits, and preference of functions and materials of brassieres for 189 women subjects in their twenties. The results of this research are as follows; Style and size are the most important in purchasing brassieres. Flat breasted and sagging breasted subjects were dissatisfied in the fit of the upper cup. 70% of the subjects were ignorant of their brassiere size. Sagging breasted subjects were less satisfied with smoothness, softness, and weight when wearing their bras in comparison with the other types. Conical type breasts were common amongst women in their 20s. They are more likely to wear size 75A and 80A where the full bust girth is 10cm larger than the under-bust. They preferred demi cup brassieres with thin or moderate padding to full cup brassieres with thick padding. On the other hand, 56.8% of subjects wore brassieres all day. The subjects were dissatisfied with the slipping down of the shoulder straps. Large-breasted subjects were concerned more with dampness and the fit on the center front of the brassiere, and brassieres with too thick padding had a poor fit on the center front. Sports-brassieres which fit close to the skin and used stretchable fabric caused more itching and dampness and dissatisfaction in removal of the brassiere.

송전선로 건설에 따른 산림훼손의 최소화 관리방안 (Strategies for Minimizing Forest Disturbance During the Construction of Power Transmission Towers)

  • 이동근;강현경
    • 한국조경학회지
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    • 제30권6호
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    • pp.66-78
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    • 2003
  • The purpose of this study was to minimize the forest disturbance around an entry road of a power transmission tower construction site between Taean and Sinsesan, Chungnam. The main study field was classified into existing materials and a GIS, remote sensing analysis, and a field examination. This information was used to identify the most suitable entry road using a degree of green naturality map, eco-naturality map, actual vegetation map, and a forest state map as the existing materials. Also, the study used an normalized difference vegetation index, altitude and slope map in order to make the evaluation materials which used an remote sensing image, and GIS. This data was used to choose an optimum area, and diagnosed the current condition of the vegetation with a field survey of the area. It analyzed vegetation structure, species diversity, the age of trees in a field examination. Subsequently, we proposed four area types based on the analysis results--preservation area, transplantation area, restoration area and development area. As a result, the preservation area was categorized into 8 grades, according to the degree of green naturality, large area of breast diameter at Pinus densiflora community, competition area of Pinus densiflora and Quercus spp. and Quercus spp. community of over 20 years old. A transplantation area established 46 optimum areas according to the GIS analysis and vegetation investigation results. Vegetation restoration plan for disturbance area should be made based on ecological value of existing vegetation to worthwhile area as Quercus spp. mixing forest proposed. The development area selected a ecological worthless place as an artificial forest where Pinus densiflora and Pinus thunbergii growth is poor. This research results suggest that restoration of vegetation will be possible in the real world. Also, ecological restoration guidelines will be made through building and analyzing data base and routine monitoring of transplantation and restoration area.