• The Korean Journal of Physiology and Pharmacology
• /
• 제17권1호
• /
• pp.15-21
• /
• 2013

Aspirin (acetylsalicylic acid) is one of the most widely used therapeutic agents based on its pharmacological actions, including anti-inflammatory, analgesic, anti-pyretic, and anti-thrombotic effects. In this study, we investigated the effects of aspirin on seizure susceptibility and hippocampal neuropathology following pilocarpine-induced status epilepticus (SE). SE was induced by pilocarpine hydrochloride (280 mg/kg, i.p.) administration in C57BL/6 mice (aged 8 weeks). Aspirin was administered daily (15 mg/kg or 150 mg/kg, i.p.) for 10 days starting 3 days before SE, continuing until 6 days after SE. After pilocarpine injection, SE onset time and mortality were recorded. Neuronal cell death was examined using cresyl violet and Fluoro-Jade staining, and glial responses were observed 7 days post SE using immunohistochemistry. In the aspirin-treated group, the onset time of SE was significantly shortened and mortality was markedly increased compared to the control group. However, in this study, aspirin treatment did not affect SE-induced neuronal cell death or astroglial and microglial responses in the hippocampus. In conclusion, these results suggest that the safety of aspirin should be reevaluated in some patients, especially with neurological disorders such as temporal lobe epilepsy.

• 제어로봇시스템학회논문지
• /
• 제15권4호
• /
• pp.406-412
• /
• 2009

ECG is used on purpose to keep good health or monitor cardiac function of aged person as well as on purpose to diagnose the disease of heart patients. The ambulatory ECG monitoring system under guarantee of safety and accuracy is very efficient to prevent the progress of heart disease and sudden death. These systems can detect the temporary change of ECG that is very significant to diagnose heart disease such as myocardial ischemia, arrhyamia and cardiac infarction. In this paper, we describe the ECG signal analysis algorithm and measurement device for ECG monitoring. The authors designed a small-size portable ECG device that consisted of instrumentation amplifier, micro-controller, filter and RF module. The device measures ECG with four electrodes on the body and detects QRS complex and ST level change in realtime. Also it transmits the measured signals to the personal computer. The developed software for ECG analysis in personal computer has the function to detect the feature points and ST level changes.

• Tuberculosis and Respiratory Diseases
• /
• 제74권3호
• /
• pp.104-110
• /
• 2013

Background: Notified tuberculosis (TB) cases in Korea have not decreased over the last decade (2001-2010). Methods: To clarify the reasons, we analyzed an annual report on notified tuberculosis patients and age-specific population drift in Korea. Results: Compared to the age-specific notified TB cases between 2001 and 2010, distinctive features in notified TB cases and new cases increased markedly in people aged 45-54 years and in patients over 65 years old, whereas those between 15-34 years in 2010 decreased drastically. In particular, notified TB individuals over 65 years old occupied 29.6% of the cases in 2010, which was 1.5 times higher than that in 2001. The main reason not to decrease in notified TB patients for the last decade (2001-2010) was due to the increasing elderly population as well as the aging of baby boomers, which have a higher risk of TB development. Conclusion: Korea needs to pay attention to the older population in order to successfully decrease the burden of TB in the future.

• 대한간호학회지
• /
• 제44권6호
• /
• pp.630-638
• /
• 2014

Purpose: The purpose of this study was to develop a scale to evaluate stress in elderly patients with coronary artery diseases (CAD) and to examine validity and reliability of the scale. Methods: The development process for the preliminary scale included construction of a conceptual framework and initial items, verification of content analysis, sentence correction, and pilot study. This study was conducted using a questionnaire survey with one-to-one interviews during January and February, 2012. Participants were 240 elderly patients with CAD. Data were analyzed using item analysis, factor analysis, criterion related validity, and internal consistency. Results: The developed scale consisted of 32 items and 6 factors - aging and disease (7 items), family relations (5 items), anxiety and withdrawal (9 items), management of daily living (3 items), compliance of medical regimen (4 items), poverty and finance (4 items), and explained 68.5% of total variance. The scale had significantly positive correlation with the Korean Perceived Stress Scale (KPSS). Cronbach's alpha was .96, and Guttman split half coefficient was .91. Conclusion: Results indicate that the Stress Scale for Elderly Patients with CAD has validity and reliability, and is a suitable scale in health care settings to assess stress in elderly patients with CAD.

• 대한유전성대사질환학회지
• /
• 제17권3호
• /
• pp.92-95
• /
• 2017

Fabry 병은 성염색체 연관 유전성 리소좀 대사 질환으로 ${\alpha}$-galactosidase A 를 코딩하는 GLA 유전자의 변이로 인한 ${\alpha}$-galactosidase A 효소의 결핍에 의해 발생한다. 이 질환은 globotriaosylceramide (GL-3) 및 관련된 글리코스핑고리피드(glycophospholipids)가 신장 사구체, 심근, 후근 신경절 및 자율 신경계, 혈관 내피 세포 및 평활근 등에 축적되어 사지 말단 동통, 신부전, 심부전 등의 다양한 임상양상을 보이게 된다. 대증적 요법으로만 치료하던 Fabry 병은 효소대체요법의 발전으로 신부전을 포함하여, 심각한 합병증의 예방 및 호전과 함께 질환의 예후를 향상시키고 있다. 또한 사지 말단 동통은 Fabry 병 환자들의 삶의 질을 특히 떨어뜨리며, 적절한 효소대체요법에 효과가 있는 것으로 알려져 있다. 저자들은 40대 후반에 Fabry 병을 진단받고 효소대체요법을 시작하여 사지 말단 동통이 호전된 중국인 남자 환자에 대해 보고하는 바이다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제8권5호
• /
• pp.489-494
• /
• 1995

Sero-epidemiological study was carried out to observe the prevalence of brucellosis in 500 slaughtered as well as in 500 healthy animals in Peshawar district of N.W.F.P. All serum samples were subjected to four serological tests i.e. Standard Plate Test (SPT), Standard Tube Test (STT), Rivanol Test (RV) and 2, Mercapto-Ethanol Test (2, ME). The incidence of disease in 500 healthy animals tested by standard plate test, standard tube test, rivanol test and 2, Mercapto-ethanol test, was 2.8%, 1.8%, 1.6% and 1.2% respectively. While the incidence of brucellosis in 500 slaughter animals from Peshawar abattoir was 3.0%, 2.2%, 2.00% and 1.2% by standard plate test, standard tube test, rivanol test and 2, Mercapto-ethanol test The disease prevalence was higher in slaughtered animals as compared to healthy animals. The disease was more common in goats than sheep, also more prevalence in aged female than younger stocks. The efficacy of SPT was found more effective as compared to STT, RV, and 2, ME tests both in slaughtered as well as apparently healthy animals at Peshawar district. Standard Plate test detected 2.9%, Standard Tube test 2.0%, Rivanol test 1.8% and 2, Mercapto-ethanol test detected 1.2% positive cases in slaughtered as well as in healthy animals. So the Standard Plate Test was found to be more reliable, sensitive, and easy to performed.

• 보건교육건강증진학회지
• /
• 제6권2호
• /
• pp.4-22
• /
• 1989

This study aims to explore the relationship between housewives' health KAP level and the physical health of families. The data used in this study are obtained from the Last Evaluation Program of the National Note for Health surveyed in July, 1989. The respondents for this study are 770 housewives residing in Chunan and Buan. The reason why this study focus on KAP level of housewives is to find out whether a housewife as a emotional supporter contributes to the physical health of her families. A housewife gives her families emotional satisfaction insteade of economic satisfaction. So she has the most interest in family health among the members of her family. Therefore, housewife's KAP level will influence her family health. The independent variables chosen for the analysis are the general characteristic variables and KAP level. And the dependent variable is the physical health of families which excluded psychosocial one. This level of family health includes weight for family health and seriouseness of disease. The result of this study was summarized as follows. (1) KAP level was significantly correlated with variables which have mainly the socioeconomic characteristics. The variables were: area of residence, education level occupation, self assessment on wealth, and exposure to mass communication. (2) In the analysis of relationship between the general characteristic variables and family health, family health was significantly correlated with almost all variables. The variables were: Presence of the aged, Health status, Experience in disease, Self assessment on health, No. of families, Occupation, Education level, Self assessment on wealth, Concern on health, and Exposure to mass communication. (3) In the analysis of relationship between family health and KAP level, family health was not significantly correlated with KAP level but. (4) Also in the stepwise regression analysis, the general variables account for about 32.1 percent of the variance in the dependent variable, family health. The variable with the greatest explanatory power was presence of the aged. On the contrary, KAP level explain about 0.4 percent of the variance in the dependent variable. In sum, the study shows that housewives' health KAP level has relatively weak relationship with the physical health of families

• 한국보건간호학회지
• /
• 제1권1호
• /
• pp.17-31
• /
• 1987

This study was carried out for the age 60years over who are attending a villa house for the aged during day time. The purpose of this study was to measure occurance rate of Diabetes by self cognitiveness about their disease of Diabetes; by result of urine test tape test and a questionaire study and self-care behavior about Diabetes. The results of the study are summarized as follow: 1. General Characteristics of the suryeyed. The population studied consisted of 143 males and 256 females comprising $73.9\%$ of the total population registered at the elderly villa house at the time of the study. The mean age group of the study was 70-79 years; educational level $77.2\%$ was below than primary education. 2. The results of Diabetes study. The number of cases who were self-recognized about their Diabetes were 19; 8 males and 11 females. The number of urine sugar positive cases was 35; 19 males and 16 females. The consistency rate of positive urine sugar test was $93.5\%$ An average degree of the results of knowledge test about Diabetes was 1. 4 point. When the correct 1 item was given 1 point for the 6 item of questions. Among 19 cases of self-recognized disease group an average degree of the knowledge test results was 2. 3 point and among the 35 cases of the urine test positive group an average degree of the knowledge test results was 1. 7 point. The average degree of self -care behavior about Diabetes was 1. 6 point when measued 3 point scale on the self-care behavior for the 7 item of questions.

• 대한의생명과학회지
• /
• 제24권4호
• /
• pp.372-379
• /
• 2018

Korean society is experiencing rapid growth due to industrialization and urbanization, and the aging of population is emerging. Degradation of the masticatory muscle due to aging and reduction of the number of mastications causes dry mouth syndrome with decreased saliva in the elderly. Changes in the amount and composition of saliva cause various oral diseases, especially, periodontal disease is closely related to the microorganisms that form the plaque. In the elderly education, stimulation saliva was collected at the first visit and the last visit to observe changes in microorganisms in the oral cavity. For the collection of the probes, the paraffin wax was chewed for 5 minutes. The samples were immediately refrigerated in a 50 cc plastic tube and then stored at $-20^{\circ}C$ until the next use. The subjects of this study were the elderly people aged 65 years or older, and the study was conducted on 16 persons, 3 males and 13 females. The distribution of saliva microorganisms according to rolling brushing method showed significant difference in all three groups (Aa & Red complex, Orange complex and Green complex) before and after the education. In the group who answered that they had dentures, it was confirmed that the amount of microorganisms before and after education was significantly reduced in all three groups. There was a significant decrease in the amount of microorganisms in the Aa & Red complex and Orange complex group in the case of hypertension related to systemic disease. In conclusion, the higher the interest of oral health and general health of the subjects, the more effective the education.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제18권3호
• /
• pp.202-208
• /
• 2015

Progressive familial intrahepatic cholestasis type 3 (PFIC3) is an autosomal recessive disorder of cholestasis of hepatocellular origin, typically seen in infancy or childhood caused by a defect in the ABCB4 located on chromosome 7. Here we report on an older patient, aged 15, who presented with biochemical testing that led to an initial consideration of a diagnosis of Wilson disease (WD) resulting in a delayed diagnosis of PFIC3. Diagnosis of PFIC3 was later confirmed by molecular studies that identified novel mutations in the ABCB4 gene. Cholestasis due to PFIC3 can cause elevated hepatic copper and increased urine copper excretion that overlap with current diagnostic criteria for WD. Molecular diagnostics are very useful for establishing the diagnosis of PFIC3. Ursodeoxycholic acid ameliorates cholestasis in PFIC3, and may help mediate a reduction in hepatic copper content in response to treatment.