• 대한수의학회지
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• 제42권1호
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• pp.65-71
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• 2002

We have utilized the PCR-RFLP method to detect the ryanodine receptor(RYR1) gene mutation and to estimate the genotype frequencies of the RYR1 gene in commercial crossbred pig population. The exon region(659bp) including point mutation(C ${\rightarrow}$T; Arg ${\rightarrow}$Cys) in the porcine ryanodine receptor gene, which is a causal mutation for PSS, was amplified by PCR and digested with Cfo I restriction enzyme. The RYR1 gene was classified into three genotypes by agarose gel electrophoresis. The normal homozygous(NN) individuals showed two DNA fragments consisted of 493 and 166bp. The mutant homozygous(nn) individuals showed only one DNA fragment of 659bp. Also, all three fragments(659, 493 and 166bp) were showed in heterozygous(Nn) carrier animals. The proportions of normal, carrier and PSS pigs within crossbred population of pigs were 81%, 15% and 4%, respectively. According to the results of analysis of variance for the association of genotypes of RYR1 of pigs at 30kg, day age at 90kg and average daily gains, the RYR1 nn genotype was very higher than RYR1 NN genotype for day age at 30kg with 5% level of significant difference, but no significant difference for association of any other genotypes with day age at 90kg and average daily gain in crossbred pigs. Therefore, DNA diagnosis by using PCR-RFLP analysis for the PSS gene was useful for large-scale screening of commercial pigs in the swine industry.

• The Korean Journal of Pain
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• 제33권2호
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• pp.192-198
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• 2020

Background: Previous studies have shown varying results between lumbosacral transforaminal epidural steroid injections (TFESIs) performed with particulate versus non-particulate corticosteroids. The purpose of this study was to investigate the difference in pain relief and functional improvement between particulate and nonparticulate lumbosacral TFESIs in patients who had undergone both injections, sequentially. Methods: This was a self-controlled, retrospective study of 20 patients who underwent both a methylprednisolone and a dexamethasone TFESI to the same vertebral level and side. Primary outcomes included pain relief according to the visual analogue scale (VAS) and functional improvement determined by a yes/no answer to questions regarding mobility and the activities of daily living. Post-injection data was recorded at 2, 3, and 6 months. Results: A decrease in VAS scores of -3.4 ± 3.0 (mean ± standard deviation), -3.1 ± 3.1, and -2.8 ± 3.4 was seen for the methylprednisolone group at 2, 3, and 6 months, respectively. Similar decreases of -3.9 ± 3.5, -3.4 ± 2.8, and -2.3 ± 3.4 were seen in the dexamethasone group. There was no significant difference in pain relief at any point between the two medications. The percentage of subjects who reported improved function at 2, 3, and 6 months was 65%, 51%, and 41%, respectively, for the methylprednisolone group and 75%, 53%, and 42% for the dexamethasone group. Conclusions: These findings support the use of non-particulate corticosteroids for lumbosacral TFESIs in the context of documented safety concerns with particulate corticosteroids.

• Journal of Trauma and Injury
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• 제36권1호
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• pp.39-48
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• 2023

Purpose: Sports offer several health benefits but are not free of injury risk. Activity dynamics vary across sports, impacting the injury profile and thereby influencing healthcare resource utilization and health outcomes. The purpose of this study was to investigate sports-related major trauma cases and compare differences across sports and activity groups. Methods: A retrospective case notes review of sports-related major traumas over a 5-year period was conducted. Demographic, hospital episode-related, and health outcome-related data were analyzed, and differences were compared across sports and activity groups. The Glasgow Outcome Scale (GOS) at discharge was used as the primary outcome measure and the length of hospital stay as the secondary outcome measure. Results: In total, 76% of cases had good recovery at discharge (GOS, 5), 19% had moderate disability (GOS, 4), and 5% had severe disability (GOS, 3). The mean length of hospital stay was 11.2 days (range, 1-121 days). The most severely injured body region was the limbs (29.1%) and vertebral/spinal injuries were most common (33%) in terms of location. A significant difference (P<0.05) existed in GOS across sports groups, with motor sports having the lowest GOS. However, no significant differences (P>0.05) were found in other health-outcome variables or injury patterns across sports or activity groups, although more competitive sports cases (67%) required admission than recreational sports cases (33%). Conclusions: Spinal injuries are the most frequent sports injuries, bear the worst health outcomes, and warrant better preventive measures. Head injuries previously dominated the worst outcomes; this change is likely due to better preventive and management modalities. Competitive sports had a higher injury frequency than recreational sports, but no difference in health outcomes or injury patterns.

• 생물정신의학
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• 제23권4호
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• pp.166-172
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• 2016

Objectives We investigated whether the catechol-O-methyltransferase (COMT) and serotonin related gene polymorphisms may be associated with agoraphobia in patients with panic disorder in Korea. Methods The COMT gene (rs4680), 5-hydroxytryptamine (serotonin) transporter linked polymorphic region (5-HTTLPR) gene (rs25531), serotonin receptor 1A (HTR1A) gene (rs6295) genotypes were analyzed in 406 patients with panic disorder and age-sex matched 206 healthy controls. Patients with panic disorder were dichotomized by the presence of agoraphobia. The following instruments were applied : the Beck Depression Inventory, the Beck Anxiety Inventory, the Panic Disorder Severity Scale. Results There was a significant difference in the distribution of 5-HTTLPR genotype between panic patients with agoraphobia and without agoraphobia (p = 0.024). That is, the panic patients with agoraphobia had a significant excess of the less active 5-HTTLPR allele (S allele). (p = 0.039) Also, we replicated previous western reports which indicated a significant difference in the distribution of COMT genotype between the patients with panic disorder and the healthy controls (p = 0.040). However, no significant associations of agora-phobia or panic disorder with HTR1A gene polymorphisms were found. Conclusions This result supports that the COMT polymorphisms may be associated with panic disorder and suggests that the 5-HTTLPR polymorphisms may play a role in the pathogenesis of agoraphobia in the Korean patients with panic disorder.

• 천문학회지
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• 제31권1호
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• pp.1-17
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• 1998

To understand the basic physics underlying large spatial fluctuations of intensity and Doppler shift, we have investigated the dynamical charctersitics of the transition region of the quiet sun by analyzing a raster scan of high resolution UV spectral band containing H Lyman lines and a S VI line. The spectra were taken from a quiet area of $100'\times100'$ located near the disk center by SUMER on board SOHO. The spectral band ranges from 906 A to 950 A with spatial and spectral resolution of 1v and $0.044 {\AA}$, respectively. The parameters of individual spectral lines were determined from a single Gaussian fit to each spectral line. Then, spatial correlation analyses have been made among the line parameters. Important findings emerged from the present analysis are as follows. (1) The integrated intensity maps of the observed area of H I 931 line $(1\times10^4 K)$ and S VI 933 line $(2\times10^5 K)$ look very smilar to each other with the same characterstic size of 5". An important difference, however, is that the intensity ratio of brighter network regions to darker cell regions is much larger in S VI 933 line than that in H I 931 line. (2) Dynamical features represented by Doppler shifts and line widths are smaller than those features seen in intensity maps. The features are found to be changing rapidly with time within a time scale shorter than the integration time, 110 seconds, while the intensity structure remains nearly unchanged during the same time interval. (3) The line intensity of S VI is quite strongly correlated with that of H I lines, but the Doppler shift correlation between the two lines is not as strong as the intensity correlation. The correlation length of the intensity structure is found to be about 5.7' (4100 km), which is at least 3 times larger than that of the velocity structure. These findings support the notion that the basic unit of the transition region of the quiet sun is a loop-like structure with a size of a few $10^3 km$, within which a number of unresolved smaller velocity structures are present.

• 대한원격탐사학회지
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• 제29권6호
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• pp.595-600
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• 2013

In order to spatially interpolate the near-surface temperature (Ta) values, satellite and reanalysis methods were used from previous studies. Accuracy of reanalysis Ta was generally better than that of satellite-based Ta, but spatial resolution of reanalysis Ta was large to use at local scale studies. Our purpose is to evaluate accuracy of reanalysis Ta and satellite-based Ta according to elevation from April 2011 to March 2012 in Northeast Asia that includes various topographic features. In this study, we used reanalysis data that is ERA-Interim produced by European Centre for Medium-Range Weather Forecasts (ECMWF), and estimated satellite-based Ta using Digital Elevation Meter (DEM), Normalized Difference Vegetation Index (NDVI), difference between brightness temperature of $11{\mu}m$ and $12{\mu}m$, and Land Surface Temperature (LST) data. The DEM data was used as auxiliary data, and observed Ta at 470 meteorological stations was used in order to evaluate accuracy. We confirmed that the accuracy of satellite-based Ta was less accurate than that of ERA-Interim Ta for total data. Results of analyzing according to elevation that was divided nine cases, ERA-Interim Ta showed higher accurate than satellite-based Ta at the low elevation (less than 500 m). However, satellite-based Ta was more accurate than ERA-Interim Ta at the higher elevation from 500 to 3500 m. Also, the width of the upper and lower quartile appeared largely from 2500 to 3500 m. It is clear from these results that ERA-Interim Ta do not consider elevation because of large spatial resolution. Therefore, satellite-based Ta was more effective than ERA-Interim Ta in the regions that is range from 500 m to 3500 m, and satellite-based Ta was recommended at a region of above 2500 m.

• 한국지역지리학회지
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• 제15권6호
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• pp.752-762
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• 2009

본 연구는 대구지역 벤처기업의 입지 및 비즈니스서비스 네트워크 특성을 실증적으로 분석하였다. 대구지역 벤처기업들은 소프트웨어분야에서 연구개발투자와 특허 신기술 분야의 사업 유형이 주를 이루고 있으며, 기업체 근무 경력이 있는 고학력자들에 의해 1990년대 중반 이후 창업된 소규모 기업들이 다양한 성장 전략을 모색하고 있다. 대구지역 벤처기업들은 달서구와 북구의 일부 지역에 집중 분포하는 경향을 보이고 있으며, 업종별로 약간의 차이는 있으나 대체로 연구 대학과의 접근, 정보 획득 용이, 저렴한 용지 이용 등이 주요 입지요인으로 작용하였다. 그리고 이들 기업들은 고객 기업과의 네트워크를 고려하여 이전 여부를 결정한다. 벤처기업과 비즈니스서비스와의 네트워크 특성을 보면, 대구지역 벤처기업들이 이용하는 비즈니스서비스 업체 수는 적은 편이지만, 그 중 정보처리 및 기타 컴퓨터 운영관련업과 전문과학 및 기술서비스업 부문의 서비스 업체 수는 많은 편이다. 비즈니스서비스산업 중 정보처리 및 기타 컴퓨터 운영 관련업, 연구 및 개발업, 사업지원서비스에 대한 이용 빈도가 높고, 전문과학 및 기술서비스업에 대한 이용 빈도는 낮다. 대구지역 벤처기업들이 이용하는 비즈니스서비스업체는 대구지역에 주로 분포하며, 기술 및 지식이 부족하기 때문에 비즈니스서비스를 이용한다.

• 부동산연구
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• 제28권1호
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• pp.91-104
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• 2018

본 연구는 시장참여자의 행태 중 하나인 군집행동의 발생 여부와 정도를 주택시장을 중심으로 분석하였다. 분석방법으로 최근 군집행동 분석에 가장 많이 활용되는 CSAD모형에 실거래가격을 적용하였다. 분석내용은 권역별, 경과년수별, 규모별, 시장조건별로 세분하여 지역성, 내부요인, 외부 요인에 대한 분석을 하고자 하였다. 분석결과 첫째, 서울시 전체에서는 군집행동이 발생하지 않았다. 권역별로는 도심권, 동남권, 서북권에서 군집행동이 발생하여 선행연구(Ngene et al., 2017)와 동일한 결과를 보였다. 둘째, 경과년수별 분석에서는 노후주택에서 군집행동이 포착되었으며, 규모별로는 $60m^2$이하의 소규모와 $85m^2$이상 $102m^2$미만의 국민주택규모에서 군집행동이 발생하는 것으로 나타났다. 셋째, 글로벌 금융위기하에서는 모든 권역에서 군집행동이 발생하지 않았으며, 시장 상황이 호황기일 경우 서북권에서 군집행동이 발생하는 것으로 분석되었다. 이는 손실공포 확대에 따라 불황기에서 군집행동이 집중적으로 발생하는 주식시장과 차이를 보이는 결과이다. 본 연구는 시장참여자의 행태를 행동경제학적 측면에서 분석하여 주택시장 이상현상에 대한 이해도를 높이고 시장분석에 시장참여자의 행동이라는 심리요인을 제시하였다는 점에서 의미가 있을 것이다.

• 한국지역지리학회지
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• 제6권3호
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• pp.153-168
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• 2000

해안습지는 육지와 해양이 만나는 점이지대에 형성된 해안퇴적지형으로, 이 중 염하구는 하천과 조류의 영향이 갯강을 통해 직접적으로 미치는 만입형 해안습지이다. 따라서 하천과 조류에 의한 퇴적작용은 염하구의 성장과 발달에 있어서 가장 중요한 프로세스이다. 해안습지는 최근 중요한 환경문제로 대두되고 있는 해수면 상승의 영향을 직접적으로 받는 지형이기 때문에, 해안습지 성장률에 관한 연구는 해안환경의 이해와 관리에 있어 중요한 자료를 제공한다. 본 연구는 순천만 염하구 해안습지를 대상으로 상이한 시간단위 속에서 진행되는 퇴적률과 조류에 의한 부유하중의 이동패턴 분석을 토대로 해안습지 성장률의 공간적 특성을 밝히고자 하였다. 조석의 일주기간의 퇴적률은 경사변환점이 염생습지보다 높은 값을 나타내었으며, 하구에서 바다로 이동하면서 퇴적률이 감소하였다. 따라서 조석의 일주기간의 퇴적률에서는 갯강과 배후 갯벌사이 경사변환점의 제방효과와 부유하중의 농도가 중요하게 작용하였다. 연간 퇴적률은 염생습지가 경사변환점보다 높은 값을 나타내어 조석의 일주기간의 퇴적률과는 다른 공간적 특성을 보였다. 그러나 하구에서 바다로 이동하면서 퇴적률이 감소하는 것은 동일하였다. 따라서 연간 퇴적률에서는 식생에 의한 부유하중 고착능력과 조류의 정체시간, 부유하중의 농도가 중요하게 작용하였다. 조류내 부유하중의 농도는 전체적으로 썰물시 영생습지를 통과한 직후가 밀물시 경사변환점을 통과한 직후보다 높은 감소율을 나타내었다. 그리고 썰물시 경사변환점을 통과한 직후의 부유하중 농도는 오히려 약간 증가하였는데, 이는 썰물에 의해 경사변환점의 퇴적물이 침식되었기 때문이다. 연구지역의 퇴적률은 시간단위와 지점에 따라 다양한 특성을 보이면서 매우 빠르게 진행되고 있다. 경사변환점은 제방효과에 의한 퇴적과 조류 및 외부요인에 의한 침식이 동시에 일어난 반면, 염생습지는 조류의 정체시간과 식생에 의한 부유하중 포획에 따라 침식보다는 퇴적이 활발하게 일어났다. 따라서 연구지역의 성장률은 갯강을 중심으로 횡적으로는 염생습지가 경사변환점보다 높고, 종적으로하는 하구지점에 가까울수록 높게 나타났다. 특히, 지난 1년간의 성장률은 다른 지역에 비해서 매우 빠른 $0.9{\sim}3.5cm/yr$로 모든 지점에서 퇴적이 침식보다 우세하게 나타났는데, 이는 연구지역이 새로운 퇴적환경으로 전이되고 있는 것과 밀접한 관계가 있는 것이다.

• Journal of Ecology and Environment
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• 제42권1호
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• pp.20-29
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• 2018

Background: For various reasons such as agricultural and economical purposes, land-use changes are rapidly increasing not only in Korea but also in the world, leading to shifts in the characteristics of local carbon cycle. Therefore, in order to understand the large-scale ecosystem carbon cycle, it is necessary first to understand vegetation on this local scale. As a result, it is essential to comprehend change of the carbon balance attributed by the land-use changes. In this study, we attempt to understand accumulated soil carbon (ASC) and soil respiration (Rs) related to carbon cycle in two ecosystems, artificially turned forest into pastureland from forest and a native deciduous temperate forest, resulted from different land-use in the same area. Results: Rs were shown typical seasonal changes in the alpine pastureland (AP) and temperate deciduous forest (TDF). The annual average Rs was $160.5mg\;CO_2\;m^{-2}h^{-1}$ in the AP, but it was $405.1mg\;CO_2\;m^{-2}h^{-1}$ in the TDF, indicating that the Rs in the AP was lower about 54% than that in the TDF. Also, ASC in the AP was $124.49Mg\;C\;ha^{-1}$ from litter layer to 30-cm soil depth. The ASC was about $88.9Mg\;C\;ha^{-1}$, and it was 71.5% of that of the AP. The temperature factors in the AP was high about $4^{\circ}C$ on average compared to the TDF. In AP, it was observed high amount of sunlight entering near the soil surface which is related to high soil temperature is due to low canopy structure. This tendency is due to the smaller emission of organic carbon that is accumulated in the soil, which means a higher ASC in the AP compared to the TDF. Conclusions: The artificial transformation of natural ecosystems into different ecosystems is proceeding widely in the world as well as Korea. The change in land-use type is caused to make the different characteristics of carbon cycle and storage in same region. For evaluating and predicting the carbon cycle in the vegetation modified by the human activity, it is necessary to understand the carbon cycle and storage characteristics of natural ecosystems and converted ecosystems. In this study, we studied the characteristics of ecosystem carbon cycle using different forms in the same region. The land-use changes from a TDF to AP leads to changes in dominant vegetation. Removal of canopy increased light and temperature conditions and slightly decreased SMC during the growing season. Also, land-use change led to an increase of ASC and decrease of Rs in AP. In terms of ecosystem carbon sequestration, AP showed a greater amount of carbon stored in the soil due to sustained supply of above-ground liters and lower degradation rate (soil respiration) than TDF in the high mountains. This shows that TDF and AP do not have much difference in terms of storage and circulation of carbon because the amount of carbon in the forest biomass is stored in the soil in the AP.