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The Effect of Water in Four Adenine-Thymine and Three Guanine-Cytosine Pairs: Combining Quantum and Statistical Mechanics

  • Lee, Jinkeong;Ham, Sihyun
    • Proceeding of EDISON Challenge
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    • 2015.03a
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    • pp.151-155
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    • 2015
  • The molecular interactions between the nucleic acid bases and water molecules are important in organism. Despite Adenine-Thymine Hoogsteen base pair and Guanine-Cytosine Watson-Crick base pair have been demonstrated to be most stable in a gas phase, the effect of water on the stability of these base pairs remains elusive. Here we report the structural and thermodynamic characteristics on possible Adenine-Thymine and Guanine-Cytosine base pairs in a gas phase as well as in an aqueous phase by using quantum mechanical method and statistical mechanical calculations. First, we optimized the direct base-pair interaction energies of four Adenine-Thymine base pairs (Hoogsteen base pair, reverse Hoogsteen base pair, Watson-Crick base pair, and reverse Watson-Crick base pair) and three Guanine-Cytosine base pairs (GC1 base pair, GC2 base pair, and Watson Crick base pair) in a gas phase at the $B3LYP/6-31+G^{**}$ level. Then, the effect of solvent was quantified by the electronic reorganization energy and the solvation free energy by statistical mechanical calculations. Thereby, we discuss the effect of water on the stability of Adenine-Thymine and Guanine-Cytosine base pairs, and argue why Adenine-Thymine Watson-Crick base pair and Guanine-Cytosine Watson-Crick base pair are most stable in an aqueous environment.

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THE EFFECT OF DOPANT OUTDIFFUSION ON THE NEUTRAL BASE RECOMBINATION CURRENT IN Si/SiGe/Si HETEROJUNCTION BIPOLAR TRANSISTORS

  • Ryum, Byung-R.;Kim, Sung-Ihl
    • ETRI Journal
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    • v.15 no.3
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    • pp.61-69
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    • 1994
  • A new analytical model for the base current of Si/SiGe/Si heterojunction bipolar transistors(HBTs) has been developed. This model includes the hole injection current from the base to the emitter, and the recombination components in the space charge region(SCR) and the neutral base. Distinctly different from other models, this model includes the following effects on each base current component by using the boundary condition of the excess minority carrier concentration at SCR boundaries: the first is the effect of the parasitic potential barrier which is formed at the Si/SiGe collector-base heterojunction due to the dopant outdiffusion from the SiGe base to the adjacent Si collector, and the second is the Ge composition grading effect. The effectiveness of this model is confirmed by comparing the calculated result with the measured plot of the base current vs. the collector-base bias voltage for the ungraded HBT. The decreasing base current with the increasing the collector-base reverse bias voltage is successfully explained by this model without assuming the short-lifetime region close to the SiGe/Si collector-base junction, where a complete absence of dislocations is confirmed by transmission electron microscopy (TEM)[1].The recombination component in the neutral base region is shown to dominate other components even for HBTs with a thin base, due to the increased carrier storage in the vicinity of the parasitic potential barrier at collector-base heterojunction.

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JAW RELATION WITH PERMANENT RECORD BASES IN THE EDENTULOUS PATIENTS (총의치 환자에 있어 Permanent record base를 이용한 악간관계 기록)

  • Heo, Yun-Seok;Shin, Sang-Wan
    • The Journal of Korean Academy of Prosthodontics
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    • v.33 no.2
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    • pp.231-239
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    • 1995
  • When the complete denture is made, the record base for jaw relation is divided into temporary record base and permanent record base. However, The temporary record base include some disadvantages such as, the lackness of intimate contact between model and base, the lackness of retention during the jaw relation registration, When we obtained jaw relation the permanent record bases made from heat curing resin were utilized. We could get several advantages as follows : 1. The permanent record base provided intimate contact between the model and record base. 2. In fabricating occlusal rim on record base, the dimensional change of record base was little because the permanent record base was lesser influenced to thermal change of occlusal rim than the temporary record base. 3. At the stage of jaw relation, the retention of final denture could be early checked. 4. It could be able to get more accurate registration of jaw relation because all procedure were done on the same base during the jaw relation, artificial teeth arrangement, try-in, and final denture construction. 5. Although there was an inconvenience due to double curing procedure, the shrinkage rate in resin polimerization was relatively reduced so that more dimensional stability could be taken.

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Lubricating Performance of Polyalkylene Glycol and Polyolester Base Oils analyzed from the Model of Interaction between Environmentally adapted Polar base oils and Additive (TCP) (환경친화적인 극성기유와 첨가제(TCP)의 상호작용모델로부터 해석된 Polyalkylene glycol 및 Polyolester Base Oil의 윤활작용)

  • ;Masabumi Masuko
    • Tribology and Lubricants
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    • v.17 no.2
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    • pp.146-152
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    • 2001
  • Environmentally adapted synthetic base oils of polyalkylene glycols (PAGs) and polyol esters (POEs) show a high polarity because of their functional groups containing oxygen atom. The lubricating performance of these polar base oils was investigated by using a four-ball tribometer under boundary lubrication condition. Four polyalkylene glycols and five polyol ester base oils were used as sample base oils of high polarity. A mineral oil (MO) and alkylnaphthalene (AN) were used as low polarity base oils. Tricrecylphosphate (TCP) was added to all the base oils, in the range of 10 mmol/L-2000 mmol/L, as an antiwear additive. All the TCP-for-mutated base oils showed optimum concentration characteristics for minimizing wear. The order of optimum concentration of all the base oils was in a good accordance with the order of relative stability of TCP in base oils. The interaction model on solvation between additive and different polar base oils can expect the stability order of TCP. Thus, the model on solvation can explain well the order of optimum concentration of all the base oils, by using the effect of polarity (dielectric constant, $\varepsilon$) and molecular size (molecular weight, MW) of them on stability of TCP in polar base oils. Finally, a good correlation of the optimum concentration for all the base oils was obtained when it was arranged as a function of C∝(M $W_{Base Oil}$/M $W_{TCP}$)$^{-2}$.71/.($\varepsilon$$_{Base Oil}$)$^{3.38}$ by these two parameters.s..

Classification and Characteristics of Neck-base Shape of Korean Females in Their Twenties (20대 여성의 목밑둘레 형태 유형화 및 특징)

  • Hwang Keun Young;Nam Yun Ja;Park Jae Kyung
    • Journal of the Korean Society of Clothing and Textiles
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    • v.29 no.3_4 s.141
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    • pp.502-510
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    • 2005
  • The purpose of this study is to identify neck shapes of women by classifying their neck-base types according to the shapes of neck and analyzing the characteristics of each type. The subjects were 58 women $18\~24$ years of age. Their body were measured directly and indirectly by using camera, 3-dimensional body scanner. The anthropometric measurements were composed of 17 items. They were measured during the months of October in 2001 The results and discussions of this study are as follows. There were three kinds of neck-base type. The first type was slant from the back neck-base to the side neck-base, and slant from the side neck-base to the front neck-base. The second type was gentle from the back neck-base to the side neck-base, and gentle from the side nect-base to the front neck-base. finally, the third type was gentle from the back neck-base to the side neck-base, and slant from the side neck-base to the front neck-base. Hopefully, understanding the shapes of neck and characteristics of each neck-base type will help to suggest computer assisted neck-base's landmark identification algorithms and measurement extraction methods from three-dimensional body scan data.

Lyapunov-based Semi-active Control of Adaptive Base Isolation System employing Magnetorheological Elastomer base isolators

  • Chen, Xi;Li, Jianchun;Li, Yancheng;Gu, Xiaoyu
    • Earthquakes and Structures
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    • v.11 no.6
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    • pp.1077-1099
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    • 2016
  • One of the main shortcomings in the current passive base isolation system is lack of adaptability. The recent research and development of a novel adaptive seismic isolator based on magnetorheological elastomer (MRE) material has created an opportunity to add adaptability to base isolation systems for civil structures. The new MRE based base isolator is able to significantly alter its shear modulus or lateral stiffness with the applied magnetic field or electric current, which makes it a competitive candidate to develop an adaptive base isolation system. This paper aims at exploring suitable control algorithms for such adaptive base isolation system by developing a close-loop semi-active control system for a building structure equipped with MRE base isolators. The MRE base isolator is simulated by a numerical model derived from experimental characterization based on the Bouc-Wen Model, which is able to describe the force-displacement response of the device accurately. The parameters of Bouc-Wen Model such as the stiffness and the damping coefficients are described as functions of the applied current. The state-space model is built by analyzing the dynamic property of the structure embedded with MRE base isolators. A Lyapunov-based controller is designed to adaptively vary the current applied to MRE base isolator to suppress the quake-induced vibrations. The proposed control method is applied to a widely used benchmark base-isolated structure by numerical simulation. The performance of the adaptive base isolation system was evaluated through comparison with optimal passive base isolation system and a passive base isolation system with optimized base shear. It is concluded that the adaptive base isolation system with proposed Lyapunov-based semi-active control surpasses the performance of other two passive systems in protecting the civil structures under seismic events.

Study about sacral base X-ray of Barge (Barge의 천골 기저부 X-ray에 대한 연구)

  • Min, Young-Kwang
    • The Journal of Churna Manual Medicine for Spine and Nerves
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    • v.6 no.1
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    • pp.19-26
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    • 2011
  • Objectives : The purpose of this study is to research the necessity of sacral base X-ray that Barge insisted. Methods : I have done a comparative analysis in side of short leg and side of sacral inferior with sacral base X-ray and pelvis A-P Xray pictures of 42 patients with lower back pain from December 1, 2010 to March 31, 2011. Results : Even though most of the subjects in study were male, 36 people had plateau of sacral base and 29 people had symmetry in sacral base X-ray. There was no statistical significance in the side of short leg and side of sacral base inferior in Sacral base X-ray, but there was a statistical significance in pelvis A-P x-ray. 22 people had same side of short leg and side of sacral base inferior in sacral base X-ray and pelvis A-P X-ray and 14 people didn't. 29 people had same side of sacral base inferior in sacral base X-ray and pelvis A-P X-ray and 13 people didn't. Conclusions : According to the result of the study, sacral base X-ray is necessary for correct sacral base inferior analysis.

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Base Metal's Price Hike and Chinese Economic Growth (Base Metal 가격상승과 중국의 경제성장)

  • Lee, Hyun-Bock
    • Economic and Environmental Geology
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    • v.43 no.5
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    • pp.523-528
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    • 2010
  • With the financial crisis from USA had negative impacts on the real economy, base metals price on LME was downward in 4 quarter of 2008. Following the deepest global downturn in recent history, economic growth solidified and broadened to advanced countries and simultaneously the price of base metal on LME showed a rising curve over 2009. There are three factors supported an upward tendency of base metal's price. The First factor is the US economy recovery, the second factor is the weak dollar, the third factor is the chinese base metal demand. Among the factors, the last one is a major factor. Therefore, this study analyze the factor of the movement of price of base metal with linear regression analysis. The result of analysis show that the chinese GDP growth has effect on the recent upward base metal price. Despite the result, the upward movement is difficult to be sustained without the full recovery of advanced economies.

Rotational behavior of exposed column bases with different base plate thickness

  • Cui, Yao;Wang, Fengzhi;Li, Hao;Yamada, Satoshi
    • Steel and Composite Structures
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    • v.32 no.4
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    • pp.497-507
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    • 2019
  • Exposed column base connections are used in low- to mid-rise steel moment resisting frames. This paper is to investigate the effect of the base plate thickness on the exposed column base connection strength, stiffness, and energy dissipation. Five specimens with different base plate thickness were numerically modelled using ABAQUS software. The numerical model is able to reproduce the key characteristics of the experimental response. Based on the numerical analysis, the critical base plate thickness to identify the base plate and anchor rod yield mechanism is proposed. For the connection with base plate yield mechanism, the resisting moment is carried by the flexural bending of the base plate. Yield lines in the base plate on the tension side and compression side are illustrated, respectively. This type of connection exhibits a relatively large energy dissipation. For the connection with anchor rod yield mechanism, the moment is resisted through a combination of bearing stresses of concrete foundation on the compression side and tensile forces in the anchor rods on the tension side. This type of connection exhibits self-centering behavior and shows higher initial stiffness and bending strength. In addition, the methods to predict the moment resistance of the connection with different yield mechanisms are presented. And the evaluated moment resistances agree well with the values obtained from the FEM model.

Conformational Study of Y-Base in Yeast tRNA$^{phe}$

  • Moon, Myung-Jun;Jhon, Mu-Shik;Kang, Young-Kee
    • Bulletin of the Korean Chemical Society
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    • v.4 no.3
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    • pp.133-139
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    • 1983
  • To understand the importance of Y-base adjacent to the anticodon stabilizing codon-anticodon interaction, a study has been undertaken for the model compound involving the interaction between Y-base and anticodon as well as the participation of water molecule by calculating the conformational free energy using an empirical potential function. We restrict our analysis to sites directly associated with Y-base by varying only the backbone torsion angles of Y-base. The hydration and $Mg^{+2}$ binding effects on the conformational stability of Y-base are calculated and discussed. The free Y-base is proved to be less stable than the hydrated one. The free energy change due to the hydration of Y-base amounts to -119.5 kcal/mole, in which the conformational energy change is -142.4 kcal/mole and the configurational entropy change is -76.9 e. u. It is found that the water molecules bound to Y-base and $Mg^{+2}$ contribute to the conformation of Y-base dominantly.