• Molecules and Cells
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• v.44 no.8
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• pp.591-601
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• 2021

Cilia are highly specialized organelles that extend from the cell membrane and function as cellular signaling hubs. Thus, cilia formation and the trafficking of signaling molecules into cilia are essential cellular processes. TULP3 and Tubby (TUB) are members of the tubby-like protein (TULP) family that regulate the ciliary trafficking of G-protein coupled receptors, but the functions of the remaining TULPs (i.e., TULP1 and TULP2) remain unclear. Herein, we explore whether these four structurally similar TULPs share a molecular function in ciliary protein trafficking. We found that TULP3 and TUB, but not TULP1 or TULP2, can rescue the defective cilia formation observed in TULP3-knockout (KO) hTERT RPE-1 cells. TULP3 and TUB also fully rescue the defective ciliary localization of ARL13B, INPP5E, and GPR161 in TULP3 KO RPE-1 cells, while TULP1 and TULP2 only mediate partial rescues. Furthermore, loss of TULP3 results in abnormal IFT140 localization, which can be fully rescued by TUB and partially rescued by TULP1 and TULP2. TUB's capacity for binding IFT-A is essential for its role in cilia formation and ciliary protein trafficking in RPE-1 cells, whereas its capacity for PIP₂ binding is required for proper cilia length and IFT140 localization. Finally, chimeric TULP1 containing the IFT-A binding domain of TULP3 fully rescues ciliary protein trafficking, but not cilia formation. Together, these two TULP domains play distinct roles in ciliary protein trafficking but are insufficient for cilia formation in RPE-1 cells. In addition, TULP1 and TULP2 play other unknown molecular roles that should be addressed in the future.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2000.06a
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• pp.57-81
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• 2000

Universal AIS technology is effective and could enhance navigational safety -The AIS provides and improved method of vessel traffic surveillance -Complement to radar in collision avoidance -Invaluable in Search And Rescue operations -Reduce voice communications -Effective Fleet management

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.5
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• pp.413-418
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• 2016

Recently, a mega project such as Korea-China or Korea-Japan undersea tunnel project has been emerged for detail discussion and the interest in undersea tunnel is on the rise. More severe damage by train fire is expected in undersea tunnel comparing to ground tunnel and thus the study on more efficient fire extinguishing system, besides existing disaster prevention design is underway. To that end, a full-scale fire tests using CAF fire extinguishing system which has been developed by modifying traditional foam fire extinguishing system for fire suppression at rescue station in timely manner were conducted over 7 times. The test was conducted after setting the rescue station in virtual tunnel with a car of KTX. As a result of using compressed air foam directly to the fire source, 30 liter of Heptane combustibles was extinguished within 1 minutes. Applicability of compressed air foam to train fire at rescue station in undersea tunnel was has been proven and further study is considered required while changing the nozzle angle and location so as to achieve quick and easy extinguishing goal, making use of the advantage of CAF, as well as to reduce the fire water and chemicals required.

• Journal of the Society of Disaster Information
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• v.13 no.3
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• pp.358-365
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• 2017

As the damage caused by disasters increases rapidly around the world, it is necessary to develop the technology for equipment to reduce human injury. Therefore in the support of fire safety and 119 rescue and rescue technology research and development project, in the "Development of a power assist device for a fireman to rescue humans(2015 ~ 2018)" for life saving restoration, we are developing equipment that satisfies the lifting performance considering the disaster environment and the disaster response scenario(Amount of load over 100 kg, height of over 1 m, height over middle 60 cm, speed over 0.2 m/s). In this study, we propose a lifting performance and environmental test method to evaluate the usefulness of the power-assisted device and analyze and verify detailed specifications of the device through dynamics analysis of the lifting performance test. This study suggests that the proposed test method can be applied practically to evaluate whether a stable performance of a power-assisted device is achieved.

• The KIPS Transactions:PartD
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• v.16D no.2
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• pp.249-256
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• 2009

This paper introduces an efficient USN (ubiquitous sensor network) for monitoring blind areas in a skiing resort, developed as a part of u-Sport showcase project of Gangwon Province. Blind areas of a skiing resort are dangerous and/or steep areas located aroud ski slopes, which are rarely traveled and not easily seen by a ski patrol. If an accident occurs in such a blind area, the main control center of the sking resort can hardly recognize the accident and provide first aid and rescue services promptly. The blind area monitoring system proposed in this paper monitors a blind area of a skiing resort using five battery-powered sensor nodes each of which has an image sensor on it and wirelessly transmits images around the blind area to the main control center on a regular basis, therebly allowing real-time monitoring of the blind area and prompt rescue services in case of accidents. Additionally, the monitoring system provides an emergency button which skiers injured in the blind area can push. If the button is pushed, an image around the button and an alarm signal are transmitted to the main control center and therefore the main control center can take prompt actions for rescuing the injured skiers.

• Korean Security Journal
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• no.34
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• pp.7-32
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• 2013

The idea of this study was derived from awareness of local governments and police's limitation on attempts to 'creating safe park'. The purpose of this study is to examine current political measures of preventing various types of possible crimes in the park and the limitation of those policies. Furthermore, this study aims to suggest possible explanations to utilize Private Security Sector for the effective and continuous way of managing park safety by considering legal and practical solutions and its expectations. The methods of analysis used in this study are, first, literature review of current park safety management policies. Second, this article examined implications of strategies of those policies throughout the case study of the USA's park safety policy. Third, this study suggested plans of action and role of Private Security Sector to improve park safety. The results present several arguments for the park safety. First, legislation of mandatory crime preventing programme in the early stages of designing park is required. Introducing the 'park special judicial police system' to the major parks for a immediate response to the crime can be one of suggestions. Moreover, proactive police response systems, such as one of the Seoul Metropolitan Police's policies- 'returning safe parks to a citizen' are required. Second, the case study of the USA regarding park safety confirmed that major parks in the USA have rigorous and detailed park regulations. It also showed that those parks take not only preventing measures, but also follow-up measures against crimes. Third, the results suggest creating human resources by contracting out Park Managers and Private Security Sector that have specialized experiences and techniques to prevent crimes and public disorders. Overall in this study, increased citizen's satisfaction level, control of continuous and systematic crimes, the spread of joint-production of public safety, and increased fields of the Private Security Sector are expected from the findings.