• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.2 s.33
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• pp.116-131
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• 2007

황기건중탕은 보비익기(補裨益氣) 및 거습열(祛濕熱)하는 효능(效能)으로 신체(身體)의 허약(虛弱)을 개선하며 염증(炎症)을 유발할 수 있는 외사(外邪)의 침입을 방어하여 인체의 면역기능(免疫機能)을 강화하는 처방으로 면역관련 세포중 하나인 microglial cell를 대상으로 면역세포에 황기건중탕이 어떠한 효능을 발휘하는 지를 살펴보았다. 물로 전탕(煎湯)한 황기건중탕을 여과한 후 실험한 결과 BV2 microglial cells에서 LPS로 자극하여 염증을 유발하는 주요 물질인 NO의 분비를 세포독성 없이 억제하였다. 또한NO를 생성하는 효소인 Cox-2의 발현도 감소시켰다. 그리고 기타 염증전구 물질들이 $TNF-{\alpha}$, $IL-1{\beta}$, IL-12도 황기건중탕의 용량이 증가함에 따라 의존적으로 감소함을 알 수 있었다. 이러한 결과를 보아 황기건중탕은 면역관련세포인 microglial cell에서 염증 관련 인자들의 분비 및 생성을 억제를 통하여 면역관련 상태를 개선시키는 것으로 사료된다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.1
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• pp.65-80
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• 2016

Objective : The purpose of this study is to report the hair regrowth effect of Gagamyeonryunggobon-dan on ICR mice from measuring the change of diverse factors.Methods : Gagamyeonryunggobon-dan was treated by oral administration with 2.5㎎/㎏/day amount for 3 weeks per mouse everyday. Hair regrowth was estimated by change of morphology, angiogenesis, hair follicle activation. The change of morphology was observed with external, internal change and sebaceous gland. Angiogenesis was estimated by image analysis, capillary distribution and angiogenic chemokine(MIP-2). Hair follicle activation was estimated by PCNA, IGF-2 and serotonin.Results : 1. Gagamyeonryunggobon-dan treated group had more and thicker hairs than the group not treated. Especially well developed sebaceous glands were seen in dermis of treated group. 2. Gagamyeonryunggobon-dan treated group had more capillaries near hair follicles of subcutaneous layer and more 2019% MIP-2 positive activity than the group not treated. 3. Gagamyeonryunggobon-dan treated group increased positive activity up to 596% in PCNA, 187% in IGF-2 and 547% in serotonin more than the group not treated.Conclusion : These results shows that Gagamyeonryunggobon-dan have the hair regrowth effect through verifying change of morphology, angiogenesis, chemokines. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.2
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• pp.1-9
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• 2013

Background : According to the rising cases of clinical researches with Traditional Korean Medicine for persistent allergic rhinitis patients, the need for developing and applying Pattern diagnosis instrument has been increasing. Objective : This study was done to investigate and pragmatize the Pattern diagnosis instrument for persistent allergic rhinitis patients launched by KFDA in 2008. Methods : Data was collected by structured survey papers from Korean Medicine doctors participate in the Conference of The Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology Society in October 2012. We investigated their representative Patterns(변증) of every questions and used the mean results for assuming agreement rates. The importance order of 8 symptom domains for considering Pattern diagnostic steps were also asked and analyzed for inducing importance rates. Finally based on above two results, we developed weight points of each questions by multiplying agrement percents with importance rates. Results : 50 Korean medicine doctors described the informed consent and survey papers. Response agreement rates of each questions of Pattern diagnosis instruments were analyzed and described in Table 2. Comparing the survey results with diagnostic references, matched percent of 肺胃熱 was the 87.9%, 肺氣虛寒 was 62.5%, 肺脾氣虛 was 62.5% and 腎元虧虛 was 50%. Mean importance rates of rhinorrhea was 7.28, otoscope diagnosis 5.12, obstruction 5.04, sneeze 4.82, symptom duration 4.63, other body condition 3.54, tongue diagnosis 3.02, nasal pruritus 2.86, accordingly. Final importance rates of each questions were assumed, and the range of them was from 1.60 to 4.72, which were listed in Table 5. Conclusion : These results might provide the rational backgrounds and practical methods for developing and utilizing methods of Pattern diagnosis questionnaire for perennial allergic rhinitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.270-278
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• 2005

Alopecia is an increasing disease recently. Alopecia has social and psychological influence on the alopecia patients. But there is no perfect treatment of alopecia. Authors performed clinical study to evaluate the therapeutic effects of herbal soap Sangmogen in patients with alopecia. Twenty patients with alopecia were included in this study. The patients shampooed with herbal soap Sangmogen everyday. Efficacy was determined by investigating counts of hair, terminal hair, vellus hair, hair follicle, hair pull test, erythema, scale and fissure. After a experiment, self-assessment was checked. As the result of the study, we found that a significant effect was observed. So we concluded that herbal soap Sangmogen has a clinical effect on the alopecia.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.250-255
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• 2007

Molluscum contagiosum(MC) is a viral disorder of the skin and mucous membranes characterized by decrete single or multiple, flesh-colored papules. There was the 6 years old woman who suffered from umbilicated papules and pruritis of back. First, Her mother choiced western medicine, and was treatded with topical(ointment applicatoin) and surgical(curettage) method. Despite of western medical treatment during 3 months, there was not recovery of symptoms. So, she visited the Dept. of Opthalmology & Otorhinolaryngology & Dermatology, College of Oriental Medicine, Kyungwon University for oriental medical treatment. The oriental medical treatment reduced the symptoms of the patient remarkably during 8weeks. So we report the healing process and result of this patient in this study. There is few report that treat MC with oriental medical method. If more clinical trials like this are proved to be effective, we can expect that oriental medical treatment will be a good method in MC.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.181-190
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• 2007

Objective : The purpose of this study is to understand preferences of patients who had visited the Dept. of Ophthalmology Otolaryngology & Dermatology Method : We conducted questionnaire survey on the patients who had visited the Dept. of Ophthalmology, Otolaryngology & Dermatology Hospital of Dong Shin University from March to September, 2007. Result : The result were as follows. 1. Distribution of sex: male 41 % female 59% 2. The age distribution of patients showed highest in 30-39 years(23%), followed by 20-29 years, 40-49 years in order. 3. The classification of patients according to disease: Skin disease (38%), Nose (23%), Face (10%), Eye (9%), Throat (8%), Ear (7%) 4. Other offices patients visited before coming to this clinic: Local clinic (41%). Hospital (18%), Oriental clinic or hospital (5%), None (22%) 5. The length of time the patient has had the disease: 2years (26%), more than 3years (15%), 2-4weeks (13%), 6months (11%), 1year (10%) in order 6. The expected length of treatment: 1week (21%), 2week (12%), 1month (21%) 7. 26% expected about 100,000 won as medical expenses. 8. 88% of the patients are willing to have a check-up when it needed and 40% expected about 50,000 won as check-up expenses. 9. 52% of the patients are not willing to withstand pain, and would rather heal slowly. 10. 69% of the patients said that treatment would be affected by company(44%), school(19%) and business(16%). 11. 73% of the respondants are positive about night-time treatment and 92% is positeve about making an appointment for the treatment. Conclusion : Through the research, we could understand preferences of patients who had visited Dept. of Ophthalmology, Otolaryngology & Dermatology

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.1
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• pp.145-154
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• 2006

A man visited the Dept. of Oriental Medical Ophthalmology & Otolaryngology & Dermatology Hospital, Dong-eui University with the dermatitis exfoliativa by drug eruption. He was suffering from the whole body itching, rubefaction, edema, scale and the feeling a chill. The drug eruption's cause assumed antibiotics. We treated a patient with Oriental Medicines(the herbal medicine of internal use and external use), aroma oils and acupuncture. After four days or so, the itching, rubefaction, edema of the skin was recovered remarkably. After one weeks or so, the scale of the skin disease was improved remarkably, we think that these are good cases to treat with Oriental Medicine, Yeongyopaedog-san. We suggest that Oriental Herb medicines have an effect with the dermatitis exfoliativa and the drug eruption.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.3
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• pp.40-55
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• 2014

Objectives : The purpose of this study is to confirm the effects of external applications(CLANCHE SM A Clinic) containing herbal extracts on patient with atopic dermatitis. Methods : A total of 24 patients who visited Semyung Oriental Medical Center from January 15th, 2014 to February 20th, 2014 were included in the study. In this study, the patients were treated with external applications(CLANCHE SM A Clinic) containing herbal extracts. For 4 weeks of gross examination and instrumental assesment were made before and after the study. Results : 1. In the primary endpoint, SCORAD index showed a statistically significant decline. 2. In the secondary endpoint, index of skin hydration and index of TEWL showed statistical significance. 3. In the secondary endpoint, index of skin pH showed no statistically significant result. 4. To evaluate the safety of the products for the human body, vital sign check were conducted and showed no statistically significant result. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. 5. In global assesment of efficacy, both experimenter and subjects evaluated external applications were effective. Conclusions : According to the above experiments, it is suggested that external applications(CLANCHE SM A Clinic) containing herbal extracts should be effective for the atopic dermatitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.1
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• pp.81-92
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• 2016

Objectives : The purpose of this study is to confirm the moisturizing effects of Herbal cosmetics containing Sinhyotakrisan(SHTL) extracts on facial skin.Methods : A total of 23 women who visited Semyung Oriental Medical Center from January 10th, 2014 to Feburary 12th, 2014 were included in the study. Provided both cosmetics containing Sinhyotakrisan extract and control products, all the subjects applied one of them to half face and another to remaining half for 4 weeks. We observed change of skin hydration, skin elasticity, skin scale in 0 week, 2 weeks, and 4weeks. Statistical anyalysis was performed by using SPSS, and statistical significance was achieved if the proability was less than 5%(p<0.05).Results : 1. After 4 weeks of using SHTL, skin hydration showed a statistically significant increase compared with using control product(p=0.011). And improvement rate also did(p=0.031). 2. After 4 weeks of using SHTL, skin elasticity showed statistically significant increase compared with using control product(p=0.025). But improvement rate didn't showed statistically significant increase(p=0.068). 3. After 4 weeks of using SHTL, skin scale showed a statistically significant decrease compared with using control product(p=0.029). And improvement rate also did(p=0.047).Conclusions : Considering the above results, herbal cosmetics containing Sinhyotakrisan extracts were effective for skin moisturizing.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.3
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• pp.1-19
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• 2017

Objectives : This study aimed to validate the effect of herbal medicine intervention to relieve the symptoms of psoriasis using systematic review and meta-analysis and provide the newest reason of effectiveness of Korean medicine to psoriasis. Methods : Data were collected through electronic database including Pubmed, Cochrane CENTRAL, NDSL OASIS, Koreantk. Two experts assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool after searching, reviewing and selecting papers. Data were analyzed using Review Manager(RevMan) 5.3 and Comprehensive Meta Analysis 2.0. Results : Total number of selected trials was 16 randomized controlled trials. This study evaluated the risk of bias and effectiveness of herbal medicine to psoriasis. There were high frequency uncertain in selection bias, performance bias and detection bias. In this meta-analysis, Korean medicine treatment was more effective than western medicine (ES:0.507, 95%CI:0.147-0.867) and placebo (ES:0.955, 95%CI:0.598-1.312). Conclusions : Herbal medicine intervention can be an effective for treatment in psoriasis. But enhancing levels of evidence, we must try to accumulate clinical researches of herbal medicine to psoriasis in Korea.