• Journal of East-West Nursing Research
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• v.19 no.2
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• pp.195-200
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• 2013

Practice evidenced by reliable knowledge is essential for professionals and practical studies. Because nursing is a human science and practical science, theory and knowledge development is an indispensable task to improve nursing. Nursing is a very special paradigm not exactly correlated to Western medicine and Oriental medicine. However, nursing was influenced by on Western medicine at the beginning, and most nursing theories were established western philosophies. Caring is the essence of nursing. To provide qualitative care which satisfies clients, it is required to respect cultures of the clients. Western and Eastern approaches of thinking are coexisting in Korea no, so the needs for developing a nursing model, East-West Nursing, which blends two approaches are increasing. In this paper, concepts of the East-West Nursing, differences between Oriental and Western medicines, and comparison of nursing metaparadigm in prospects from and Western Philosophies were briefly covered to define the East-West Nursing. Strategies and directions to develop the East-West Nursing were also discussed.

• Journal of Environmental Science International
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• v.10 no.3
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• pp.179-185
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• 2001

To investigate daily variations of water mass distribution in the west and the east parts of Jeju Island, we implemented observations from June 20 to 22, 1997. (The results are as follows : Temperatures in the east and the west were similar in the surface, but $15.02^{\circ}C$ and $13.8^{\circ}C$ in the bottom, respectively.) In the east and west, the surface and the deep salinities are 33.81, 33.34 and 34.33, 34.11 respectively. The east shows higher temperature and salinity than the west. The distributions of nitrate in the east and the west were very similar in the surface regions.(In the deep regions, however, the east shows higher than the west.) The east shows higher phosphates than the west both in surface and deep regions. The silicate had similar distributions to nitrate. Chlorophyll-a of the west was twice higher than that of the east. The daily variations of temperature and salinity were largest at 30m depth, and pH was not much changed in the depth and the pH in day was higher than that at night. The variations of nutrients were much changed in the depth, and nitrate and phosphate at night were higher than those in day. Daily variations of silicate, however, was not much changed in the observation times. Ratio of N/P in the east and the west were 13 and 16, respectively, so that the west was higher than the east. However the ratios were two times higher both in the east and the west in day, when planktons are more active than at night. Si/P ratio showed little different between day and night and between surface and deep regions. The correlation of nitrogen and phosphorus was high (plus relation), and the correlation of AOU, nitrogen and phosphorus was high(plus relation) in the east, however, not high in the west.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.144.1-144.1
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• 2000

• Proceedings of the KSCN Conference
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• 2001.05a
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• pp.459.2-460
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• 2001

• Biomolecules & Therapeutics
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• v.22 no.1
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• pp.17-26
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• 2014

${\alpha}$-Asarone exhibits a number of pharmacological actions including neuroprotective, anti-oxidative, anticonvulsive, and cognitive enhancing action. The present study investigated the effects of ${\alpha}$-asarone on pro-inflammatory cytokines mRNA, microglial activation, and neuronal damage in the hippocampus and on learning and memory deficits in systemic lipopolysaccharide (LPS)-treated C57BL/6 mice. Varying doses of ${\alpha}$-asarone was orally administered (7.5, 15, or 30 mg/kg) once a day for 3 days before the LPS (3 mg/kg) injection. ${\alpha}$-Asarone significantly reduced TNF-${\alpha}$ and IL-$1{\beta}$ mRNA at 4 and 24 hours after the LPS injection at dose of 30 mg/kg. At 24 hours after the LPS injection, the loss of CA1 neurons, the increase of TUNEL-labeled cells, and the up-regulation of BACE1 expression in the hippocampus were attenuated by 30 mg/kg of ${\alpha}$-asarone treatment. ${\alpha}$-Asarone significantly reduced Iba1 protein expression in the hippocampal tissue at a dose of 30 mg/kg. ${\alpha}$-Asarone did not reduce the number of Iba1-expressing microglia on immunohistochemistry but the average cell size and percentage areas of Iba1-expressing microglia in the hippocampus were significantly decreased by 30 mg/kg of ${\alpha}$-asarone treatment. In the Morris water maze test, ${\alpha}$-asarone significantly prolonged the swimming time spent in the target and peri-target zones. ${\alpha}$-Asarone also significantly increased the number of target heading and memory score in the Morris water maze. The results suggest that inhibition of pro-inflammatory cytokines and microglial activation in the hippocampus by ${\alpha}$-asarone may be one of the mechanisms for the ${\alpha}$-asarone-mediated ameliorating effect on memory deficits.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.68-73
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• 2009

Type 2 diabetes mellitus (T2DM) is a progressive disorder caused by a combination of insulin resistance and 𝛽 cell dysfunction. Sogal(消渴) is a traditional Korean medical term referring to a condition pertaining 3 major symptoms - thirst, polyphasia, polyuria. Sogal has been reported to have similar characteristics with DM. This case report demonstrates a patient with T2DM complaining of typical Sogal symptoms. We diagnosed him as So-yang person Sogal and treated him with acupuncture and herbal medicine.

• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.76-84
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• 2005

Objective: The purpose of this study was to examine the protective efficacy of GHT on alcoholic liver injury. Methods: We measured the rate of alcohol oxidation, serum level of liver enzyme, lipid peroxidation level in liver tissue, and inflammatory related cytokine expressions in the liver. Results : GHT showed liver protective effects, lowered the levels of AST and LDH in serum and inhibited lipid peroxidation in liver tissue, and enhanced alcohol oxidation. GHT treatment up-regulated IL-10 in the liver, whereas it down­regulated $TNF-\alpha,\;TGF-\beta$, and Fas ligand. Conclusion : From these results, GHT is presumed to work in the liver in protective roles not through the pathway of alcohol metabolism but mainly by anti-inflammation activity in our model.

• The Journal of Korean Medicine
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• v.25 no.4
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• pp.161-170
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• 2004

Objective : The purpose of this study was to investigate the effects of Armillaria mellea extract (AME) on immune modulation focused on anti-cancer activity. Methods : To prove the effects of AME, we performed NO assay, NK cytotoxicity assay and RT-PCR of cytokine related with macrophage and NK cell activity. Results : AME increased NO production produced by macrophages in part. AME also enhanced the NK cell activities in destroying target cells (YAC-1 cells). AME up-regulated gene expression of IL-l, iNOS, TNF-a in RAW 264.7 cells and IL-l, IL-2, IFN-(equation omitted), TNF-a in splenocytes, respectively. Conclusion : From the above results, we assumed that AME is a potential drug for anti-cancer by activation of the macrophages and NK cells.

• Proceedings of the Korean Nutrition Society Conference
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• 2001.05a
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• pp.307.2-307
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• 2001

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.377.3-378
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• 2002

Eight compounds were isolated from the MeOH extracts of Erythrina senegalensis for HIV-1 protease inhibitors. Their structures were elucidated as eight isoflavonoids by spectroscopic analysis. These compounds showed dose dependent inhibitory activities on HIV-l protease with $IC_{50}$ values from 0.5 to 30.0 ${\mu}$M. (omitted)