• Journal of Korean Ophthalmic Optics Society
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• v.7 no.2
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• pp.79-87
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• 2002

To analyze the current status of contact-lens in domestic, we analyzed the data of "The Spectacles-wearing Rate Analysis in 1999 (Korea Gallup Research)", "Industry current status(Korea Medical Instruments Industrial cooperative}", "Export & Import current status (Korea Customs Service)", and finally reached the following conclusions. 1. The number of contact-lens wearers in domestic could be assumed 2.13 millions. 2. The size of contact lens market in domestic(on year 2000 basis) was about 25.3 billion Korean wons(\) in total ; 10.8 billion Korean wons on the basis of production unit price (Domestic Gross Production Amount-Export Amount : used the subtraction in math), 14.5 billion Korean wons on Import unit price basis. 3. According to the year 2001 data, the import amount of contact lens is 1.7 times greater than export amount of that. 4. The contact lens export status in year 2001 was Japan, Singapore, Taiwan, U.S.A, China, Hong Kong, Malaysia, Thai, - in order. Especially, the contact lens export of China has increased gradually every year since 1998, the first export year of contact lens. 5. The import status of contact lens was U.S.A, Japan, England, Indonesia, Argentina, Taiwan, Hong Kong, - in order. In addition, the consumption trend of contact lens consumers in domestic reflects that famous foreign contact lens brands were much preferred than lower price contact lens imported from several developing countries.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.7
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• pp.952-961
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• 2003

In the first part of the study, rates of estrus occurrence and success of A.I. service in the Thai-native and Friesian crossbred, and purebred Friesian cows fed in the National Dairy Training and Applied Research Institute in Chiang Mai, Thailand were traced monthly throughout a year. An electric fan and a water sprinkler cooled the stall for the purebred cows during the hot season (March-September). Both rates in pure Friesians were at their highest in the cold-dry season (October- February), but they decreased steadily during the hot-dry season (March-May) and were at their lowest in the hot-wet season (June-September). Seasonal change of a similar pattern was observed in the incidence of estrus, but not in the success rate of insemination in the crossbred cows. By the use of reproductive data, compiled in the same institute, on the 75 % cross- and purebred Friesian cows, and climatological data in Chiang Mai district, effects of ambient temperature and humidity on the reproductive traits of cows were examined by regression analysis in the second half of the study. Significant relationships in the crossbred, expressed by positive-linear and parabola regressions, were found between reproductive parameters such as days to the first estrus (DTFE), A.I. service (DTFAI), and conception, the number of A.I. services required for conception and some climatic factors. However, regarding this, no consistent or intelligible results were obtained in purebred cows, perhaps because electric fans and water sprinklers were used for this breed in the hot season. Among climatic factors examined, the minimum temperature (MINT) in early lactation affected reproductive activity most conspicuously. As the temperature during one or two months prior to the first estrus and A.I. service rose, DTFE and DTFAI steadily became longer, although, when MINT depleted below $17-18^{\circ}C$, the reproductive interval tended to be prolonged again on some occasions. The maximum temperature also affected DTFE and DTFAI, but only in limited conditions. The effect of humidity was not clear, although the inverse relationship between DTFE and minimum humidity during 2 months before the first estrus in the crossbred seemed to be significant. Failure to detect any definite effect of climate on the reproductive traits of pure Friesians seemed to indicate that forced ventilation by electric fans and water sprinklers were effective enough to protect the reproductive ability of this breed from the adverse effects of a hot climate.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.1
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• pp.73-81
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• 2011

Six male crossbred (Thai Native${\times}$Anglo Nubian) goats, with an average initial weight of $22{\pm}2\;kg$, were randomly assigned according to a $3{\times}2$ factorial arrangement in a $6{\times}6$ Latin square design with a 21-d period to evaluate the effect of feeding rubber seed kernel (RSK) and palm kernel cake (PKC) in combination on nutrient utilization, rumen fermentation characteristics, and nitrogen utilization. The dietary treatments were as follows: i) concentrate containing 0% RSK and 20% PKC ($T_1$), ii) 0% RSK and 30% PKC ($T_2$), iii) 20% RSK and 20% PKC ($T_3$), iv) 20% RSK and 30% PKC ($T_4$), v) 30% RSK and 20% PKC ($T_5$), and vi) 30% RSK and 30% PKC ($T_6$). During the experiment, signal hay was given on an ad libitum basis as the roughage. It was found that RSK levels and PKC levels had no interaction effects on feed intake, apparent digestibility, $NH_3$-N, blood metabolites, VFA concentrations, and nitrogen utilization, but there were interactions between RSK levels and PKC levels with respect to total DMI (kg/d) and total VFA concentrations, and goats receiving 30% RSK had lower values (p<0.05) than those receiving 0 and 20% RSK, respectively. Feeding different PKC levels did not affect (p>0.05) feed intake, digestibility, rumen fermentation patterns, blood metabolites, and nitrogen utilization. However, increasing RSK levels (>20%) resulted in a slightly lower daily DMI (% BW and g/kg $BW^{0.75}$), apparent digestibility (NDF and ADF), total N intake, and N excretion than in goats fed on 0 and 20% RSK. BUN, blood glucose, and propionate were variable among treatment and were highest in 0% RSK with the 20% PKC fed group having values which were higher than those in other groups. However, there were no differences (p>0.05) among treatments with respect to N retention, PD output, and microbial N supply. Based on this study, RSK levels up to 20% and PKC at 20-30% in concentrate could be efficiently utilized for goats fed on signal hay.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4597-4606
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• 2012

Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median $IC_{50}$ (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and $27.86{\mu}g/ml$, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4549-4553
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• 2012

This study was designed to investigate the frequency of CYP2D6 polymorphisms and evaluate the association between genetic polymorphisms of CYP2D6 and tamoxifen therapeutic outcome in Thai breast cancer patients. We recruited 48 breast cancer patients who received adjuvant tamoxifen for evaluating CYP2D6 genetic polymorphisms using microarray-based technology. Associations between genotypes-phenotypes and disease free survival were analyzed. Median follow up time was 5.6 years. The mean age of the subjects was 50 years. The 3 common allelic frequencies were 43.8% ($^*10$), 36.5 ($^*1$) and 10.4% ($^*2$) which are related to extensive metabolizer (EM) and intermediate metabolizer (IM) with 70.8% and 29.2 %, respectively. No association between CYP2D6 genotypes and DFS was demonstrated. Nevertheless, exploratory analysis showed statistically significant shorter DFS in the IM group of post-menopause patients (HR, 6.85; 95%CI, 1.48-31.69; P=0.005). Furthermore, we observed statistically significant shorter DFS of homozygous $CYP2D6^*10$ when compared with heterozygous CYP2D6*10 and other genotypes (P=0.005). $CYP2D6^*10$ was the most common genotype in our subjects. Post-menopause patients with homozygous $CYP2D6^*10$ and IM have shorter DFS. To confirm this relationship, larger samples and comprehensively designed trials in Thailand are required.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3653-3661
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• 2013

Along with rapid economic growth and enhanced agricultural productivity, particulate matter emissions in the northern cities of Thailand have been increasing for the past two decades. This trend is expected to continue in the coming decade. Emissions of particulate matter have brought about a series of public health concerns, particularly chronic respiratory diseases. It is well known that lung cancer incidence among northern Thai women is one of the highest in Asia (an annual age-adjusted incidence rate of 37.4 per 100,000). This fact has aroused serious concern among the public and the government and has drawn much attention and interest from the scientific community. To investigate the potential causes of this relatively high lung cancer incidence, this study employed Fourier transform infrared spectroscopy (FTIR) transmission spectroscopy to identify the chemical composition of the $PM_{2.5}$ collected using Quartz Fibre Filters (QFFs) coupled with MiniVol$^{TM}$ portable air samplers (Airmetrics). $PM_{2.5}$ samples collected in nine administrative provinces in northern Thailand before and after the "Haze Episode" in 2013 were categorised based on three-dimensional plots of a principal component analysis (PCA) with Varimax rotation. In addition, the incremental lifetime exposure to $PM_{2.5}$ of both genders was calculated, and the first derivative of the FTIR spectrum of individual samples is here discussed.

• Journal of Korean society of Dental Hygiene
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• v.2 no.1
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• pp.97-113
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• 2002

This research is an attempt to establish a basic material in discovering the subjective types of the dental coordinators occupational consciousness, utilizing the Q-Method Theory, which is capable of measuring the subjective nature of human being by scientific and systematic method. The characteristics of each type were analyzed so as to have the dental coordinator to possess the desirable understanding of the occupational view together for them to have self-confidence as a lifetime specialty occupation. Upon completion of the study, it was found that there are three types of subjective views pertaining to the occupational consciousness on the dental coordinator. The result on the analysis of the characteristics is as follows : Type 1 is the Taking Serious View on the Patient Service, which priority is placed on kindness and looking after any difficulties of the patient, namely, it is the type that puts the importance on the high level medical examination and treatment based on good service. Because of the kind service to the patient, those under this category considered their job satisfaction have been improved. It goes without saying that they were developing the services, which satisfy themselves, and it was confirmed that they thought that they should make things smooth for any development of problems that may arise between the patient and the dentist. Type 2 is the Taking Serious View on Career and Organizational Strength. This is a type that aims on the systematic nature of the internal job, namely, organizational strength itself viewed from the stand point thai either self-confident or work merit is proportional to experience. This type is to actively treat the problem and endeavor to solve the issue when dissatisfaction is held by the dental hospital system, which is either followed according to the work responsibility or by an organization having an appropriate system on remuneration, Type 3 is the Placing of Importance on the Overall Circumstances. This is the type that places importance on the overall now of the dental hospital, and it is the type, that most greatly recognizes the importance of the role of the dental coordinator. The dental coordinator should provide the sense of reliability to both the dentist and to the staff of the medical examination and treatment and should be able to adjust smoothly the overall now of the medical treatment. The dental coordinator is expected to be a medical service specialist, who is capable to solve the problems of the staff of the medical treatment intuitively and to adjust the relation between the employees. With the above result, it was found that although there was no mutual exclusiveness between the respective types, there are particular characteristics among each type. Therefore, this research has discovered and analyzed the subjective view types relative to the occupational consciousness of the dental coordinator for the proper understanding on the characteristics of each type to enable the dental sanitary students and the graduates of the Dental Sanitary Department, who are aspiring to become dental coordinator, as the basic guide material to be actively utilized.

• Journal of Korean society of Dental Hygiene
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• v.2 no.1
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• pp.85-95
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• 2002

The purpose of this study was to examine dental hygienists' knowledge of implant operation, which is recently emerging as one of the important medical services in the dental treatment sector. It's ultimately intended to serve as a basis for the preparation of more effective, appropriate implant-education programs for dental hygienists and to help them, who take a crucial part in implant operation, provide better dental services to patients who are in need of implant operation. The subjects in this study were 368 selected dental hygienists who were working in the dental institutions in the region of Taegu. The results of this study were as below: 1. The largest number of the dental hygienists investigated, 34.1%, were at age 25 to 27. The second most common age was 24 and under, and the third most common age group was 28 to 30. For educational level, most of them, 91.0%, were junior-college graduates, and 9.0% were being in or graduated from four-year-course university. Concerning career, 52.7%, the greatest percentage, had worked for one to three years, and 41.3% had a four-year or higher career. 812%, most of them, were working in dental clinics, and 18.3% were serving in dental hospital or general hospital. 2. Many of the dental institutions were providing implant operation services, as the dental institutions where 64.9% of the subjects were working conducted implant operation. In relation to the necessity of implant operation, the dominant opinion, 73.0%, was thai it's needed to make oral slate healthier. So there was a strong tendency to ad mit implant as one of the necessary treatments in the dental treatment sector. 3. Their collective mean implant knowledge got $57.02{\pm}14.11$. And the collective average of 21 items was $2.7153{\pm}0.6720$ on the basis of 5 points, which was below the average(3 points of Likert scale). This meant that the dental hygienists didn't have a good knowledge or understanding of implant. When it's taken into account what role should be performed by dental hygienists, their implant knowledge should be increased. 4. As a result of examining the effect of the general characteristics on their implant knowledge, the educational level(t=-3.481, P=0.001) and the type of dental institution where they were working(F=16.476, P=0.001) made a significant difference. 5. Their implant knowledge was significantly different according to whether or not the dental institution they were serving conducted implant operation (t=7.199, P=0.001). And, whether or not they agreed to the necessity of implant operation also generated a significant difference to their implant knowledge(F=8.610, P=0.000).

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.8
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• pp.1111-1119
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• 2016

Mao seed is a by-product of the wine and juice industry, which could be used in animal nutrition. The current study was designed to determine the effect of supplementation of mao (Antidesma thwaitesianum Muell. Arg.) seed meal (MOSM) containing condensed tannins (CT) on rumen fermentation, nitrogen (N) utilization and microbial protein synthesis in goats. Four crossbred (Thai Native${\times}$Anglo Nubian) goats with initial body weight (BW) $20{\pm}2kg$ were randomly assigned to a $4{\times}4$ Latin square design. The four dietary treatments were MOSM supplementation at 0%, 0.8%, 1.6%, and 2.4% of total dry matter (DM) intake, respectively. During the experimental periods, all goats were fed a diet containing roughage to concentrate ratio of 60:40 at 3.0% BW/d and pangola grass hay was used as a roughage source. Results showed that supplementation with MOSM did not affect feed intake, nutrient intakes and apparent nutrient digestibility (p>0.05). In addition, ruminal pH and ammonia nitrogen ($NH_3$-N) were not influenced by MOSM supplementation, whilst blood urea nitrogen was decreased quadraticly (p<0.05) in goats supplemented with MOSM at 2.4% of total DM intake. Propionate was increased linearly with MOSM supplementation, whereas acetate and butyrate were remained the same. Moreover, estimated ruminal methane ($CH_4$) was decreased linearly (p<0.05) when goats were fed with MOSM at 1.6% and 2.4% of total DM intake. Numbers of bacteria and protozoa were similar among treatments (p>0.05). There were linear decreases in urinary N (p<0.01) and total N excretion (p<0.01) by MOSM supplementation. Furthermore, N retention was increased linearly (p<0.05) when goats were fed with MOSM supplementation at 1.6% and 2.4% of total DM intake. Microbial protein synthesis were not significantly different among treatments (p>0.05). From the current study, it can be concluded that supplementation of MOSM at 1.6% to 2.4% of total DM intake can be used to modify ruminal fermentation, especially propionate and N utilization in goats, without affecting the nutrient digestibility, microbial populations and microbial protein synthesis.

• Journal of Korean society of Dental Hygiene
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• v.4 no.2
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• pp.193-207
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• 2004

The aims of the study are as following : First, define and clarify the role and function of the dental hygienist. Second, based on thai definition, present an improved dental hygienist curriculum, improving their special competence. This study seeks to present a way for promoting role of dental hygienists as independent specialists, rather than as auxiliaries, contributing to better dental service in the process. The research was pursued by surveying by questionnaire those directly related to dental hygiene. They are 58 professors of dental hygiene, 164 dentists, 253 dental hygienists and 496 dental hygiene students, selected by the method of simple random sampling. Due to the small size of the sample, professors' group was analysed only through frequency and probabilities. For groups with larger samples(dentists, dental hygienists, dental hygiene students), methods of chi square(${\chi}^2$) tests, frequency analysis and one-way ANOVA were used in their analysis. Conclusions of the study are as following : First, role and function of the dental hygienist was defined and clarified. According to the analysis of the survey, main role of the dental hygienists as perceived by 62.9% of dentists was supporting treatments and managing patients and facility. This perception by dentists differs significantly to perception of other groups, which saw main role of dental hygienists as preventive dental treatment and dental hygiene education. Also, only 20.2% of dental hygienists perceived patients and facility management as their main role. This divergence of perception between groups weakens speciality competence of dental hygienists. To strengthen dental hygienists' speciality competence, preventive dental treatment and dental hygiene education must be defined as main role of dental hygienists. Furthermore, role of dental hygienists can be categorized into cooperative and auxiliary role. Second, in order to strengthen speciality competence of dental hygienists, their education must be augmented with curriculum emphasizing cooperative role. Specifically, courses on preventive dental treatment, dental hygiene education and dental X-ray photography must become compulsory, as well as becoming more comprehensive and organized. Also, training in schools and hospitals must be focused on those subjects. In addition, courses concerning auxiliary role must be incorporated into optional courses and more pedagogical courses are needed to widen students' career choices. Third, practical relevance of national dental hygienist certification examination must be heightened. In the survey, all groups gave negative response to questions concerning practical relevance of national dental hygienist certification test. Specifically, contents of the tests must be changed to test participants' competence in the cooperative area. Also, the test itself must be strengthened by adding practical examination to the certification scheme, as well as having more difficult examinations.