• Archives of Pharmacal Research
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• v.12 no.1
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• pp.48-51
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• 1989

A new polyacetylene compound with cytotoxic activity against L1210 cells having diyne-ene and epoxy moiety, named panaxyne epoxide, was isolated from Panax ginseng C.A. Meyer. The chemical structure of the polyacetylene was determined to be tetradeca-13-ene-1,3-diyne-6,7-epoxide by UV, IR, $^1H-NMR,\;^{l3}$C-NMR and mass spectra.

• Korean Journal of Pharmacognosy
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• v.20 no.2
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• pp.71-75
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• 1989

A new polyyne, panaxyne, was isolated from the Korean red ginseng. The structure was determined as tetradeca-13-ene-1, 3-diyne-6, 7-diol by comparison of spectral data. The $ED_{50}\;value$ of panaxyne as cytotoxicity against L1210 cell was $11.0\;{\mu}g/ml$. The lower cytotoxic activity of the substance relative to other ginseng polyynes is presumably due to lack of the essential structural part of hept-1-en-4, 6-diyne-3-ol.