• Proceedings of the PSK Conference
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• 2002.10a
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• pp.344.3-345
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• 2002

For the development of novel anticancer agent. we have designed. synthesized. and tested novel 4-phenyl-1(N)-arylsulfonylimidazolidinones. As a result. much more potent cytotoxicities of these compounds against the various cancer cell lines than those of doxorubicin were demonstrated. Elaboration on aryl motif on sulfonyl moiety led us to find highly potent 4-phenyl-1-(N-acylindoline-5-sulfonyl)imidazolidinones. Among them, 4-phenyl-l- ［N-(p-aminobenzoyl)indoline-5-sulfonyl］imidazolidinone (PA) was proved to have good pharmacological profile. (omitted)

• YAKHAK HOEJI
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• v.46 no.1
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• pp.24-29
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• 2002

Enoyl-Acyl Carrier Protein Reductase (Fabl) of bacteria is hem as an important target for new antibacterial drugs and plays a determinant role in completing cycles of elongation in type-H fatty acid synthase system. In this study, a fabI gene from Staphylococcus aureus 6538p cloned in pET-l4b vector and FabI protein was over-produced in Escherichaia coli BL2l (DE3). $NH_2$-terminal His-tagged FabI protein was purified by nickel-nitrilotriacetic acid (Ni-NTA) metalaffinity chromatography Purified 6xHis-tagged FabI showed a catalytic activity on tram - 2 - octenoyl - N -acethlcysteamine by utilizing NADPH as a cofactor. For the discovery of new FabI inhibitors from chemical libraries, a target-oriented screening system using a 96-well plate was developed. About 10,000 chemical libraries from Korea Chemical Bank wore tested in this screening system, and 26 chemicals (0.25%) among them showed an inhibitory activity against FabI enzyme. This result showed that a new screening system can be used for the discovery of new FabI inhibitors.

• Journal of the Korean Society for Railway
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• v.3 no.4
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• pp.194-202
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• 2000

Fatigue behavior of shear joints between the combined reinforced concrete(RC) and the reinforced steel fiber concrete(SFRC) specimens has been experimentally investigated. Experimental parameters used are the amount of steel fiber and the type of shear joint. Six specimens have been tested under static load, and eight specimens have been subjected to the fatigue load in a range of 50 % and 5 % of the ultimate static load. The purpose of this research is to propose an empirical formula for fatigue shear behavior of the combined RC and SFRC structures on the basis of experimental result. It can be observed from experimental results that addition of steel fibers to concrete specimen increases the static ultimate load by approximately 25 %, enhances the fatigue behavior, and also reduces vertical and lateral displacements at the shear joint for a given load cycle after the occurrence of first crack.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.1446-1448
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• 2004

Communication line used in the rail-road have different use from subscriber line in the public telecommunication. But, when an existing communication equipment is replaced, by applying new high-speed transfer technology, we can anticipate the increase of transmission rate and decrease of waiting time according to high-speed of communication line. cost reduction of infrastructure construction and maintenance/repair according to centralization of communication line and transmission equipment. In this study, the transmission scheme of several xDSL(Digital Subscriber Line) modems were compared and analyzed. The way of applying xDSL modem to the metal cable which is used in the JR(Japan Railroad) is analyzed. In addition, the result tested in railroad communication line was reviewed.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.15 no.2
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• pp.152-158
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• 2003

Titration method is one of the widely used methods for the concentration measurement of absorbent ammonia/water. However, this method is inconvenient because the solution should be extracted for the measurement. Moreover, significant error can be introduced by the evaporation of ammonia during the sampling and measuring procedure. In this study a reliable in-line concentration measurement method was proposed. To prove the validity of the concept, a measuring apparatus was designed, built, and tested with water. It is found that the location of flow inlet and exit is important in the measurement accuracy. The flow inlet and exit located in the middle of the test cell showed the best result. By the error analysis, it is expected that the ammonia concentration can be measured within the error of $\pm$0.18% assuming the error of 0.1 K in temperature measurement and 0.1 g in weight measurement.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 1998.11a
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• pp.137-141
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• 1998

A chemical has been aging in soil environment is more less bioavailable than freshly added chemical. The amount of bioavailability of the aged chemical is different by bacterial strains. The difference could be depend on physiochemical properties of each strain. Phenanthrene was employed as an aged chemical. Seven bacteria were isolated from activated sludge and petroleum disposed soil. These strains were able to degrade phenanthrene and to grow using phenanthrene as a sole carbon source. According to the result of materialization and chemical extraction experiment, the bioavailable amount of aged phenanthrene which has been aged in Lima loam is different by each bacteria. Several physiochemical properties of each strain were tested to certify correlation with their different amount of bioavailability.

• Bulletin of the Society of Naval Architects of Korea
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• v.22 no.2
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• pp.12-26
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• 1985

This paper describes the experimental method to predict the propeller induced fluctuating pressure on the hull surface. Cavitations of the three model propellers with varying degree of skews, $0^{\circ},\;36^{\circ}\;and\;72^{\circ}$, were observed and the fluctuating pressure induced by the cavitating propellers in the flat plate above these propellers were measured simultaneously at 9 points in the wake field generated by the wire-mesh screens. Another model propeller designed for the dummy model ship was tested in a similar way behind the dummy model ship. The effects of skew variation on the cavitation patterns and fluctuating pressures were illustrated, and the influence of tip-clearances on the fluctuating pressures was also demonstrated. As a result, it is shown that the level of fluctuating pressure and cavity extent could be controlled to some extent by introducing the skews and tip clearances.

• Fisheries and Aquatic Sciences
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• v.4 no.1
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• pp.25-31
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• 2001

4-Aminobutyrate aminotransferase plays an essential role in the 4-aminobutyric acid shunt, converting 4-aminobutyrate to succinic semi aldehyde. We isolated and sequenced' a fish cDNA fragment that encodes 4-aminobutyrate aminotransferase. A brain cDNA library from flounder (Paralichthys olivaceus) was constructed using the ZAP- III XR vector and screened for the fish 4-aminobutyrate aminotransferase gene using a probe derived from the conserved sequences of known mammalian 4-aminobutyrate aminotransferases. A partial cDNA for 4-aminobutyrate aminotransferase was cloned and found to be 700 bp in length corresponding to 66 amino acids. Nucleotide sequence of the clone was aligned with NCBI (National Center for Biotechnology Information) DNA sequence data base. The result showed high sequence identity with previously reported mammalian 4-aminobutyrate aminotransferases. The trans­criptional level of flounder 4-aminobutyrate aminotransferase was detected with the presence of mRNA at different flounder tissues by reverse transcription-polymerase chain reaction (RT-PCR). The expression of flounder 4-aminobutyrate aminotransferase was also tested and detected from the flounder tissues of the brain, liver, kidney and pancreas.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 2003.10a
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• pp.455-458
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• 2003

A hydraulic scale model test with movable bed was performed to obtain design data for groins to protect the coast in front of the Sang-ri seadike in Sukmodo, located in the Han-river estuary area. The vertical scale of the model is 1/100 and the horizontal scale 1/250 according to Froude similitude. The result of test for original coast and groins showed that the coast in front of the Sang-ri seadike was eroded by tidal current. Three alternatives for the planning of new groins were tested. It is concluded that the alternative B-3 test scheme was the best plan to protect the coast among others.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.186-189
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• 2005

In a clinical setting, developing a reliable method for the automated drug infusion system would improve a drug therapy under the unexpected and acute changes of hemodynamics. The conventional proportional-integral-derivative (PID) controller might not be able to achieve maximum performance because of the unexpected change of the intra- and inter-patient variability. The fuzzy PID control and the conventional PID control were tested under the unexpected response of mean arterial blood pressure (MAP) to a vasopressor agent during acute hypotension. Compared with the conventional PID control, the fuzzy PID control performed the robust MAP regulation regardless of the unexpected MAP response (average absolute value of the error between target value and actual MAP: 0.98 vs. 2.93 mmHg in twice response of the expected MAP and 2.59 vs. 9.75 mmHg in three-times response of the expected MAP). The result was due to the adaptive change of the proportional gain in PID parameters.