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Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination

  • Hongrui Li;Xianyun Wang;Xiaoying Li;Xueyang Zhou;Xuan Wang;Tiantian Li;Rong Xiao;Yuandi Xi
    • Nutrition Research and Practice
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    • v.17 no.2
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    • pp.371-385
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    • 2023
  • BACKGROUND/OBJECTIVES: Soy isoflavone (SIF) and soy lecithin (SL) have beneficial effects on many chronic diseases, including neurodegenerative diseases. Regretfully, there is little evidence to show the combined effects of these soy extractives on the impairment of cognition and abnormal cerebral blood flow (CBF). This study examined the optimal combination dose of SIF + SL to provide evidence for improving CBF and protecting cerebrovascular endothelial cells. MATERIALS/METHODS: In vivo study, SIF50 + SL40, SIF50 + SL80 and SIF50 + SL160 groups were obtained. Morris water maze, laser speckle contrast imaging (LSCI), and hematoxylin-eosin staining were used to detect learning and memory impairment, CBF, and damage to the cerebrovascular tissue in rat. The 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the oxidized glutathione (GSSG) were detected. The anti-oxidative damage index of superoxide dismutase (SOD) and glutathione (GSH) in the serum of an animal model was also tested. In vitro study, an immortalized mouse brain endothelial cell line (bEND.3 cells) was used to confirm the cerebrovascular endothelial cell protection of SIF + SL. In this study, 50 µM of Gen were used, while the 25, 50, or 100 µM of SL for different incubation times were selected first. The intracellular levels of 8-OHdG, SOD, GSH, and GSSG were also detected in the cells. RESULTS: In vivo study, SIF + SL could increase the target crossing times significantly and shorten the total swimming distance of rats. The CBF in the rats of the SIF50 + SL40 group and SIF50 + SL160 group was enhanced. Pathological changes, such as attenuation of the endothelium in cerebral vessels were much less in the SIF50 + SL40 group and SIF50 + SL160 group. The 8-OHdG was reduced in the SIF50 + SL40 group. The GSSG showed a significant decrease in all SIF + SL pretreatment groups, but the GSH showed an opposite result. SOD was upregulated by SIF + SL pretreatment. Different combinations of Genistein (Gen)+SL, the secondary proof of health benefits found in vivo study, showed they have effective anti-oxidation and less side reaction on protecting cerebrovascular endothelial cell. SIF50 + SL40 in rats experiment and Gen50 + SL25 in cell test were the optimum joint doses on alleviating cognitive impairment and regulating CBF through protecting cerebrovascular tissue by its antioxidant activity. CONCLUSIONS: SIF+SL could significantly prevent cognitive defect induced by β-Amyloid through regulating CBF. This kind of effect might be attributed to its antioxidant activity on protecting cerebral vessels.

Analyses of SGTR Accident With Mihama Unit Experience (미하마 원전경험에 대한 SGTR 사고해석)

  • Lee, S.H.;Kim, K.;Kim, H.J.;Eun, Y.S.
    • Nuclear Engineering and Technology
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    • v.26 no.1
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    • pp.41-53
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    • 1994
  • A SGTR accident postulated at Kori unit 1 is simulated with Mihama unit experience, which occurred on February 1991, to evaluate the capability of plant to cope with the transient. The system design and plant conditions of Kori Unit 1 are much similar with those of Mihama Unit 2. Therefore, special concern has been given to evaluate the sequence and the resulting consequence of the postulated SGTR accident at the Kori unit 1 An analysis is peformed as realistically as possible, with following the EOP of Kori unit 1. The result indicates that the leak through tube break terminates within about forty minutes, and the Kori unit 1 may be sufficient to cope with SGTR accident with same type of sequence. However, the reconsideration may be required for the design of Kori unit 1 which disconnects non-safety AC power from off-site power on SI signal generation. It may be pointed out that the content of EOP for SGTR accident is not enough to require operator's proper judgements. An analysis of SGTR accident tested in the LSTF which simulated the SGTR accident at the Mihama Unit 2 is peformed using the RELAP5/MOD3. The results indicates that the code yields in general good agreement with the test, except the break flowrate at the early stage of the event.

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The Influence of Ethical Leadership and Collaborative Communication on IS Behavior in Organizations: The Role of Trust and Person-Organization Fit (조직 내 정보보안 행동 관련 윤리적 리더십과 협력적 커뮤니케이션의 영향: 신뢰 및 개인-조직 적합성 역할)

  • In-Ho Hwang
    • The Journal of the Korea institute of electronic communication sciences
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    • v.18 no.3
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    • pp.465-474
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    • 2023
  • As the effective use and strong protection of an organization's information resources are recognized as a condition for the growth of an organization, they are increasing technological and policy investments in IS(information security). However, information exposure can occur from external invasions such as hacking and incidents related to misuse and abuse by insiders. This study proposes a mechanism that considers the organizational environment and individual characteristics from the viewpoint of promoting employees' IS participation activities. In other words, the study presents the complex effects of organizational environmental factors (ethical leadership, IS collaborative communication) and personal factors (person-organization fit) on organization trust and IS voice behavior. We surveyed office workers who asked for IS-related business activities and tested hypotheses using 422 samples. As a result, ethical leadership influenced organization trust through collaborative communication, and organization trust strengthened IS voice behavior by having an interaction effect with person-organization fit. This study suggests direction for establishing an organizational environment for promoting IS-related activities by office workers, so it provides practical implications for organizations with goals related to internal information exposure control.

Rotational Prism Stitching Interferometer for High-resolution Surface Testing (고해상도 표면 측정을 위한 회전 프리즘 정합 간섭계)

  • In-Ung Song;Woo-Sung Kwon;Hagyong Khim;Yun-Woo Lee;Jong Ung Lee;Ho-Soon Yang
    • Korean Journal of Optics and Photonics
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    • v.34 no.3
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    • pp.117-123
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    • 2023
  • The size of an optical surface can significantly affect the performance of an optical system, and high spatial frequency errors have a greater impact. Therefore, it is crucial to measure the surface figure error with high frequency. To address this, a new method called rotational prism stitching interferometer (RPSI) is proposed in this study. The RPSI is a type of stitching interferometer that enhances spatial resolution, but it differs from conventional stitching interferometers in that it does not require the movement of either the mirror tested or the interferometer itself to obtain sub-aperture interferograms. Instead, the RPSI uses a beam expander and a rotating Dove prism to select particular sub-apertures from the entire aperture. These sub-apertures are then stitched together to obtain a full-aperture result proportional to the square of the beam expander's magnification. The RPSI's effectiveness was demonstrated by measuring a 40 mm diameter spherical mirror using a three-magnification beam expander and comparing the results with those obtained from a commercial interferometer. The RPSI achieved surface testing results with nine times higher sampling density than the interferometer alone, with a small difference of approximately 1 nm RMS.

Study on the Effect of Emissivity for Estimation of the Surface Temperature from Drone-based Thermal Images (드론 열화상 화소값의 타겟 온도변환을 위한 방사율 영향 분석)

  • Jo, Hyeon Jeong;Lee, Jae Wang;Jung, Na Young;Oh, Jae Hong
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.40 no.1
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    • pp.41-49
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    • 2022
  • Recently interests on the application of thermal cameras have increased with the advance of image analysis technology. Aside from a simple image acquisition, applications such as digital twin and thermal image management systems have gained popularity. To this end, we studied the effect of emissivity on the DN (Digital Number) value in the process of derivation of a relational expression for converting DN to an actual surface temperature. The DN value is a number representing the spectral band value of the thermal image, and is an important element constituting the thermal image data. However, the DN value is not a temperature value indicating the actual surface temperature, but a brightness value indicating high and low heat as brightness, and has a non-linear relationship with the actual surface temperature. The reliable relationship between DN and the actual surface temperature is critical for a thermal image processing. We tested the relationship between the actual surface temperature and the DN value of the thermal image, and then the radiation adjustment was performed to better estimate actual surface temperatures. As a result, the relation graph between the actual surface temperature and the DN value similarly show linear pattern with the relation graph between the radiation-controlled non-contact thermometer and the DN value. And the non-contact temperature after adjusting the emissivity was closer to the actual surface temperature than before adjusting the emissivity.

The Effect of Experiential Aspect of Meaning out on Improvement of Self-esteem and Subjective Well-being (미닝아웃의 체험적 측면이 자아존중감과 주관적 안녕감 향상에 미치는 영향)

  • Jeong, Yun-Hee;Kang, So-Young
    • Journal of Convergence for Information Technology
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    • v.12 no.3
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    • pp.108-115
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    • 2022
  • Recently, consumers are showing interest in social and environmental issues. In addition, consumers are increasingly participating in meaning-out that give meaning to their consumption and express moral values. However, unlike the spread of meaning-out, existing studies are lacking. This study approaches meaning out, which has become a recent issue, from an experiential point of view, and aims to study how the experiential characteristics of meaning out affect psychological effects such as improvement of self-esteem and subjective well-being. First, we hypothesized that the experience of meaning out(feel, think, act, relate) had an effect on subjective well-being through improvement of self-esteem. We tested the hypothesis on a total of 197 data using the structural equation model. As a result, it was found that three experiences excluding 'feel' have a positive effect on the improvement of self-esteem, and and improved self-esteem had a positive effect on improving subjective well-being. This study expands existing studies and provides practical implications by confirming that meaning out has a positive psychological effect.

CNN Classifier Based Energy Monitoring System for Production Tracking of Sewing Process Line (봉제공정라인 생산 추적을 위한 CNN분류기 기반 에너지 모니터링 시스템)

  • Kim, Thomas J.Y.;Kim, Hyungjung;Jung, Woo-Kyun;Lee, Jae Won;Park, Young Chul;Ahn, Sung-Hoon
    • Journal of Appropriate Technology
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    • v.5 no.2
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    • pp.70-81
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    • 2019
  • The garment industry is one of the most labor-intensive manufacturing industries, with its sewing process relying almost entirely on manual labor. Its costs highly depend on the efficiency of this production line and thus is crucial to determine the production rate in real-time for line balancing. However, current production tracking methods are costly and make it difficult for many Small and Medium-sized Enterprises (SMEs) to implement them. As a result, their reliance on manual counting of finished products is both time consuming and prone to error, leading to high manufacturing costs and inefficiencies. In this paper, a production tracking system that uses the sewing machines' energy consumption data to track and count the total number of sewing tasks completed through Convolutional Neural Network (CNN) classifiers is proposed. This system was tested on two target sewing tasks, with a resulting maximum classification accuracy of 98.6%; all sewing tasks were detected. In the developing countries, the garment sewing industry is a very important industry, but the use of a lot of capital is very limited, such as applying expensive high technology to solve the above problem. Applied with the appropriate technology, this system is expected to be of great help to the garment industry in developing countries.

A Research on the Creation of Floral Art Works Applying Characteristics of Contemporary Materials (현대적 소재의 특징을 활용한 화예작품 창작에 관한 연구)

  • Yun, Hwa Jin;Yoo, Taek Sang
    • Journal of the Korean Society of Floral Art and Design
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    • no.41
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    • pp.115-132
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    • 2019
  • Today, the expansion of the possibility of new expressions of plastic arts is largely due to emergence and application of new materials. In the field of flower design, it is found that there is a tendency to seek a new expression by utilizing various new materials instead of natural material that used in the past. This study is an attempt of applying methodological approach in the creation of floral art works utilizing the characteristics of contemporary materials in such context. The researcher gathered cases of specific effect and sensation in the expression of art works using various contemporary materials and extracted the characteristics using descriptive sentences applying behavior setting analysis technique. Reporting detailed result of the research total 100 guidelines under 41 sub-categories, 24 mid-categories, and 6 top categories such as transparency, lighting, combination of objects, combination of materials, reflection, shape construction. The researcher tested the effectiveness of the theories by applying deducted theories as the guidelines in creation process of her own floral art works. The significance of this study lies at experimenting the possibilities of applying methodological approach which could supplement intuitive approach in pursuit of expression for artists in the field of floral art and design.

An Empirical Analysis on the Appeal Case of Origin Verification for Korean Import Goods Using Bootstrapping Technique (부트스트랩 기법을 활용한 한국 수입 상품의 원산지검증 불복사례 실증분석)

  • Kim, Jong-Hyuk;Heo, Sang-Hyun;Kim, Suk-Chul
    • Korea Trade Review
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    • v.42 no.4
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    • pp.93-114
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    • 2017
  • Under the FTA agreement, preferential tariffs between FTA members will result in tariff reductions. In order to ensure the stable use of the FTA tariff system, it is necessary for the customs authorities to determine whether the origin goods are clearly applicable. This study analyzed the procedure of appeal according to the origin verification system based on the decision made by Korea Customs Service and Tax Tribunal. From this, we examined whether the rate of re-claiming a case rejected in the 'Review System of the Legality Before Taxation' differs. In addition, we carried out a quantitative analysis using bootstrapping technique in order to overcome the scarcity cases of verification of origin among FTA members. The implications of this paper are summarized as follows: First, we tested the hypothesis that the re-claiming rate of Western countries is higher. Second, some issues represented higher re-claiming rate. Third, there was no significant difference between the verification group and the re-claiming rate. Finally, even if an applicant makes a claim again, there is a possibility of being rejected again.

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A Study on the Effect of Physical Upward and Downward Movement Experience on Psychological Judgements (신체의 상향·하향 이동경험이 심리적 판단에 미치는 영향에 관한 연구)

  • Lee, Luri;Lee, Seung-yon;Chung, Hyun Jung
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.8 no.4
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    • pp.183-196
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    • 2018
  • Studies that approach from the point of view that human thoughts or minds are dominated by behavior as well as that human behavior is dominated by thoughts or minds, have begun to attract attention from the late 2000s. The physical experience is reminiscent of a metaphorically connected abstract concept, which ultimately affects the judgment or evaluation of a particular object. However, studies that have been carried out so far have been limited to studies on the difference in perception and judgment depending on the objects to be viewed, the objects to be touched, and the objects to which they are carried. In this study, we tried to find out that the physical movement of the body in the upward or downward direction affects the psychological judgment differently. In the first experiment, a pair of words that were considered to be connected metaphorically was tested. In the second experiment, the subjects tried to solve the complicated calculation problem in a short time, and then they watched the video related to the upward movement or downward movement, and then proceeded to measure the psychological judgment. As a result, it was found that 'downward movement' of the body has a metaphorical connection with 'closure', while 'upward movement' is related to 'progress'. In the case of downward-experienced group compared to upward-experienced group, the reverse intentions of their own decision were low, and the confidences in their own decision and the expectations for performance were high.