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Comparative Studies of Adriamycin and 28-Deacetyl Sendanin on In Vitro Growth Inhibition of Human Cancer Cell Lines

  • Kim, Hwan-Mook;Oh, Goo-Taeg;Han, Sang-Bae;Hong, Dong-Ho;Hwang, Bang-Yeon;Kim, Young-Ho;Lee, Jung-Joon
    • Archives of Pharmacal Research
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    • v.17 no.2
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    • pp.100-103
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    • 1994
  • The limonoid compound (28-deacetyl sendanin0 isolated from the fruit of Melia toosendan SIEB. et ZUCC. was evaluated on anticancer activity. According to a standard in vitro cytotoxicity assy, eight human cancer cell lines and SRB assay were introduced for present evaluation. As a positive standard, adriamycin was tested in parallel. The cell lines were originated from six different organs. In view of dose-response profiles to 28-deacetyl sendanin, the most sensitive cells were SF-539 and PC-3 which were derived from CNS and prostate, respecitively. In contrast, all the cell lines responded similarly to adriamycin to give rise to nearly indentical six cell lines were more sensitive to 28-deacetyl sendanin and two were more resistant. As a result, 28-deacetyl sendanin had more senstive and selective inhibitory effects on in vitro growth of human cancer cell lines in a comparison with adriamycin.

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Quality Characteristics of fish Meat Paste Containing Mulberry Leaf Powder (뽕잎 분말 함유 어묵의 품질 특성)

  • Shin Young-Ja;Park Geum-Soon
    • Journal of the East Asian Society of Dietary Life
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    • v.15 no.6
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    • pp.738-745
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    • 2005
  • This study was conducted in order to promote the utilization of fish meat paste added mulberry leaf powder(EPM) as food. The tested concentrations of mulberry leaf powder were 0, 0.1, 3, 0.5 and Ito The weight of the fish meat paste with FPM was heavier than the control(p<0.001). Oil absorption was the highest in the one with $0.3\%$ mulberry leaf powder, The It a and b values of the fish meat paste were decreased as increasing the concentration of mulberry leaf powder in Hunter color value(p<0.001). Good flexibility was shown not only in the control but also in the one with FPM in folding test. In texturometer test, the hardness was increasing, but the cohesiveness, springiness, gumminess, and brittleness were decreasing in according to increasing the concentration of mulberry leaf powder. In sensory evaluation, color and oily taste were getting higher as increasing the concentration of mulberry leaf powder. The fish meat paste added with $0.5\%$ mulberry leaf powder showed the highest acceptance scores in flavor, texture and overall quality. The result suggest that mulberry leaf powder can be applied to fish meat paste for both quality and functionality.

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Quality Characteristics of Cookies with Varied Concentrations of Blueberry Powder (블루베리 분말을 첨가한 쿠키의 품질 특성)

  • Ji, Jeong-Ran;Yoo, Seung-Seok
    • Journal of the East Asian Society of Dietary Life
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    • v.20 no.3
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    • pp.433-438
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    • 2010
  • To manufaure cookies with blueberry, cookies with 0%, 1%, 3%, 5%, or 7% added blueberry were prepared and tested for quality. Their pH was decreased by addition of blueberries' addition, and the influence of the pH also decreased the sugar level. For the cookies' color, L and b (yellowness) were decreased, and a was increased. The same result was shown when anthocyanin foods were added. Cookies' diameter, spreadability, and thickness were increased as blueberries were added. The cookies' hardness was lowered with increasing addition of blueberries. 3% and 5% blueberry-added cookies received the highest sensory-test scores, so these blueberry cookie showed its possibility of success to develop it as a product.

Optimized Design of the Head restraint according the regional seat safety assessment (국가별 좌석 안전성 평가 방법에 따른 머리지지대 최적화 설계)

  • Yoo, Hyukjin;Yim, Jonghyun;Yoon, Ilsung
    • Journal of Auto-vehicle Safety Association
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    • v.5 no.2
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    • pp.45-50
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    • 2013
  • The whiplash Injuries due to rear collision occur frequently. As result, in many countries, seat performance is being assessed and developed to improve head whiplash injury in rear collision of passenger car. This study compares whiplash assessment methods in each country. Using the DFSS(Design for Six Sigma) method, the correlation between influence parameters of head restraints and whiplash injury criteria is analyzed. Four control factors are used in this study. And total 11 whiplash injury criteria from NCAP(New Car Assessment Program) of Korea, Europe, China and IIHS(Insurance Institute for Highway Safety) of USA are used for output response. By the experimental design, L9 orthogonal coordinate system is configured and is tested by sled test equipment, twice. By using average assay value and ANOVA, the correlation between control factors and injury criteria has been comprehended. Optimization design of head restraint according the regional seat safety assessment was derived through the correlation.

A Study on Evaluation Method of the HDA Test in Domestic Road Environment (국내도로 환경에서의 HDA 시험평가 방법에 관한 연구)

  • Bae, Geon Hwan;Kim, Bong Ju;Lee, Seon Bong
    • Journal of Auto-vehicle Safety Association
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    • v.11 no.4
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    • pp.39-49
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    • 2019
  • Autonomous vehicle is a car which drives itself without any human interaction. SAE provides technical definitions for autonomous and international standards for test evaluation. Accordingly, automobile industry is actively researching development and evaluation of various ADAS (Advanced Driver Assistance Systems), : representative technology of autonomous technology. Recently, ADAS is in the commercialization level such as ACC, LKAS, AEB, and HDA etc. And it also has issues about safety evaluation. The purpose of HDA in ADAS is reduced the driving load on highway. It has a function which can maintain lane keeping and control distance from forward vehicle. This function is evaluated to be useful for accident prevention. Therefore, this paper proposes the safety evaluation scenario of HDA, considering the domestic highway design criteria and the situation that may arise on the actual highway. We compared and analyzed the data acquired through simulation and actual vehicle test. And verified the reliability of the proposed safety evaluation scenario. The verified result is expected safety evaluation of HDA is possible even under the bad condition, which cannot be tested.

RESIDUAL STRESS MEASUREMENT ON THE BUTT-WELDED AREA BY ELECTRONIC SPECKLE PATTERN INTERFEROMETRY

  • KIM, KYEONGSUK;CHOI, TAEHO;NA, MAN GYUN;JUNG, HYUNCHUL
    • Nuclear Engineering and Technology
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    • v.47 no.1
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    • pp.115-125
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    • 2015
  • Background: Residual stress always exists on any kind of welded area. This residual stress can cause the welded material to crack or fracture. For many years, the hole-drilling method has been widely used for measuring residual stress. However, this method is destructive. Nowadays, electronic speckle pattern interferometry (ESPI) can be used to measure residual stress with or without the hole-drilling method. ESPI is an optical nondestructive testing methods that use the speckle effect. Mechanical properties can be measured by calculation of the phase difference by the variation of temperature, pressure, or loading force. Methods: In this paper, the residual stress on the butt-welded area is measured by using ESPI with a suggested numerical calculation. Two types of specimens are prepared. Type I is made of pure base metal part and type II has a welded part at the center. These specimens are tensile tested with a material test system. At the same time, the ESPI system was applied to this test. Results: From the results of ESPI, the elastic modulus and the residual stress around the welded area can be calculated and estimated. Conclusion: With this result, it is confirmed that the residual stress on the welded area can be measured with high precision by ESPI.

Advanced Structural Silicone Glazing

  • Kimberlain, Jon;Carbary, Larry;Clift, Charles D.;Hutley, Peter
    • International Journal of High-Rise Buildings
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    • v.2 no.4
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    • pp.345-354
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    • 2013
  • This paper presents an advanced engineering technique using finite element analysis to improve structural silicone glazing (SSG) design in high-performance curtain wall systems for building facade. High wind pressures often result in bulky SSG aluminum extrusion profile dimensions. Architectural desire for aesthetically slender curtain wall sight-lines and reduction in aluminum usage led to optimization of structural silicone bite geometry for improved stress distribution through use of finite element analysis of the hyperelastic silicone models. This advanced design technique compared to traditional SSG design highlights differences in stress distribution contours in the silicone sealant. Simplified structural engineering per the traditional SSG design method lacks accurate forecasting of material and stress optimization, as shown in the advanced analysis and design. Full scale physical specimens were tested to verify design capacity in addition to correlate physical test results with the theoretical simulation to provide confidence of the model. This design technique will introduce significant engineering advancement to the curtain wall industry and building facade.

Investigation of Optimal Channel Doping Concentration for 0.1\;μm SOI-MOSFET by Process and Device Simulation ([ 0.1\;μm ] SOI-MOSFET의 적정 채널도핑농도에 관한 시뮬레이션 연구)

  • Choe, Kwang-Su
    • Korean Journal of Materials Research
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    • v.18 no.5
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    • pp.272-276
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    • 2008
  • In submicron MOSFET devices, maintaining the ratio between the channel length (L) and the channel depth (D) at 3 : 1 or larger is known to be critical in preventing deleterious short-channel effects. In this study, n-type SOI-MOSFETs with a channel length of $0.1\;{\mu}m$ and a Si film thickness (channel depth) of $0.033\;{\mu}m$ (L : D = 3 : 1) were virtually fabricated using a TSUPREM-4 process simulator. To form functioning transistors on the very thin Si film, a protective layer of $0.08\;{\mu}m$-thick surface oxide was deposited prior to the source/drain ion implantation so as to dampen the speed of the incoming As ions. The p-type boron doping concentration of the Si film, in which the device channel is formed, was used as the key variable in the process simulation. The finished devices were electrically tested with a Medici device simulator. The result showed that, for a given channel doping concentration of $1.9{\sim}2.5\;{\times}\;10^{18}\;cm^{-3}$, the threshold voltage was $0.5{\sim}0.7\;V$, and the subthreshold swing was $70{\sim}80\;mV/dec$. These value ranges are all fairly reasonable and should form a 'magic region' in which SOI-MOSFETs run optimally.

A Study on Satisfaction of Internet Shopping-mall between Customer's Lifestyle (라이프스타일에 따른 인터넷쇼핑몰 소비자의 만족도에 관한 연구)

  • Lee, Jung-Sae;Kim, Jin-Sup
    • Journal of the Korea Society of Computer and Information
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    • v.15 no.4
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    • pp.119-128
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    • 2010
  • The purpose of this thesis is to analyze and test hypotheses that the internet shopping customer's satisfaction would be differences between customer's lifestyle and a type of buying product characteristics. In addition, this study tested differences between lifestyle groups and product type in terms of customer's transaction continuity. In result, we find that there are significant differences of customer's satisfaction and customer's continuity in terms of the lifestyle, but not in the product types. This study provide useful informations on market segmentation strategy to the firms which had been doing on-line shopping and will help them minimize the possible risks when firms enter into internet shopping market.

A Studies on the Akabane Disease Antibody in Incheon Area (인천지역 유우의 Akabane병 항체조사)

  • 강태선;배도권;강석영;최진영;손봉환
    • Korean Journal of Veterinary Service
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    • v.17 no.1
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    • pp.9-18
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    • 1994
  • Neutralized antibody titer of Akabane disease virus were performed from 810 dairy cows in 45 farming households from May 1992 to December 1993 in Incheon area. The 503 dairy cows at the 21 farming household were conducted from May to December 1992, 307 cows were from January to December 1993 The results obtained are summarized as follows 1. Evaluation of neutralized antibody titer of 810 dairy cows tested during two yews revealed that 68.1% (552 hearts) , during the four year revealed that 69.6% (350 heads), the later year was 65.8%(202 heads ) was more than antibody titer 16. 2. Antibody investigation according to area and years, showed no significant difference in the whole area and both years as 65-73% from 1992, and as 65-70% from 1993 had an antibody titer of above 16 or more. 3. Antibody investigation according to age, showed that 34.4% of cows aged below 2 had a titer of above 16, compared with 80.8% for cows aged above 5. It demonstrated that the younger cows had the lower titer level, and the older the higher. 4. Monthly variation of antibody titer showed that the highest level of antibody titer was observed in September, the lowest was in June. It meant that the best periods of vaccination were April, May, June. 5. The result of epidemidogical study to 40 farming households showed that 35 farms (87.5%) had abortions of which were 14 stillbirths, 5 abnormal births, and 13 farms (32.5%) had vaccination.

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