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Synthesis and Phytopathogenic Activities of Isopropylphenyl Derivatives (Isopropylphenyl 유도체들의 합성과 식물병원균에 대한 항균활성)

  • Jang, Do-Yeon;Choi, Kyoung-Gil;Lee, Byung-Ho;Kim, Tae-Jun;Jung, Bong-Jin;Choi, Won-Sik
    • Applied Biological Chemistry
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    • v.50 no.3
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    • pp.178-186
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    • 2007
  • 42 compounds such as ester, sulfonyl ester, phosphoyl ester and ether derivatives of 4-isopropylphenol (I) and 2-isopropylphenol (II) were synthesized. These derivatives were identified by IR, GC/MS and $^{1}H-NMR$ spectra. Their in vitro antifungal activities were tested against 10 plant pathogenic fungi. Among them, several compounds showed potent in vitro antifungal activity. The selected compounds showing potent in vitro antifungal activity were tested for their in vivo antifungal acitvities against 5 plant diseases such as rice blast, rice sheath blast, cucumber anthracnose, cucumber gray mold and tomato late blight. As a result, 2-isopropylphenyl piperonyloate (II-7a) showed a potent in vivo antifungal activity against cucumber anthracnose and tomato late blight, 4-isopropylphenyl 4-methoxybenzenesulfonate (I-6b) effectively inhibited the development of rice blast.

The Effect of the Structured Education on the Early Rehabilitation Knowledge and Activity Performance of the C.V.A. Patients (구조화된 환자교육이 뇌졸중 환자의 조기재활에 관한 지식과 활동수행에 미치는 영향)

  • 이혜진;이향련
    • Journal of Korean Academy of Nursing
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    • v.27 no.1
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    • pp.109-119
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    • 1997
  • This study has been attempted to set up the strategies of the nursing which can promote the activity performance for early rehabilitation for the patients by examining the effect of the structured patient education on the early rehabilitation knowledge and activity performance of the C.V.A patients. The study method has been done by investigating the experiment group and control group in advance through the question papers and interview and observation on 65 patients who had been hospitalized at oriental medicine hospital of K Medical Center from July 1st 1995 to the end of Sep, 1995. The analysis of the collected material had been done for the homogeneity test in which general characters of experiment group and control group had been tested by X²and the homogeneity test of ADL by t-test. To test the hypothesis the t-test had been given for the difference of the early rehabilitation knowledge and activity performance between the two groups and the correlation between early rehabilitation knowledge and activity performance had been tested by Pearson's Correlation Coefficient. The result of the test of the hypothesis is as the below. 1 The 1st hypothesis “The experiment group which had received the structured education should be higher in the early rehabilitation knowledge than the control group” was supported(t=4.45. p=.000). 2. The 2nd hypothesis “The experiment group which received the structured education should be higher in the early rehabilitation activity performance than the control group”was supported(t=2.11, p=.036). 3. The 3rd hypothesis “The higher the early rehabilitation knowledge of the patient the higher the activity performance degree” was rejected (r=.1546, p=.219). In conclusion, the patients who received the structured education showed the increase in the degree of early rehabilitation knowledge and activity performance, so it has been judged that education has been prerequisite in increasing the knowledge and activity performance of early rehabilitation.

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Antibiotic susceptibility of Porphyromonas gingivalis and Prevotella intennedia from the Patients with Adult Periodontitis (성인성 치주염환자에서 분리한 Porphyromonas gingivalis와 Prevotella intennedia의 항생제 내성에 관한 연구)

  • Kim, Heung-Shik;You, Hyung-Keun;Shin, Hyung-Shik
    • Journal of Periodontal and Implant Science
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    • v.26 no.3
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    • pp.625-639
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    • 1996
  • The purpose of this study was to an in estimate the antibiotic susceptibility of P. gingivalis and P. interrnedia isolate from the subgingival plaque to adult periodontitis. Six P. gingivalis and five P. intermedia bacterial strains were tested for their susceptibility to 10 antimicrobial agents under disc diffusion method and broth dilution method. Ten patients with deep pocket(6mm) were selected for this study. They had not taken antibiotics for 6 months and no history of dental treatment for 6 months before this study. The result were as follow : 1. For antibiotic disc diffusion method, six P. gingivalis and five P. interrnedia were tested with 10 antimicrobial agents which comprised penicillin, gentamycin, clindamycin, lincomycin, ampicillin, erythromycin, tetracycline, amikacin, chloramphenicol, vancomycin. The sensitive antibiotics were tetracycline, penicillin, ampicillin, vancomycin, chloramphenicol and resisitent antibiotics were lincomycin. The other antimicrobial agents were less active. 2. From the study of determination on the minimal inhibitory concentration(MIC) by broth dilution method, the MIC of tetracycline to P. gingivalis and P. intermedia were $0.5-1.0{\mu}g/ml$, $0.5{\mu}g/ml$, that of ampicillin were $1-8{\mu}g/ml$, that of clindamycin were $1-32{\mu]g/ml$, $8-16{\mu}g/ml$, that of lincomycin were $16-32{\mu}g/ml$, $2-32{\mu}g/ml$. These data suggest that tetracycline and ampicillin may be valuable drug in the elemination of P. gingivalis and P. interrnedia from the patients with adult periodontitis.

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초임계 유체 기술로 추출한 목초액 첨가 장류의 품질향상효과 및 보존성

  • Yun, Seon-Gyeong;Yun, Seong-Ok;Jeon, Byeong-Su
    • 한국생물공학회:학술대회논문집
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    • 2003.04a
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    • pp.701-705
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    • 2003
  • The study was done to determine the effect of storage property and qualities of soybean sauce and paste by adding different amount of pyroligneous liquor obtained by supercritical fluid extraction(SFE). Purified pyroligneous liquor obtained by SFE at $40^{\circ}C$/110bar contained ${\rho}$-cresol, o-cresol and m-cresol food sterilizers, but no toxic substances such as tar, scorched, furfuraland and monophenol. Thus pyroligneous liquor was suitable as natural food preservative. In case of soybean sauce, pyroligneous liquor was tested for the possibility of utilizing it as natural food preservative to prevent film formation on soybean sauce for the test period of 15days at $30^{\circ}C$. In case of paste, pyroligneous liquor was tested for the possibility of utilizing it as natural food preservative to inhibit browning on paste for the test period of 60days at $30^{\circ}C$. As a result, purified pyroligneous liquor offered a promising way of improving the quality and storage property of soybean sauce and paste .

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A Study on Shear-Fatigue Behavior of Reinforced Concrete Beams (철근(鐵筋)콘크리트보의 전단피로거동(剪斷疲勞擧動)에 관(關)한 연구(硏究))

  • Chang, Dong Il;Kwak, Kae Hwan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.8 no.1
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    • pp.173-185
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    • 1988
  • This study is intended to investigate the shear fatigue behaviour of reinforced concrete beams based on a series of experiments, and verify the test results in comparison with the analysis result obtained by using a nonlinear finite element method. The experiments are divided into the tests under the static loading and the test under the dynamic fatigue loading. In order to investigate the shear failure behaviour under static loadings, four specimens for three different cases were made and tested. The behaviour of stirrups with the static stress and strain variations were observed based on the results of these tests. In the fatigue fracture tests, eleven specimens for four different cases were made and tested. Various observations on mid-span deflection of test beams and tensile strains of reinforcing steels as well as stirrups were made against various fatigue loadings. It may be concluded that the shear fatigue strengths of R.C. specimens at one million cycles turn out to be approximately 65 percent of the static ultimate shear strength.

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Synthesis and Fungicidal Activities of Substituted Phenyl Hydrazono-3-Methyl-1, 2-Isoxazol-5-One Derivatives. (치환 Phenyl Hydrazono-3-Methyl-1, 2-Isoxazol-5-One 유도체의 합성과 살균활성)

  • Park, Kwang-Wook;Keum, Young-Su;Park, Chang-Kyu
    • Korean Journal of Environmental Agriculture
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    • v.15 no.2
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    • pp.239-245
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    • 1996
  • Fungicidal activity has been examined for a series of substituted phenylhydrazono-3-methyl-1,2-isoxazol-5-one against plant pathogenic fungi. 3-methyl isoxazol-5-one was obtained from ethyl acetoacetate and hydroxyl amine. Final products were prepared by aromatic diazo coupling with 3-methyl isoxazol-5-one. Fungicidal activities against Rhizoctonia solani, Colletotrichum gloeosporioides, Cladosporium cucumerinum, Pythium ultimum were tested and Pythium ultimum were tested and Pythium ultimum was selected for quantitative measurement of activity. Methyl, halogen, nitro derivatives possessed high fungicidal activity at p-, o-, p- position, respectively. Methyl, halogen derivatives were much more active than alkoxy, nitro derivatives and the order of activity of halogen derivatives was F > Cl > I. This result implied that the activity was related to the molecular volume of substitutents.

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Flowering and Maturing Response to Seeding Date and Short-day Treatment in Vegetable Perilla (잎들깨의 개화 및 결실에 미치는 파종기와 단일처리의 영향)

  • 한상익;곽재균;오기원;배석복;김정태;곽용호
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.42 no.4
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    • pp.466-472
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    • 1997
  • Vegetable perilla, "Ipdlkkae 1"(Perilla frutescens var japonica Hara), was tested about the flowering and maturing responce in summer and winter. In summer season, it was researched about those responses according to the change of seeding date from May 15th to Oct. 15th at one month interval in the field. "Ipdlkkae 1" flowered Oct. 2nd under the day length of eleven hours and fourty-one minutes, compared with Sep. 6th (day length of twelve hours and fourty-three minutes) of "Yepsildlggae". And those responses showed that vegetable perilla was have to seeded before July 15th for two reason. The first is a unique response of perilla to day length. If perilla stay under short-day condition for some days, perilla will flower after four weeks. The second is a weather, especially frost and cold. In the test of latest seeding at Oct. 15th, the plants flowered more late than normal flowering period and they were not able to mature for frost of early winter. And this result showed that any other species, which has the characteristic of later flowering than that of "Ipdlkkae 1", could not able to mature in the field. In winter time, this species was tested about the same responses according to the change of short-day treatments. In the case of the test from May 1st (above fourteen hours day length), even if the test plants were stayed under short-day condition for more than 10 days, they were not able to mature, but flowerd. From the test of Apr. 15th, day length of thirteen hours, the plants were showed variable reaction to the short-day treatment. In this test, 11days for short-day treatment was a basic day to decide whether flowering was delayed or not. In the test from Apr. 1st, perilla seeds were able to harvest at least 5 days short-day treatment. In the final test from Mar. 15th, it had no need to take short-day treatment for harvesting of normal seeds, because the day length of that are twelve hours, which is an enough time to induce flowering and maturing, previously reported.

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Mechanism Improvement of the Heat Exchanger for the Thermal Efficiency Increase of Hot Air Heater (온풍난방기의 열효율 증대를 위한 열교환기 구조개선)

  • Kang, Geum-Choon;Kang, Yoen-Ku;Ryou, Young-Sun;Kim, Young-Joong;Lee, Si-Young;Paek, Yee
    • Journal of Biosystems Engineering
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    • v.34 no.5
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    • pp.363-370
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    • 2009
  • Hot air heater with light oil combustion is used as the most common heater for greenhouse heating in the winter season. Hot air heaters of 256,246 units have been supplied as main greenhouse heating equipment until 2008 and greenhouse heating cost has reached to 620 billions won in Korea. In order to improve the thermal efficiency of the hot air heater and to reduce the expenses for greenhouse heating, prototype hot air heater was manufactured and tested in this experiment. The heat exchanger of tested prototype hot air heater was circular and hexagonal pipe type and inline and stagger arrangement type. Capacity of the heating was 43,062 kJ/h and total heat transfer area of the heat exchanger was $10.728\;m^2$. According to the performance test, it could supply heat of 38,240 to 35,100 kJ/h depending on the fan motor speed of 1,740~1,220 rpm, respectively. Thermal efficiency of hot air heater was 87.0% to 80.8% in the same conditions. As a result, thermal efficiency of hot air heater with hexagonal pipe-stagger arrangement heat exchanger developed in this study was higher 10.2% than that of conventional hot air heater and heating energy saving rate of 14.3% increased.

SD Methodological Evaluation of the Visual Cognition to the Urban Landscape (SD 기법을 활용한 주거단지의 시지각적 평가)

  • Hwang J.W.;Chai B.S.;Kwon T.K.;Hong C.U.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.06a
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    • pp.1918-1920
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    • 2005
  • The color and structure of urban constructions is a factor of urban landscape and shows their characteristics. Hence the modern buildings with their materials and external appearance makes up the urban image. But still yet, it was not easy to evaluate the value of visual landscape of buildings with objective measuring method. Most of all, it depends on the subjective estimation of a few talented or high educated experts with a sense of beauty. In relation to this kind of problems, it was tried here in this study to analyse the human response of brain wave pattern (EEG) with use of SD method, while the tested persons watched the urban landscape constructed in a visual reality. The tested persons were 10 adult males and females with no color blindness and intact cognitive function. Light source with color filter was used for color environment in chamber room. The signal of EEG is analysed digitally and grouped into the $\alpha$ and $\beta$ waves. The result showed that relative power of $\alpha$ wave ratio increased in natural landscape scenary clearly. From these results it was possible to evaluate the human response, which was affected by urban color and structure stimulation and it might be useful as an indicator of visual cognition amenity toward the design of urban construction environment.

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Chemical Constituents from the Leaf and Twig of Acer okamotoanum Nakai and their Cytotoxicity

  • Jin, Wen-Yi;Min, Byung-Sun;Youn, Ui-Jung;Hung, Tran-Manh;Song, Kyung-Sik;Seong, Yeon-Hee;Bae, Ki-Hwan
    • Korean Journal of Medicinal Crop Science
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    • v.14 no.2
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    • pp.77-81
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    • 2006
  • As a result of cytotoxic compounds against cancer cell lines from natural sources, senven compounds were isolated from the leaf and twig of Acer okamotoanum Nakai. The compounds (1-7) were identified as ethyl gallate (1), methyl gallate (2), gallic acid (3), trans $resveratrol-3-O-{\beta}-D-glucopyranoside$ (4), acertannin (5), nikoenoside (6), and fraxin (7) by physicochemical and spectroscopic data (including mp, UV, IR, MS, $^1H-NMR,\;^{13}C-NMR$, DEPT, and HMBC) in comparison with those of published papers. All the compounds were tested for their cytotoxic activity against L1210, HL-60, K562, and B16F10 cancer cell lines in vitro by MTT assay method. Compounds 1-3 and 5 showed cytotoxic activity against all tested cell lines with $IC_{50}$ values ranged from 12.5 to $72.2\;{\mu}M$. Of the compounds, methyl gallate (2) exhibited the most potent cytotoxic activity against L1210, HL-60, K562, and B16F10 tumor cells with $IC_{50}$ values of 12.5, 48.3, 22.8, and $22.8\;{\mu}M$, respectively. Other compounds did not show any cytotoxic activity against four cancer cell lines.