• BMB Reports
• /
• v.49 no.8
• /
• pp.431-436
• /
• 2016

Human papillomavirus (HPV) is the major cause of cervical cancer, a deadly threat to millions of females. The early oncogene product (E7) of the high-risk HPV16 is the primary agent associated with HPV-related cervical cancers. In order to understand how E7 contributes to the transforming activity, we investigated the structural features of the flexible N-terminal region (46 residues) of E7 by carrying out N-15 heteronuclear NMR experiments and replica exchange molecular dynamics simulations. Several NMR parameters as well as simulation ensemble structures indicate that this intrinsically disordered region of E7 contains two transient (10-20% populated) helical pre-structured motifs that overlap with important target binding moieties such as an E2F-mimic motif and a pRb-binding LXCXE segment. Presence of such target-binding motifs in HPV16 E7 provides a reasonable explanation for its promiscuous target-binding behavior associated with its transforming activity.

• Animal cells and systems
• /
• v.6 no.1
• /
• pp.65-68
• /
• 2002

Female genital morphology of Cryptocercus Kyebangensis is described, focusing on the structural features of ovipositors at each developmental stage. Ovipositor valves were the first genital structures to appear in female nymphs. The caudal margin of the 9th sternum was nearly straight in the 1st instars of both sexes, with a slight median notch, but was deeply concave in the female nymphs of the End instar. The 1st valve of ovipositor budded off from membranous fold between the 8th 8nd 9th sternum and a pair of the 2nd valve came from the 9th sternum. Separation of styli occurred in the female nymphs of the 8th or 9th instar. Some parts of the female genitalia were sclerotized after the final molt. Spermathecae were the fork type and leaned a little to the right in the middle line of the genital chamber from ventro-posterior view. The trace sealed with sclerite materials existed on the spermathecal opening. The genital segments (segments Ⅷ, IX, and X) were concealed completely by the 7th tergum and sternum posteriorly expanded. Terminal lobes which exist in the Blattidae were not observed in C. Kyebangensis. Instead, the apicolateral emargination existed on the terminal abdominal segment of C. Kyebangensis females.

• Proceedings of the IEEK Conference
• /
• 2004.08c
• /
• pp.576-580
• /
• 2004

In this paper, we present a design and implementation of a TV-Anytime compliant STB to provide personalized content consumption according to user preferences and various terminal/network conditions. This paper mainly details with a metadata engine which consists of meta data de-multiplexing, metadata decoding, and metadata-based content browsing. For personalized content consumption, the proposed metadata engine provides the following key functionalities: advanced EPG, non-linear segment navigation wirh Tables-of-Content and/or event-based summary, automatic recommendation of user-preferred programs, and etc. The implemented STB employing the metadata engine is successfully tested with a set of service scenarios in an end-to-end broadcasting test-bed.

• Animal cells and systems
• /
• v.2 no.4
• /
• pp.427-434
• /
• 1998

Canthocamptus morimotoi Miura, a cave-dwelling harpacticoid species belonging to C. mirabilis species group, is fully redescribed and illustrated on the basis of the material newly collected from the type locality, Simpigul Cave, South Korea. C. morimotoi is the only genuine subterranean species in the C, mirabilis group, and claimed to be a relict species restricted to its type locality. The sexually isomorphic ornamentation of the outer terminal seta on the distal exopodal segment of male leg 4 and the well-developed spines on the disteromedial corner of anal somite are the most significant features differentiating this species from ther members of the mirabilis-group.

• Animal cells and systems
• /
• v.6 no.2
• /
• pp.95-105
• /
• 2002

Early zoeal stages of two snapping shrimps Alpheus digitalis De Haan, 1850 and Alpheus japonicus Miers, 1879 are described and illustrated in detail for the first time based on the laboratory-reared materials. The first zoeas of Alpheus are more related to those of Vexillipar than to Athanas, Automate, and Synalpheus by having rostrum absent, the tip of the endopod of the antenna with a long plumose seta as well as a spine, the endopod of the maxilla with a basal and two terminal setae, the exopod of the maxilla shorter than the endopod, and the endopod of the second maxilliped with a seta on the proximal segment. A list of larval descriptions and described stages of the Alpheidae reported from Indo-West Pacific waters are included.

• Macromolecular Research
• /
• v.12 no.1
• /
• pp.63-70
• /
• 2004

We have synthesized various types of poly(ethylene glycol) (PEG)-ibuprofen conjugates by the nucleophilic substitution of bromo-terminated PEG with ibuprofen-Cs salt; PN (Pluronic) was also used in place of PEG. All the bromo-terminated PEGs and PN were obtained in high yield. Conversions of the terminal hydroxyl groups to bromo-termini were quantitative, as were the drug conjugation processes. The Ι$_1$/Ι$_3$values obtained from solutions of the ibuprofen-conjugated prodrugs are summarized in relation to those of ibuprofen in water and in aqueous solutions of the original PEG, PN, and several ordinary surfactants. We believe that the fully hydrophilic PEG is completely hydrated and forms no hydrophobic pocket by segment aggregation. These results indicate that the probe environment is significantly hydrophobic, particularly in the solution of prodrug PN, for which the ratio is similar to that obtained from typical micelles of surfactants. The results suggest, therefore, that the present synthetic method is very useful for preparing PEG-based prodrugs from pharmaceuticals having carboxyl functionalities.

• Proceedings of the Korean Biophysical Society Conference
• /
• 1999.06a
• /
• pp.35-35
• /
• 1999

Amylases catalyze the hydrolysis of starch material and play central roles in carbohydrate metabolism. The structure and a size exclusion column chromatography proved that the enzyme is a dimer in solution. The N -terminal segment of the enzyme folds into a distinct domain and comprises the enzyme active site together with the central (${\alpha}$/ ${\beta}$)$\sub$8/ barrel of the adjacent subunit.(omitted)

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.24 no.2
• /
• pp.238-243
• /
• 2021

Caudal regression syndrome (CRS) is a rare neural tube defect that affects the terminal spinal segment, manifesting as neurological deficits and structural anomalies in the lower body. We report a case of a 31-month-old boy presenting with constipation who had long been considered to have functional constipation but was finally confirmed to have CRS. Small, flat buttocks with bilateral buttock dimples and a short intergluteal cleft were identified on close examination. Plain radiographs of the abdomen, retrospectively reviewed, revealed the absence of the distal sacrum and the coccyx. During the 5-year follow-up period, we could find his long-term clinical course showing bowel and bladder dysfunction without progressive neurologic deficits. We present this case to highlight the fact that a precise physical examination, along with a close evaluation of plain radiographs encompassing the sacrum, is necessary with a strong suspicion of spinal dysraphism when confronting a child with chronic constipation despite the absence of neurologic deficits or gross structural anomalies.

• International Journal of Internet, Broadcasting and Communication
• /
• v.16 no.1
• /
• pp.29-35
• /
• 2024

TCP is considered as one of the major candidate transport protocols even for constrained IoT networks..In our previous work, we investigated the congestion control mechanism of the uIP TCP. Since the uIP TCP sets the window size to one segment by default, managing the retransmission timer is the primary approach to congestion control. However, the original uIP TCP sets the retransmission timer based on the fixed RTO, it performs poorly when a radio duty cycling mechanism is enabled and the hidden terminal problem is severe. In our previous work, we proposed a TCP retransmission timer adjustment scheme for uIP TCP which adopts the notion of weak RTT estimation of CoCoA, exponential backoffs with variable limits, and dithering. Although our previous work showed that the proposed retransmission timer adjustment scheme can improve performance, we observe that the scheme often causes a node to set the retransmission timer for an excessively too long time period. In this work, we show that slightly modifying the dithering mechanism of the previous scheme is effective for improving TCP fairness.

• Journal of Advanced Navigation Technology
• /
• v.24 no.6
• /
• pp.500-507
• /
• 2020

This paper presents a risk assessment methodology for standard flight procedures using recorded automatic dependent surveillance-broadcast (ADS-B) data. Utilizing the proposed methodology, the results of risk analyses in RKSI (incheon international airport) and RKSS (gimpo international airport) using trajectories that are regenerated based on 100 days of ADS-B data are presented. For the risk metric, detect and avoid well clear (DWC) is used. With this index, each procedure was evaluated for the sections with highest level of risk. Among the standard instrument departure (SID) of RKSI, the section between SI712 and RANOS of RNAV BOPTA 1L showed the highest level of risk. For the standard terminal arrival route (STAR) of RKSI, section between SI947 and DANAN of RNAV GUKDO 1N wasthe one with the highest level of risk. For RKSS, the segment between SS726 and SS727 of RNAV BULTI 1X and the segment between KAKSO and KALMA of RNAV OLMEN 1D showed the highest level of risk among the SIDs and STARs, respectivly.