• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4084-4092
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• 2012

Theoretical calculations based on density functional theory (DFT) were performed to study the substituent effect on the geometric and electronic structures as well as the biological behavior of technetium-99m-labeled diphosphonate complexes. Optimized structures of these complexes are surrounded by six ligands in an octahedral environment with three unpaired 4d electrons ($d^3$ state) and the optimized geometry of $^{99m}Tc$-MDP agrees with experimental data. With the increase of electron-donating substituent or tether between phosphate groups, the energy gap between frontier orbitals increases and the probability of non-radiative deactivation via d-d electron transfer decreases. The charge distribution reflects a significant ligand-to-metal electron donation. Based on the calculated geometric and electronic structures and biologic properties of $^{99m}Tc$-diphosphonate complexes, several structure-activity relationships (SARs) were established. These results may be instructive for the design and synthesis of novel $^{99m}Tc$-diphosphonate bone imaging agent and other $^{99m}Tc$-based radiopharmaceuticals.

• Satellite Communications and Space Industry
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• v.2 no.3
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• pp.83-92
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• 1994

Outer Space is existing as the opening-up frontier. The space activities included benefit-and-risk are now confronted with the challenge of arriving at just and effective rules for the use of space serving many technical, practical and conflicting legal, economic, political and military interests. Therefore many governments have developed domestic and international policies to respond to the opportunities and constraints engendered by space exploration and exploitation. the challenges of outer space toward the 21st century are being internationalized, commercialized, and privatized, militarized through the international cooperation and competition in space activities. For the future of mankind, futhermore the right to live of humankind, we must be positively interested in international space law which may give rise to international repercussions. I suggeste that many issues be resolved by international coordinating organization.

• The KIPS Transactions:PartD
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• v.16D no.2
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• pp.257-264
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• 2009

The purposes of e-Government are to connect government agencies without boundary, and to deliver better quality e-services to citizens. The frontier countries try to reach the e-Government goals using Government Interoperability Framework(GIF). Even though Korea also has interoperability regulations, that is obscure. So we have some limitations to take the e-Government interoperability advantages. This study analyzes the cases of advanced countries (EU, U.S., U.K., and Australia), and reviews Korea's regulations. After that, we suggest EA based Korean e-Government Interoperability Framework(K-GIF), that is to manage the interoperability from business to information technology over the whole IT life cycle.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2006.06a
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• pp.204-205
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• 2006

In the response to the demand for electrical energy, much effort aimed to develop and commercialize high temperature superconducting (HTS) power equipments has been made around the world. In Korea, companies and universities are developing a power distribution and transmission class HTS transformer that is one of the 21st century superconducting frontier projects. The composite winding of transmission class HTS transformer is concentrically arranged H1-L-H2 from center. H1 is continuous disk type, L is layer type and H3 is continuous disk type. For the development of transmission HTS transformer with composite winding, the cryogenic insulation technology should be established. We have been analyzed insulation composition and investigated electrical characteristics such as breakdown of $LN_2$, barrier, kapton films, surface flashover on FRP in $LN_2$. We are going to compare with measured each value and apply the value to most suitable insulating design of the HTS transformer.

• Parasites, Hosts and Diseases
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• v.49 no.3
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• pp.221-228
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• 2011

Rodent malaria parasites, such as Plasmodium berghei, are practical and useful model organisms for human malaria research because of their analogies to the human malaria in terms of structure, physiology, and life cycle. Exploiting the available genetic sequence information, we constructed a cDNA library from the erythrocytic stages of P. berghei and analyzed the expressed sequence tag (EST). A total of 10,040 ESTs were generated and assembled into 2,462 clusters. These EST clusters were compared against public protein databases and 48 putative new transcripts, most of which were hypothetical proteins with unknown function, were identified. Genes encoding ribosomal or membrane proteins and purine nucleotide phosphorylases were highly abundant clusters in P. berghei. Protein domain analyses and the Gene Ontology functional categorization revealed translation/protein folding, metabolism, protein degradation, and multiple family of variant antigens to be mainly prevalent. The presently-collected ESTs and its bioinformatic analysis will be useful resources to identify for drug target and vaccine candidates and validate gene predictions of P. berghei.

• Analytical Science and Technology
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• v.20 no.4
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• pp.339-346
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• 2007

To search the ninhydrin derivatives that have high chromogenic and fluorogenic properties, molecular holographic quantitative structure property relationship (HQSPR) models on the reactivity between glycine and ninhydrin analogues as latent fingerprint detector were derived and investigated quantitatively. The ${\varepsilon}LUMO$ (e.v.) energy of ninhydrin molecule was an important factor to reactivity of ninhydrin. And, it is suggested that the nucleophilic reaction by orbital-controlled reaction from the frontier molecular orbital (FMO) interaction between glycine and ninhydrin derivatives was more superior than that of electrophilic reaction by charged controlled reaction. The analytical results in atomic contribution maps also shows that the reactivity of ninhydrin was increased by meta-substituents as strong electron withdrawing groups on the benzo ring. Therefore, it is sugested by HQSPR and QSPR model that the 5,6-dinitroninhydrin molecule would increase the reactivity as much as three times as compared to none substituted ninhydrin molecule.

• Korean Journal of Food Science and Technology
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• v.37 no.4
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• pp.660-670
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• 2005

Standard procedure for development of food list was established based on food intake data of 2001 National Health and Nutrition Survey and 2002 Seasonal Nutrition Survey for Total Diet Study. Foods were sorted in descending order of mean intake, and 54 items within cumulative percentage of 80 were selected, followed by selection of 16 additional items with consumption frequency of 10% or higher. Based on higher consumption in certain seasons, regions, sexes, and age classes, 14 additional items were added. Additional 17 items with probable high contents of heavy metals or 23 items with probable high pesticide residues were added. Altogether, 101 and 107 individual food items were included for heavy metal and pesticide residue lists, accounting for 84.9 and 83.3% mean energy intakes of Korean population, respectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.518-527
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• 2020

The establishment of a green remodeling strategy is focused on technology, so the necessity of establishing a customized strategy considering the field situation has emerged. This paper examined the technology strategy through sensitivity analysis as a methodology for guiding strategy. For a 90-square-meter detached house, nine models of the construction standards of pre-1980s, 1984, and 2010 in Seoul, Daejeon, and Busan were assessed using the optimization method that combines the energy plus engine and the ModeFrontier. Sensitivity analysis was performed, and the remodeling strategy priority was derived. For pre-1980 models, the strategy for enhancing the roof insulation performance had a significant priority. The SHGC values of the windows were found to have the next highest priority regardless of the region and the time of completion, showing that the performance standard, including the SHGC, needs to be expanded. The possibility of remodeling while maintaining the existing geometry was confirmed because the adjustment of the window wall ratio accompanying large-scale demolition works has low priority. The priorities of technology strategies in each case showed very different patterns, suggesting the possibility of establishing a remodeling strategy by a comprehensive evaluation along with economics and constructability analysis.

• Applied Biological Chemistry
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• v.43 no.1
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• pp.52-56
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• 2000

The influence of the 2-(4-(6-chloro-2-benzoxazolyloxy)phenoxy)-N-phenyl- propionamide derivatives on the herbicide activities against rice plant with pre-emergence and post-emergence in down land were examined and the structure activity relationship (SAR) were analyzed by Free-Wilson and Hansch method. In pre-emergence, the SAR approach is shown that the optimal, $({\pi})_{opt}=0.91$, hydrophobicity with electron donating effect of the ortho substituted mono substituents and 2,3,4-substituted three substituents were found to be contribute the herbicidal activity. Whereas, in post-emergence, the optimal, ({\pi})_{opt}=0.50$, hydrophobicity with electron withdrawing effect of meta substituted mono subsituents and 2,3-substituted two substituents were found to be contribute the herbicide activity. The herbicide activities with post-emergence more increase than that of pre-emergence. It is assumed from the SAR equations that the 2-methyl-3-methoxy-4-cyano group substituent is selected as the most lowest herbicide activity against rice plant with post-emergence in green house. The hydrolysis reaction was proceeded through nucleophilic addition-elimination (Ad_{Nu-E})$ with the orbital control between LUMO of substrate and HOMO of water molecule. And molecular electrostatic potential (MEP) of none (H) substituent was discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.91-102
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• 2020

This study constructed production frontiers of inputs and outputs in a sequential manner, measured inefficiencies by applying a non-radial sequential weighted Russell directional distance function to these frontiers, and analyzed Luenberg productivity indices and the contribution of each of input and output factor based on these distances. The results are as follows. First, the productivity of banks increased due to technical changes after the global financial crisis. Second, productivity growth decreased between 2009 and 2014 due to technical changes after the recession, as previous studies have shown that technology progressed before the global financial crisis but then largely decreased or remained the same thereafter. After 2014, the productivity of banks improved. This result may be due to both technology improvement after 10 years of stagnation and reduction of inputs and non-performing loans. Third, the 3.6% annual of productivity growth for 10 years was comprised of 1.77% household loans, 0.67% corporate loans, 0.98% manpower, 1.18% non-performing loans, -0.5% total deposits, and -1.25% securities. Finally, this study has limitations since it could not control risks such as capital structure and interest volatility.