• Journal of Microbiology and Biotechnology
• /
• v.13 no.2
• /
• pp.317-320
• /
• 2003

Genome-wide systematic deletion mutants were generated using a PCR-based targeted mutagenesis of Schizosacchaaromyces pombe. In a drug-sensitivity assay using thiabendazole(TBZ), an inhibitor of microtubule assembly, a heterozygous nda2 mutant ($nda2^+/nda2^-$), deleting one copy of nda2 encoding the microtubule subunit alpha1 demonstrated a distinct sensitivity to TBZ, indicating TBZ-induced haploinsufficiency. This result suggests that profiling drug-induced haploinsufficiency can be exploited to identify target genes for drugs and discover new drugs.

• Smart Structures and Systems
• /
• v.7 no.4
• /
• pp.263-274
• /
• 2011

A reliability-based slope stability assessment method considering fluctuations in the monitored matric suction was proposed for real-time identification of slope risk. The assessment model was based on the limit equilibrium model for infinite slope failure. The first-order reliability method (FORM) was adopted to calculate the probability of slope failure, and results of the model were compared with Monte-Carlo Simulation (MCS) results to validate the accuracy and efficiency of the model. The analysis shows that a model based on Advanced First-Order Reliability Method (AFORM) generates results that are in relatively good agreement with those of the MCS, using a relatively small number of function calls. The contribution of random variables to the slope reliability index was also examined using sensitivity analysis. The results of sensitivity analysis indicate that the effective cohesion c' is a significant variable at low values of mean matric suction, whereas matric suction ($u_a-u_w$) is the most influential factor at high mean suction values. Finally, the reliability indices of an unsaturated model soil slope, which was monitored by a wireless matric suction measurement system, were illustrated as 2D images using the suggested probabilistic model.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.32 no.4
• /
• pp.313-319
• /
• 2019

Induction motors connected with a three-phase AC system may malfunction due to reverse phase or open phase faults. Conventional overcurrent relays and overheating relays are used to prevent such accidents; however, their drawbacks include a low response speed and false operation. Therefore, in this study, a digital relay for the reverse-open phase was designed and fabricated. This relay can detect the reverse phase and open phase faults and send a trigger signal to the control circuit. The proposed relay was developed based on a microcontroller. The detection times of the reverse phase and open phase were verified as 320ms and 80ms, respectively. Compared with conventional relays that only protect the motor from one type of fault, the proposed relay can detect both, reverse phase and open phase faults. In addition, the fault detection, identification criterion, and trigger signal patterns can be modified by programming according to the requirements of users.

• Korean Journal of Plant Taxonomy
• /
• v.49 no.3
• /
• pp.203-208
• /
• 2019

Sparganium coreanum, a barely recognized species in Korea, was rediscovered during a field survey by the authors, who conducted a re-examination of specimens deposited in the Herbarium of the Korea National Arboretum (KH). This species was described initially by H. $L{\acute{e}}veill{\acute{e}}$ from a specimen collected by F. Taquet from Jeju-do (Taquet 2150). Subsequently, however, it was overlooked and unrecognized among South Korean flora. Several populations of S. coreanum were found in the southern part of the Korean Peninsula and on Jeju-do, although it has long been recognized as S. erectum owing to certain vegetative morphological characteristics shared between the two species, such as robust stems, a similar plant height, and globose rhizomes. However, it is distinct from S. erectum by the number of female heads on the lowest inflorescence branch and the size and shape of the fruit. In this study, we provide a detailed description, illustrations, and photographs with a revised taxonomic key for identification of Sparganium species in Korea.

• Clinical and Experimental Pediatrics
• /
• v.64 no.9
• /
• pp.443-458
• /
• 2021

In Korea, several national cross-sectional surveys monitor the diet, nutritional status, and health status of children. This continual dedicated national surveillance system contributes to the identification of nutritional and health issues, establishment of public health policies, and development of nutrition recommendations. This paper provides recent information about the Korea National Health and Nutrition Examination Survey and the Korean Youth Risk Behavior Web-based Survey and describes key nationwide survey findings published in the last 5 years on infant feeding practices and the dietary intake and nutritional status of Korean infants, children, and adolescents. There have been increasing trends in children, and teenagers who skip breakfast, eat fast food, consume sugary drinks, have vitamin D deficiency, and are obese. This review will inform pediatricians, nutritionists, and other health care practitioners who track children's growth and development. It may also help researchers and policymakers identify diet-related policies and strategies for chronic disease prevention in Korean infants, children, and adolescents.

• International journal of advanced smart convergence
• /
• v.11 no.2
• /
• pp.194-204
• /
• 2022

This study is a one-group pretest-posttest design to evaluate the effect of problem-based learning (PBL) for patient safety on self-leadership, patient safety competencies, and reflective thinking of nursing students. The research was conducted from March 2 to April 15, 2022, in which 57 nursing students participated. PBL for patient safety was examined in a total of 8 sessions in the order of motivation, problem identification, task performance planning, problem-solving methods, summary and solution, presentation, and evaluation. The following topics of patient safety were selected for each team: nursing records, high-alert medication, medication error and intravenous fluid regulation, blood transfusion care, fall, bedsore, infection control, and pain management. We provided feedback on the learning process and outcomes of nursing students. According to the results, self-leadership showed a statistically significant improvement in self-expectations (t=2.60, p=0.01), goal setting (t=2.84, p<0.01), self-reward (t=3.32, p<0.01), and self-criticism (t=2.32, p=0.02). Patient safety competencies showed a statistically significant improvement in patient safety knowledge (t=13.05, p<0.001) and patient safety skills (t=4.87, p<0.001) but not in reflective thinking. The results prove that PBL for patient safety is an effective teaching-learning strategy to improve self-leadership and patient safety competencies. Future studies must develop and validate specific and long-term teaching-learning methods to improve reflective thinking.

• Archives of Craniofacial Surgery
• /
• v.24 no.4
• /
• pp.145-158
• /
• 2023

Vascular anomalies encompass a variety of malformations and tumors that can result in severe morbidity and mortality in both adults and children. Advances have been made in the classification and diagnosis of these anomalies, with the International Society for the Study of Vascular Anomalies establishing a widely recognized classification system. In recent years, notable progress has been made in genetic testing and imaging techniques, enhancing our ability to diagnose these conditions. The increasing sophistication of genetic testing has facilitated the identification of specific genetic mutations that help treatment decisions. Furthermore, imaging techniques such as magnetic resonance imaging and computed tomography have greatly improved our capacity to visualize and detect vascular abnormalities, enabling more accurate diagnoses. When considering reconstructive surgery for facial vascular anomalies, it is important to consider both functional and cosmetic results of the procedure. Therefore, a comprehensive multidisciplinary approach involving specialists from dermatology, radiology, and genetics is often required to ensure effective management of these conditions. Overall, the treatment approach for facial vascular anomalies depends on the type, size, location, and severity of the anomaly. A thorough evaluation by a team of specialists can determine the most appropriate and effective treatment plan.

• Korean Journal of Radiology
• /
• v.22 no.5
• /
• pp.811-828
• /
• 2021

Following the introduction of a novel pathological concept of usual interstitial pneumonia (UIP) by Liebow and Carrington in 1969, diffuse interstitial pneumonia has evolved into UIP, nonspecific interstitial pneumonia (NSIP), and interstitial lung abnormality (ILA); the histopathological and CT findings of these conditions reflect the required multidisciplinary team approach, involving pulmonologists, radiologists, and pathologists, for their diagnosis and management. Concomitantly, traction bronchiectasis and bronchiolectasis have been recognized as the most persistent and important indices of the severity and prognosis of fibrotic lung diseases. The traction bronchiectasis index (TBI) can stratify the prognoses of patients with ILAs. In this review, the evolutionary concepts of UIP, NSIP, and ILAs are summarized in tables and figures, with a demonstration of the correlation between CT findings and pathologic evaluation. The CT-based UIP score is being proposed to facilitate a better understanding of the spectrum of pulmonary fibrosis, from ILAs to UIP, with emphasis on traction bronchiectasis/bronchiolectasis.

• Nuclear Engineering and Technology
• /
• v.55 no.12
• /
• pp.4695-4702
• /
• 2023

Nuclear power plants play a pivotal role in the global energy infrastructure, fulfilling a substantial share of the world's energy requirements in a sustainable way. The management of these facilities, especially the handling of spent nuclear fuel (SNF), necessitates meticulous inspections to guarantee operational safety and efficiency. However, the prevailing inspection methodologies lean heavily on human operators, which presents challenges due to the potential hazards of the SNF environment. This study introduces the design of a novel Pre-Batched Inspection Strategy (PBIS) that integrates robotic automation and image processing techniques to bolster the inspection process. This methodology deploys robotics to undertake tasks that could be perilous or time-intensive for humans, while image processing techniques are used for precise identification of SNF targets and regulating the robotic system. The implementation of PBIS holds considerable promise in minimizing inspection time and enhancing worker safety. This paper elaborates on the structure, capabilities, and application of PBIS, underlining its potential implications for the future of nuclear energy inspections.

• The Journal of Internal Korean Medicine
• /
• v.43 no.6
• /
• pp.1105-1121
• /
• 2022

Objectives: The purpose of this study is to explore the effectiveness and safety of frequently used clinical herbal medicines (Yijung-tang [Lizhong-tang, LJT], Pyeongwi-san [Pingwei-san, PWS], and Shihosogan-tang [Chaihu Shugan-tang, SST]) in patients with functional dyspepsia (FD) when administered according to herbal medicine and Korean medicine pattern identification. The results of this study will be used to standardize the diagnostic instrument used in Korean medicine and to investigate biomarkers of Korean medicine pattern identification. Methods: This study will be a randomized, assessor-blind, 3-arm, parallel, open-label, multi-center clinical trial. A total of 300 FD participants will be recruited from 3 Korean medical hospitals and assigned to the LJT (n=100), PWS (n=100), and SST (n=100) groups according to FD pattern identification. The patients will take the medication for 8 weeks, 3 times a day, before or between meals. The primary outcome will be total dyspepsia symptom (TDS) and the secondary outcomes will be adequate relief (AR) for dyspepsia, overall treatment effect (OTE), visual analogue scale (VAS), functional dyspepsia-related quality of life (FD-QoL), gastrointestinal symptom score (GIS), and pattern identification questionnaires. For the exploratory outcomes, we will analyze blood and fecal metabolome profiles, microbiota from fecal and saliva samples, single nucleotide polymorphism (SNP), and results of Korean medicine diagnosis device measurements (heart rate variability, and tongue, pulse, and abdominal diagnosis). Conclusions: The results of this study will prove objectivity for Korean medicine pattern identifications, and the effectiveness and safety of herbal medicines for the population with FD.