• Molecules and Cells
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• 제41권7호
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• pp.646-652
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• 2018

Neurodegeneration can result in memory loss in the central nervous system (CNS) and impairment of taste and smell in the peripheral nervous system (PNS). The neurodegeneration seen in Parkinson's disease (PD) is characterized by functional loss of dopaminergic neurons. Recent studies have also found a role for dopaminergic neurons in regulating taste memory rewards in insects. To investigate how taste memories and sugar sensitivity can be affected in PD, we utilized the $DJ-1{\beta}$ mutant fruit fly, $DJ-1{\beta}^{ex54}$, as a PD model. We performed binary choice feeding assays, electrophysiology and taste-mediated memory tests to explore the function of the $DJ-1{\beta}$ gene in terms of sugar sensitivity as well as associative taste memory. We found that PD flies exhibited an impaired ability to discriminate sucrose across a range of sugar concentrations, with normal responses at only very high concentrations of sugar. They also showed an impairment in associative taste memory. We highlight that the taste impairment and memory defect in $DJ-1{\beta}^{ex54}$ can be recovered by the expression of wild-type $DJ-1{\beta}$ gene in the dopaminergic neurons. We also emphasized the role of dopaminergic neurons in restoring taste memory function. This impaired memory property of $DJ-1{\beta}^{ex54}$ flies also allows them to be used as a model system for finding supplementary dietary foods that can improve memory function. Here we provide evidence that the associative taste memory of both control and $DJ-1{\beta}^{ex54}$ flies can be enhanced with dietary supplementation of the medicinal plant, omija.

• Journal of Microbiology and Biotechnology
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• 제34권5호
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• pp.1092-1100
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• 2024

The global elderly population, aged 65 and over, reached approximately 10% in 2020, and this proportion is expected to continue rising. Therefore, the prevalence of neurodegenerative diseases such as Parkinson's disease (PD), which are characterized by declining memory capabilities, is anticipated to increase. In a previous study, we successfully restored the diminished memory capabilities in a fruit fly model of PD by administering an omija extract. To identify functional ingredients that can enhance memory akin to the effects of the omija extract, we conducted screenings by administering halophyte extracts to the PD model. Halophytes are plants that thrive in high-salt environments, and given Korea's geographic proximity to the sea on three sides, it serves as an optimal hub for the utilization of these plants. Upon examining the effects of the oral administration of 12 halophyte extracts, Salicornia herbacea and Calystegia soldanella emerged as potential candidates for ameliorating memory loss in PD model flies. Moreover, our findings suggested that C. soldanella, but not S. herbacea, can mitigate oxidative stress in DJ-1β mutants.

• Molecules and Cells
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• 제44권2호
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• pp.68-78
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• 2021

Secondary metabolites enable plants to protect themselves from herbivorous insects. Among these, cucurbitacin B (cuc-B) is a bitter-tasting compound with promising pharmacological potential. Dietary exposure to cuc-B lowered the hemolymph glucose levels of Drosophila melanogaster fed with a high carbohydrate diet, which is homologous to high blood glucose in humans, and its effect was comparable to that of metformin, a well-known glucose-lowering drug. Furthermore, cuc-B reduced tissue sugar levels and glycogen levels, as well as triacylglycerol levels. Our results thus highlight the potential applicability of this compound to treat chronic metabolic diseases such as diabetes and obesity. Additionally, we analyzed sleep quality and taste-associative memory enhancement after cuc-B and metformin treatment. Both supplements increased nighttime bout length and metformin increased memory consolidation. Therefore, discarded shell of Cucurbitaceae could be processed into health supplements.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권11호
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• pp.2849-2865
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• 2012

In order to block mobile junk messages automatically, many studies on spam filters have applied machine learning algorithms. Most previous research focused only on the accuracy rate of spam filters from the view point of the algorithm used, not on individual user's preferences. In terms of individual taste, the spam filters implemented on a mobile device have the advantage over spam filters on a network node, because it deals with only incoming messages on the users' phone and generates no additional traffic during the filtering process. However, a spam filter on a mobile phone has to consider the consumption of resources, because energy, memory and computing ability are limited. Moreover, as time passes an increasing number of feature words are likely to exhaust mobile resources. In this paper we propose a spam filter model distributed between a users' computer and smart phone. We expect the model to follow personal decision boundaries and use the uniform resources of smart phones. An authorized user's computer takes on the more complex and time consuming jobs, such as feature selection and training, while the smart phone performs only the minimum amount of work for filtering and utilizes the results of the information calculated on the desktop. Our experiments show that the accuracy of our method is more than 95% with Na$\ddot{i}$ve Bayes and Support Vector Machine, and our model that uses uniform memory does not affect other applications that run on the smart phone.

• 대한한의학방제학회지
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• 제16권1호
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• pp.131-145
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• 2008

With tablets and powder, decoction has been a widely-used method of medicine formula. However, for these formulas have unique bitter tastes and flavors of herbal component materials as it is, the compliance of herbal medicine is severly decreased especially for female and younger patients. Consequently, expected treatment effects can't be acquired completely. If loathsome tastes and flavors of decoction were effectively reduced while pharmacological activity were kept intact, the compliance could be promoted Chong-Myung-Tang has been widely prescribed for student patients with memory This study shows that Chong-Myung-Tang+chocolate have no difference from Chong-Myung-Tang in terms of pharmacological activity. Sensory difference with net chocolate was also surved. In order to observe the difference of Chong-Myung-Tang+chocolate and Chong-Myung-Tang, memory impairment was induced by intraventricular injection of $A{\beta}_{25-35}$ peptides on mice and Chong-Myung-Tang and Chong-Myung-Tang+chocolate were administered orally for 14 days. In water maze task, improvement of learning ability during acquisition period and significant increase of memory score during retention period resulted from the treatment of Chong-Myung-Tang and Chong-Myung-Tang+chocolate with respect to the $A{\beta}-injected$ control animals. Furthermore, the $A{\beta}_{25-35}$ toxicity on the hippocampus was assessed with immunohistochemistry (Bax, TUNEL), and differences in antioxidant activity was observed through TBARS and DPPH test. We employed sensory tests using chocolate flavor, herb flavor, and bitter taste & hardness as standards to show sensory differences with net chocolate. In this study, it is demonstrated that Chong-Myung-Tang+chocolate do not disturb the pharmacological activity of Chong-Myung-Tang, and have no sensory difference with net chocolate. Chong-Myung-Tang+chocolate can be used to enhance the compliance remarkably and thought of as an effective, functional formula to maximize expected treatment.

• 한국콘텐츠학회논문지
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• 제9권9호
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• pp.191-198
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• 2009

21세기는 기술 발달로 인해 소재의 다양화와 학문적 연계를 통한 디자인 결합은 우리의 삶에 있어 다양한 욕구의 변화를 가져왔으며, 그로인해 시각적인 관심과 함께 기능적 역할의 조화로 자기 개성에 맞는 디자인 개발이 관심의 대상이 되고 있다. 최근 다양한 소재를 이용한 디자인 개발이 추세이고 이러한 디자인 경향은 개인의 감성과 취향을 존중하고 있으며, 이에 따라 다변화 되고 있다. 생활수준의 향상으로 건강과 개성에 대한 관심과 향기에 대한 관심이 높아지고 향(香)은 기억이나 감성 등 개인의 취향과 개성에 맞게 다양한 형태로 개발되고 있다. 이에 본 연구자는 향기 나는 소재를 사용하여 기계적인 특성과 미적 요소를 가미한 소재를 가지고 소비자의 감성적 욕구에 맞게 장신구 분야에 적용하고 시각적 디자인에 후각을 접목하면서 여성의 보조적 디자인에서 벗어나 남성만의 개성과 감성을 표현 할 수 있는 남성 신변장신구에 대한 활용 방안을 제시 하고자 한다.

• 한국콘텐츠학회논문지
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• 제9권1호
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• pp.23-29
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• 2009

본 논문은 일생동안 한 개인이 느끼는 오감 정보를 모두 저장하는 데 필요한 기억 용량을 분석하고 저장공간을 추정하였다. 추정된 저장 공간은 현대 압축 기술을 사용하였고, 오감 정보는 입거나 이식 가능한 유비쿼터스 환경하에서 얻어지는 센싱 정보이다. 저장 공간의 약 76%가 일반 텔레비젼 수준의 화질인 비디오 시각 정보를 저장하는 데 사용되고 저장 공간의 나머지 부분은 인덱스 정보를 포함하는 음성, 미각, 후각, 촉각 정보를 저장한다. 한 개인의 태아기를 포함한 일생 동안, 약 100년간의 데이터 저장에는 약 600 tera bytes의 저장 용량이 필요한 것으로 분석되었다.

• BMB Reports
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• 제49권10호
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• pp.542-547
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• 2016

Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. Proton sensing by ASICs has been known to mediate pain, mechanosensation, taste transduction, learning and memory, and fear. In this study, we investigated the differential subcellular localization of ASIC2a and ASIC3 in heterologous expression systems. While ASIC2a targeted the cell surface itself, ASIC3 was mostly accumulated in the ER with partial expression in the plasma membrane. However, when ASIC3 was co-expressed with ASIC2a, its surface expression was markedly increased. By using bimolecular fluorescence complementation (BiFC) assay, we confirmed the heteromeric association between ASIC2a and ASIC3 subunits. In addition, we observed that the ASIC2a-dependent surface trafficking of ASIC3 remarkably enhanced the sustained component of the currents. Our study demonstrates that ASIC2a can increase the membrane conductance sensitivity to protons by facilitating the surface expression of ASIC3 through herteromeric assembly.

• 임상간호연구
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• 제14권1호
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• pp.61-70
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• 2008

Purpose: Women with gynecologic cancer often experience various physical and psychological symptoms relating to the cancer and its treatment. The purpose of this study was to identify symptom clusters. Method: A survey was conducted on 184 women with diagnoses of cervical, ovarian or endometrial cancer. Fifty symptoms were assessed for prevalence, severity and interference, and symptom clusters were identified. Cluster analysis was done using SPSS version 12.0. Results: Fatigue was identified as the most prevalent symptom (81.52%), lack of vaginal lubrication (2.26) as the most severe symptom, and lack of vaginal lubrication as the most interfering one (2.15). Identified six clusters were: Anorexia-pain cluster (loss of appetite, taste change, weight loss, appearance change, alopecia, weakness, pain), Fatigue cluster (lack of concentration, lack of memory, fatigue, dry mouth), Urinary-bowel distress cluster (urinary difficulty, constipation), Abdominal discomfort cluster (lower abdominal pain, abdominal pain, bloating), Emotional distress (sadness, anxiety-worry, nervousness, restlessness), and Menopausal cluster (sweating, hot flush, fever). Conclusion: The result of this study provides fundamental data to health care professionals in developing interventions for effective symptom management for women with gynecologic cancer by understanding identified 6 symptom clusters.

• 감성과학
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• 제13권4호
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• pp.635-646
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• 2010

본 논문에서는 Funology(퍼놀로지)와 몸의 체험 통해 형성된 언어개념 및 사고를 바탕으로 새로운 어플리케이션 분류 체계를 연구하고, 이를 Funology Body로 명명하였다. Funology Body는 크게 몸, 세계(환경), 디바이스 툴의 구성을 가진 분류 및 검색 체계이다. 몸은 신체의 부위에 따라 Brain, Eyes, Ears, Nose, Mouth, Hand, Torso, Feet, Heat로 구분할 수 있는데, 몸 부분의 개념과 관련된 앱을 연결시켜 분류체계를 구성함으로써 쉽고 직관적이며, 체험적인 검색을 가능하게 하였다. 봄의 구성 중 Brain은 사고와 관련된 어플리케이션을 포함할 수 있도록 Book, Account, Business, Memory, Education, Search, Aphorism로 하위분류되어 있으며, Eyes는 시각과 관련된 Video, Photography, Broadcast로, Ears는 청각과 관련된 Music, Instrument, Audio, Radio로, Nose는 후각과 관련된 Perfume, Smell로, Mouth는 먹을 것 및 의사소통과 관련된 Food, SNS, Chatting, Email, Blog로 Hand는 조작하고 만들고 장난치는 것과 관련된 Games, Kits, Editing으로 Torso는 내장을 보호하고 몸의 중심을 이루는 개념과 관련된 Health, Medical, Dance, Sport, Fashion, Testyuorself로 Feet는 이동하여 영토를 넓히는 개념과 관련된 Travel, Transportation, Map, Outdoor로, Heat는 감정과 관련된 Fear, Anger, Joy, Sadness, Acceptance, Disgust, Expectation, Surprise로 이루어져 있다. 그밖에 세계(환경)는 News, Time, Weather, Map, Fortune, Shop으로 디바이스 툴은 Interface, Utilities로 구성되어 있다. 직관적이고, 감각적인 재미를 줄 수 있다는 것뿐만 아니라 변화하는 어플리케이션 사용자의 태도와 취향을 유연성 있게 반영할 수 있다는 점에서 기존 분류체계와는 다른 Funology Body의 특정을 찾을 수 있다.