• Journal of Information Technology Applications and Management
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• 제28권1호
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• pp.83-93
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• 2021

The purpose of this study was to develop a personalized SMT (smart monitor target) game interface for game users who enjoy airsoft sports as individual purchases of SMT have increased since the advent of the untouched era. For this study, the UX (user experience) of the game interface was designed based on previous research. In particular, the personalized game service was reinforced by adding the CP (command post) of the SMT system that performs the home function of the console game, which was intended to help the user maintain immersed in the game in the personalized space of the SMT. Major design elements for the SMT game interface included layout, color, graphics, buttons, and text, and the interface design was proceeded based on them. After composing a grid with a layout in which the tab function was applied to the interface with a vertical three-segment structure and the outer margin value secured, the military camouflage pattern and texture were applied to the colored tone to perform graphics work. Targets and thumbnails were produced as illustrations using experts to ensure the consistency of the interface, and then function buttons and texts on each page were used concisely for intuitive information delivery. The design sources organized in this way were developed using the Unity engine. In the future, we hope that game user-centered personalized interfaces will continue to develop and provide differentiated services unique to SMT systems in the airsoft gun market.

• Journal of Microbiology and Biotechnology
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• 제19권3호
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• pp.217-228
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• 2009

Mobile genetic segments, or transposons, are also referred to as jumping genes as they can shift from one position in the genome to another, thus inducing a chromosomal mutation. According to the target site-specificity of the transposon during a transposition event, the result is either the insertion of a gene of interest at a specific chromosomal site, or the creation of knockout mutants. The former situation includes the integration of conjugative transposons via site-specific recombination, several transposons preferring a target site of a conserved AT-rich sequence, and Tn7 being site-specifically inserted at attTn7, the downstream of the essential glmS gene. The latter situation is exploited for random mutagenesis in many prokaryotes, including IS (insertion sequence) elements, mariner, Mu, Tn3 derivatives (Tn4430 and Tn917), Tn5, modified Tn7, Tn10, Tn552, and Ty1, enabling a variety of genetic manipulations. Randomly inserted transposons have been previously employed for a variety of applications such as genetic footprinting, gene transcriptional and translational fusion, signature-tagged mutagenesis (STM), DNA or cDNA sequencing, transposon site hybridization (TraSH), and scanning linker mutagenesis (SLM). Therefore, transposon-mediated genetic engineering is a valuable discipline for the study of bacterial physiology and pathogenesis in living hosts.

• 대한안전경영과학회지
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• 제19권1호
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• pp.203-210
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• 2017

Companies are pursuing the management of small quantity batch production or JIT(Just-in-time) system for improving the delivery response and LOB(Line Balancing) in order to satisfy consumers' increasing demands in the current global economic recession. And in order to improve the growth of production for reducing manufacturing cost, improvements of the Load Balancing have become an important reformation factor. Thus this paper is aimed at warehouse which procures materials on the assembly line in procurement logistics of automotive logistics and proceed with research on heuristic algorithm development which can increase the Load Balancing of workers. As a result of this study, when applied the primary target value, it was verified that the whole workers decreased from 28 to 24. Furthermore, when specified the secondary target value and applied algorithm once more, it was verified that the Load Balance Ratio was improved from 44.96% to 91.7%.

• 한국국방경영분석학회지
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• 제28권2호
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• pp.70-84
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• 2002

This paper deals with the attrition rate of major facility such as a particular building that is one of the most important target in the war time. In order to estimate the attrition rate, we use JAWS, WinJMEM which are programed by JTCG/ME of AMSAA and spreadsheet package which is able to assist the limitation of those programs and calculate all the procedure of this computation. This method uses the effectiveness index(El) which indicates the numerical measure of the effectiveness of a given weapon of a given target. The range error probable(REP) and the deflection error probable(DEP) in the ground plane also should be used. Those mean the measure of delivery accuracy of the weapon system. In this paper, it is improved that the El can be obtained from the regression analysis using the weight of the warhead explosive as the independent variable. It implies that we are able to obtain the El and the conditional probability of damage of the enemy weapon. After that, the single-sortie probability of damage can be computed using WinJMEM or another assistant program such as the spreadsheet package which shows the result immediately.

• 산업진흥연구
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• 제9권1호
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• pp.103-111
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• 2024

본 연구는 여성의 사회진출 확대와 맞벌이 부부의 증가로 인한 아동 돌봄 공백의 문제점이 발생하였고, 자녀의 초등학교 입학 이후의 돌봄 절벽 현상이 여성의 경력 단절을 심화하고 저출산의 원인 중 하나로 밝혀지며 돌봄 문제 해결과 일·가정의 양립을 위한 아동 돌봄서비스가 시작되었다. 코로나19 상황에서 아동의 등교 제한과 보호자가 부재한 상황에서 아동의 안전과 복지에 돌봄서비스의 중요성이 대두되었다. 정부는 정책적 노력을 통해 아동 돌봄 공백을 줄이기 위한 복지서비스를 제공했지만, 돌봄서비스 시행에 있어서 부처별·사업별로 대상자 선정과 전달체계의 불안정으로 인한 돌봄 제도의 효과성과 효율성의 문제점이 발생하였다. 따라서 본 연구에서는 방과 후 돌봄서비스의 사각지대를 해소하고 통합 전달체계의 효율적 운영방안을 마련하기 위해 각 부처에서 시행하는 돌봄서비스를 살펴보고, 아동 돌봄서비스 발전을 위한 방향을 모색해 보고자 한다.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.804-811
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• 2024

Foamy viruses (FVs) are generally recognized as non-pathogenic, often causing asymptomatic or mild symptoms in infections. Leveraging these unique characteristics, FV vectors hold significant promise for applications in gene therapy. This study introduces a novel platform technology using a pseudo-virus with single-round infectivity. In contrast to previous vector approaches, we developed a technique employing only two vectors, pcHFV lacking Env and pCMV-Env, to introduce the desired genes into target cells. Our investigation demonstrated the efficacy of the prototype foamy virus (PFV) dual-vector system in producing viruses and delivering transgenes into host cells. To optimize viral production, we incorporated the codon-optimized Env (optEnv) gene in pCMV-Env and the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE) at the 3' end of the transgene in the transfer vector. Consequently, the use of optEnv led to a significant enhancement in transgene expression in host cells. Additionally, the WPRE exhibited an enhancing effect. Furthermore, the introduced EGFP transgene was present in host cells for a month. In an effort to expand transgene capacity, we further streamlined the viral vector, anticipating the delivery of approximately 4.3 kbp of genes through our PFV dual-vector system. This study underscores the potential of PFVs as an alternative to lentiviruses or other retroviruses in the realm of gene therapy.

• 생명과학회지
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• 제33권9호
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• pp.754-765
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• 2023

엑소좀은 단백질, mRNA 및 miRNA를 포함하고 모든 유형의 세포에서 분비되는 세포 외 소포의 일종이다. 방출된 엑소좀은 인접하거나 멀리 있는 다른 세포에 의해 선택적으로 흡수되어 그 내용물을 방출하고 표적 세포를 재프로그래밍한다. 엑소좀은 세포에 의해 생성되는 작은 천연 소포이므로 무독성과 비면역원성의 특징이 있는 것으로 받아들여지고 있다. 최근에는 엑소좀이 중추신경계에 대한 약물 전달체로 과학적 관심을 받고 있다. 중추신경계에는 약물의 침투를 어렵게 하는 혈뇌장벽이 있고 이는 퇴행성신경질환의 치료제 개발에 큰 걸림돌이 되어왔다. 그러나 축적된 연구결과들을 볼 때, 엑소좀이 주로 트랜스사이토시스를 통해 혈뇌장벽을 통과할 수 있음이 제시되었다. 이러한 결과를 종합하면, 엑소좀은 혈뇌장벽을 넘어 뇌 실질조직에 약물을 전달할 수 있는 새로운 전달 수단이 될 것으로 기대된다. 또한 세포의 종류와 질병상태에 따라 분비되는 엑소좀의 종류가 다르기 때문에 엑소좀은 중추신경계 질환의 진단을 위한 바이오마커로도 활용될 수 있다. 본 총설 논문에서는 중추신경계 질환에 대한 바이오마커 및 치료 옵션으로서의 임상시험을 포함한 엑소좀에 대한 최근 연구동향을 정리하였다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.81-82
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• 2006

Conveyor-type transporters have been widely used as a typical delivery system of semi-conductor, FPD and other IT-related products. However, as the IT-product is getting larger in size and higher in resolution, several problems are caused by mechanical contacts between the transporter and target object. In this context, recently, lots of efforts are being devoted for development of various contact-free handling systems to get rid of deffets and oil contaminations. The objectives of this paper are to characterize suspension mechanisms and to investigate air flow effects on air levitation transport system. For this purpose, a series of CFD analyses were carried out and the simulation data showed a good agreement with the corresponding experimental ones. It is anticipated that the promising result can be used as a basis for concept design of the transport system.

• 한국응용과학기술학회지
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• 제38권1호
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• pp.147-156
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• 2021

생활체육 정책은 스포츠복지 정책의 개념적 범주에서 다루어질 필요가 있다. 스포츠복지의 개념을 넘어서 일반적인 복지의 중요한 부분으로 인식될 수 있어야 스포츠복지 정책이 가지는 효과성을 더욱 증대시킬 수 있다. 그리고 대상자인 국민에게 스포츠복지 정책을 효과적으로 전달하기 하기 위해서는 스포츠복지 정책이 다른 복지 서비스와 마찬가지로 국가적 차원의 전달체계 안에 편입될 필요가 있다. 본 연구에서는 스포츠복지 정책이 국가적 차원의 전달체계에 편입되는 방안 중 하나로 스포츠복지 거버넌스의 구성과 이를 총괄할 수 있는 스포츠복지 조직을 신설하는 복지전담 독립형 정책 모델을 제안하였다.

• 한국의학물리학회지:의학물리
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• 제29권3호
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• pp.92-100
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• 2018

The manufacturer of a linear accelerator (LINAC) has reported that the target melting phenomenon could be caused by a non-recommended output setting and the excessive use of monitor unit (MU) with intensity-modulated radiation therapy (IMRT). Due to these reasons, we observed an unexpected beam interruption during the treatment of a patient in our institution. The target status was inspected and a replacement of the target was determined. After the target replacement, the beam profile was adjusted to the machine commissioning beam data, and the absolute doses-to-water for 6 MV and 10 MV photon beams were calibrated according to American Association of Physicists in Medicine (AAPM) Task Group (TG)-51 protocol. To verify the beam data after target replacement, the beam flatness, symmetry, output factor, and percent depth dose (PDD) were measured and compared with the commissioning data. The difference between the referenced and measured data for flatness and symmetry exhibited a coincidence within 0.3% for both 6 MV and 10 MV, and the difference of the PDD at 10 cm depth ($PDD_{10}$) was also within 0.3% for both photon energies. Also, patient-specific quality assurances (QAs) were performed with gamma analysis using a 2-D diode and ion chamber array detector for eight patients. The average gamma passing rates for all patients for the relative dose distribution was $99.1%{\pm}1.0%$, and those for absolute dose distribution was $97.2%{\pm}2.7%$, which means the gamma analysis results were all clinically acceptable. In this study, we recommend that the beam characteristics, such as beam profile, depth dose, and output factors, should be examined. Further, patient-specific QAs should be performed to verify the changes in the overall beam delivery system when a target replacement is inevitable; although it is more important to check the beam output in a daily routine.