• Title/Summary/Keyword: taking herbal medicine for a long

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Effect of Herbal Medicines Including Licorice on Serum Potassium Levels (감초가 포함된 한약 복용 시 혈중 포타슘 수치의 저하에 영향을 미치는 요인)

  • Bae, Jeong-Hwa;Kim, Jung-Tae;Chung, Sung-Hyun
    • Korean Journal of Clinical Pharmacy
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    • v.22 no.2
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    • pp.153-159
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    • 2012
  • Licorice is a very useful herbal medicine frequently prescribed, but glycyrrhizin, one of its components, can cause pseudoaldosteronism presenting hypokalemia, metabolic alkalosis and hypertension as a result of prolonging a biological half-life of systemic steroid by strongly inhibiting the enzyme $11{\beta}$-hydroxysteroid dehydrogenase type 2. The risk factors for this side effect are still unclear. Here, 479 hospitalized patients taking herbal medicines including licorice for more than five days were recruited to analyze their serum potassium levels, under following parameters ; age and gender of patient, dose and period of licorice, disease state such as hypertension and with or without diuretics. They were divided into the non-occurrence group (over 3.5 mEq/L) and the occurrence group (under 3.5 mEq/L) of hypokalemia based on serum potassium levels during hospitalization. The average ages of the non-occurrence group and the occurrence group were $52.6{\pm}17.8$ and $68{\pm}10.5$, respectively (p < 0.001). But there were no noticeable differences in the daily dose of licorice, days of taking, and total dose between groups. Regression analysis showed that odd ratio of age (>60) and taking diuretics inducing hypokalemia was 3.5 (95%CI 1.5-8.1), 4.6 (95%CI 2.0-10.9) that indicates significant correlation with hypokalemia. Based upon this analysis, it is imperative to monitor regularly the risk of pseudoaldosteronism or hypokalemia not only when administered licorice of high dose for long period but also when combined it with diuretics causing hypokalemia to the elderly patients over 60 year old.

Action of the Therapeutic Principle of Strengthening the Body Resistance and Restoring Normal Functioning of the Body to Consolidate the Constitution in Tumor Treatment (부정배본법재치료중 유중적작용)

  • Shin, Sung-Hye;Lin, Hong-Sheng
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.4
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    • pp.897-902
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    • 2005
  • Internal deficiency of vital Qi is origination of cancer and root cause of its development from the viewpoint of traditional Chinese medicine(TCM). For about 40 years, China has developed a combined system of TCM and Western medical system in treatment of cancers, laying stress on the therapeutic principle of strengthening the body resistance and restoring normal functioning of the body to consolidate the constitution (Fu Zheng Pei Ben). According to the results of the latest clinical and experimental studies, Chinese medicine not only increases curative effectiveness, but also reduces the side effect caused by the toxic, radio and chemical treatment of cancer cases in the western medical system as well as various complications. Long-term taking Chinese herbal medicine prevents recurrence and metastasis of tumor, and heightens long-term curative effectiveness after western medical treatments. It also helps to relieve symptoms, improve the quality of life, and prolong life of terminal cancer patients who have already lost opportunities of western medical treatments. In addition, it can prevent and cure premonitory symptoms of cancer.

A Case Report on Post-stroke Epilepsy Treated by Korean Medicine with Uwhangchungsimwon and Jingansikpungtang-gagambang (뇌졸중 후 발생한 뇌전증 환자에 우황청심원과 진간식풍탕가감방을 활용한 한의 치료 증례 보고 1례)

  • Park, Jiwon;Kim, Seo-Hee;Lee, Jieun;Im, Jisung;Lyu, Yeoung-Su;Jo, Eun-Heui
    • Herbal Formula Science
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    • v.28 no.4
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    • pp.451-458
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    • 2020
  • Post-stroke epilepsy (PSE) slows the recovery process and reduces the quality of life of stroke survivors. Antiepileptic drugs are empirically prescribed to prevent PSE. However, the long-term use of antiepileptic drugs increases the risk of atherosclerosis, and up to 25% of patients have drug-resistant epilepsy. Herein, We report a patient with PSE who was treated with Korean medicine including Jingansikpungtang-gagambang and Uwhangchungsimwon. A 51-year-old patient had a past medical history of cerebral infarction that occurred in 2014. His first seizure occurred in January 2020 and he was diagnosed with PSE through a brain magnetic resonance imaging. The patient had a partial seizure with secondary generalization. After the initiation of taking Korean medicine, both the rate of progression to generalized seizures and the frequency of seizures was progressively and significantly reduced. This case report suggests that Korean medicine-based treatment may be safe and effective for PSE.

Case Report on Long Term Survival of Glioblastoma Patient Treated with Integrative Medicine (한양방결합치료로 장기간 생존하고 있는 교모세포종 증례 보고)

  • Yang, Juno;Yun, Youngju;Hong, Jinwoo;Han, Changwoo;Kwon, Jungnam;Lee, In;Park, Seongha;Kim, Soyeon;Choi, Junyong;Lee, Hyeyoon
    • The Journal of Korean Medicine
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    • v.39 no.1
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    • pp.75-85
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    • 2018
  • Objectives: This is a long-term survival case report about glioblastoma treated with western medicine and traditional Korean medicine. 28 year-old man diagnosed glioblastoma in 2003 went through 2 year's chemotherapy first. After emergency brain surgery he took acupuncture and Korean herbal medication including Dohongsamul-tang and Boan-Manyeongdan in addition to conventional radiotherapy and chemotherapy for 3 years. Since May 2008, he was exclusively treated with traditional Korean medicine except taking antiplatelets only for 9 years. Though he has sequelae of tumor necrosis such as facial palsy and hemiparesis, he has survived without recurrence more than 14 years. We suggest that integrative approach including traditional Korean medicine can be a meaningful treatment option for malignant brain tumor. Further studies with more cases should be performed to establish proper treatment protocol of integrative medicine for brain tumor.

A Clinical Study to Assess the Safety of GyoGam-Dan (교감단의 안정성과 임상적 적용에 대한 연구)

  • Kang, Hyung-Won;Kim, Ji-Hwon;Kim, Jin-Heong;Lee, Chung-Sik;Lee, Sang-Eon;Kim, Tae-Heon;Kim, Tae-Heon
    • Journal of Oriental Neuropsychiatry
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    • v.19 no.3
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    • pp.195-203
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    • 2008
  • Objective: 'GyoGam-Dan' is known as a medicine to cure depression in Donguibogam (traditional Korean oriental medicine book). GyoGam-dan which is composed of Cyperi Rhizoma L. and Poria cum Radix pini has been used by basic prescription of asymptom related to all kinds of Qi(氣) disease. Although it has been clinically used for a long time, its safety have never been proved till now. Methods: We had collected data of 610 cases of patients taking 'GyoGam-Dan' at Wonkwang univ. oriental medical center for a period of three years (2005.3.09-2008.04.30). On the patients' blood, the levels of LFT and RFT were examined and the residual levels of heavy metals and pesticides were measured. Results: There were 610 patients who had taken GyoGam-Dan for about three years. In the patients, the most common diseases is depression, followed by palpitation, and then insomnia. Among the patients' estimations on its effectiveness, there were many of positive ones. The blood analyses of patients who had taken GyoGam-Dan did not show any problems and moreover there was not any problems in the levels of residual heavy metals and agricultural pesticides. Taken together, GyoGam-Dan was proved to be a safe medicine for health. Conclusions: Our clinical and chemical studies show that GyoGam-dan has the anti-stress effect and is a safe medicine of which side effect does not exist. Hereafter, Nigorous clinical trial on GyoGam-dan is required.

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The correlation between 『Shanghanlun』 'Seizure' and epilepsy : Case series (『상한론(傷寒論)』 '발작(發作)'과 뇌전증의 연관성 : 다수증례보고)

  • Sung Jun Lee;Min hwan Kim;Young Gap Yun;Kyu Sang Lim;Soong-in Lee
    • 대한상한금궤의학회지
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    • v.14 no.1
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    • pp.1-26
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    • 2022
  • Objectives: We aimed to confirm the safety and effectiveness of the decoction of Sibjo-tang, which is a powder type purgative. In addition, we checked whether the '發作' of 『Shanghanlun』 can be interpreted to have the same meaning as "seizure" in English. By confirming these objectives, we intend to lead the progress in the application of Sibjo-tang and to expand the clinical application of the 152nd provision and Sibjo-tang. Methods: We analyzed the medical records of patients who visited Apgujeongjeongin Oriental Clinic and Almyeon Oriental Clinic for seizures. We confirmed side effects in patients who took Sibjo-tang for a long time. Sibjo-tang was prepared as a hot water extract by using 5 g each of Euphorbiae Pekinensis Radix, Eurphobiae Kansui Radix, and Genkwae Flos and 15 g of Zizyphi Fructus. The "seizure" recorded in the 152nd provision was interpreted through the shape analysis of Oracle bone scripts. The seizure frequency of patients diagnosed with epilepsy after taking Sibjo-tang was compared, and we analyzed other symptoms and psychosocial conditions associated with seizures at the first episode. Results: No side effects were found in 7 patients who took Sibjo-tang for 16.57 ± 14.10 months. Seizures were eliminated in 6 cases while taking Sibjo-tang and significantly decreased in 1 case. Frequent indigestion (in 7 cases), mild exhaustion (in 5 cases), and inferiority complex (in 5 cases) were identified as accompanying pathogenic conditions. The "seizure" in the 152nd provision was interpreted as "a state of being stabbed by a sharp substance in clothes", confirming a deep connection with epileptic seizures. Conclusions: The results suggest that using a decoction of Sibjo-tang is safe and efficacious. In addition, the necessity of conducting an advanced study on epileptic seizures accompanied by frequent indigestion using Sibjo-tang was confirmed.

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Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia

  • Rami Lee;Ji-Hun Kim;Won-Woo Kim;Sung-Hee Hwang;Sun-Hye Choi;Jong-Hoon Kim;Ik-Hyun Cho;Manho Kim;Seung-Yeol Nah
    • Journal of Ginseng Research
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    • v.48 no.3
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    • pp.245-252
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    • 2024
  • Ginseng is a traditional herbal medicine used for prevention and treatment of various diseases as a tonic. Recent scientific cohort studies on life prolongation with ginseng consumption support this record, as those who consumed ginseng for more than 5 years had reduced mortality and cognitive decline compared to those who did not. Clinical studies have also shown that acute or long-term intake of ginseng total extract improves acute working memory performance or cognitive function in healthy individuals and those with subjective memory impairment (SMI), mild cognitive impairment (MCI), or early Alzheimer's disease (AD) dementia who are taking AD medication(s). Ginseng contains various components ranging from classical ginsenosides and polysaccharides to more recently described gintonin. However, it is unclear which ginseng component(s) might be the main candidate that contribute to memory or cognitive improvements or prevent cognitive decline in older individuals. This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when coadministered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented. Additionally, this review shows how ginseng components can contribute to SMI, MCI, or early AD dementia when used as a supplementary food and/or medicine, and proposes a novel combination therapy of current AD medicines with ginseng component(s).

A Historical Study on Treatment Records of Queen Jangyeol's Convulsion - Focusing on Cases Recorded in "The Daily Records of Royal Secretariat of Joseon Dynasty 『承政院日記 (Seungjeongwonilgi)』" - (조선 장렬왕후의 경련에 대한 치병기록 연구 - 『승정원일기』의 의안을 중심으로 -)

  • Park, Joo-Young;Cha, Wung-Seok;Kim, Namil
    • The Journal of Korean Medical History
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    • v.29 no.1
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    • pp.79-87
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    • 2016
  • Queen Jangyeol was proclaimed as the second wife of King Injo at the age of 15 in 1638. This study was carried out in order to confirm if Queen Jangyeol actually came down with epilepsy or if she pretended to do. The keywords, "Jungjeon" and "Junggungjeon" were searched among the articles from "Seungjeongwonilgi" in the 16th reign to the 27th reign of King Injo. After that, articles only related to convulsion were selected. The symptom of convulsion and the therapy were analyzed. King Injo gave an order, and royal doctors diagnosed the queen's illness as epilepsy in August in the 23th reign. The Queen was confined in Gyeongdeok in November, and took herbal drugs for treating the epilepsy. After the death of King Injo, she stopped taking the drugs. As the Queen's epilepsy took place consistently more than 1~2 times in a month, it is the generalized tonic-clonic seizure. Also, it is the epilepsy overlapping reiteration with the brain function disorder because the convulsion lasted throughout 1 hour. However, after King Injo died, she lived for long without the brain function disorder. So it is difficult to judge she actually came down with the epilepsy.

The Comparative Study of Oriental Medicine in Korea, Japan and China (한국(韓國)과 일본(日本) 및 중국(中國)의 동양의학(東洋醫學)에 대한 비교연구(比較硏究))

  • Cho, Ki-Ho
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.271-298
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    • 1998
  • During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.

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A clinical case report of somatization disorder patient (신체화장애 환아 증례 1례)

  • Ha, Su-Yun;Kim, Ha-Yan;Kim, Sun-Mi;Ha, Kwang-Su;Song, In-Sun;Kim, Kyeong-Hye
    • The Journal of Pediatrics of Korean Medicine
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    • v.20 no.3
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    • pp.75-85
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    • 2006
  • Objectives : The somatization is various physical symptoms that have no pathologic manifestation. It is very common to Korean children and adolescents as well as adults, because cultural background and immature verbal expression. DSM-Ⅳ(Diagnostic and Statistical Manual of Mental Disorders Fourth Edition) presented diagnostic criteria for Somatization disorder by grouping some symptoms out of somatization. This report is on a case of somatization disorder patient. The patient is 13-year-old female. She has been suffered from various physical symptoms those are coincided with diagnostic criteria for Somatization disorder by DSM-Ⅳ. Methods : The authors treated her by acupuncture and 3 kinds of herb medicine-Bunsimgium, Hyungbangdojuksan, Yangguksanwhatang. Results : Bunsimgium was showed a little improvement but could not solved chief complaint. Hyungbangdojuksan was not given a help. After her taking Yangguksanwhatang, most symptoms were subsided. Conclusions : A patient with the somatization disorder was improved by herbal medication and acupuncture. But the Somatization disorder repeats to take a good turn and a bad turn and continues for long time, so we need to follow up her condition.

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