• 제목/요약/키워드: tPA

검색결과 462건 처리시간 0.024초

Yonsei Evolutionary Population Synthesis (YEPS) Model -III. Spectrophotometric Evolutions of Simple Stellar Population Models based on Empirical Spectra

  • Chung, Chul;Yoon, Suk-Jin;Lee, Young-Wook
    • 천문학회보
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    • 제38권2호
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    • pp.38.1-38.1
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    • 2013
  • We present the Yonsei evolutionary population synthesis (YEPS) models based on the high-resolution empirical spectral energy distributions (SEDs). We have adopted the MILES library in the optical wavelength, and our new models based on the MILES library show good agreements with our previous models presented in the YEPS I. The effect of hot horizontal-branch (HB) stars on the integrated properties of simple stellar populations (SSPs) is again confirmed by our models based on empirical SEDs. In addition, we have extended our empirical models to the near-IR wavelength and predicted the strengths of the calcium II triplet (CaT) and the Paschen triplet (PaT) based on the INDO-US and the Cenarro library. We find that the effect of HB stars and the age of SSPs on the CaT is almost negligible. On the other hands, the PaT models are very sensitive to the existence of hot stars, e.g., HB stars and young turn-off stars, and show very similar results with Balmer lines. Interestingly, the CaT distribution of GCs in NGC 1407, which is at odds with the optical (B-I) color distribution, can be explained by the unique feature of the CaT-[Fe/H] relations that show almost the same equivalent widths in the metal-rich regime. We will also discuss the impact of the second-generation populations on the strength of the CaT.

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흉부 측와위 촬영 시 전후방향과 후전방향 검사의 유용성 비교 (Utility Comparison of Chest Lateral Decubitus Projection with AP and PA Position)

  • 최규락
    • 한국방사선학회논문지
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    • 제7권3호
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    • pp.233-238
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    • 2013
  • Chest lateral decubitus 촬영은 일반적으로 PA 검사를 시행하여 왔으나, 응급환자나 몸이 불편한 환자의 검사에 있어 많은 불편이 있었다. 이에 본 연구에서는 AP 검사와 PA 검사를 비교하여 영상의 질, 환자의 안전성, 검사 효율성을 분석하고 두 검사간의 유용성을 알아보고자 하였다. 본원에서 2011.10.1 ~ 2012.7.30까지 늑막염 또는 기흉으로 의심되거나 진단된 환자들 중 chest lateral decubitus 촬영을 시행한 30명(남자 20명, 여자 10명)을 대상으로 하였다. 영상 화질 평가방법은 폐야의 미세구조, 진단영역의 넓음, air-fluid 경계면의 명확 유무, 환자 회전유무, 심장음영과 횡격막의 선명유무를 기준으로 하였으며, 영상의학과 전문의 2명, 호흡기내과 전공의 2명이 blind test로 평가하였다. 환자 안정성 및 방사선 검사의 효율성 평가는 환자 position의 안정성, 환자 상태 확인 등의 기준으로 일반촬영 5년 이상 경력의 방사선사 15명이 5점 척도로 평가를 하였고, 통계 분석은 Paired T-test로 분석하였다. Chest decubitus 촬영 시 AP와 PA자세에 따른 검사의 유용성을 비교 분석한 결과 영상의 화질에서 AP와 PA자세는 큰 차이가 없었던 반면, 환자의 안정성 및 방사선사의 검사 효율성에 있어 PA자세에 비해 AP자세의 평가 점수가 높게 나타났다. 이에 특별히 PA자세가 요구되지 않는다면 AP자세로 검사하여도 무방할 것으로 사료된다.

자기 공명 탄성 검사를 이용한 대퇴 근육의 탄성도의 정량화: 초기 경험 (Quantification of the Elastic Property of Normal Thigh Muscles Using MR Elastography: Our Initial Experience)

  • 김정훈;류정아;이주한
    • 대한영상의학회지
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    • 제82권6호
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    • pp.1556-1564
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    • 2021
  • 목적 정상 대퇴 근육의 탄성도를 정량적으로 측정함에 있어 자기 공명 탄성 검사의 실현 가능성을 확인하고 정상 대퇴 근육의 탄성도를 측정한다. 대상과 방법 이 전향적 연구는 일상적인 보행에 지장이 없는 자원자를 대상으로 대퇴부의 T2 강조 축상 영상과 대퇴 근육의 자기 공명 탄성 검사를 시행하였고 최종적으로 10명의 피실험자가 포함되었다[평균 연령, 32.5세, (범위, 23~45세)]. 탄성 특성은 휴식 상태에서 각 대퇴 근육에서의 전단 탄성 계수를 정량적으로 다음 4개의 대퇴 근육에 대해 측정하였다; 내측넓은근, 외측넓은근, 대내전근, 대퇴이두근. 결과 대퇴 근육의 평균 전단 탄성 계수는 각각 두 명의 판독자에서 내측넓은근은 0.98 ± 0.32 kPa, 1.00 ± 0.33 kPa, 외측넓은근은 1.10 ± 0.46 kPa, 1.07 ± 0.43 kPa, 대내전근은 0.91 ± 0.41 kPa, 0.93 ± 0.47 kPa, 대퇴이두근은 0.99 ± 0.37 kPa, 0.94 ± 0.32 kPa으로 측정되었다. 성별에 따른 전단 탄성 계수의 차이는 유의미하지 않게 나타났다(p < 0.05). 내측넓은근(판독자 1; p = 0.194; 판독자 2; p = 0.355)을 제외한 나머지 대퇴 근육에서 연령은 각 근육의 전단 탄성 계수와 유의미하게 일관된 음의 상관관계를 보였다. 결론 자기 공명 탄성 검사는 개별적인 근육의 탄성 특성을 정량적으로 측정할 수 있는 유용한 검사이다. 내측넓은근을 제외한 대퇴 근육에서 나이는 근육의 전단 탄성계수와 통계학적으로 유의미한 일관된 음의 상관관계를 보였다.

$BiI_3$에 대한 승화압과 승화 표준 엔탈피 (The Sublimation Pressure and Standard Enthalpy of Sublimation of Bismuth Triiodide)

  • 김준학
    • 한국세라믹학회지
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    • 제27권7호
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    • pp.943-951
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    • 1990
  • Steady-state sublimation vapour pressures of anhydrous bismuth triiodide have been measured by the continuous gravimetric Kundsen-effusion method from 430.0 to 558.9 K and equilibrium sublimation pressures were obtained from the steady-state data. Condensation coefficients and their temperature dependence have been derived from the effusiion measurement. Condensation coefficients ranged from 0.159 to 0.048(475 to 500K), the activation enthalpy and entropy for condensation have been obtained as -93.38kTmol-1 and -212.70JK-1mol-1. The standard sublimation enthalpy changes derived by both second(modified sigma function) and third(average enthalpy method) law methods were 138.261$\pm$0.023, 138.74$\pm$0.002kJmol-1 respectively. The standard sublimation entropy change derived by modified sigma function was 191.98$\pm$0.047 JK-1mol-1. The reliable standard sublimation enthalpy change based on a correlation of ΔgcrHom(298.15K) and ΔgcrSom(298.15K), a recommended p(T) equation has been obtained for BiI3(cr) ; 1g(p/Pa)=-C/(T/K)+5.0711g(T/K)-2.838$\times$10-3(T/K)-7.758$\times$103(K/T)2+1.4519 where p is in Pa, T in Kelvin, ΔgcrHom(298.15K) in kJmol-1 and C=(ΔgcrHom(298.15K)-8.7358)/1.9146$\times$10-2.

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정적법을 이용한 중진공 국가표준기 개발 (Development of a national medium vacuum standard by static expansion method)

  • 홍승수;임인태;신용현;정광화
    • 한국진공학회지
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    • 제14권2호
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    • pp.59-68
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    • 2005
  • 부피가 다른 세 개의 진공용기를 조합하여 정적법 (static expansion method)을 이용한 중진공영역의 국가표준기를 개발하였다. 이 장치를 이용하여 133pa 범위의 용량형 진공게이지 (capacitance diaphragm gauge)를 교정하여 국제표준화기구의 측정불확도 표현지침에 따라 분석하였다. 그 결과 표준압력 0.553Pa에서의 확장불확도 (expanded uncertainty)가 95% 신뢰수준 (confidence level), 포함인자 (coverage factor) k=2에서 $2.628\times10^{-3}Pa$로 우수한 성능을 보였다.

Optimized Recombinant DNA for the Secretion of Pediocin PA-1 in Escherichia coli

  • Moon, Gi-Seong
    • Preventive Nutrition and Food Science
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    • 제15권4호
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    • pp.360-363
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    • 2010
  • To enhance the expression and secretion of pediocin PA-1 from heterologous bacterial hosts, the promoter and deduced signal sequence (PS) of an $\alpha$-amylase gene from a Bifidobacterium adolescentis strain was fused with pediocin PA-1 structural and immunity genes (AB) and the resulting functions were evaluated in Escherichia coli. Two recombinant PCR products were created-one with just the deduced signal sequence and one with the sequence plus the Ser and Thr sequences that are the next two amino acids of the signal sequence. These two products, the PSAB (---AQA::KYY---) and PSABST (---AQA$\underline{ST}$::KYY---), respectively, were inserted into a TA cloning vector (yT&A) and named pPSAB, which was previously reported, and pPSABST. The two recombinant plasmid DNAs were transferred into E. coli JM109 and the transformants displayed antimicrobial activity, where the activity of E. coli JM109 (pPSAB) was stronger than that of E. coli JM109 (pPSABST), indicating that the ST amino acid residues were not necessary for secretion and might have even decreased the antimicrobial activity of recombinant pediocin PA-1.

Dynamic of heat production partitioning in rooster by indirect calorimetry

  • Rony Lizana, Riveros;Rosiane, de Sousa Camargos;Marcos, Macari;Matheus, de Paula Reis;Bruno Balbino, Leme;Nilva Kazue, Sakomura
    • Animal Bioscience
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    • 제36권1호
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    • pp.75-83
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    • 2023
  • Objective: The objective of this study was to describe a methodological procedure to quantify the heat production (HP) partitioning in basal metabolism or fasting heat production (FHP), heat production due to physical activity (HPA), and the thermic effect of feeding (TEF) in roosters. Methods: Eighteen 54-wk-old Hy Line Brown roosters (2.916±0.15 kg) were allocated in an open-circuit chamber of respirometry for O2 consumption (VO2), CO2 production (VCO2), and physical activity (PA) measurements, under environmental comfort conditions, following the protocol: adaptation (3 d), ad libitum feeding (1 d), and fasting conditions (1 d). The Brouwer equation was used to calculate the HP from VO2 and VCO2. The plateau-FHP (parameter L) was estimated through the broken line model: HP = U×(R-t)×I+L; I = 1 if t<R or I = 0 if t>R; Where the broken-point (R) was assigned as the time (t) that defined the difference between a short and long fasting period, I is conditional, and U is the decreasing rate after the feed was withdrawn. The HP components description was characterized by three events: ad libitum feeding and short and long fasting periods. Linear regression was adjusted between physical activity (PA) and HP to determine the HPA and to estimate the standardized FHP (st-FHP) as the intercept of PA = 0. Results: The time when plateau-FHP was reached at 11.7 h after withdrawal feed, with a mean value of 386 kJ/kg0.75/d, differing in 32 kJ from st-FHP (354 kJ/kg0.75/d). The slope of HP per unit of PA was 4.52 kJ/mV. The total HP in roosters partitioned into the st-FHP, termal effect of feeding (TEF), and HPA was 56.6%, 25.7%, and 17.7%, respectively. Conclusion: The FHP represents the largest fraction of energy expenditure in roosters, followed by the TEF. Furthermore, the PA increased the variation of HP measurements.

Diagnostic Performance of Spin-Echo Echo-Planar Imaging Magnetic Resonance Elastography in 3T System for Noninvasive Assessment of Hepatic Fibrosis

  • Se Woo Kim;Jeong Min Lee;Sungeun Park;Ijin Joo;Jeong Hee Yoon;Won Chang;Haeryoung Kim
    • Korean Journal of Radiology
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    • 제23권2호
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    • pp.180-188
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    • 2022
  • Objective: To validate the performance of 3T spin-echo echo-planar imaging (SE-EPI) magnetic resonance elastography (MRE) for staging hepatic fibrosis in a large population, using surgical specimens as the reference standard. Materials and Methods: This retrospective study initially included 310 adults (155 undergoing hepatic resection and 155 undergoing donor hepatectomy) with histopathologic results from surgical liver specimens. They underwent 3T SE-EPI MRE ≤ 3 months prior to surgery. Demographic findings, underlying liver disease, and hepatic fibrosis pathologic stage according to METAVIR were recorded. Liver stiffness (LS) was measured by two radiologists, and inter-reader reproducibility was evaluated using the intraclass correlation coefficient (ICC). The mean LS of each fibrosis stage (F0-F4) was calculated in total and for each etiologic subgroup. Comparisons among subgroups were performed using the Kruskal-Wallis test and Conover post-hoc test. The cutoff values for fibrosis staging were estimated using receiver operating characteristic (ROC) curve analysis. Results: Inter-reader reproducibility was excellent (ICC, 0.98; 95% confidence interval, 0.97-0.99). The mean LS values were 1.91, 2.41, 3.24, and 5.41 kPa in F0-F1 (n = 171), F2 (n = 26), F3 (n = 38), and F4 (n = 72), respectively. The discriminating cutoff values for diagnosing ≥ F2, ≥ F3, and F4 were 2.18, 2.71, and 3.15 kPa, respectively, with the ROC curve areas of 0.97-0.98 (sensitivity 91.2%-95.9%, specificity 90.7%-99.0%). The mean LS was significantly higher in patients with cirrhosis (F4) of nonviral causes, such as primary biliary cirrhosis (9.56 kPa) and alcoholic liver disease (7.17 kPa) than in those with hepatitis B or C cirrhosis (4.28 and 4.92 kPa, respectively). There were no statistically significant differences in LS among the different etiologic subgroups in the F0-F3 stages. Conclusion: The 3T SE-EPI MRE demonstrated high interobserver reproducibility, and our criteria for staging hepatic fibrosis showed high diagnostic performance. LS was significantly higher in patients with non-viral cirrhosis than in those with viral cirrhosis.

수지말단(手指末端) 체온(體溫)과 인성검사(人性檢査)와의 상관성(相關性)에 관(關)한 연구(硏究) (A Study on the Correlation between the Fingertip's Temperature and MMPI)

  • 윤상희;류희영
    • 동의신경정신과학회지
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    • 제3권1호
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    • pp.46-55
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    • 1992
  • This clinical study aims to find out the effect of the fingertip's temperature and beverage-taking on the personality test by MMPI (Minnesota Multiphasic Personality Inventory). This is based on the sample survey on the 5 groups ; two or more-veined-handed group (15 persons), one-veined-handed group (22 persons), non-veined-hanede group(13 persons), beverage-taking group (41 persons) and beverage-non-taking group (14 persons). The result was obtained as follows ; 1. In the comparative examination on the two or mire-veined-haned group and the non-veined-handed group, there was significant difference of the temperature between the scale D and the scales of Mf, Pa, Pt, and Sc. 2. For the scales of Hs, D, Hy and the scales of Pd, Pa, Pt, Sc, the one-veined-handed group showed higher T-scores and lower fingertip's temperature than the non-veined-handed group without singnificant difference between them. 3. For the scales of D, Hy and the scales of Pd, Pa, Pt, Sc, the beverage-taking group showed higher T-scores and lower fingertip's temperature than the beverage-non-taking group without significant difference between them. As a result, I could find that low temperature on the fingertip, protruded vein on three knuckles(三關) of the finger and beverage-taking would cause the blood-extravasation(血瘀) and the lack of the transports in the spleen(脾不運化) and have an influence on Neurosis and Psychosis.

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