• Journal of Yeungnam Medical Science
• /
• v.38 no.1
• /
• pp.27-33
• /
• 2021

The gut is a complex organ that has played an important role in digestion, absorption, endocrine functions, and immunity. The gut mucosal barriers consist of the immunologic barrier and nonimmunologic barrier. During critical illnesses, the gut is susceptible to injury due to the induction of intestinal hyperpermeability. Gut hyperpermeability and barrier dysfunction may lead to systemic inflammatory response syndrome. Additionally, gut microbiota are altered during critical illnesses. The etiology of such microbiome alterations in critical illnesses is multifactorial. The interaction or systemic host defense modulation between distant organs and the gut microbiome is increasingly studied in disease research. No treatment modality exists to significantly enhance the gut epithelial integrity, permeability, or mucus layer in critically ill patients. However, multiple helpful approaches including clinical and preclinical strategies exist. Enteral nutrition is associated with an increased mucosal barrier in animal and human studies. The trophic effects of enteral nutrition might help to maintain the intestinal physiology, prevent atrophy of gut villi, reduce intestinal permeability, and protect against ischemia-reperfusion injury. The microbiome approach such as the use of probiotics, fecal microbial transplantation, and selective decontamination of the digestive tract has been suggested. However, its evidence does not have a high quality. To promote rapid hypertrophy of the small bowel, various factors have been reported, including the epidermal growth factor, membrane permeant inhibitor of myosin light chain kinase, mucus surrogate, pharmacologic vagus nerve agonist, immune-enhancing diet, and glucagon-like peptide-2 as preclinical strategies. However, the evidence remains unclear.

• East Asian Journal of Business Economics (EAJBE)
• /
• v.11 no.2
• /
• pp.71-80
• /
• 2023

Purpose - The pandemic has magnified and deepened existing socioeconomic disparities, including healthcare, education, income, gender, and housing. This study aims to examine the intersectionality of these disparities and their implications for promoting equity and justice. Research design, data, and methodology - This study is a comprehensive review of the literature on the impact of the COVID-19 pandemic on socioeconomic disparities. The review includes empirical studies, policy reports, and academic articles on healthcare, education, income, gender, and housing disparities. Result - The pandemic has exposed significant disparities in healthcare, education, income, gender, and housing. Healthcare disparities have been highlighted, and there is a need for more equitable access to care and addressing social determinants of health. Educational and income disparities are closely linked, perpetuating cycles of poverty and inequality. Gender disparities have been exacerbated, with women experiencing disproportionate impacts on their health, well-being, and economic security. The pandemic has highlighted the need for safe, stable, and affordable housing. Conclusion - The pandemic has brought to light numerous socioeconomic disparities that require systemic change to address. Promoting equity and justice requires a comprehensive, long-term approach that addresses systemic factors and promotes social and economic equity. By taking action to address these issues, we can create a more just and equitable society that promotes the health and well-being of all its members.

• Korean System Dynamics Review
• /
• v.13 no.1
• /
• pp.133-157
• /
• 2012

This paper aims to propose the strategy making in social enterprise for ensuring organizational sustainability and governance of social enterprise from systems thinking's perspective. Based on previous reviews on organizational sustainability and theories of governance currently advocated in the social enterprise literature, we use 'Holon Dynamics' approach, which is a synthesis of System Dynamics and Soft Systems Methodology (SSM), offers the problem-solving method for dealing with social contexts and "ill-defined" situations. To do so, a researcher carried out the interpretive action research using 'Holon Dynamics' approach from September, 2009 to August, 2010. The outcomes of research are summarized as follows. Firstly, systems methodologies are useful to offer a strategic choice that makes to achieve an organizational sustainability in the case of Korean social enterprise; 'the Rediscovery of Korea'. Secondly, systems thinking offers an alternative concept of system, which is known as an 'appreciative system' that is evolved from the mental constructs amongst participants in given situations. Lastly, the paper delineates the usefulness of systems thinking and the process of inquiry, which deal with social contexts (including cultural and political factors), are contributed to making the necessary conditions for organizational legitimacy and the appropriate strategic choice for social enterprise within combined functioning of the two roles of social and commercial activities from systemic perspectives.

• The Journal of Asian Finance, Economics and Business
• /
• v.3 no.1
• /
• pp.33-41
• /
• 2016

Essences, needs and features of formation of national innovative development model of Kazakhstan are proved on the basis of analysis of various research approaches to realization of the modernization that exist in the world economic theory. For studying the problems of innovative development of the country, there was a need for the formulation of a number of definitions, disclosure of their contents, changing the approaches to reform, as well as adjusting their targets. In the article the general scientific research methods used dialectic, abstraction, systemic and situational approach, empirical and theoretical and analytical methods, and logic modeling. The proposed approach to the implementation of innovative development based on the use of evolutionary and institutional approaches to the study of the problems of implementing an effective innovation policy. This approach is intended to contribute to the development of a forward strategy of modernization, innovative development and higher competitiveness of the national economy. The study proved the causes and features of the implementation of innovative development model in Kazakhstan.

• Molecules and Cells
• /
• v.38 no.7
• /
• pp.587-596
• /
• 2015

Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized.

• Corrosion Science and Technology
• /
• v.3 no.2
• /
• pp.72-80
• /
• 2004

Recently, the demand on the practical application of life-cycle cost effective design and rehabilitation of bridges is rapidly growing in civil engineering practice. However, in spite of impressive progress in the researches on the Life-Cycle Cost (LCC), the most researches have only focused on the theoretical point but did not fully incorporate the critical issues for the practical implementation. Thus, this paper is intended to suggest a systemic integrated approach to the practical application of various LCC methodologies for the design and rehabilitation of bridges, For that purpose, hierarchical definitions of LCC models are presented to categorize the approach of LCC assessment applicable for the practical implementation. And then, an integrated LCC system model is introduced with an emphasis on data uncertainty assessment and user-friendly knowledge-based database for its successful implementation. Finally, in order to demonstrate the LCC effectiveness for design and rehabilitation of real bridge structures, illustrative examples are discussed.

• Journal of Yeungnam Medical Science
• /
• v.11 no.2
• /
• pp.221-229
• /
• 1994

Tuberous sclerosis is reported rarely and is associated with systemic lesions including central nervous system, skin, heart, eye and kidney. Approximately 5-15% of individuals with tuberous sclerosis will develope brain neoplasia, almost invariably subependymal giant-cell astrocytoma (SGCA). We experienced a case of SGCA with tuberous sclerosis operated by the transcallosal approach and report with literature review.

• Asia-Pacific Journal of Business
• /
• v.5 no.1
• /
• pp.43-53
• /
• 2014

Social and economic changes in the world, along with changes in the culture of government and structural changes in the relationship between the state, the market and higher education institutions, have resulted in new approaches pursued by states towards higher education (Konstantinov & Philonovich, 2007; Peterka, 2011). Higher education institutions, in its turn, enjoy more freedom in choosing to focus on various tasks and goals to their academic activities. This contributes to the diversity of expectations when it comes to the various roles modern academic institutions take on with regard to their development. Among many existing concepts in the current academic environment, the concept of "entrepreneurial university" is becoming a critically important concept in Russia. In this article, we consider the concept of the Entrepreneurial University as developed in Clark and Etzkowitz's theories, and the ways the concept is being adjusted in the higher education system in Russia. We analyze comparatively both contemporary and prior historical [1990s-mid2000s] state policies pertaining to higher-education institutions in Russia in order to provide an insight into how the national market of knowledge intensive production is being established in the country. As a consequence of these analyses, we present a new model of how universities can take a more systemic and meaningful approach to creating research-based innovation entrepreneurial activities. This approach is also viewed as making universities' innovation activities more sustainable and thus less dependent on the state support.

• The Journal of Korean Physical Therapy
• /
• v.11 no.3
• /
• pp.23-36
• /
• 1999

The very definitions of posture and balance have changed, as has our understanding of the underlying neural mechanisms, In rehabilitation science, there awe at least two different conceptual theories to describe the neural control of posture and balance : the reflex/hierarchical theory and system theory. A reflex/hierarchical theory suggests the posture and balance result from hierarchically organized reflex responses triggered by independent sensory systems. The systems approach suggests that action emerges from an interaction of the individual with the task and environment. That is to say, the systems approach implies that the ability to control our body's position in space emerges from a complex interaction of musculoskeletal and neural systems, collectively referred to as the postural control system. The specific organization of postural systems determined both by the functional task and the environment in which it is being performed, The postural control system is divided into three basic functional components for assessment : 1) musculoskeletal components, 2) motor coordination components, and 3) sensory organization components. It is proposed that a systemic functional understanding of human balance is critical to effective programs for balance rehabilitation. Thus, this article briefly reviews the basic functional components to consider in designing treatment plan and for the benefit of the balance assessment.

• Animal cells and systems
• /
• v.7 no.3
• /
• pp.213-219
• /
• 2003

The response of plants to pathogens and wounding is dependent upon very sensitive perception mechanisms. Although genetic approaches have revealed a variety of resistance genes that activate common defense responses, defense-related proteins are not well characterized in plants. Therefore, we used a proteomic approach to determine which defense-related proteins are induced by salicylic acid (SA) and wounding in Chinese cabbage. We found that SA and wounding induce pathogenesis-related protein 1a (PR1a) at both protein and mRNA levels using proteomics and Northern blot analysis, respectively. This indicates that our proteomic approach is useful for identifying defense-related proteins. We also identified several other proteins that are induced by SA or wounding. Among the seven SA-induced proteins identified, four may be defense-related, including defense-related protein, phospholipase D (PLD), resistance protein RPS2 homolog, and L-ascorbate peroxidase. Out of the six wounding-induced proteins identified, three may be defense-related: heat shock cognate protein 70 (HSC70), polygalacturonase, and peroxidase P7. The precise functions of these proteins in plant defense responses await further study. However, identification of the defense-related proteins described in this study should allow us to better understand the mechanisms and signal transduction pathways involved in defense responses in Chinese cabbage.