• Journal of Pharmaceutical Investigation
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• v.20 no.4
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• pp.223-228
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• 1990

The contribution of endogenous transport systems to the blood-brain barrier (BBB) transport of basic and acidic drugs was studied by using a carotid injection technique in rats and an isolated bovine cerebrovascular disease state were compared between the normotensive rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) which have been well established as an animal model with pathogenic similarities to humans. Basic drugs such as eperisone, thiamine and scopolamine inhibited, in a concentration dependent manner the in vivo uptake of $[{^3}H]choline$ through BBB, whereas amino acids and acidic drugs such as salicylic acid and valproic acid did not inhibit the uptake. The uptake of $[^3H]choline$ by B-CAP increased with time and showed a remarkable temperature dependency. The uptake of $[^3H]choline$ by B-CAP showed the very similar inhibitory effects as observed in the in vivo brain uptake, and was competitively inhibited by a basic drug, eperisone. The in vivo BBB uptakes of $[^3H]acetic$ acid and $[^{14}C]salicylic$ acid were dependent on pH of the injectate and the concentration of drugs. Several acidic drugs such such as salicylic acid, benzoic acid and valproic acid inhibited the in vivo uptake of $[^3H]acetic$ acid, whereas amino acid, choline and a basic drug such as eperisone did not inhibit the uptake. The uptake of acetic acid by B-CAP was competitively inhibited by salicylic acid. The permeability surface area product (PS) through BBB for $[^3H]choline$ in SHRSP was significantly lower than that in WKY. The concentration of choline in the brain dialysate in SHRSP was about half of that in WKY, while no significant difference was observed in the plasma concentration of choline between SHRSP and WKY. No significant difference was observed in the transport of monocarboxylic acids, glucose and neutral amino acid through BBB between SHRSP and WKY. From these results, it was concluded that BBB transport system of choline contributes to the transport of basic drugs through BBB, that acidic drugs can be transported via a moncarboxylic acid BBB transport system and that the specific dysfuntion of the BBB choline transport in SHRSP was ascribed to the reduction of the maximum velocity of choline concentration in the brain interstitial fluids.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.9
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• pp.781-788
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• 2016

In this paper, a real-time on-board orbit determination algorithm using the high precise orbit propagator is suggested and its performance is analyzed. Orbit determination algorithm is designed with the Extended Kalman Filter. And it utilizes the orbit calculated from the Pseudo-range as observed data. The performance of the on-board orbit determination method implemented in the GPS-12 receiver is demonstrated using the GNSS simulator. Orbit determination performance using high precise orbit propagator was analyzed in comparison to the orbit determination result using $J_2$ orbit propagator. The analysis result showed that position and velocity error are improved from 43.61 m($3{\sigma}$) to 23.86 m($3{\sigma}$) and from 0.159 m/s($3{\sigma}$) to 0.044 m/s($3{\sigma}$) respectively.

• Journal of the Korean Institute of Gas
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• v.17 no.5
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• pp.1-7
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• 2013

In this study, simulation work of HCNG refueling system was performed. The hydrogen was produced from steam reforming process by natural gas. The conversion of natural gas is increased as SCR is increased. but it was no significant difference more than 3 of SCR and fuel throughput is increased as GHSV is increased. Both conversion and fuel throughput levels was optimized when the $1700h^{-1}$ of GHSV. CNG was compressed from low pressure natural gas. For the mixing of $H_2$ and CNG is mixed with the high pressure conditions such as 400bar of $H_2$ and 250bar of natural gas. Single-stage compression was required more power than multi stage. So, multi stage compression was suggested for high pressure compression. We calculated the intermediate pressure to minimize total required power of compressors. The intermediate pressure for $H_2$ and natural gas were derived at 61 and 65 bar, respectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3792-3799
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• 2012

The dedusting characteristics of pulse air jet type dedusting system which is widely applied in the industries were identified by utilizing the computational fluid dynamics (CFD) and the dedusting performance in modified shape of dedusting unit was compared in this study. The review on the dedusting air volume, air stream distribution and inflow velocity distribution on each shape of dedusting part showed that the case of installing the nozzle on the blow tube (Case-3) and the case of installing the double intaking tube to the venturi (Case-4 and Case-5) were more excellent than the structure (Case-1) which is widely applied in the field in its amplification effect on the air volume and extension of stream width. The specification of venturi was decided to apply the selected Case-5 for the option of the commercial back filter. It is considered that the dedusting air volume will be maintained in maximum in the case of 50 mm and 90 mm for the diameter of internal and external intaking pipe respectively.

• Bulletin of the Korean Chemical Society
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• v.7 no.5
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• pp.367-371
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• 1986

Dynamic and equilibrium properties of n-alkane chains immersed in solvent molecules have been investigated by a molecular dynamics method. The n-alkane chain is assumed to be a chain of elements (CH$_2$) interconnected by bonds having a fixed bond length and bond angle, but each bond of the chain is allowed to execute hindered internal rotation. We studied the effect of the number of the chain elements (N$_c$ = 10, 15 and 20) on the equilibrium properties of the system, e.g., the pair correlation functions between a chain element and solvent molecules, g$_{cs}$(r), and between the chain elements, g$_{cc}$(r), and the configurational properties such as the mean-square end-to-end distance < R$^2$ >, the mean-square radius of gyration < S$^2$ >, and the eigenvalues of the moment-of-inertia tensor < S$_i^2$ > / < S$^2$ > (i = 1, 2 and 3). We also studied the dynamic properties of the system, e.g., the autocorrelation function C(A;t) where A = R$^2$(t), = S$^2$(t), or = ${\vec{V}}(t)({\vec{V}}$ = velocity of the center of mass), and the diffusion coefficient D. The g$_{cs}$(r)'s are almost equal irrespective of the change of Nc while g$_{cc}$(r) becomes larger as N$_c$ increases; The MD computed configurational properties < R$^2$2 > and < S$^2$ > were found to be a little different from the values calculated from the statistical equations of < R$^2$ > and < S$^2$ >, it may be due to the fact that our model for the MD simulations includes a long-range volume effect. From the < S$_i^2$ > / < S$^2$ >, it is found that the chain molecule has a nearly spherical shape irrespective of the variation of N$_c$. For the dynamic properties we found that the C(R$^2$;t) and C(S$^2$;t) of lower N$_c$ decay faster than those of higher N$_c$, while the C($\vec V$;t) of the center of mass in the chain is weakly dependent on the N$_c$. The center of mass diffusion coefficient D$_c$ decreases as N$_c$ increases while the end point diffusion coefficient D$_e$ is nearly equal irrespective of the change of N$_c$.

• Journal of Wetlands Research
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• v.23 no.1
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• pp.85-93
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• 2021

Sewage separation which often involves installing a new pipe to separate wastewater flow from stormwater runoff flow can be costly and depends highly on its feasibility in a site. To be able to develop a potentially more economical alternative that can also lessen major road traffic disturbance during this process, a different approach where a smaller sewage separator pipe is installed inside an existing combined sewer pipe was investigated. A small-scale of a box sewer and the proposed sewage separator pipe was constructed in the laboratory to observe and compare the deposition of solids and other solid-associated major pollutants at different flow rates. In addition, three-dimensional flow simulations considering five different scenarios were conducted using Ansys Fluent to observe the effect of the proposed sewage separator pipe to the hydraulic flow if installed inside the combined sewer pipe. Results revealed that the deposition of TSS, TCOD, TN, and TP were reduced by at least 60% when the wastewater was conveyed by the sewage separator pipe instead of the combined sewer pipe. Moreover, the flow simulations conducted showed that there was little to no major disturbance in hydraulic flow and velocity distribution when the sewage separator was installed inside a straight pipe and even at pipe transitions such as intersections, turns, and drop in elevation. Considering the pipe dimensions and the results of the study, the proposed approach can be promising in terms of reduction in pollutant deposition without a major effect on the hydraulic flow. Further investigation and cost-analysis should be done in the future to support these preliminary findings and help alleviate the problems caused by combined sewer overflows by introducing an alternative approach.

• Applied Chemistry for Engineering
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• v.33 no.6
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• pp.613-617
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• 2022

The equipment for fabricating the large-area PTFE nanofiber coated-PTFE foam filter for use as filtration parts of the baghouse that removes particulate matter (PM) in industrial sites was designed and manufactured in this study. The PTFE nanofiber was coated on a commercial PTFE foam filter to increase its PM collection efficiency. The equipment and fabrication processes using a roll-to-roll system were proposed to continuously coat PTFE nanofibers on the surface of the PTFE foam filter. The electrospinning and annealing parts were designed and made by optimizing the equipment for the roll-to-roll system. The surface morphology, composition, and filtration characteristics of the large-area filter fabricated by this equipment were confirmed. PTFE nanofibers were uniformly coated on the large-area filter, and the PTFE nanofiber coated-PTFE foam filter showed PM_2.5 collection efficiency of 91.79% and an appropriate pressure drop of 62 Pa with a face velocity of 1 m/min at 280 ℃.

• PNF and Movement
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• v.21 no.1
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• pp.27-35
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• 2023

Purpose: Hallux valgus (HV) is one of the most common chronic foot disorders, occurring when the first toe deviates laterally toward the other toe. HV impairs muscle strength and affects gait function (postural sway and gait speed). Thus, this study aims to investigate using the FDM system the effect of wearing braces on gait while wearing a virtual reality (VR) device. Methods: This study was conducted on 28 healthy adults with HV of 15 degrees or more. To compare differences in walking, depending on whether a toe brace can be worn, the subject walked without wearing anything, walked after wearing the VR device, and walked after wearing the VR device and the toe brace, and the FDM system was used for the gait ability measurement analysis. Results: As a result of a one-way repeated analysis of variance, the walking speed-related variables (cadence, velocity, etc.) in the HV group were higher during comfortable walking. In addition, walking while wearing a VR device and walking while wearing a VR device and a toe brace demonstrated more significant values in terms of six gait parameters (double stance phase, loading response, stage, stage, stage, and stage). The maximum pressure of the forefoot was significantly reduced when walking while wearing a VR device and a toe brace compared to comfortable walking, but in all variables, there was no statistically significant difference between walking while wearing a VR device and walking while wearing a VR device and a toe brace. Conclusion: Orthosis with a VR device during gait (OVG) and gait with a VR device (GVR) affect gait in HV patients. However, there was no significant difference between GVR and OVG. Thus, it is necessary to conduct experiments on various HV angles and increase the duration of wearing the toe brace.

• Physical Therapy Korea
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• v.30 no.2
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• pp.128-135
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• 2023

Background: Despite the fact that aquatic exercise is one of the most popular alternative treatment methods for children with cerebral palsy (CP), there are few research regarding its effectiveness. Objects: The purpose of this study was to examine the effects of aquatic exercise on upper extremity function and postural control during reaching in children with CP. Methods: Ten participants (eight males and two females; 4-10 years; Gross Motor Function Classification System levels II-IV) with spastic diplegia were recruited to this study. The aquatic exercise program consisted of four modified movements that were selected from the Halliwick 10-point program to enhance upper extremity and trunk movements. The participants attended treatment two times a week for 6 weeks, averaging 35 minutes each session. The Box and Block Test (BBT), transferring pennies in the Bruininks-Oseretsky Test (BOT), and pediatric reaching test (PRT) scores were used as clinical measures. Three-dimensional motion analysis system was used to collect and analyze kinematic data. Differences in BBT and BOT values among pre-treatment, post-treatment, and retention (after 3 weeks) were analyzed using a Friedman test. In addition, the PRT scores and variables (movement time, hand velocity, straightness ratio, and number of movement units) from the three-dimensional motion analysis were tested using a Wilcoxon signed-rank test. The significance level was established at p < 0.05. When the results appeared to be statistically significant, a post-hoc test for multiple comparisons was performed with the Wilcoxon signed-rank test. Results: All clinical measures, which included BBT, transferring pennies of BOT, and PRT, were significantly increased between pre-intervention and post-intervention scores and between pre-intervention and retention scores after treatment (p = 0.001). Three-dimensional motion analysis mostly were significantly improved after treatment (p = 0.001). Conclusion: Aquatic exercise may help to improve body function, activity, and participation in children with varying types of physical disabilities.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.3
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• pp.185-192
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• 2023

In this study, fluctuating wind velocity for time history analysis is simulated by a single variate, single-dimensional random process using the KBC2022 spectrum about across-wind direction. This study analyzed and obtained the inelastic dynamic response for structures modeled as a single-degree-of-freedom system. It is assumed that the wind response is excellent in the primary mode, the change in vibration owing to plasticization is minor, along-wind vibration and across-wind vibration are independent, and the effect of torsional vibration is small. The numerical results, obtained by the Newmark-𝛽 method, shows the time-history responses and trends of maximum displacements. As a result of analyzing the inelastic dynamic response of the structure with the second stiffness ratio(𝛼) and yield displacement ratio (𝛽) as variables, it is identified that as the yield displacement ratio (𝛽) increases when the second stiffness ratio is constant, the maximum displacement ratio decreases, then reaches a minimum value, and then increases. When the stiffness ratio is greater than 0.5, there is a yield point ratio at which the maximum displacement ratio is less than 1, indicating that the maximum deformation is reduced compared to the elastically designed building even if the inelastic behavior is permitted in the inelastic wind design.