• 제어로봇시스템학회:학술대회논문집
• /
• 1987.10b
• /
• pp.198-202
• /
• 1987

The regulator problem can be considered as some impulsive disturbance rejection one. In this point of view, the rate of decay is one of important factors for regulation and depends on how negative the real parts of the eigenvalues of closed-loop system. The algorithm that the closed-loop system has eigenvalues lying within a vertical. strip is useful for rapid disturbance rejection. This paper presents a design method for a linear quadratic regulator of two-time scale system with eigenvalues in a vertical strip by use of time-scale separation property.

• Journal of Biomedical Engineering Research
• /
• v.8 no.1
• /
• pp.75-80
• /
• 1987

With the conventional CW Doppler velocity meter, bl-directional velocities cannot be separated. The new CW Doppler system uses quadrature detection and phase rotation to produce simultaneous independent audio and velocity signals for forward and reverse blood flow direction, is fabricated. Specially, this system shows that phase rotation method for flow direction separation provides easy and satisfactory feature. From in vivo blood flow measurement, we can easily differentiate typical artery flow from vein flow, and measure both velocity characteristics qualitatively.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2005.10a
• /
• pp.141-146
• /
• 2005

This paper an application example of PIV system for analyzing the flow of submerged structure. In this paper, we introduce an analysis method to predict the characteristics of flow around the neighboring fields of tetrapod and fishing reef in order to develop a high performance model. Flowing phenomenon according to velocity distribution and flow separation around the submersed body were obtained by PIV system. Flow visualization has conducted in a circulating water channel by a high speed camera and etc.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.2
• /
• pp.587-596
• /
• 2014

A new ${\pi}$-stacked donor-acceptor (D-A) system, [Ru(1-([2,2'-bipyridine]-6-yl-methyl)-3-(2-cyclohexa-2',5'-diene-1,4-dionyl)-1H-imidazole)(2,2':6',2"-terpyridine)]$[PF_6]_2$ (ImQ_T), has been synthesized and characterized. Similar to its precedent, [Ru(6-(2-cyclohexa-2',5'-diene-1,4-dione)-2,2':6',2"-terpyridine)(2,2':6',2"-terpyridine)]$[PF_6]_2$ (TQ_T), this system has a cofacial alignment of terpyridine (tpy) ligand and quinonyl (Q) group, which facilitates an electron transfer through ${\pi}$-stacked manifold. Despite the presence of lowest-energy charge transfer transition from the Ru-based-HOMO-to-Q-based-LUMO (MQCT) predicted by theoretical calculations by using time-dependent density functional theory (TD-DFT), the experimental steady-state absorption spectrum does not exhibit such a band. The selective excitation to the Ru-based occupied orbitals-to-tpy-based virtual orbital MLCT state was thus possible, from which charge separation (CS) reaction occurred. The photo-induced CS and thermal charge recombination (CR) reactions were probed by using ultrafast visible-pump/mid-IR-probe (TrIR) spectroscopic method. Analysis of decay kinetics of Q and $Q^-$ state CO stretching modes as well as aromatic C=C stretching mode of tpy ligand gave time constants of <1 ps for CS, 1-3 ps for CR, and 10-20 ps for vibrational cooling processes. The electron transfer pathway was revealed to be Ru-tpy-Q rather than Ru-bpy-imidazol-Q.

• Proceedings of the IEEK Conference
• /
• 2007.07a
• /
• pp.335-336
• /
• 2007

The blanking interface between an ES system and a radar system on the same platform cause the unwanted radar signal separation in the process of the signal measurement of the ES system. In this paper, we propose the novel radar signal blanking method for ES. The proposed method extracts a standard of judgement which we can decide whether a radar signal is separated by the blanking interface and presents how to merge the separated signals. Test result is presented to show the performance of the proposed method.

• KSBB Journal
• /
• v.23 no.2
• /
• pp.135-141
• /
• 2008

SMB (simulated moving bed) chromatography is a very useful utility for the separation of binary system. We simulated the separation of L-arabinose and L-ribose from the mixture by using lab-scale 4(1-1-1-1)-zone SMB chromatography. Preliminary experiments of PIM (pulse input method) were performed to measure adsorption isotherms of L-ribose and L-arabinose in $NH_2$ HPLC column, and experimental and simulated results from ASPEN chromatography were compared. To find the most suitable separation condition in SMB, we carried out a simulation in $m_2-m_3$ plane base on the triangle theory and calculated operating parameters (flow rate of four zone, switching time and feed concentration and so on) using ASPEN chromatography under the conditions of linear isotherms obtained from PIM.

• Journal of Aerospace System Engineering
• /
• v.16 no.6
• /
• pp.123-128
• /
• 2022

This paper proposes a non-explosive separation device for the deployable SAR antenna. This device utilises a Ni-Cr wire to restrain the antenna's belt mechanism, and joule-heating is used to minimise the impact of deployment. After the Ni-Cr wire has been cut, the device is deployed through the preload of the belt mechanism. Considering the design load(99g) and preload conditions, FEM analysis for AL7050 and Ti was performed. This analysis revealed that the amount of deformation for AL7050 was 0.256 mm with a margin of +0.09. In addition, by performing orbital thermal analysis, the temperature distribution for AL7050 in the worst cold case is confirmed as -50 to +2℃ and -10 to +90℃ in the worst hot case. This analysis confirmed that the separation device would remain stable even in the worst environment.

• Journal of Dairy Science and Biotechnology
• /
• v.33 no.4
• /
• pp.271-275
• /
• 2015

Colloidal semiconductor CdSe-ZnS core-shell nanocrystal quantum dot (Qdot) are luminescent inorganic fluorophores that show potential to overcome some of the functional limitations encountered with organic dyes in fluorescence labeling applications. Salmonella Enteritidis has emerged as a major cause of human salmonellosis worldwide since the 1980s. A rapid, specific, and sensitive method for the detection of Salmonella Enteritidis was developed using Qdot as a fluorescence marker coupled with immunomagnetic separation. Magnetic beads coated with anti-Salmonella Enteritidis antibodies were employed to selectively capture the target bacteria, and biotin-conjugated anti-Salmonella antibodies were added to form sandwich immune complexes. After magnetic separation, the immune complexes were labeled with Qdot via biotin-streptavidin conjugation, and fluorescence measurement was carried out using a fluorescence measurement system. The detection limit of the Qdot method was a Salmonella Enteritidis concentration of $10^3$ colony-forming units (CFU)/mL, whereas the conventional fluorescein isothiocyanate-based method required over $10^5CFU/mL$. The total detection time was within 2 h. In addition to the potential for general nanotechnology development, these results suggest a new rapid detection method of various pathogenic bacteria from a complex food matrix.

• Analytical Science and Technology
• /
• v.32 no.5
• /
• pp.185-195
• /
• 2019

Over the past decades, chiral switch of the proton pump inhibitors (PPIs) has been received widespread attention in therapeutic advantages as well as pharmaceutical analysis. In present study, the influence of cyclodextrins (CDs) on the chiral separation of four common PPIs (lansoprazole, omeprazole, pantoprazole, and rabeprazole) was investigated. The results demonstrated that capillary electrophoresis (CE) with dual CDs as a chiral selector system is a possible and promising method for the enantioseparation of these PPIs. Rabeprazole, which is the most challenging and acid-labile candidate among four PPIs, was selected for further development of the technique. To optimize CE condition, the effects of capillary parameters and background electrolytes on the enantioseparation were investigated. Finally, the best chiral separation was acheived by using sulfobutyl ether-${\beta}$-CD, and ${\gamma}$-CD as dual chiral selectors. The developed CE method not only provided the effective chiral separation but also showed the good stability of rabeprazole. The proposed method was successfully validated according to the International Conference on Harmonization guideline and effectively applied to determine rabeprazole enantiomers in commercial rabeprazole tablets, with recoveries ranging from 97.17 % to 103.29 % of the label content.

• Mass Spectrometry Letters
• /
• v.12 no.1
• /
• pp.1-10
• /
• 2021

A simple, specific, and economical LC-MS/MS method was investigated for the screening of 43 prescribed antihypertensive and related drugs in human urine. The urine samples were simply prepared by diluting and mixing with internal standard before directly introduced to the LC-MS/MS system, which is fast, straightforward, and cost-effective. Fractional factorial, Box-Behnken, and I-optimal design were applied to screen and optimize the mass spectrometric and chromatographic factors. The analysis was carried out on a triple quadrupole mass spectrometer system utilizing multiple reaction monitoring with positive and negative electrospray ionization method. Chromatographic separation was performed on a Thermo Scientific Accucore RP-MS column (50 × 3.0 mm ID., 2.6 ㎛) using two separate gradient elution programs established with the same mobile phases. Chromatographic separation was performed within 12 min. The optimal method was validated based on FDA guideline. The results indicated that the assay was specific, reproducible, and sensitive with the limit of detection from 0.1 to 50.0 ㎍/L. The method was linear for all analytes with coefficient of determination ranging from 0.9870 to 0.9981. The intra-assay precision was from 1.44 to 19.87% and the inter-assay precision was between 2.69 and 18.54% with the recovery rate ranges from 84.54 to 119.78% for all drugs measured. All analytes in urine samples were stable for 24 h at 25℃, and for 2 weeks at -60℃. The developed method improves on currently existing methods by including larger number of cardiovascular medications and better sensitivity of 12 analytes.