• Journal of IKEEE
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• v.18 no.3
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• pp.341-348
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• 2014

When several resuable semiconductor IPs are connected and implemented into an integrated chip, each semiconductor IP should provide code files for synthesis and interface modeling files for simulation and verification. However, description methods and levels of abstraction of interface modeling files are different because these semiconductor IPs are designed by different designers, which makes some problems in simulation and verification. This paper proposes a standardized modeling method of semiconductor IP interfaces. It restricts semiconductor IP interfaces to several predefined level of abstraction. The proposed method helps the chip integration designer to easily connect different semiconductor IPs and to simulate and verify them.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.6
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• pp.1882-1892
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• 1996

This paper is concerned with the position control of the ond degree-of freedom manipulator using pneumatic artificial muscle actuator which is built to have a proper compliance. For t his pneumatic artificial muscle actuator though, it is difficult to make an effective control scheme due to the nonlinearity and uncertainties on the dynamics of the actuator. In this paper, a third-order equation of motion is derived for the actuator including the dynamics of the pneumatic servovalve. Later, various modeling uncertainties due to the nonlinearity and unmodeled dynamics of the servo vlave and the actuator are taken care of, as a trade-off between the closed-loop performance of the controlled system and its robustness to uncertainties. A controller using .mu. synthesis thchnique is designed, and robust performance against measurement noise, various modeling uncertainties due to the dynamics of the servo valve and actuator is achieved. The effectiveness of the proposed control methods is illustrated through simulations and experiments.

• Journal of Microbiology and Biotechnology
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• v.17 no.10
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• pp.1598-1606
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• 2007

A new series comprising 7 analogs of N-(sulfanyl ethanoyl)-L-HSL derivatives, 2 analogs of N-(fluoroalkanoyl)-$_L$-HSL derivatives, N-(fluorosulfonyl)-L-HSL, and 2,2-dimethyl butanoyl HSL were synthesized using a solid-phase organic synthesis method. Each of the 11 synthesized compounds was analyzed using NMR and mass spectroscopies, and molecular modeling studies of the 11 ligands were performed using SYBYL packages. Thereafter, a bacterial test was designed to identify their quorum-sensing inhibition activity and antifouling efficacy. Most of the synthesized compounds were found to be effective as quorum-sensing antagonists, where antagonist screening revealed that 10 among the 11 synthesized ligands were able to antagonize the quorum sensing of A. tumefaciens.

• Journal of Microbiology and Biotechnology
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• v.23 no.10
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• pp.1395-1402
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• 2013

Reductases convert some achiral ketone compounds into chiral alcohols, which are important materials for the synthesis of chiral drugs. The Saccharomyces cerevisiae reductase YOR120W converts ethyl-4-chloro-3-oxobutanoate (ECOB) enantioselectively into (R)-ethyl-4-chloro-3-hydroxybutanoate ((R)-ECHB), an intermediate of a pharmaceutical. As YOR120W requires NADPH as a cofactor for the reduction reaction, a cofactor recycling system using Bacillus subtilis glucose dehydrogenase was employed. Using this coupling reaction system, 100 mM ECOB was converted to (R)-ECHB. A homology modeling and site-directed mutagenesis experiment were performed to determine the NADPH-binding site of YOR120W. Four residues (Q29, K264, N267, and R270) were suggested by homology and docking modeling to interact directly with 2'-phosphate of NADPH. Among them, two positively charged residues (K264 and R270) were experimentally demonstrated to be necessary for NADPH 2'-phosphate binding. A mutant enzyme (Q29E) showed an enhanced enantiomeric excess value compared with that of the wild-type enzyme.

• Journal of KSNVE
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• v.8 no.1
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• pp.180-186
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• 1998

Vibration test fixture is used in random vibration control testing. The specified reference spectrum should be transmitted equally to the specimen attachment points on the fixture. In most practical cases, however, spectrum at each of specimen attachment points may be quite different from the specified reference spectrum because of the dynamic characteristics of vibration test fixture. This paper proposes the method of experimental dynamic modification of fixture system for vibration test so that the reference spectrum can be transmitted to the specimen attachment points without distortion. The stiffness of mounts of specimen and the thickness of fixture are considered as design variables. The frequency response functions of specimen used for input data are obtained from vibration testing, and the frequency response functions of fixture are obtained from finite element modeling. The sensitivities of frequency response functions at specimen attachment points to the mount stiffness are derived from synthesis method of transfer function. And the sensitivities to the thickness of fixture are also derived from finite element modeling. The presented method is verified by computer simulation and vibration testing.

• 한국가스학회:학술대회논문집
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• 2005.05a
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• pp.231-231
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• 2005

• Journal of the Korean Institute of Gas
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• v.5 no.2 s.14
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• pp.1-8
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• 2001

Fault tree construction for hazard assessment requires so much time and labor, so it is very difficult to be applied to the large scale chemical plant. In this study, for the synthesis of fault tree in chemical processes, the object-oriented knowledge framework is proposed to represent the deviations of process variables in the equipment and cause-consequence relationship with equipment faults. The cause of fault is searched by using the object-oriented modeling of equipments and the connectivity among equipments, and then a fault tree is synthesized. we have discussed the performance of the methodology on nitric acid cooling process to evaluate its effectiveness.

• The Journal of the Acoustical Society of Korea
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• v.28 no.2
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• pp.119-126
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• 2009

This paper describes the non-stringed guitar composed of laser strings, frets, sound synthesis algorithm and a processor. The laser strings that can depict stroke and playing arpeggios comprise laser modules and photo diodes. Frets are implemented by voltage divider. The guitar body does not need to implement physically because commuted waveguide synthesis is used. The proposed frets enable; players to represent all of chords by the chord glove as well as guitar solo. Sliding, hammering-on and pulling-off sounds are synthesized by using parameters from the voltage divider. Because the pitch shifting corresponds to the time-varying propagation speed in the digital waveguide model, the proposed model can synthesize vibrato as well. After transformation of signals from the laser strings and frets into parameters for synthesis algorithm, the digital signal processor, TMS320F2812, performs the real-time synthesis algorithm and communicates with the DAC. The demonstration movieclip available via the Internet shows one to play a song, 'Arirang', synthesized by proposed algorithm and interfaces in real-time. Consequently, we can conclude that the proposed synthesis algorithm is efficient in guitar solo and there is no problem to play the non-stringed guitar in real-time.

• Journal of the Institute of Convergence Signal Processing
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• v.10 no.2
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• pp.141-145
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• 2009

A C-to-SystemC synthesizer which processes the input behavior according to high-level synthesis, and then transforms the synthesis result into SystemC module code is implemented in this paper. In the synthesis process, the input behavioral description in C source code is scheduled using list scheduling algorithm and register allocation is performed using left-edge algorithm on the result of scheduling. In the SystemC process, the output from high-level synthesis process is transformed into SystemC module code by combining it with SystemC features such as channels and ports. The operation of the implemented C-to-SystemC synthesizer is validated through simulating the synthesis of elliptic wave filter in SystemC code. C-to-SystemC synthesizer can be used as a part of tool-chain which helps to implement SystemC design methodology covering from modeling to synthesis.

• Bulletin of the Korean Chemical Society
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• v.28 no.8
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• pp.1335-1340
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• 2007

β-Ketoacyl acyl carrier protein synthase (KAS) III is a particularly attractive target in the type II fatty acid synthetic pathway, since it is central to the initiation of fatty acid synthesis. Enterococcus faecalis, a Grampositive bacterium, is one of the major causes of hospital acquired infections. The rise of multidrug-resistant of most bacteria requires the development of new antibiotics, such as inhibition of the KAS III. In order to block the fatty acid synthesis by inhibition of KAS III, at first, three dimensional structure of Enterococcus faecalis KAS III (efKAS III) was determined by comparative homology modeling using MODELLER based on x-ray structure of Staphylococcus aureus KAS III (saKAS III) which is a gram-positive bacteria and is 36.1% identical in amino acid sequences with efKAS III. Since His-Asn-Cys catalytic triad is conserved in efKAS III and saKAS III, substrate specificity of efKAS III and saKAS III and the size of primer binding pocket of these two proteins are expected to be similar. Ligand docking study of efKAS III with naringenin and apigenin showed that naringenin docked more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Also, only naringenin showed antibacterial activity against E. faecalis at 256 μg/mL. This study may give practical implications of flavonoids for antimicrobial effects against E. faecalis.