• 제목/요약/키워드: symptomatology

검색결과 169건 처리시간 0.031초

화병과 주요우울증 환자의 신경인지기능 (Neurocognitive Function in Patients with Hwa-byung and with Major Depressive Disorder)

  • 윤영환;이소희;최종혁
    • 생물정신의학
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    • 제12권2호
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    • pp.181-188
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    • 2005
  • Objectives:Hwa-byung has been studied clinically for several years and introduced as Korean Culture- Bound Syndrome. However, the definition and the diagnostic method are not yet clarified, and there has not been any sufficient comparative study on this disease entity. This study was conducted to determine the clinical symptoms and the profile of the neurocognitive functions in Hwa-byung(HB) and Major Depressive Disorder(MDD), and We wish to identify any critical factors that differentiate the disorders. Methods:A total of 102 participants were examined, including 34 participants with MDD, 34 with HB, and 34 healthy controls. The MDD and HB patients were recruited from among inpatients and outpatients at the National Medical Center for the period from May to December of 2004. As a major diagnostic tool of MDD, diagnostic reference of DSM-IV-TR was used and as HB's diagnostic tool, We used computerized neurocognitive function test. Psychiatric symptomatology was evaluated by the Beck Depression Inventory(BDI), and Symptom Checkist-90-Revision(SCL-90-R). Oneway ANOVA, Scheffe post-hoc test and Chi-Squre Tests were used for statistical analysis. Results:The participants in three groups did not differ in terms of age, sex, and education. Assessment of BDI indicated that the MDD group had significantly higher total score than the HB group. MDD and HB groups showed significantly higher total scores on the SCL-90-R in comparison to the controls. The MDD group was found to have significantly more symptoms of depression than the HB group, based on the depression subscale of the SCL-90-R. The computerized neurocognitive function test suggest several results 1) Within the memory domain, it was found that one of the two memory tests in MDD and HB groups were significantly impaired in comparison to the control group. 2) Within the attention domain, it was found that only the MDD group was significantly impaired in comparison to the control group. 3) Within the higher cortical function domain, it was found that significant impairment exist in MDD group and HB group compared to the control group; the severity of impairment was found to be more profound in the MDD group than in the HB group. Conclusion:These results suggest that both HB group and MDD group have significantly decreased neurocognitive function than the control group, and neurocognitive function of the HB group is better than that of the MDD group.

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한방병원에 내원한 위마비 및 비위마비성 기능성 소화불량증 환자에 대한 위 운동성 및 임상적 속성에 관한 연구 (Study of Gastric Electrical Activity and Clinical Characteristics in Patients with Gastroparesis or Non-gastroparetic Functional Dyspepsia in Eastern Traditional Medicine)

  • 이준석;이선령;엄국현;김현경;장선영;유종민;김진성;류봉하;류기원;윤상협
    • 대한한방내과학회지
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    • 제26권4호
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    • pp.785-794
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    • 2005
  • Little is known concerning the pathophysiology and symptomatology of gastric dysmotility of patients who have sought treatment in eastern traditional medicine. The aim of this study was to investigate gastric electrical activity and clinical characteristics between gastroparesis and non-gastroparetic functional dyspepsia(FD) and assess the necessity to distinguish them for eastern traditional medical treatment. 60 patients were surveyed by questionnaire. Gastric electrical activity was recorded and analyzed using electrogas-trography. Patients were divided into gastroparesis and non-gastroparetic FD by 1.0 of power ratio. Healthy persons were used as reference. Postprandial normogastria of gastroparesis decreased and that of non-gastroparetic functional dyspepsia increased compared before and after meals. Suggested causes of onset were the meat diets that most patients were on in the gastroparesis group, and that drugs that patients in the non-gastroparetic FD group were taking. Distribution of main symptom was equally regular in patients with gastroparesis, but patients with non-gastroparetic FD showed mainly upper abdominal pain and fullness. Values for the gastroparesis group were double those for the non-gastroparesis FD group in frequency of upper GI endosopic examination. Results suggest that effective application of eastern traditional medical treatment requires that first a clear distinction be made in state of gastric dysmotility and clinical characteristics of gastroparesis and non-gastroparesis FD when treating dyspepsia.

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Isolation and Characterization of Pepper mottle virus Infecting Tomato in Korea

  • Kim, Mi-Kyeong;Kwak, Hae-Ryun;Han, Jung-Heon;Ko, Sug-Ju;Lee, Su-Heon;Park, Jin-Woo;Jonson, Miranda Gilda;Kim, Kook-Hyung;Kim, Jeong-Soo;Choi, Hong-Soo;Cha, Byeong-Jin
    • The Plant Pathology Journal
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    • 제24권2호
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    • pp.152-158
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    • 2008
  • A peculiar virus-like disease of tomato showing yellow mosaic and necrotic spots on leaves and necrosis on veins, petioles and stems was observed at the Tomato Experimental Station (TES), Buyeo, Chungcheongnamdo, Korea. The disease incidence at TES fields ranged from 21 to 35% infecting different tomato cultivars. For this reason, to identify the virus infecting tomato and to characterize the virus based on biology, serology, cytology and at molecular level. Here, leaf samples were randomly collected from different infected tomato cultivars at TES fields and greenhouses and tested by ELISA using Pepper mottle virus (PePMoV) and Tomato mosaic virus (ToMV) antisera. Infected saps were mechanically inoculated in different host plants to test for pathogenicity, symptomatology and host ranges. Infected tissues and ultrathin sections were examined by electron microscopy. Finally, putative coat protein and 3'-untranslated region (CP/3'-UTR) fragment was amplified and cloned for sequence determination and analyzed its genetic relationship to existing PepMoV and PVY sequences at the Genbank. Results showed 69% of the samples were positive with PepMoV, 13% with ToMV and 19 % were doubly infected with PepMoV and ToMV. Symptoms greatly varied from different host plants inoculated with tomato leaf sap infected with PepMoV alone and discussed in detailed in this paper. Electron microscopy from infected tissues showed filamentous particles of 720-750nm in length, a typical morphology and size of PepMoV. In addition, cylindrical inclusion bodies, pinwheels, scrolls and laminates with masses of fibrillar inclusions were also found in ultrathin sections. Alignment of the sequences of the CP/3'-UTR revealed >96% sequence identity with PepMoV and only <61% with PVY. Taken together, all these evidences presented clearly indicated that the causal agent infecting tomato at TES was PepMoV and we designated this PepMoV infecting tomato as Tom-sd2 strain in this study.

Evaluation of Women with Myofascial Abdominal Syndrome Based on Traditional Chinese Medicine

  • Mitidieri, Andreia;Gurian, Maria Beatriz;Silva, Ana Paula;Tawasha, Kalil;Poli-Neto, Omero;Nogueira, Antonio;Reis, Francisco;Rosa-e-Silva, Julio
    • 대한약침학회지
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    • 제18권4호
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    • pp.26-31
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    • 2015
  • Objectives: This study used semiology based on traditional Chinese medicine (TCM) to investigate vital energy (Qi) behavior in women with abdominal myofascial pain syndrome (AMPS). Methods: Fifty women diagnosed with chronic pelvic pain (CPP) secondary to AMPS were evaluated by using a questionnaire based on the theories of "yin-yang," "zang-fu", and "five elements". We assessed the following aspects of the illness: symptomatology; specific location of myofascial trigger points (MTrPs); onset, cause, duration and frequency of symptoms; and patient and family history. The patients tongues, lips, skin colors, and tones of speech were examined. Patients were questioned on various aspects related to breathing, sweating, sleep quality, emotions, and preferences related to color, food, flavors, and weather or seasons. Thirst, gastrointestinal dysfunction, excreta (feces and urine), menstrual cycle, the five senses, and characteristic pain symptoms related to headache, musculoskeletal pain, abdomen, and chest were also investigated. Results: Patients were between 22 and 56 years old, and most were married (78%), possessed a elementary school (66%), and had one or two children (76%). The mean body mass index and body fat were 26.86 kg/cm2 (range: 17.7 - 39.0) and 32.4% (range: 10.7 - 45.7), respectively. A large majority of women (96%) exhibited alterations in the kidney meridian, and 98% had an altered gallbladder meridian. We observed major changes in the kidney and the gallbladder Qi meridians in 76% and 62% of patients, respectively. Five of the twelve meridians analyzed exhibited Qi patterns similar to pelvic innervation Qi and meridians, indicating that the paths of some of these meridians were directly related to innervation of the pelvic floor and abdominal region. Conclusion: The women in this study showed changes in the behavior of the energy meridians, and the paths of some of the meridians were directly related to innervation of the pelvic floor and abdominal region.

산지유통조직의 차이점 분석을 통한 산지조직화 활성화 방안 연구 (A Study on Activating a Producing Organization by Analyzing the Difference)

  • 김창환;박주섭
    • 유통과학연구
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    • 제12권12호
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    • pp.65-73
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    • 2014
  • Purpose - Distribution of agricultural products is collapsing due to recent changes in the environment balance between retailers and producers. Further, the increase in the imports of agricultural products due to free trade has caused revenue problems for producers. Agricultural producers are faced with increasing difficulties, and the organized producing center's importance is growing each day. Korean organized producing centers' policies have been conducted since 2000, and have thus been sustained for more than 10 years. Organizing a producing center's business is focused on agricultural cooperative and farming association corporation this has already have been carried out. In addition, it has achieved significant results through these organizations, but it still has many problems. Research design, data, and methodology - Organized producing centers were classified for each type. The survey covered 90 organizations, based on factor analysis, analysis of balance, and logistic regression analysis. The results of the conducted factor analysis are as follows. Production, marketing, human resources management, organizational skills, post management, safety, and scale were classified as the seven kinds of factors. These are the factors that affect the organized producing centers through the variance analysis and logistic regression analysis. The purpose of such research and analysis is to suggest the direction for the future organized producing centers' policies. Result - Results of the analysis of the variance are listed below. Items by type, production, marketing, human resource management, and organizational skills are shown to depict differences between the factors. Organization form results show that production and marketing showed a difference between the factors. The size of the organization, production, and marketing showed the difference between the factors. The factors affect organized producing centers differently depending on the type shown, as seen from the results. In contrast, the logistic regression results of the analysis are as follows. Considering the results by the type of item, and the horticulture type of marketing, human resource management has a (+) influence. Grain type and production showed a (+) influence. New types of income affecting organizational skills have a (+) influence. Considering the results for each type of organization, the agricultural cooperative type of marketing and human resource management have (+) influence. Farming association corporation type of production has a (+) influence. As a result, the size of the organization is as follows. Large organizations are production, expressed in marketing with a (+) impact. Medium-size organizations are expressed with their size factor having a (+) impact. Small organizations are expressed with a safety factor having a (+) impact. Conclusions - The types of factors display different effects. One factor is that the type of a (+) represents the influence of other factors (-) as per factor symptomatology. Therefore, the type of measures to organize a strategy to maximize the benefits of your organization should be pursued. In addition, based on the support for small organizations, improving the quality of the producer organization should be considered.

한국 여성에서 비만과 우울증의 연관성 (The Relationship between Obesity and Depression in Korean Women)

  • 윤대현;박진호;이철민;신찬수;조상헌;오병희
    • 정신신체의학
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    • 제15권1호
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    • pp.51-55
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    • 2007
  • 연구목적 : 비만과 우울증은 모두 심각한 공공 의료 문제이고 특히 주된 심혈관계 질환 위험인자이다. 비만과 우울증 상에 관한 해외 연구는, 일정한 결론은 아니나, 여러 연구에서 연관성 존재를 보고하고 있고 특히 일부 연구는 여성에서 그 연관 정도가 큼을 보고 한 바 있다. 본 연구는 한국 여성에서 있어 비만, 특히 복부비만과 우울증상의 연관성을 분석하고자 한다. 방법: 여성 연구 대상자 4,609명을 대상으로 Beck 우울 척도 및 체계측을 시행한 결과를 이용 우울증상과 비만과의 연관성을 분석하였다. 비만도는 체질량지수로 정하였으며 체질량지수 $25kg/m^2$ 이상을 비만으로 하였고 복부비만은 허리둘레 85cm 이상으로 정의하였다. 임상적으로 우울증을 의심할 수 있는 Beck 우울척도 분할점은 16점으로 하였다. 결과: 정상 체중군에 비해 비만 여성군에서 우울 여성의 비율이 유의미하게 높았고(27.6% VS. 23.2%, p<0.01), 복부 비만 여성에서도 우울 여성군의 비율이 통계적으로 유의하게 높았고(26.9% VS. 22.7%, p<0.01), 비만 여성군 중 우울 여성에서 복부 비만 가진 비율이 통계적으로 유의미하게 높았다(93.2% VS. 86.9%, p<0.01). 결론 : 본 연구의 결과는 한국 여성에서 비만, 특히 복부비만과 우울증간 연관성이 존재함을 보였고 향후 전향적 연구를 통한 비만과 우울증간 상호 역할에 대한 적극적 이해가 필요함을 시사한다.

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기면병(嗜眠炳)의 야간(夜間) 수면분절(睡眠分節) 및 임상적(臨床的) 의미(意味) (Nocturnal Sleep Fragmentation in Narcoleptics and Its Clinical Implications)

  • 박두흠;손창호;정도언
    • 수면정신생리
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    • 제3권1호
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    • pp.47-55
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    • 1996
  • Narcolepsy is characterized by sleep attack with excessive daytime sleepiness(EDS), cataplexy, sleep paralysis, and hypnagogic hallucination. Paradoxically, narcoleptics tend to complain of frequent arousals and shallow sleep during the night time despite their excessive sleepiness. However, nocturnal sleep fragmentation in narcoleptics is relatively ignored in treatment strategies, compared with sleep attack/EDS and cataplexy. In our paper, we attempted to investigate further on the poor nocturnal sleep in narcoleptics and to discuss possible treatment interventions. Out of consecutively seen patients at Seoul National University Sleep Disorders Clinic and Division of Sleep Studies, we recruited 57 patients, clinically assessed as having sleep attack and/or EDS. Nocturnal polysomnography and multiple sleep latency test(MSLT) were done in each of the subjects. We selected 19 subjects finally diagnosed as narcolepsy(mean age $26.0{\pm}18.3$ years, 16 men and 3 women) for this study, depending on the nocturnal polysomnographic and MSLT findings as well as clinical history and symptomatology. Any subject co-morbid with other hypersomnic sleep disorders such as sleep apnea or periodic limb movements during sleep was excluded. Sleep staging was done using Rechtschaffen and Kales criteria. Sleep parameters were calculated using PSDENT program(Stanford Sleep Clinic, version 1.2) and were compared with the age-matched normal values provided in the program. In narcoleptics, compared with the normal controls, total wake time was found to be significantly increased with significantly decreased sleep efficiency(p<.01, p<.05, respectively), despite no difference of sleep period time and total sleep time between the two groups. Stage 2 sleep%(p<.05), slow wave sleep%(p<.05), and REM sleep%(p<.01) were found to be significantly decreased in narcoleptics compared with normal controls, accompanied by the significant increase of stage 1 sleep%(p<.01). Age showed negative correlation with slow wave sleep%(p<.05). The findings in the present study indicate significant fragmentation of nocturnal sleep in narcoleptics. Reduction of REM sleep% and the total number of REM sleep periods suggests the disturbance of nocturnal REM sleep distribution in narcoleptics. No significant correlations between nocturnal polysomnographic and MSLT variables in narcoleptics suggest that nocturnal sleep disturbance in narcoleptics may be dealt with, in itself, in diagnosing and managing narcolepsy. With the objective demonstration of qualitative and quantitative characteristics of nocturnal and daytime sleep in narcoleptics, we suggest that more attention be paid to the nocturnal sleep fragmentation in narcoleptics and that appropriate treatment interventions such as active drug therapy and/or circadian rhythm-oriented sleep hygiene education be applied as needed.

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강낭콩에서 종자전염된 Bean Common Mosaic Virus의 분류동정에 관한 연구 (Identification of Bean Common Mosaic Virus Obtained from Seeds of Phaseolus vulgaris)

  • 최용문;이순형;박종성;김정수
    • 한국응용곤충학회지
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    • 제23권1호
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    • pp.15-21
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    • 1984
  • 강낭콩에서 종자전염된 바이러스병을 동정하기 위하여 각지역 농가 및 시장에서 종자를 수집파종하여 종자전염을 조사한 결과 수원, 장수, 진주에서 채집한 종자가 $2.0\~3.5\%$ 이병되어 있었으며 종자전염된 바이러스를 지표식물에 접종한 결과 강낭콩에 상엽에 모자익, Chenopodium quinoa의 접종엽에 대형의 국부병반이 형성되었다. Dip법에 의하여 시료를 제작하여 입자를 관찰한 결과 약 750nm의 계상입자가 관찰되었다. 이병 강낭콩의 조직에서 Cylinder와 Pinwheel형 및 bundle형의 봉입체(Inclusion hody)가 관찰되었다. 복숭아진딧물에 의하여 충매전염 되었으며 즙액전염된 이병주로부터 채집한 종자의 전염율은 $18.2\%$였다. 물리적성질은 내희석성이 $1,000\~5,000$배 였으며 내보존성은 실온에서 $2\~3$일, 내열성은 $55\~60^{\circ}C$였다. 항혈청검정 결과 혼합침강반응에서 양성의 반응을 나타냈으며 SDS처리에 의한 한천내이중확산법에서 BCMV 항혈청과 band를 형성하였으며 AzMV와는 spur가 형성되지 않았으며 CAMV와는 spur를 형성하였다. 이상의 결과로 강낭콩에서 종자전염된 바이러스는 Bean common mosaic virus로 동정되었다.

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건강한 성인을 대상으로 면역증강 및 상기도 감염 예방에 대한 동충하초주정추출물의 유효성 평가 : 이중맹검 플라세보 대조 연구 (Effects of Cordyceps militaris supplementation on the immune response and upper respiratory infection in healthy adults: a randomized, double-blind, placebo-controlled study)

  • 정수진;황지현;오미라;채수완
    • Journal of Nutrition and Health
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    • 제52권3호
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    • pp.258-267
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    • 2019
  • 본 연구는 한국인 건강한 성인에게서 12주간 동충하초 주정추출물의 섭취가 면역기능 증진 및 상기도감염 예방효과에 대해 확인하였다. 면역관련 지표인 NK-cell activity는 시험식품 섭취군이 플라세보군에 비해 유의적으로 증가하여 (p = 0.047) 면역증강 효과에 대해 확인하였다. 또한, 점막 면역에 주요 역할을 하는 항체 IgA 변화량은 시험식품 섭취군에서 플라세보군에 비해 통계적으로 유의하게 증가하였다 (p = 0.035). 본 연구대상자의 상기도감염(URI) 발생률은 시험식품 섭취군과 플라세보군, 두 군 간 유의한 차이는 관찰할 수 없었다. 안전성 평가인 진단검사의학 검사와 활력진후 결과에서도 섭취군 내 및 섭취군 간 의미 있는 변화 또는 차이는 관찰되지 않았다. 본 연구에서 동충하초주정추출물의 섭취가 URI 발생률에 대한 유의한 변화는 관찰할 수는 없었으나 면역지표인 NK-cell 활성 증가와 혈청 IgA 농도 증가를 통해 선천성 면역과 후천성 면역을 증진시키는 작용이 있어, 잠재적인 상기도감염 예방 효과에 관련성 있을 것으로 사료되며, 항생제의 약물 의존도를 낮추며 삶의 질 개선 및 국민보건 향상에 기여할 것으로 사료된다.

Stem Rot of Pearl Millet Prevalence, Symptomatology, Disease Cycle, Disease Rating Scale and Pathogen Characterization in Pearl Millet-Klebsiella Pathosystem

  • Vinod Kumar Malik;Pooja Sangwan;Manjeet Singh;Pavitra Kumari;Niharika Shoeran;Navjeet Ahalawat;Mukesh Kumar;Harsh Deep;Kamla Malik;Preety Verma;Pankaj Yadav;Sheetal Kumari;Aakash;Sambandh Dhal
    • The Plant Pathology Journal
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    • 제40권1호
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    • pp.48-58
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    • 2024
  • The oldest and most extensively cultivated form of millet, known as pearl millet (Pennisetum glaucum (L.) R. Br. Syn. Pennisetum americanum (L.) Leeke), is raised over 312.00 lakh hectares in Asian and African countries. India is regarded as the significant hotspot for pearl millet diversity. In the Indian state of Haryana, where pearl millet is grown, a new and catastrophic bacterial disease known as stem rot of pearl millet spurred by the bacterium Klebsiella aerogenes (formerly Enterobacter) was first observed during fall 2018. The disease appears in form of small to long streaks on leaves, lesions on stem, and slimy rot appearance of stem. The associated bacterium showed close resemblance to Klebsiella aerogenes that was confirmed by a molecular evaluation based on 16S rDNA and gyrA gene nucleotide sequences. The isolates were also identified to be Klebsiella aerogenes based on biochemical assays, where Klebsiella isolates differed in D-trehalose and succinate alkalisation tests. During fall 2021-2023, the disease has spread all the pearl millet-growing districts of the state, extending up to 70% disease incidence in the affected fields. The disease is causing considering grain as well as fodder losses. The proposed scale, consisting of six levels (0-5), is developed where scores 0, 1, 2, 3, 4, and 5 have been categorized as highly resistant, resistant, moderately resistant, moderately susceptible, susceptible, and highly susceptible disease reaction, respectively. The disease cycle, survival of pathogen, and possible losses have also been studied to understand other features of the disease.