• Genomics & Informatics
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• 제6권4호
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• pp.181-191
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• 2008

RAS guanyl-releasing protein 3 (RasGRP3), a member of the Ras subfamily of GTPases, functions as a guanosine triphosphate (GTP)/guanosine diphosphate (GDP)-regulated switch that cycles between inactive GDP- and active GTP-bound states during signal transduction. Various growth factors enhance hepatocellular carcinoma (HCC) proliferation via activation of the Ras/Raf-1/extracellular signal-regulated kinase (ERK) pathway, which depends on RasGRP3 activation. We investigated the relationship between polymorphisms in RasGRP3 and progression of hepatitis B virus (HBV)-infected HCC in a Korean population. Nineteen RasGRP3 SNPs were genotyped in 206 patients with chronic liver disease (CLD) and 86 patients with HCC. Our results revealed that the T allele of the rs7597095 SNP and the C allele of the rs7592762 SNP increased susceptibility to HCC (OR=1.55, p=0.04 and OR=1.81${\sim}$2.61, p=0.01${\sim}$0.03, respectively). Moreover, patients who possessed the haplotype (ht) 1 (A-T-C-G) or diplotype (dt) 1 (ht1/ht1) variations had increased susceptibility to HCC (OR=1.79${\sim}$2.78, p=0.01${\sim}$0.03). In addition, we identified an association between haplotype1 (ht1) and the age of HCC onset; the age of HCC onset are earlier in ht1 +/+ than ht1 +/- or ht1 -/- (HR=0.42${\sim}$0.66, p=0.006${\sim}$0.015). Thus, our data suggest that RasGRP3 SNPs are significantly associated with an increased risk of developing HCC.

• 전자공학회논문지 IE
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• 제45권1호
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• pp.31-37
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• 2008

A Wibro RF down converter of 2.3GHz band is designed and implemented in this paper. The problems that can occur in the receiver LNA(Low Noise Amplifier) to minimize additional purposes. In addition, 2.3GHz band from the 75 MHz downward to minimize the losses in the process, transform and improve efficiency, and achieve stable characteristics can be used to make high frequency characteristics of the device. Wibro repeater uses a TDMA(Time Division Multiplexing Access) method is needed because the RF switch. Production criterion specification, the input voltage from +8 V 1.2A of current consumption, 60dB gain and the noise figure of less than 2.5dB, VSWR(Voltage Standing Wave Ratio) less than 1.5, more than IMD(Inter Modulation Distortion) 60dB satisfied. Environmental conditions ($-20^{\circ}C$ to $70^{\circ}C$) to pass the test of reliability in a long time, that seemed crafted Wibro down converter be applied to the Wibro repeater.

• Journal of rehabilitation welfare engineering & assistive technology
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• 제7권2호
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• pp.55-62
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• 2013

The exoskeleton robot to assist walking of hemiplegia patients or disabled persons has been studied in this paper. The exoskeleton robot with degrees of freedom of 2 axis has been developed and tested for joint motion. The obtained EMG signal from normal person was analyzed and the control signal was extracted from it for convenient and automotive performance of assistance robot to help hemiplegia patient walks as normal person does. the purpose of using FES(Functional Electrical Stimulation) for hemiplegia patient's walk is to restore damaged body function by this, but this could give fatal electrical shock to patients by wrong use or cause quick fatigue in muscle by continuous stimulation. The convenient movement of hemiplegia patients with minimum muscle fatigue was looked possibly by operation of assistance robot exoskeleton using control signal. and the walking assistance exoskeleton robot seemed works more efficiently than using FES stimulator. The experiment in this study was performed based on usual motion in our life like walking, standing-up, sitting-down, and particularly feedback control system using Piezo sensor along with button switch was applied for smooth swing motion in walking. The experiment also shows that hemiplegia patients can move conveniently by using electromyogram signal of healthy leg for the operation signal of assistance robot system attached at damaged symmetrical leg.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제17권10호
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• pp.2395-2402
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• 2013

An active-RC channel selection filter (CSF) with the bandwidth of 40MHz and the improved linearity is proposed in this paper. The proposed CSF is the fifth butterworth filter which consists of a first order low pass filter, two second order low pass filters of a biquad architecture, and DC feedback circuit for cancellation of DC offset. To improve the linearity of the CSF, a body node of a MOSFET for a switch is connected to its source node. The bandwidth of the designed CSF is selected to be 10MHz, 20MHz and 40MHz and its voltage gain is controlled by 6 dB from 0 dB to 24 dB. The proposed CSF is designed by using 40nm 1-poly 8-metal CMOS process with a 1.2V. When the designed CSF operates at the bandwidth of 40 MHz and voltage gain of 0 dB, the simulation results of OIP3, in-band ripple, and IRN are 31.33dBm, 1.046dB, and 39.81nV/sqrt(Hz), respectively. The power consumption and layout area are $450{\times}210{\mu}m^2$ and 6.71mW.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제13권10호
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• pp.4773-4779
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• 2012

In this paper we propose two types of reconfigurable 3-D beam steering antenna for intelligent or smart antenna system. Proposed antennas are composed of triangular(structure1.) or circuler(structure2.) loop structure and bended dipole antenna structure. This antenna can steer beam pattern of 6 direction at xy-plane state (0, 1, 2) and xz-plane state (3, 4, 5) by 4 switch motion with one antenna element. Antenna structure1. is symmetric equilibrium structures based on feeding point. There is no grounding point. As a result, designed antenna's gain is similar to dipole antenna. Also, As unbalanced structure by using CPWG in the form of a semicircular, structure2. is enhanced directivity. The operation frequency of antenna are 2.5 GHz(Structure1.) and 2.55 GHz(Structure2.), maximum gain is 1.04 ~ 2.06 dBi(Structure1. : Omni-directional beam), 1.6 ~ 4 dBi(structure2. : Directional beam). The overall HPBW is about over $160^{\circ}$ in the both of the xy-plane and xz-plane at structure1. and over $125^{\circ}$ at structure2.

• Korean Journal of Construction Engineering and Management
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• 제13권6호
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• pp.3-12
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• 2012

The slowdown of private building industry resulted in growth of remodeling market as a way to improve energy performance. Remodeling is considered more cost-effective and eco-friendly approach for energy efficient building than new construction. Since 2008, Seoul has promoted Building Retrofit Project (BRP) preponderantly to attract energy-saving renovation by supporting building owners to switch building system into energy-saving system when they remodel their old buildings. According to 2012 press release, 254 Private sectors participated in this green building project and annually reduced 41000ton of greenhouse gas emission, 14000TOE, which also result in 7.5 billion won energy cost savings per year. The paper focuses on the building envelope remodeling as a way to improve energy efficiency. Different components of the building envelope such as wall insulation, window, and shading, were applied to the baseline model and the comparison was analyzed to come up with the ideal solution. This study only assesses the building envelope as to suggest the way to redesign the better energy performing building. Offering solution focusing on the architectural feature is essential because it will provide basic information and standard when remodeling a building for energy efficiency, especially, for the nonresidential buildings used as rental offices.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• 제48권6호
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• pp.467-478
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• 2020

Hypervisor virtualize hardware resources to utilize them more effectively. At the same time, hypervisor's characteristics of time and space partitioning improves reliability of flight software by reducing a complexity of the flight software. Korea Aerospace Research Institute chooses one of hypervisors for space, XtratuM, and examine its applicability to the flight software. XtratuM has strong points in performance improvement with high reliability. However, it does not support SMP. Therefore, it has limitation in using it with high performance applications including satellite altitude orbit control systems. This paper proposes RTEMS XM-SMP to support SMP with RTEMS, one of real time operating systems for space. Several components are added as hypercalls, and initialization processes are modified to use several processors with inter processors communication routines. In addition, all components related to processors are updated including context switch and interrupts. The effectiveness of the developed RTEMS XM-SMP is demonstrated with a GR740 board by executing SMP benchmark functions. Performance improvements are reviewed to check the effectiveness of SMP operations.

• Journal of the Institute of Electronics Engineers of Korea CI
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• 제46권3호
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• pp.96-106
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• 2009

Extending the scale of the distributed processing in a single Ethernet cluster is physically restricted by maximum ports per switch. This paper presents an implementation of MPI-based multicluster consisting of multiple Ethernet switches for extending the scale of distributed processing, and a asymptotical analysis for communication overhead through execution-time analysis model. To determine an optimum task partitioning, we analyzed the processing time for various partitioning schemes, and AAP(accumulator array partitioning) scheme was finally chosen to minimize the overall communication overhead. The scope of data partitioned in AAP was modified to fit for incremented nodes, and suitable load balancing algorithm was implemented. We tried to alleviate the communication overhead through exploiting the pipelined broadcast and flat-tree based result gathering, and overlapping of the communication and the computation time. We used the linear pipeline broadcast to reduce the communication overhead in intercluster which is interconnected by a single link. Experimental results shows nearly linear speedup by the proposed parallel distributed GHT implemented on MPI-based Ethernet multicluster with four 100Mbps Ethernet switches and up to 128 nodes of Pentium PC.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6813-6823
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• 2015

Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive of human brain tumors and has a stunning progression with a mean survival of one year from the date of diagnosis. High cell proliferation, angiogenesis and/or necrosis are histopathological features of this cancer, which has no efficient curative therapy. This aggressiveness is associated with particular heterogeneity of the tumor featuring multiple genetic and epigenetic alterations, but also with implications of aberrant signaling driven by growth factors. The transforming growth factor ${\beta}$ ($TGF{\beta}$) superfamily is a large group of structurally related proteins including $TGF{\beta}$ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF). It is involved in important biological functions including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. This superfamily is also considered to impact on cancer biology including that of GBM, with various effects depending on the member. The $TGF{\beta}$ subfamily, in particular, is overexpressed in some GBM types which exhibit aggressive phenotypes. This subfamily impairs anti-cancer immune responses in several ways, including immune cells inhibition and major histocompatibility (MHC) class I and II abolishment. It promotes GBM angiogenesis by inducing angiogenic factors such as vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI-I) and insulinlike growth factor-binding protein 7 (IGFBP7), contributes to GBM progression by inducing metalloproteinases (MMPs), "pro-neoplastic" integrins (${\alpha}v{\beta}3$, ${\alpha}5{\beta}1$) and GBM initiating cells (GICs) as well as inducing a GBM mesenchymal phenotype. Equally, Nodal promotes GICs, induces cancer metabolic switch and supports GBM cell proliferation, but is negatively regulated by Lefty. Activin promotes GBM cell proliferation while GDF yields immune-escape function. On the other hand, BMPs target GICS and induce differentiation and sensitivity to chemotherapy. This multifaceted involvement of this superfamily in GBM necessitates different strategies in anti-cancer therapy. While suppressing the $TGF{\beta}$ subfamily yields advantageous results, enhancing BMPs production is also beneficial.

• Journal of the Economic Geographical Society of Korea
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• 제20권3호
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• pp.267-286
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• 2017

The main purpose of this paper is to identify the spatiality of North Korea and China border regions through investigating the exceptional characteristics of the regions with the concept of positionality, which allows us to realize the relative position between subject and object. Border regions could be identified appropriately by considering the concept of switching positionality, as it is a kind of multiple space in which its sudden closure and opening should be configured in accordance with geopolitical and geoeconomic changes centering around border line. The main arguments of this research concerned with border regions with the concept of switching positionality are fallen into three. Firstly, changes in border regions should be analyzed by investigating more broader contexts and conjunctural perspectives, and even an internal condition stemmed from locality. Secondly, trajectories of border regions could be analyzed by the assemblages of various powers. Finally, the positionality of economic actors should be examined by identifying dynamic relations between geoeconomics and geopolitics. In particular, the concept of positionality has led to a number of insights into discussions on time-space, and spatiality in relational-dialectical, socio-spatial, and power-topological perspectives. Based upon this concept of positionality, the research has identified exceptional characteristics in North Korea and China border regions. It argues that the exceptionality of the region has stemmed from the intersection between the unstability of geopolitical security and various geoeconomic benefits.